JPH11228354A - Preparation for external use for head - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for the head applicable to thin hair or alopecia caused by various origins, synergistically improving preventing actions on the alopecia and trichogenous and hair growing actions and having high safety for the scalp. SOLUTION: This preparation for external use for the head is obtained by including an extract from a fruit body of Agaricus blazei Murill and one or more kinds selected from respective extracts from Salvia officinalis L., Humulus lupulus L., Rosmarinus officinalis L., Hypericum erectum Thunb., Mentha arvensis L. var. piperascens Malinv., Mentha piperita L., Matricaria chamomilla L., Arnica montana L. and Thymus vulgaris L. therein.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for a head having a synergistically improved hair growth effect such as a hair loss preventing effect and a hair growth effect, and more particularly, to an agaricus mushroom ( Agaricus blaze).
i Murill) fruit body extract and sage ( Salvia officin)
alis L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), hypericum ( H.
ypericum erectum Thunb.), Mentha ( Mentha arvensis )
L. var. Piperascens Malinv.), Mentha ( Me )
ntha piperita L.), chamomile ( Matricaria chamomill )
a L.), Arnica ( Arnica montana L.), Thyme ( Thy
mus vulgaris L.), or an external preparation for the head, comprising as an active ingredient one or more selected from each extract.

[0002]

BACKGROUND OF THE INVENTION Alopecia is caused by poor nutritional intake, decreased scalp physiological function due to excessive occurrence of dandruff, decreased hair metabolism in hair follicles and hair bulbs caused by decreased blood flow in the scalp subcutaneous tissue and peripheral blood vessels, and It is caused by various causes such as mental stress.

In order to treat and improve such alopecia, estrogen such as estrone, estradiol, ethinyl estradiol, vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, cepharanthin, chloride Peripheral vascular blood flow promoters such as carpronium and minoxidil, local stimulants such as pepper tincture, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, keratolytic agents such as resorcin, salicylic acid, lactic acid, pyridoxine and Antiseborrheic agents such as derivatives thereof, bactericides such as zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, hinokitiol, pantothenic acid and derivatives thereof,
Placental extract, biotin, hair root activator such as pentadecanoic acid glyceride, glycyrrhizic acid and its derivatives, anti-inflammatory agents such as β-glycyrrhetinic acid, allantoin, azulene, ε-aminocaproic acid, hydrocortisone, vitamins A, B ₂ , B ₁₂ , D and the like, and amino acids such as cysteine, serine, methionine, leucine and tryptophan, and many other hair growth and hair growth components have been used.

Further, mainly for the treatment and improvement of male pattern baldness, testosterone 5α- catalyzes the conversion of testosterone to active dihydrotestosterone.
Many that inhibit reductase activity have been screened. Known inhibitors of the enzyme include steroid substances such as progesterone and deoxycorticosterone, as well as extracts of various types of plants. Also, oxendrone, spironolactone, cyproterone acetate, and the like are said to inhibit dihydrotestosterone from binding to its receptor.

[0005] However, some of the conventionally used hair-growth and hair-growth components and testosterone 5α-reductase inhibitors have side effects, such that the amount that can be incorporated is limited or the effect is insufficient. In many cases, there are problems such as poor stability in the preparation for external use for the head such as a hair restorer, or difficulty in obtaining a certain quality.

[0006]

Accordingly, the present invention is applicable to hair loss and alopecia caused by various causes in addition to male pattern baldness, and synergistically improves hair loss preventing action and hair growth and hair growth action. An object of the present invention is to provide an external preparation for the head that is highly safe for the scalp.

[0007]

Various studies have been conducted to solve the above-mentioned problems, and as a result, Agaricus blaz
ei Murill) fruit body extract and sage ( Salvia officin)
alis L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), hypericum ( H.
ypericum erectum Thunb.), Mentha ( Mentha arvensis )
L. var. Piperascens Malinv.), Mentha ( Me )
ntha piperita L.), chamomile ( Matricaria chamomill )
a L.), Arnica ( Arnica montana L.), Thyme ( Thy
mus vulgaris L.) to prevent hair loss and hair growth,
It has been found that the hair growth effect is synergistically improved. Also,
Extracts of Agaricus blazei Murill fruit body and extracts such as sage show effective effects at low concentrations, and have negative effects on skin such as skin irritation and contact sensitization. And both showed stable quality.

