JP3382148B2 - External preparation for head - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a topical external preparation for the head, which has synergistically improved hair-growth-preventing action, hair-growth action, and the like. More specifically, it relates to an Agaricus blaze mushroom.
i Murill) fruit body extract and sage ( Salvia officin
alis L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), hypericum ( H )
ypericum erectum Thunb.), peppermint ( Mentha arvensis )
L. var. Piperascens Malinv.), Atlantic peppermint ( Me
ntha piperita L.), chamomile ( Matricaria chamomill )
a L.), Arnica montana L., Thy ( Thy
mus vulgaris L.) and one or more kinds selected from the respective extracts of mus vulgaris L.) as an active ingredient.

[0002]

Alopecia is a problem of poor nutritional intake, decreased physiological function of the scalp due to excessive occurrence of dandruff, subcutaneous scalp tissue, decreased metabolic function of hair follicles and hair bulbs due to decreased blood flow in peripheral blood vessels, and It is caused by various causes such as mental stress.

In order to treat and ameliorate such alopecia, estrogen, estradiol, ethinyl estradiol and other follicular hormones, vitamin E and its derivatives, cembly extract, garlic extract, carrot extract, aloe extract, cepharanthin, chloride Peripheral blood flow enhancers such as carpronium and minoxidil, Capsicum tincture, Cantharis tincture, Ginger tincture, Mint oil, Local stimulants such as l-menthol and camphor, Keratolytic agents such as resorcin, salicylic acid and lactic acid, pyridoxine and Antiseborrheic agents such as their derivatives, zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, bactericides such as hinokitiol, pantothenic acid and its derivatives,
Placental extract, hair root activators such as biotin and pentadecanoic acid glyceride, glycyrrhizic acid and its derivatives, anti-inflammatory agents such as β-glycyrrhetinic acid, allantoin, azulene, ε-aminocaproic acid and hydrocortisone, vitamins A, B ₂ and B ₁₂ , D and other vitamin agents, cysteine, serine, methionine, leucine, tryptophan and other amino acids, and many other hair growth and nourishing ingredients have been used.

Furthermore, testosterone 5α- which catalyzes the conversion of testosterone to active dihydrotestosterone mainly for the purpose of treating and improving male pattern baldness.
Many have been screened for those that inhibit the activity of reductase. As the enzyme inhibitor, steroid substances such as progesterone and deoxycorticosterone, as well as various plant extracts are known. Further, oxendron, spironolactone, cyproterone acetate and the like are said to inhibit the binding of dihydrotestosterone to its receptor.

However, among the above-mentioned hair-growth and hair-growth components and testosterone 5α-reductase inhibitors which have been conventionally used, there are side effects, so that the compoundable amount is limited or the effect is insufficient. Many of them have problems such as poor stability in external preparations for the head such as hair nourishing agents, or difficulty in obtaining products of constant quality.

[0006]

Therefore, in the present invention, the present invention is applicable to androgenetic alopecia, as well as thin hair and alopecia caused by various causes, and synergistically improves anti-hair loss and hair growth and hair growth effects. And an external preparation for the head that is highly safe for the scalp.

[0007]

[Means for Solving the Problems] Various investigations were conducted to solve the above problems. As a result, Agaricus blazers
ei Murill) fruit body extract and sage ( Salvia officin
alis L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), hypericum ( H )
ypericum erectum Thunb.), peppermint ( Mentha arvensis )
L. var. Piperascens Malinv.), Atlantic peppermint ( Me
ntha piperita L.), chamomile ( Matricaria chamomill )
a L.), Arnica montana L., Thy ( Thy
mus vulgaris L.) combined with one or more selected from each extract to prevent hair loss and hair growth,
It has been found that the hair-growth action is synergistically improved. Also,
Since the extract of Agaricus blazei Murill fruiting body and each extract such as sage show a sufficiently effective action at a low concentration, adverse effects on the skin such as skin irritation and contact sensitization are also observed. Moreover, both of them showed stable quality.

