JP2001139436A - Hair tonic and grower - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic and grower having excellent preventing effects on alopecia and hair tonic and growing effects. SOLUTION: This hair tonic and grower is characterized as comprising an extract from Myrrha.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention provides an excellent hair loss preventing effect,
The present invention relates to a hair growth and hair growth agent having a hair growth effect such as a hair growth effect.

[0002]

2. Description of the Related Art Causes of baldness and hair loss include activation of androgens in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and abnormal scalp due to production of peroxide. It has been considered that components for removing or reducing the above-mentioned causes have been added to conventional hair-growth and hair-growth agents.

[0003]

However, conventional hair-growing and hair-growing agents have not always had sufficient hair-growth effects such as a hair loss-preventing effect and a hair-growth effect.

[0004]

Means for Solving the Problems The present inventor has made intensive studies in view of the above-mentioned circumstances, and as a result, by blending an extract of myrrh, a hair-growth / hair-growth effect having an excellent hair-growth-preventing effect and a hair-growth / hair-growth effect. It has been found that an agent can be obtained, and the present invention has been completed.

That is, the present invention provides a hair restorer / hair restorer characterized by containing a myrrh extract.

The myrrh of the crude drug used in the hair restorer and hair restorer of the present invention may be prepared from a resin obtained by coagulating the secretion of a tree of Burseraceae. It is not limited. As a base plant for myrrh, for example, Commiphora molmol ENGL. (= C. Myrr
ha ENGL.) and Balsamodendron ehrenbergianum BERG.
B. gileadense KUNTH; B. opobalsammum KUNTH; B. m
eccaensis GLED.), etc., and can be obtained by cutting the stems of these plants or collecting the resin that has flowed out and solidified naturally.

[0007] Myrrh is distinguished by its original plant and locality, and is called Somali myrrh;
rrh), Arabian myrrh (Eadhli myrr)
h), Yemen myrrh, Bissabol myrrh and the like.

[0008] Myrrh contains resin, essential oils such as pinene and limonene, gum, and the like, and is used internally as a stomachic, menstrual and tonic, or as an astringent for toothpaste and gargle. However, it has not been known that the myrrh extract has a hair-growth / hair-growth effect.

The myrrh extract used in the present invention can be obtained by pulverizing the myrrh resin into a suitable size and extracting it with a solvent at room temperature or under heating conditions. As the extraction solvent, for example, water or lower alcohols such as methanol and ethanol or water-containing lower alcohols, propylene glycol, polyhydric alcohols such as 1,3-butylene glycol or water-containing polyhydric alcohols, dichloromethane, organic solvents such as ethyl acetate and the like. No. Among them, ethanol or hydrous ethanol (ethanol 10 to 95%)
Is preferred. Hereinafter, the compounding amount is indicated based on the dry weight of the extract obtained by extraction with each extraction solvent.

The amount of the myrrh extract used in the present invention is preferably 0.0001 to 10% by weight. Particularly preferably, it is 0.0005 to 5% by weight. If the amount is less than 0.0001% by weight, sufficient hair-growth and hair-growth effects cannot be obtained, and
No further effect can be obtained even if the content exceeds% by weight.

In the present invention, although a sufficient effect can be obtained by using only a myrrh extract, it is also possible to combine the extract with a cell activator or a blood circulation promoting agent conventionally used in hair growth and hair growth agents.

The cell activator that can be used in the present invention includes:
Pantothenic acid and its derivatives (pantothenyl ethyl ether), photosensitizer No. 301, carrot extract, biotin,
Mononitroguaiacol, hinokitiol, allantoin, pentadecanoic acid glyceride and the like.

[0013] The blood circulation promoter that can be used in the present invention includes:
Carpronium chloride, Assembly extract, Pepper tincture, Cepharanthin, Benzyl nicotinate, Garlic extract, Touki extract, Gentian extract, γ-Oryzanol, Licorice, Minoxidil, Senkyu, Ginseng ginseng, Panax ginseng, Ginger, Jio, Aloe, Spironolactone, Vitamin B ₆ hydrochloride, D- camphor, DL-camphor, DL-alpha-tocopherol, iodide garlic extract, DL-alpha-tocopherol Reno maleic acid esters, inositol hexa nicotinate, vitamin E, sodium dextran sulfate, nicotinic acid, DL- α-tocopherol nicotinic acid ester,
Butoxyethyl nicotinate, methyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol succinate, DL-α-tocopherol acetate, canthalistin tincture, ginger tincture and the like, in particular, carpronium chloride, cepharanthin, DL-α -Tocopherol, garlic iodide extract, assembly extract, DL-α
-Tocopherol nicotinic acid ester, benzyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol acetate, pepper tincture, cantaris tincture, ginger tincture, and the like are preferable from the viewpoint of hair-growth effect.