[0008] Agaricus blazei Murill
Is a kind of agaric genus of the basidiomycete agaricaceae agaricaceae, also known as Kawari agaric or Himematsutake. Agaricus mushrooms are distributed in the southeastern and southern parts of North America, and in the southeastern part of Brazil, are a type of mushroom that has been used by residents for a long time. Many reports have been made on the effectiveness of this Agaricus mushroom, especially on its antitumor activity. For example,
A polysaccharide having an antitumor effect can be obtained by extracting the fruit body or mycelium of Agaricus mushroom with an aqueous solvent (JP-A-55-74797, JP-A-55-108).
292, JP-A-1-67194, JP-A-1
JP-A-67195, JP-A-6-128164, etc.), that a nucleic acid component having an antitumor effect can be obtained from the fruit body of Agaricus mushroom (JP-A-1-66127), from the hot water extraction residue of Agaricus mushroom Isolation of a protein polysaccharide having antitumor activity (JP-A-2-7863)
No. 0), that a glycoprotein having an antitumor activity can be obtained from an 85% ethanol extraction residue of Agaricus mushroom (Japanese Patent Laid-Open No. 6-9423), and that ergosterol having an antitumor activity present in the fruit body of Agaricus mushroom Derivatives (JP-A-1-246299) and the like are disclosed. Also, as a physiological activity of Agaricus mushroom, a liver function improving agent containing an Agaricus mushroom fruit body extract as an active ingredient (Japanese Patent Laid-Open No. 2-124
No. 829), the antiallergic effect of the Agaricus mushroom mycelium culture extract (Japanese Patent Application Laid-Open No. 1-228480), and the effect of the Agaricus mushroom fruiting body extract on the reduction of the immune function (Japanese Patent Application Laid-Open No.
-258107) and the like. further,
It has been disclosed that Agaricus mushroom fruit body extract has a hair root activating action (Japanese Patent Application No. 9-26793).
7).

On the other hand, sage ( Salvia officinalis)
L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), Hypericum ( Hyper
icum erectum Thunb.), Mentha ( Mentha arvensis L.)
var. piperascens Malinv.), peppermint (Mentha
piperita L.), chamomile ( Matricaria chamomilla )
L.), Arnica ( Arnica montana L.), Thyme ( Thymu
s vulgaris L.), one or two selected from each extract
More than one species are disclosed to have testosterone 5α-reductase inhibitory activity (Japanese Patent Publication No. 6-47).
554).

[0010] The present inventors have developed a solvent extract of Agaricus mushroom fruit body, sage ( Salvia officinalis L.), hop ( Humulus lupulus L.), and rosemary ( Rosmarinus ).
officinalis L.) and Hypericum ( Hypericum erectum )
Thunb.), Mentha ( Mentha arvensis L. var. Piperas)
cens Malinv.), Mentha piperita
L.), chamomile ( Matricaria chamomilla L.), arnica ( Arnica montana L.), thyme ( Thymus vulgaris )
L.) by combining one or two or more selected from each extract in the external preparation base for the head, thereby synergistically improving the hair loss preventing action and the hair growth and hair growth actions. This led to the completion of the present invention.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Agaricus mushroom ( Aga
ricus blazei Murill) is already widely known and has been deposited with the National Institute of Advanced Industrial Science and Technology under the deposit number of Life Science Bacteria No. 4731.

When an extract is obtained from the fruit body of Agaricus mushroom, the fruit body may be used as it is, or may be used after shredding, drying, pulverizing and the like. Solvents used for extracting Agaricus mushroom fruit bodies include water, methanol, ethanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, and n-ethylbutanol.
Alcohols such as octyl alcohol, glycerin,
Polyhydric alcohols such as ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and derivatives thereof ,
Suitable are polar solvents such as ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; esters such as ethyl acetate and isopropyl acetate; and ethers such as ethyl ether, isopropyl ether and n-butyl ether. Listed as
One or more of these are selected and used. Also,
Physiological saline, phosphate buffer, phosphate buffered saline and the like can also be used. Further, a surfactant may be added to the solvent before use.

As the extraction method, a method of immersing in an extraction solvent at room temperature, cooled or heated, extraction, a method of homogenizing in the extraction solvent, a method of extraction using a distillation method such as steam distillation, a method of Examples include a squeezing method in which an agaricus mushroom is directly squeezed to obtain an extract. These methods are used alone or in combination of two or more.