Agaricus blazei Murill
Is a kind of agaricaceae, agaricaceae, agaricaceae, and is also called Kawariharatake or Himematsutake. Agaricus edulis are distributed in the southeastern part of South America and South America, and in the southeastern part of Brazil, it is a kind of edible mushrooms that residents have traditionally eaten. Regarding the effectiveness of this Agaricus edulis, many reports have been made especially on its antitumor activity. For example,
Extraction of fruiting bodies or mycelium of Agaricus edulis with an aqueous solvent to obtain a polysaccharide having an antitumor effect (Japanese Patent Laid-Open Nos. 55-74797 and 55-108).
292, JP-A-1-67194, JP-A-1
-67195, JP-A-6-128164, etc.), that a nucleic acid component having an antitumor effect can be obtained from the fruiting body of Agaricus edulis (JP-A-1-66127), and from hot water extraction residue of Agaricus edulis. Isolation of a protein polysaccharide having antitumor activity (JP-A-2-7863)
No. 0), a glycoprotein having antitumor activity can be obtained from 85% ethanol extract residue of Agaricus edulis (JP-A-6-9423), and ergosterol having antitumor activity present in Agaricus edulis fruiting bodies. Derivatives (JP-A-1-246299) and the like are disclosed. As a physiological activity of Agaricus edulis, a liver function improving agent containing Agaricus edulis extract as an active ingredient (JP-A-2-124).
No. 829), an antiallergic action of agaricus mushroom mycelium culture extract (JP-A-1-228480), and an action of agaricus mushroom body extract for improving immunopotency (JP-A-7).
No. 258107) and the like have been reported. further,
It has already been disclosed that Agaricus edulis extract has a root-activating effect (Japanese Patent Application No. 9-26793).
7).

On the other hand, sage ( Salvia officinalis
L.), Hop ( Humulus lupulus L.), Rosemary ( Rosmarinus officinalis L.), Hypericum ( Hyper )
icum erectum Thunb.), mint ( Mentha arvensis L.
var. piperascens Malinv.), peppermint (Mentha
piperita L.), chamomile ( Matricaria chamomilla )
L.), Arnica montana L., Thymu
s vulgaris L.) one or two selected from each extract
It is disclosed that the above species have testosterone 5α-reductase inhibitory activity (Japanese Patent Publication No. 6-47).
554).

This time, the present inventor has found that a solvent extract of Agaricus edulis fruit body, sage ( Salvia officinalis L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus )
officinalis L.), Hypericum ( Hypericum erectum )
Thunb.), Mint ( Mentha arvensis L. var. Piperas
cens Malinv.), Mentha piperita
L.), chamomile ( Matricaria chamomilla L.), arnica ( Arnica montana L.), thyme ( Thymus vulgaris
The combined use of one or more selected from each extract of L.) in the external preparation base for the head enhances synergistically the hair loss prevention effect and the hair growth and hair growth effects. As a result, they have completed the present invention.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Agaricus mushrooms ( Aga
ricus blazei Murill) has already been widely known, and has been deposited at the Institute of Biotechnology, Institute of Industrial Science and Technology with a deposit number of No. 4731, Life Research Institute.

When an extract is obtained from the fruiting body of Agaricus edulis, the fruiting body may be used as it is, or may be used after being shredded, dried, crushed and the like. The solvent used for the extraction of Agaricus mushroom body is water, methanol, ethanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-
Alcohols such as octyl alcohol, glycerin,
Polyhydric alcohols such as ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol and hexylene glycol, or derivatives thereof. ,
Suitable ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl-n-propyl ketone, esters such as ethyl acetate and isopropyl acetate, polar solvents such as ethers such as ethyl ether, isopropyl ether, n-butyl ether As
From these, one kind or two or more kinds are selected and used. Also,
Physiological saline, phosphate buffer, phosphate buffered saline, etc. can also be used. Further, a surfactant may be added to the solvent and used.

The extraction method includes a method of immersing in an extraction solvent at room temperature, cooling or heating, a method of homogenizing in an extraction solvent, a method of extracting by using a distillation method such as steam distillation, and a raw method. A squeezing method or the like in which an extract is obtained by directly squeezing Agaricus edulis is exemplified, and these methods are used alone or in combination of two or more to perform extraction.

The ratio of the agaricus mushroom body to the solvent at the time of extraction is not particularly limited, but the solvent is 0.5 to 1,000 times the weight of the agaricus mushroom body, especially the extraction operation and efficiency. From the point of, 0.5 to 100 times by weight is preferable.
The extraction temperature is conveniently in the range of about 5 ° C. to the boiling point of the solvent or less under normal pressure, and the extraction time is preferably in the range of 2 hours to 2 weeks, although it varies depending on the extraction temperature and the like.