The amount of these cell activators or blood circulation promoters is preferably 0.0001 to 10% by weight. 0.0
If it is less than 001% by weight, sufficient hair-growth and hair-growth effects cannot be obtained, and if it exceeds 10% by weight, no further effect can be obtained.

In addition to the above-mentioned active ingredients, benzalkonium chloride, salicylic acid, chlorhexidine hydrochloride, Photosensitizer 201, chlorhexidine gluconate, chlorxylenol, trichlorocarbanilide, Fungicides such as halocarban; glycyrrhizin and its derivatives, diphenhydramine hydrochloride, guaiazulene,
Anti-inflammatory agents such as carbenoxolone disodium, sicon extract, age, l-menthol, hydrocortisone acetate, prednisolone, etc .; moisturizing agents such as sodium hyaluronate, glycerin, sodium pyrrolidone carboxylate, mini sasanishiki extract, chondroitin sulfate, cordyceps extract, saffron extract, etc. Keratolytic agents such as salicylic acid, resorcinol and lactic acid; local stimulants such as peppermint oil; estrogen such as estrone, estradiol and ethinyl estradiol; pyridoxine and its derivatives;
Antiseborrheic agents such as thioxolone, vanside, lecithin; nutrients such as amino acids, cystine, cysteine, methionine, serine, vitamins, and oils (isopropyl myristate, lecithin, squalane, higher fatty acids, higher alcohols, etc.), interface Activator (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, glycerin fatty acid ester, etc.), polyhydric alcohol (propylene glycol, glycerin, macrogol, etc.), antioxidant (dibutylhydroxytoluene, isopropyl gallate) ), Sequestering agents (such as ethylenediaminetetraacetate or a salt thereof), water, ethanol, a thickener,
Dyes, fragrances, and the like can be appropriately compounded as long as the effects of the present invention are not impaired.

The hair restorer / hair restorer of the present invention comprises one to several times a day,
An appropriate amount is applied to the scalp and used. In addition, the hair growth of the present invention
Hair restorer can be prepared according to a conventional method, the dosage form is not particularly limited, conventionally known hair tonic, hair lotion, hair cream, hair conditioner, shampoo, rinse, hair gel, hair mist, hair foam,
It can be in the form of an aerosol, an ointment or the like.

[0017]

BEST MODE FOR CARRYING OUT THE INVENTION Preparation Example 1 (Preparation of Myrrh Extract) 30 g of ground myrrh resin was extracted with 300 ml of ethanol for 1 day at room temperature and filtered to obtain an extract. This was concentrated under reduced pressure, and the solvent was distilled off to obtain 6 g of a myrrh extract as a solid.

Next, the effects of the myrrh extract of the present invention on hair growth and hair growth are shown by cell proliferation test. <Test of hair papilla cell proliferation> A test of hair papilla cell proliferation was performed according to the following procedure. 1) Rat hair papilla cells (manufactured by Toyobo Co., Ltd.)
DMEM (Dulbecco modified Eagl) containing CS (fetal calf serum)
60mm dish (Type I collagen coa)
ted). 2) When it becomes Confluent, trypsinize and then DME
M (containing 10% FCS) to prepare a cell suspension, and put it in a 96-well microplate (Type I collagen coated).
Cell seeding at a cell concentration of × 10 ³ / well. 3) One day culture in DMEM (containing 10% FCS). 4) Myrrh extract prepared in Production Example 1 was added to DMEM (10%
FCS compounded). 5) The culture medium of the dermal papilla cells cultured in the 96-well microplate was removed, washed with a phosphate buffer solution [PBS (-)], and then 4 μl of the culture medium containing the myrrh extract of 4) was added. 6) The cells were cultured for 3 days under conditions of 37 ° C. and 5% CO ₂ . 7) 0.5 mg / ml M
TT (3- (4,5-dimethylthiazoyl-2-yl)
100 μl of DMEM (containing 10% FCS) in which −2,5-diphenyltetrazolium bromide) reagent is dissolved
The mixture was added at 37 ° C. and cultured at 37 ° C. for 5 hours under 5% CO ₂ . 8) After removing the medium and washing with PBS (-), formazan extract (0.04 N isopropanol hydrochloride diluted 300 times with isopropanol) was added in an amount of 100 μl and shaken. 9) The absorbance at 570 nm was measured using a microplate reader. As a control, an experiment in which the myrrh extract was not added was performed in the same manner, and the cell proliferation degree at each concentration was calculated with the cell proliferation degree obtained from the absorbance at this time as 100. Table 1 shows the results.