The ratio of the Agaricus mushroom fruit body to the solvent at the time of extraction is not particularly limited, but the solvent is 0.5 to 1,000 times the weight of Agaricus mushroom fruit body 1, especially the extraction operation and efficiency. In this respect, the weight is preferably 0.5 to 100 times by weight.
The extraction temperature is conveniently in the range of about 5 ° C. under normal pressure to the boiling point of the solvent or lower, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.

The extract of Agaricus mushroom fruit body obtained as described above can be used as it is, but purification operations such as deodorization, decolorization, and concentration are performed within a range that does not impair the hair root activation. It may be added or used as a fraction by column chromatography or the like.
These extracts, purified products, and fractionated products can be dried or lyophilized by removing the solvent from them, and can be further dissolved in a solvent such as alcohol or in the form of an emulsion. It can be added to the external preparation for the head.

The amount of the Agaricus mushroom fruit body extract to be added to the external preparation for the head is not generally defined because the hair root activating effect varies depending on the preparation method.
Suitably, the concentration ranges from 001 to 10% by weight.

On the other hand, sage ( Salvia officinalis L.)
Such plant extracts are obtained by immersing these plants in an extraction solvent. For extraction, each part such as a flower, a leaf, a stem, a root and the like of each plant and a whole plant can be used. These plants may be subjected to an extraction treatment as it is, but in order to increase the extraction efficiency, it is preferable to extract after shredding, pulverizing or the like, or to homogenate in an extraction solvent. As the extraction solvent, a polar solvent is preferable. In addition to water, lower alcohols such as methanol, ethanol, propanol, isopropanol and butanol, propylene glycol, dipropylene glycol,
Preferred are polyhydric alcohols such as 1,3-butylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone. And one or more of these are selected and used. Phosphate buffer, physiological saline, and phosphate buffered saline can also be used favorably. Extraction with ethanol is particularly preferred from the viewpoint of testosterone 5α-reductase inhibitory activity. 5-5 as extraction temperature
About 0 ° C. and an extraction time of about 4 hours to about 1 week are appropriate.

The above-mentioned plant extract may be added to the base of the external preparation for the head as it is, but the concentrated and dried one may be redissolved in water or a polar solvent, or may have an inhibitory activity on testosterone 5α-reductase. May be added after purification treatments such as decolorization, deodorization, and desalting are performed within a range that does not impair. Further, after concentration and drying, or after performing a purification treatment, it may be freeze-dried and added as a powder.

The amount of the above-mentioned plant extract in the external preparation for the head also depends on the testosterone 5α-reductase inhibitory activity of the extract, but is preferably about 0.0001 to 10% by weight.

In the external preparation for head according to the present invention, the active ingredients of Agaricus mushroom fruit body extract and sage ( Sa
lvia officinalis L.), hops ( Humulus lupulus )
L.), rosemary ( Rosmarinus officinalis L.),
Hypericum erectum Thunb., Mentha arvensis L. var. Piperascens Malinv.,
Mentha piperita L., chamomile Ma
tricaria chamomilla L.), Arnica ( Arnica montana )
L.) and thyme ( Thymus vulgaris L.), in addition to one or more selected from each extract, follicles such as estrone, estradiol, ethinylestradiol, etc. to further enhance hair growth and hair growth promoting effects Hormones, vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, cepharanthin,
Peripheral vascular blood flow enhancers such as carpronium chloride and minoxidil; local stimulants such as pepper tincture, tincture tincture, ginger tincture, peppermint oil, l-menthol, camphor; keratolytic agents such as resorcin, salicylic acid, and lactic acid; pyridoxine Antibacterial agents such as zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine and hinokitiol; pantothenic acid and its derivatives; placental extracts; hair root activators such as biotin and pentadecanoic acid glyceride; glycyrrhizin Acid and its derivatives, β-glycyrrhetinic acid and its derivatives, allantoin, azulene, ε-aminocaproic acid, anti-inflammatory agents such as hydrocortisone, vitamin A, B ₂ ,
Vitamins such as B ₁₂ and D, and amino acids such as cysteine, serine, methionine, leucine, tryptophan, and the like can be simultaneously added.

Further, oils and fats, lower alcohols, polyhydric alcohols, surfactants, humectants, antibacterial and antifungal agents, ultraviolet absorbers, fragrances, and the like, as long as the effects of the present invention are not impaired.
Raw materials and additives generally used in external preparations for the head, such as pigments and pigments, can be contained.