The extract of Agaricus edulis body thus obtained can be used as it is, but may be subjected to purification operations such as deodorization, decolorization and concentration within a range not impairing the hair root activating action. In addition, it may be used as a fractionated product using column chromatography or the like.
These extracts, purified products, and fractionated products can be made into a dry solid by removing the solvent from them, or can be freeze-dried, and can be further solubilized in a solvent such as alcohol, or in the form of an emulsion. It can be added to the external preparation for head.

The amount of these Agaricus edulis extract extracted into the external preparation for the head cannot be determined unconditionally because the hair root activating action differs depending on the preparation method, but it is generally 0.0
A concentration range of 001 to 10% by weight is suitable.

On the other hand, sage ( Salvia officinalis L.)
Plant extracts such as are obtained by immersing these plants in an extraction solvent. For the extraction, each part of the plant such as flowers, leaves, stems, roots, and the whole plant can be used. These plants may be subjected to extraction treatment as they are, but in order to increase the extraction efficiency, it is preferable to carry out extraction after slicing, crushing, etc., or to perform homogenization in an extraction solvent. The extraction solvent is preferably a polar solvent, and in addition to water, lower alcohols such as methanol, ethanol, propanol, isopropanol, butanol, propylene glycol, dipropylene glycol,
Preferred examples include polyhydric alcohols such as 1,3-butylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone. Therefore, one kind or two or more kinds are selected from these and used. Further, a phosphate buffer solution, a physiological saline solution, or a phosphate buffered saline solution can also be favorably used. From the viewpoint of testosterone 5α-reductase inhibitory activity, extraction with ethanol is particularly preferable. 5 to 5 as the extraction temperature
About 0 ° C. and an extraction time of about 4 hours to 1 week is suitable.

The above plant extract may be added as it is to the base of the external preparation for the head, but the concentrated and dried product may be redissolved in water or a polar solvent, or the testosterone 5α-reductase inhibitory activity may be obtained. It may be added after purification treatments such as decolorization, deodorization, and desalting within the range that does not impair the above. In addition, after concentration and drying, or after performing a purification treatment, it may be freeze-dried and added as a powder.

The amount of the plant extract blended in the external preparation for the head part also varies depending on the testosterone 5α-reductase inhibitory activity of the extract, but it is appropriately about 0.0001 to 10% by weight.

In the external preparation for head according to the present invention, the active ingredients Agaricus edulis extract and sage ( Sa
lvia officinalis L.), hop ( Humulus lupulus
L.), Rosemary ( Rosmarinus officinalis L.),
Hypericum ( Hypericum erectum Thunb.), Peppermint ( Mentha arvensis L. var. Piperascens Malinv.),
Mentha piperita L., Chamomile ( Ma )
tricaria chamomilla L., Arnica montana
L.) and thyme ( Thymus vulgaris L.), in addition to one or more selected from each extract, follicles such as estrone, estradiol, ethinyl estradiol for further enhancing hair growth and hair growth promoting effect. Hormones, vitamin E and its derivatives, cucumber extract, garlic extract, carrot extract, aloe extract, cepharanthin,
Peripheral blood flow promoters such as carpronium chloride and minoxidil, local stimulants such as capsicum tincture, canthari tincture, ginger tincture, peppermint oil, l-menthol and camphor, keratolytic agents such as resorcin, salicylic acid and lactic acid, pyridoxine And anti-seborrheic agents such as derivatives thereof, zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, hinokitiol and other fungicides, pantothenic acid and its derivatives, placental extract, biotin, pentadecanoic acid glyceride and other hair root activating agents, glycyrrhizin Acids and their derivatives, β-glycyrrhetinic acid and its derivatives, allantoin, azulene, ε-aminocaproic acid, anti-inflammatory agents such as hydrocortisone, vitamins A, B ₂ ,
Vitamin preparations such as B ₁₂ and D, amino acids such as cysteine, serine, methionine, leucine and tryptophan can be simultaneously mixed.

Further, within the range that does not impair the effects of the present invention, oils and fats, lower alcohols, polyhydric alcohols, surfactants, moisturizers, antibacterial and antifungal agents, ultraviolet absorbers, fragrances,
Raw materials and additives that are generally used for external preparations for the head such as dyes and pigments may be contained.