[0019]

[Table 1]

From the results shown in Table 1, it can be seen that the myrrh extract exhibits hair papilla cell proliferation activity.

[0021]

Next, an embodiment of the present invention will be described.
The present invention is not limited to these examples. Hair growth and hair growth agents of Examples 1 and 2 and Comparative Examples 1 and 2 shown in Table 2 were prepared by a conventional method. In the comparative example, carpronium chloride and assembly extract, which have been widely used as a hair restorer / hair restorer, were used.

[0022]

[Table 2]

<Hair Growth Test> C at 7 weeks of age in telogen
The back hair of the 3H mouse (♂) was shaved over 2 × 4 cm ² using an electric clipper and an electric razor. Each group consisted of 10 mice, and the hair-growing and hair-growing agents of Examples 1 and 2 and Comparative Examples 1 and 2 shown in Table 2 were applied to the shaved site 0.1 ml at a time once a day. To observe the state of hair regeneration,
A photograph of the shaved area was taken at a fixed magnification, and the hair regeneration area ratio (regenerated hair area / shaved area) was calculated using an image analyzer. Table 3 shows the average value of the regenerated hair area ratio (%) of each group on day 14 after the start of sample application.

<Practical test> Ten men worried about dandruff and itching with daily hair loss and hair loss using the hair-growing and hair-growing agents of Examples 1-2 and Comparative Examples 1-2 shown in Table 2. Practical tests were carried out for each (25 to 50 years old) on the effects of preventing hair loss, dandruff and itching. The method of use was basically twice a day, in the morning and before bedtime. When the hair was washed, an appropriate amount was applied to the scalp after the hair was washed and massaged. In addition, during the test period, commercial shampoos were used in a unified manner, and the use of other rinsing agents, tonic agents, hair styling agents, and treatments for permanents and hair dyes were prohibited. The effect was determined by washing the hair by a hairdresser once every two weeks, collecting the hair that had fallen off during the washing, measuring the number of hair loss, and observing and classifying the state of the hair root. Further, 48 hours after the hair was washed by the hairdresser, the presence or absence and degree of occurrence of dandruff and itching were confirmed by visual judgment and consciousness of the person. The evaluation criteria are shown below.

<Evaluation Criteria> (1) Hair loss-Effective; the number of hair loss is reduced. The hair root is a clean club-shaped normal hair root. -Invalid; the number of hair loss does not change or increases. The hair root is an abnormal hair root in which atrophy, deformation and the like are observed. (2) Dandruff (visual judgment) ・ Valid; slight dandruff is observed-no dandruff is observed. ・ Invalid; dandruff is occurring very much to dandruff. (3) Itching (identity) ・ Valid ; Itching or forgetting after a while ~ no itch feeling ・ Invalid; Itching that can not be tolerated ~ can be tolerated but itchy Table 3 shows the results. The numbers in the table indicate the number of people who answered valid or invalid.

[0026]

[Table 3]

From the results in Table 3, it can be seen that the hair growth and
It can be seen that the hair restorer shows excellent results in a hair growth test, and also has a remarkable effect in preventing hair loss, dandruff and itch in a practical test.

Further, hair growth and hair growth agents of the following examples were prepared by a conventional method. As in Example 1, all of these had remarkable effects on hair loss prevention and dandruff / itch prevention.

Example 3 (Lotion Type) Weight% Myrrh Extract 1.0 95% Ethanol 65.0 Propylene Glycol 5.0 Photosensitizer 301 0.1 Minoxidil 0.5 DL-α-Tocopherol Linoleate 0. 1 Appropriate amount of purified water

Example 4 (Gel Type) Weight% Myrrh Extract 3.0 Carboxyvinyl Polymer 0.4 95% Ethanol 40.0 Propylene Glycol 1.0 Glycerin 5.0 Carrot Extract 0.2 Assembly Extract 0.2 di Isopropanolamine 0.4 Purified water qs