The external preparation for the head according to the present invention can be provided in the form of a lotion, emulsion, gel, cream, ointment or the like. Further, it is also provided as a head cosmetic in the form of hair lotion, hair tonic, hair milk, hair gel, hair cream, hair pack, hair treatment, hair shampoo, and hair rinse.

[0023]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, examples of producing plant extracts such as Agaricus mushroom fruit body extract and sage used in Examples of the present invention are shown below.

[Preparation Examples 1 to 4] Agaricus mushroom fruit body extract was prepared using the extraction solvents shown in Table 1.
The dried Agaricus mushroom fruit body was pulverized, and an extraction solvent 10 times the weight of the dried Agaricus mushroom fruit body was added. The filtrate was immersed at 20 ° C. for 3 days and filtered.
To Production Example 4).

[Table 1]

[Production Examples 5 to 13] The plants shown in Table 2 were cut into small pieces, and immersed in the solvents shown in Table 2 at 20 ° C. for 3 days to perform extraction. The filtrate obtained by filtering the extract was used as an extract such as sage (Production Examples 5 to 13).

[Table 2]

Using the above-mentioned production examples, the hair growth promoting effect of the combined use of the Agaricus mushroom fruit body extract and a plant extract such as sage was examined. The back of the C57 / Black mouse was shaved to a size of 2 × 4 cm with a hair clipper, treated with a depilatory foam to completely remove hair, and after 24 hours, each of the sample solutions shown in Table 3 was changed to 0 once a day. .1 ml was applied continuously for 20 days. All hairs that grew on the last day of the test were extracted, and their total weight was measured. The test was performed with 10 animals per group, and the average value was calculated and shown in Table 4. At that time, a group to which only a 50% by weight aqueous ethanol solution of a solvent was applied was set as a control.

[Table 3]

[0027]

[Table 4] As is clear from Table 4, the agaricus mushroom fruit body extract of Production Example 1 to Production Example 4 and the plant extract of Production Example 5 to Production Example 13 were significantly more significant than the control even in the group applied alone. However, when these were used in combination, the amount of hair growth was significantly increased.

[Examples 1 to 4] Hair Nourishing Lotion A hair nourishing lotion was prepared using the Agaricus mushroom fruit body extract and the plant extract shown in Table 5 according to the following formulation. (Prescription) (1) Ethanol 50.00 (% by weight) (2) Vitamin B ₆ 0.10 (3) Agaricus mushroom fruit body extract 0.05 (4) Plant extract 0.50 (5) 1,3 -Butylene glycol 2.50 (6) Fragrance 0.10 (7) Purified water 46.75 Manufacturing method: (1) to (6) are added to (7) sequentially and mixed to make uniform.

[Table 5]

A use test was conducted on Examples 1 to 4 to evaluate the hair nourishing effect. At that time, the plant extract was replaced with purified water in Comparative Examples 1 and 2, and Examples 3 and 4 in which the extract of the Agaricus mushroom fruit body was replaced with purified water in Examples 1 and 2. The test was carried out in the same manner as Comparative Examples 3 and 4, and the same as Comparative Example 5 except that both the Agaricus mushroom fruit body extract and the plant extract were replaced with purified water. In the use test, 20 male and female panelists who were worried about thinning and hair loss were taken as one group, and each of the examples and comparative examples was blinded to each group for 2 days a day.
The hair was continuously used for six months, and the condition of improvement of thinning hair and hair loss symptoms and the presence or absence of irritation during use were evaluated. The state of improvement of the hair thinning and hair loss symptoms was evaluated by scoring the condition of the hair before and after the end of the use test according to the criterion shown in Table 6 by photographing, and the score was calculated, and the average value of 20 subjects was calculated. Regarding irritation during use, "I do not feel; 0 points",
Points were scored as "feel slightly; 1 point", "slightly felt; 2 points", "clearly felt; 3 points", and "very much felt; 4 points", and the average value of 20 people was obtained. The above results are summarized in Table 7.