The external preparation for head according to the present invention can be provided in the form of lotion, emulsion, gel, cream, ointment and the like. Further, it is also provided as a head cosmetic in the form of hair lotion, hairnic, hair milk, hair gel, hair cream, hair pack, hair treatment, hair shampoo, hair rinse.

[0023]

EXAMPLES The features of the present invention will be described in detail with reference to Examples. First, production examples of Agaricus edulis extract and plant extracts such as sage used in Examples of the present invention are shown below.

[Production Examples 1 to 4] Using the extraction solvents shown in Table 1, agaricus mushroom body extracts were prepared.
The dried agaricus mushroom body was pulverized, 10 times by weight of the extraction solvent was added, and the mixture was immersed at 20 ° C. for 3 days and then filtered to obtain a filtrate, which was an agaricus mushroom body extract (Production Example 1
~ Production Example 4).

[Table 1]

[Production Examples 5 to 13] The plants shown in Table 2 were shredded and immersed in each solvent shown in Table 2 at 20 ° C for 3 days for extraction. The filtrate obtained by filtering the extract was used as an extract such as sage (Production Example 5 to Production Example 13).

[Table 2]

Using the above-mentioned production example, the hair growth promoting action when the Agaricus edulis extract and the plant extract such as sage were used in combination was examined. The back of the C57 / Black mouse was shaved with a clipper to a size of 2 × 4 cm, treated with a hair removal foam to completely remove hair, and after 24 hours, each sample solution shown in Table 3 was applied once a day. 1 ml was continuously applied for 20 days. On the last day of the test, all the hair that had grown was extracted and the total weight was measured. The test was conducted with 10 animals per group, and the average value was calculated and shown in Table 4. At that time, a group to which only a 50 wt% ethanol aqueous solution of a solvent was applied was used as a control.

[Table 3]

[0027]

[Table 4] As is clear from Table 4, the Agaricus mushroom body extract of Production Example 1 to Production Example 4 and the plant extracts of Production Example 5 to Production Example 13 are significant compared to the control even in the groups applied individually. The amount of hair growth was remarkably increased when these were used in combination.

[Examples 1 to 4] Hair nourishing lotion Using the Agaricus mushroom body extract and plant extract shown in Table 5, hair nourishing lotions were prepared according to the following formulations. (Prescription) (1) Ethanol 50.00 (wt%) (2) Vitamin B ₆ 0.10 (3) Agaricus mushroom body extract 0.05 (4) Plant extract 0.50 (5) 1,3 -Butylene glycol 2.50 (6) Perfume 0.10 (7) Purified water 46.75 Manufacturing method: (1) to (6) are sequentially added to (7) and mixed to homogenize.

[Table 5]

A usage test was conducted on Examples 1 to 4 to evaluate the hair-feeding effect. At that time, in Example 1 and Example 2, the plant extract was replaced with purified water in Comparative Example 1 and Comparative Example 2, Example 3 and Example 4 by substituting purified water for the Agaricus mushroom body extract. Comparative examples 3 and 4 were obtained by substituting the same, and comparative example 5 was also conducted by further substituting purified water for both the agaricus mushroom body extract and the plant extract. In the use test, 20 male and female panelists who are worried about thinning hair and hair loss were set as one group, and each of the example and the comparative example was blinded to each group for 2 days a day.
After continuous use for 6 months, the state of improvement of thinning hair and hair loss symptoms and the presence / absence of irritation during use were evaluated. The improvement status of thinning hair and hair loss symptoms was evaluated by scoring the condition of the hair before and after the use test according to the criteria shown in Table 6, and the average value of 20 persons was calculated. Regarding feeling of irritation during use, "I do not feel it; 0 point",
The points were scored as "delicately felt; 1 point", "a little felt; 2 points", "clearly felt; 3 points", and "very felt; 4 points", and the average value of 20 persons was calculated. The above results are summarized in Table 7.

[Table 6]

[0030]

[Table 7] As is clear from Table 7, in the groups used in the examples of the present invention, most of the panelists in each group showed hair growth and hair growth that were equal to or more than whole hair, and some panelists also found vellus hair. A very good hair loss symptom and improvement of thinning hair were observed, such as a considerable number of them. On the other hand, in Comparative Example 1 to Comparative Example 4 application groups containing only one of Agaricus edulis extract or plant extract, hair loss symptoms and improvement of thinning hair were observed, but the extent of each was The size was smaller than that of the application group. In the Comparative Example 5 application group containing neither Agaricus edulis extract nor plant extract, no significant change in hair condition was observed.