Example 5 (Cream Type) Weight% Myrrh Extract 5.0 Polyoxyethylene (20) Sorbitan Monostearate 5.0 Sorbitan Monostearate 5.0 Cetanol 2.0 Stearyl Alcohol 2.0 Liquid Paraffin 10 2.0 DL-α-tocopherol acetate 0.2 minoxidil 1.0 pantothenyl ethyl ether 0.5 inositol hexanicotinic acid ester 0.1 methyl parahydroxybenzoate 0.1 propylene glycol 10.0 purified water qs

Example 6 (Aerosol Type) Weight% Myrrh Extract 1.0 Hinokitiol 0.5 Cepharanthin 0.5 Benzyl Nicotinate 0.3 Panax Ginseng 0.1 Propylene Glycol 5.0 Polyoxyethylene (20) Monooleate 0 95% ethanol 50.0 Liquefied petroleum gas 4.0 Purified water qs

Example 7 (Gel Type) Weight% Myrrh Extract 2.0 Carboxyvinyl Polymer 0.4 95% Ethanol 40.0 Propylene Glycol 5.0 Diisopropanolamine 0.4 Biotin 0.5 Pepper tincture 0.3 Cepharanthin 0.3 Vitamin E 0.1 Nicotinic acid 0.1 Purified water qs

Example 8 (Lotion type)% by weight Myrrh extract 2.0 Mononitroguaiacol 1.0 Benzyl nicotinate 0.5 Garlic extract 0.1 1,3-Butanediol 2.0 Propylene glycol 4.0 Poly Oxyethylene (20) polyoxypropylene (6) decyltetradecyl ether 3.0 95% ethanol 55.0 purified water qs

Example 9 (Lotion Type) Weight% Myrrh Extract 0.5 Allantoin 0.2 Touki Extract 0.1 Spironolactone 0.1 Gentian Extract 0.1 Glycyrrhetinic Acid 0.2 Glyceryl Monoisostearate 1.0 Propylene Glycol 5.0 Polyoxyethylene (20) sorbitan monooleate 1.5 95% ethanol 70.0 Purified water qs

Example 10 (Lotion type)% by weight Myrrh extract 0.2 Glyceride pentadecanoate 0.1 γ-Oryzanol 0.1 Licorice 0.2 Butoxyethyl nicotinate 0.1 95% Ethanol 65.0 Propylene glycol 5 0.0 Purified water qs

Example 11 (Gel Type) Weight% Myrrh Extract 3.0 Sengyu 0.1 Ginseng 0.1 Ginger 0.1 Dio 0.1 Aloe 0.5 Carboxyvinyl Polymer 0.4 95% Ethanol 40 2.0 Propylene glycol 1.0 Glycerin 5.0 Diisopropanolamine 0.4 Purified water qs

Example 12 (Cream Type) Weight% Myrrh Extract 2.0 Vitamin B6 Hydrochloride 0.1 DL-Camphor 0.2 DL-α-Tocopherol 0.2 Methyl Nicotinate 0.1 Polyoxyethylene (20 ) Sorbitan monostearate 5.0 Sorbitan monostearate 3.0 Cetanol 2.0 Stearyl alcohol 2.0 Liquid paraffin 10.0 Methyl parahydroxybenzoate 0.1 Propylene glycol 10.0 Purified water

Example 13 (lotion type)% by weight Myrrh extract 3.0 Vanillyl amide nonanoate 0.1 DL-α-tocopherol succinate 0.1 DL-α-tocopherol acetate 0.2 Pepper tincture 0.1 Cantharis Tincture 0.1 1,3-butanediol 5.0 polyoxyethylene (60) hydrogenated castor oil 0.4 octyldodecyl myristate 1.0 glyceryl monoisostearate 1.0 95% ethanol 65.0 purified water qs

Example 14 (aerosol type)% by weight Myrrh extract 2.0 Carpronium chloride 0.2 Garlic iodide extract 0.1 DL-α-tocopherol nicotinic acid ester 0.1 Shower tincture 0.2 D-Camphor 0.1 Sodium dextran sulfate 0.5 Propylene glycol 5.0 Polyoxyethylene (20) monooleate 5.0 95% ethanol 50.0 Liquefied petroleum gas 4.0 Purified water qs

[0041]

According to the present invention, a hair restoration / hair restoration agent having excellent hair loss prevention and hair restoration / hair restoration effects can be provided by blending a myrrh extract.

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Claims (2)

[Claims] 1. A hair restorer / hair restorer comprising a myrrh extract. 2. The hair restorer / hair restorer according to claim 1, further comprising one or more members selected from the group consisting of a cell activator and a blood circulation promoting agent.