[Table 6]

[0030]

[Table 7] As is clear from Table 7, in the group using the examples of the present invention, hair growth and hair growth more than overall hair growth were observed in most of the panelists in each group, and panelists in which hard hair was observed were also observed. Very good alopecia symptoms and improvement of thinning hair were observed, including the presence of a considerable number. On the other hand, in the application group of Comparative Example 1 to Comparative Example 4 containing only one of the agaricus mushroom fruit body extract and the plant extract, improvement of alopecia and thinning hair was observed, but the degree of the improvement was confirmed by The sample was smaller than the group applied. In the group applied with Comparative Example 5 containing neither the Agaricus mushroom fruit body extract nor the plant extract, no significant change was observed in the hair condition.

Regarding the feeling of irritation during use, no particularly problematic feeling of irritation was observed in any of the coating groups of Examples 1 to 4 and Comparative Examples 1 to 5 of the present invention.

Next, the formulation of another embodiment of the present invention will be described.

Example 5 Head Cream (1) Liquid Paraffin 15.00 (% by weight) (2) Vaseline 15.00 (3) Beeswax 2.00 (4) Polyoxyethylene (50E.O.) Hardened castor oil 3.00 (5) Glycerin 5.00 (6) Carboxyvinyl polymer 0.10 (7) Xanthan gum 0.10 (8) Disodium ethylenediaminetetraacetate 0.10 (9) Purified water 59.10 (10 ) Sodium hydroxide 0.05 (11) Agaricus mushroom fruit body extract (Production Example 1) 0.25 (12) Hypericum extract (Production Example 8) 0.15 (13) Chamomile extract (Production Example 11) 0 .15 Production method: Heat and dissolve the oil phase of (1) to (3) to 80 ° C. On the other hand, the aqueous phase components (4) to (9) are mixed and dissolved by heating to 80 ° C. The oil phase is added to the aqueous phase with stirring, and the mixture is uniformly emulsified by a homogenizer. After cooling, (10) is added at 30 ° C., and after mixing, (11) to (13) are added and mixed uniformly.

Example 6 Gel for Head (1) Carboxyvinyl polymer 0.7 (% by weight) (2) Polyvinylpyrrolidone 2.0 (3) Glycerin 5.0 (4) Sodium hydroxide 0.2 (5) Ethanol 20.0 (6) Disodium ethylenediaminetetraacetate 0.1 (7) Agaricus mushroom fruit body extract (Production Example 2) 0.2 (8) Mint extract (Production Example 9) 1.0 ( 9) Purified water 70.8 Production method: (1) is dispersed in (3) and part of (9). (2),
(5) to (8) are dissolved and added to the remainder of (9), and then (4) is added to thicken.

Example 7 Set lotion (1) Polyvinylpyrrolidone / vinyl acetate copolymer 5.00 (% by weight) (2) Methyl parahydroxybenzoate 0.10 (3) Fragrance 0.10 (4) Agaricus mushroom Fruiting body extract (Production Example 3) 0.01 (5) Ethanol 30.00 (6) Polyoxyethylene / polyoxypropylene modified 0.50 Dimethylpolysiloxane (7) Glycerin 2.00 (8) Arnica extract ( Production Example 12) 0.25 (9) Purified water 62.04 Production method: (1) to (4) are sequentially added to (5) and dissolved. On the other hand (6)
The aqueous phases of (9) to (9) are mixed and dissolved, and added to the above solution, mixed, and made uniform.

Example 8 Hair Liquid (1) Ethanol 50.00 (% by weight) (2) Polyoxypropylene (40 PO) butyl ether 20.00 (3) Polyoxyethylene (50 EO) cured Castor oil 1.00 (4) Methyl paraoxybenzoate 0.15 (5) Agaricus mushroom fruit body extract (Production Example 4) 0.10 (6) Hop extract (Production Example 6) 0.50 (7) Thyme Extract (Production Example 13) 1.00 (8) Fragrance 0.10 (9) Blue No. 1 (1% aqueous solution) 0.10 (10) Purified water 27.05 Production method: (1) to (2) to (2) The components of 10) are added sequentially and dissolved to homogenize.

Example 9 Water Grease (1) Carboxyvinyl polymer 0.5 (% by weight) (2) Glycerin 50.0 (3) Purified water 38.5 (4) Polyoxyethylene (20E.O.) Octyldodecyl 0.2 ether (5) Sodium hydroxide 0.1 (6) Ethanol 10.0 (7) Agaricus mushroom fruit body extract (Production Example 1) 0.2 (8) Agaricus mushroom fruit body extract (Production Example 3) 0.2 (9) Sage extract (Production Example 5) 0.2 (10) Fragrance 0.1 Production method: (1) is dispersed in a part of (2) and (3). (4),
(6) to (10) are dissolved and added to the remainder of (3), and then (5) is added to thicken.