Regarding the feeling of irritation during use, no particular problem of irritation was observed in any of the coating groups of Examples 1 to 4 and Comparative Examples 1 to 5 of the present invention.

Next, the formulation of another embodiment of the present invention will be shown.

Example 5 Head Cream (1) Liquid Paraffin 15.00 (wt%) (2) Vaseline 15.00 (3) Beeswax 2.00 (4) Polyoxyethylene (50E.O.) Hydrogenated castor oil 3.00 (5) Glycerin 5.00 (6) Carboxyvinyl polymer 0.10 (7) Xanthan gum 0.10 (8) Ethylenediaminetetraacetic acid disodium 0.10 (9) Purified water 59.10 (10 ) Sodium hydroxide 0.05 (11) Agaricus mushroom body extract (Production Example 1) 0.25 (12) Hypericum extract (Production Example 8) 0.15 (13) Chamomile extract (Production Example 11) 0 .15 Production method: The oil phases of (1) to (3) are dissolved by heating to 80 ° C. On the other hand, the water phase components (4) to (9) are mixed, heated and dissolved to 80 ° C. The oil phase is added to the aqueous phase while stirring, and the mixture is uniformly emulsified by a homogenizer. After cooling, (10) is added at 30 ° C., mixed, and then (11) to (13) are added and uniformly mixed.

Example 6 Head Gel Agent (1) Carboxyvinyl Polymer 0.7 (wt%) (2) Polyvinylpyrrolidone 2.0 (3) Glycerin 5.0 (4) Sodium Hydroxide 0.2 (5) Ethanol 20.0 (6) Disodium ethylenediaminetetraacetate 0.1 (7) Agaricus mushroom body extract (Production Example 2) 0.2 (8) Mint extract (Production Example 9) 1.0 ( 9) Purified water 70.8 Manufacturing method: Disperse (1) in (3) and part of (9). (2),
(5) to (8) are dissolved in the rest of (9) and added, and then (4) is added to increase the viscosity.

[Example 7] Set lotion (1) Polyvinylpyrrolidone / vinyl acetate copolymer 5.00 (% by weight) (2) Methyl paraoxybenzoate 0.10 (3) Perfume 0.10 (4) Agaricus mushroom Fruit Body Extract (Production Example 3) 0.01 (5) Ethanol 30.00 (6) Polyoxyethylene / polyoxypropylene modified 0.50 Dimethylpolysiloxane (7) Glycerin 2.00 (8) Arnica extract ( Production Example 12) 0.25 (9) Purified water 62.04 Production method: (1) to (4) are sequentially added to (5) and dissolved. Meanwhile (6)
The aqueous phase of (9) is mixed and dissolved, and the solution is added to the above solution and mixed to homogenize.

Example 8 Hair Liquid (1) Ethanol 50.00 (wt%) (2) Polyoxypropylene (40 P.O.) Butyl Ether 20.00 (3) Polyoxyethylene (50 E.O.) Curing Castor oil 1.00 (4) Methyl paraoxybenzoate 0.15 (5) Agaricus mushroom body extract (Production Example 4) 0.10 (6) Hop extract (Production Example 6) 0.50 (7) Thyme Extract (Production Example 13) 1.00 (8) Perfume 0.10 (9) Blue No. 1 (1% aqueous solution) 0.10 (10) Purified water 27.05 Production method: (1) to (2) to ( The components of 10) are sequentially added and dissolved to homogenize.

Example 9 Water Grease (1) Carboxyvinyl Polymer 0.5 (wt%) (2) Glycerin 50.0 (3) Purified Water 38.5 (4) Polyoxyethylene (20E.O.) Octyldodecyl 0.2 Ether (5) Sodium hydroxide 0.1 (6) Ethanol 10.0 (7) Agaricus mushroom body extract (Production Example 1) 0.2 (8) Agaricus mushroom body extract (Production Example 3) 0.2 (9) Sage extract (Production Example 5) 0.2 (10) Perfume 0.1 Production method: (1) is dispersed in a part of (2) and (3). (4),
(6) to (10) are dissolved in the rest of (3) and added, and then (5) is added to increase the viscosity.

[Example 10] Hair foam (stock solution formulation) (1) Silicone oil 5.00 (% by weight) (2) Polyoxyethylene (50 E.O.) hydrogenated castor oil 1.00 (3) Dipropylene glycol 7.00 (4) Cationized cellulose 3.00 (5) Purified water 67.00 (6) Ethanol 15.00 (7) Agaricus mushroom body extract (Production Example 2) 0.25 (8) Rosemary extraction Product (Production Example 7) 1.50 (9) Methyl paraoxybenzoate 0.15 (10) Perfume 0.10 (filling prescription) Undiluted solution 90.0 Liquefied petroleum gas 10.0 Manufacturing method: (1) as (2) Add to the lysate of (3) and emulsify uniformly with a homogenizer. Add (4), (6) to (10) to (5) dissolved in (5) and mix to homogenize, and use this as the stock solution. Filling is performed by filling the can with the stock solution, mounting the valve, and then filling with liquefied petroleum gas.

Example 11 Hair Shampoo (1) Polyoxyethylene (3E.O.) Lauryl Sulfate 30.00 (wt%) Ester Sodium Salt (30 wt% Aqueous Solution) (2) Lauryl Sulfate Ester Sodium Salt 10. 00 (30% by weight aqueous solution) (3) Coconut oil fatty acid diethanolamide 4.00 (4) Glycerin 1.00 (5) Sodium dehydroacetate 0.20 (6) Ethylenediaminetetraacetic acid disodium 0.25 (7) Purified water 53.55 (8) Agaricus edulis extract (Production Example 4) 0.50 (9) Hypericum perforatum extract (Production Example 8) 0.20 (10) mint extract (Production Example 10) 0.20 ( 11) Perfume 0.10 Production method: (7) is heated to 70 ° C., (1) to (6) are added and uniformly dissolved, and then cooled, and (8) to (11) are added and mixed at 30 ° C. ,
Make it uniform.

[Example 12] Hair rinse (1) Silicone oil 3.0 (wt%) (2) Liquid paraffin 1.0 (3) Cetanol 1.5 (4) Stearyl alcohol 1.0 (5) Stearyl trimethyl chloride Ammonium 0.7 (6) Glycerin 3.0 (7) Methyl paraoxybenzoate 0.2 (8) Purified water 88.3 (9) Agaricus mushroom body extract (Production Example 2) 0.3 (10) Sage Extract (Production Example 5) 0.2 (11) Hop extract (Production Example 6) 0.2 (12) Thyme extract (Production Example 13) 0.5 (13) Perfume 0.1 Production method: (1) The oil phase components of (4) and the aqueous phase components of (5) to (8) are mixed, dissolved and heated to 70 ° C. The oil phase is added to the aqueous phase to emulsify, and after cooling, (9) to (13) are sequentially added and mixed at 30 ° C. to homogenize.

Examples 1 to 12 of the present invention described above are
All of them had good stability, and even when stored at 25 ° C. for 6 months, no change in color, odor, phase separation, appearance of precipitates or sediments was observed. In addition, as a result of a 48 hour dorsal blockage application test by a male panelist, no skin irritation was observed.

[0042]

INDUSTRIAL APPLICABILITY As described above, the present invention can be applied to androgenetic alopecia, as well as thinning hair and alopecia caused by various causes, and synergistically prevents hair loss, hair growth and hair growth. It was possible to provide an external preparation for the head which is improved and highly safe for the scalp.

─────────────────────────────────────────────────── --- Continuation of the front page (56) Reference JP-A-11-79949 (JP, A) JP-A-1-228480 (JP, A) JP-A-7-316026 (JP, A) JP-A-9- 328415 (JP, A) JP-A-9-221413 (JP, A) JP-A-8-310923 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/00-7 / 50 JISST file (JOIS) CA (STN)

Claims (2)

(57) [Claims] 1. Agaricus blazei Muril
l) Fruit body extract and sage ( Salvia officinalis
L.), Hop ( Humulus lupulus L.), Rosemary ( Rosmarinus officinalis L.), Hypericum ( Hyper )
icum erectum Thunb.), mint ( Mentha arvensis L.
var. piperascens Malinv.), peppermint (Mentha
piperita L.), chamomile ( Matricaria chamomilla )
L.), Arnica montana L., Thymu
s vulgaris L.) one or two selected from each extract
An external preparation for the head, which comprises at least one kind. 2. Agaricus blazei Muril
l) The external preparation for head according to claim 1, wherein the fruit body extract is an extract with a polar solvent.