[Example 10] Hair foam (stock solution formulation) (1) Silicone oil 5.00 (wt%) (2) Polyoxyethylene (50EO) hydrogenated castor oil 1.00 (3) Dipropylene glycol 7.00 (4) Cationized cellulose 3.00 (5) Purified water 67.00 (6) Ethanol 15.00 (7) Agaricus mushroom fruit body extract (Production Example 2) 0.25 (8) Rosemary extraction Product (Production Example 7) 1.50 (9) Methyl paraoxybenzoate 0.15 (10) Fragrance 0.10 (filling formulation) Stock solution 90.0 Liquefied petroleum gas 10.0 Production method: (1) was replaced with (2) Add to the solution of (3) and emulsify uniformly with a homogenizer. This is added to and dissolved in (4), (6) to (10) dissolved in (5), and mixed to make a uniform solution. Filling is performed by filling a can with a stock solution, mounting a valve, and then filling with liquefied petroleum gas.

Example 11 Hair Shampoo (1) Polyoxyethylene (3E.O.) lauryl sulfate 30.00 (% by weight) sodium salt of ester (30% by weight aqueous solution) (2) Lauryl sulfate sodium salt 00 (30% by weight aqueous solution) (3) Coconut oil fatty acid diethanolamide 4.00 (4) Glycerin 1.00 (5) Sodium dehydroacetate 0.20 (6) Disodium ethylenediaminetetraacetate 0.25 (7) Purified water 53.55 (8) Agaricus mushroom fruit body extract (Production Example 4) 0.50 (9) Hypericum extract (Production Example 8) 0.20 (10) Common peppermint extract (Production Example 10) 0.20 ( 11) Fragrance 0.10 Production method: (7) is heated to 70 ° C, (1) to (6) are added and uniformly dissolved, then cooled, and (8) to (11) are added and mixed at 30 ° C. ,
Be uniform.

[Example 12] Hair rinse (1) Silicone oil 3.0 (% by weight) (2) Liquid paraffin 1.0 (3) Cetanol 1.5 (4) Stearyl alcohol 1.0 (5) Stearyl trimethyl chloride Ammonium 0.7 (6) Glycerin 3.0 (7) Methyl parahydroxybenzoate 0.2 (8) Purified water 88.3 (9) Agaricus mushroom fruit body extract (Production Example 2) 0.3 (10) Sage Extract (Production Example 5) 0.2 (11) Hop extract (Production Example 6) 0.2 (12) Thyme extract (Production Example 13) 0.5 (13) Fragrance 0.1 Production method: (1) The oil phase component of (4) and the aqueous phase component of (5) to (8) are mixed and dissolved, respectively, and heated to 70 ° C. The oil phase is added to the water phase to emulsify, and after cooling, (9) to (13) are sequentially added and mixed at 30 ° C. to make uniform.

The above-described embodiments 1 to 12 of the present invention
In all cases, the stability was good, and even when stored at 25 ° C. for 6 months, no change in the state such as a change in color or odor, phase separation, or appearance of precipitates and precipitates was observed. Further, as a result of a 48-hour back obstruction sticking test by a male panelist, no skin irritation was observed.

[0042]

As described in detail above, the present invention can be applied to hair loss and alopecia caused by various causes in addition to male pattern baldness, and has a synergistic effect on hair loss prevention and hair growth and hair growth. It was possible to provide an external preparation for the head that was improved and highly safe for the scalp.

Claims (2)

[Claims] 1. Agaricus blazei Muril
l) fruiting body extract and sage ( Salvia officinalis)
L.), hops ( Humulus lupulus L.), rosemary ( Rosmarinus officinalis L.), Hypericum ( Hyper
icum erectum Thunb.), Mentha ( Mentha arvensis L.)
var. piperascens Malinv.), peppermint (Mentha
piperita L.), chamomile ( Matricaria chamomilla )
L.), Arnica ( Arnica montana L.), Thyme ( Thymu
s vulgaris L.), one or two selected from each extract
An external preparation for the head, comprising at least one species. 2. Agaricus blazei Muril
l) The external preparation for a head according to claim 1, wherein the fruiting body extract is an extract with a polar solvent.