JP2001002532A - Hair growing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair-growing agent having excellent trichogenous effect and falling-off preventing effect and effective for the amelioration and cure of male alopecia by including a component selected from blood flow promoting agent and hair follicle activation agent in combination with a polar solvent extract of eucalyptus. SOLUTION: The hair-growing agent contains (A) a component selected from a blood flow promoting agent such as extract of Swertia japonica and d,l-α-tocopherol acetate and a hair follicle activation agent such as panthenol and ethyl pantothenate and (B) a polar solvent extract of eucalyptus. In the above hair-growing agent, the amount of the component A is preferably 0.0001-5 wt.% and that of the component B is preferably 0.0001-10 wt.% in dry basis. The polar solvent extract of eucalyptus is produced e.g. by extracting the leaf, stalk, etc., of a plant of the genus Eucalyptus with a polar solvent (e.g. acetone, ethanol or butylene glycol).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer used in the field of quasi-drugs, pharmaceuticals or cosmetics. More specifically, the present invention relates to a hair-growing agent having excellent hair-growth / hair-growth effects and hair loss-inhibiting effects and having high safety.

[0002]

BACKGROUND OF THE INVENTION Male pattern baldness is thinning or baldness commonly seen in middle-aged and elderly men. In recent years, this alopecia has been remarkably young and has been increasing, and there has been a particular demand for hair loss control and improvement by quasi-drugs and hair growth agents belonging to pharmaceuticals. Conventionally, a natural product extract or a synthetic agent having various actions has been used as a hair restorer, but none of these can provide a sufficient effect by addition of a small amount.
The addition of a large amount gives an unpleasant irritating sensation at the site of adaptation, and has the disadvantage of causing dermatitis when used continuously.

[0003] Eucalyptus is a woody plant of the genus Eucalyptus belonging to the family Myrtaceae, and the essential oil obtained by steam distillation has been used in cosmeceuticals, daily necessities and fragrances. There are approximately 600 species of Eucalyptus plants, and a particularly frequently used Eucalyptus species is Eucalyptus globra [scientific name: Eucaryptus glo
bulus , eucalyptus] and contains components such as essential oils, flavones and tannins. Numerous studies have been conducted on bioactive substances contained in other Eucalyptus plants, and they have been described in a review (Hiroyuki Nishimura, Eucalyptus Future Bioresource, 1987).
Year). In recent years, eucalyptus extracts obtained by solvent extraction have been used as bath additives as moisturizing components.

With respect to the use of eucalyptus plants in hair growth agents, a 5α-reductase inhibitor (JP-A-8-310923) containing an essential oil obtained by steam distillation from Eucalyptus globulus as an active ingredient has been proposed. . As for hair preparations, a hair care product containing macrocarpals having antibacterial activity derived from Eucalyptus macrocarpa (Japanese Patent Application Laid-Open No. 9-104610) has been proposed. This patent describes that Eucalyptus extract has a poor hair loss inhibitory effect.

[0005]

However, extracting a specific chemical component from a specific tree species is very troublesome. Extracts from typical eucalyptus such as Eucalyptus globulus have many other uses as described above. Therefore, if the extract can be used effectively as it is, there are great advantages in terms of production efficiency and economic efficiency. There is. Therefore, an object of the present invention is to provide a hair restorer having a sufficient effect even when a eucalyptus extract is used as it is.

[0006]

In order to solve the above problems, the present invention employs the following constitution. That is, the present invention
It is "a hair restorer characterized by containing one or more components selected from a blood circulation promoter and a hair follicle activator and a polar solvent extract of eucalyptus".

[0007] In a preferred embodiment of the present invention, the blood circulation promoter is assembly extract or tocopherol acetate, and the hair follicle activator is panthenol or ethyl pantothenate.

The present inventors have conducted intensive studies to solve the above problems. As a result, when eucalyptus extract and the above components are used in combination, the hair growth promoting action is synergistically improved, and the safety is high for a long period of time. This has led to the present invention.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail. The raw material of the eucalyptus extract used in the present invention is not particularly limited as long as it is a leaf of a plant belonging to the genus Eucalyptus in the family Myrtaceae, and may be used alone or in combination of two or more. Eucalyptus plants are evergreen broad-leaved trees distributed in temperate regions around the world, and in recent years, Australia, New Zealand,
It is a tree species that is actively planted in Vietnam and elsewhere. In addition to being used as pulp materials and medicinal products, park trees, garden trees,
It has a wide range of uses, such as building materials, equipment materials, civil engineering materials, and marine materials. The site of the plant is not particularly limited, but is preferably a branch and leaf that can be easily collected, and particularly preferably a leaf.

The eucalyptus extract referred to in the present invention is an extract obtained by extracting eucalyptus leaves, branches and the like with a polar solvent. When used, it is used as a concentrated solution of the extracted solvent, and this solution is referred to as eucalyptus extract. Examples of the polar solvent include alcohols, glycols, ketones, esters, ethers, and halogenated carbons. As lower alcohols, ethanol,
And methanol and propanol. Examples of the glycols include ethylene glycol, diethylene glycol, butylene glycol, propylene glycol and the like. Examples of ketones include acetone and methyl ethyl ketone, and examples of esters include ethyl acetate, propyl acetate, and ethyl formate. These solvents may be used singly or as an aqueous solution, or may be used as a mixture of two or more optional solvents. Among the above solvents, acetone, ethanol, butylene glycol and propylene glycol are more preferred from the viewpoint of hair growth promoting activity.

The eucalyptus extract is obtained, for example, as follows. The dry matter of Eucalyptus leaves is crudely extracted with acetone, lower alcohol or glycols. Prior to the crude extraction, the dried leaves are pre-treated, for example, by pulverizing the dried leaves into a suitable size or pulverizing the dried leaves to facilitate solvent extraction.

The extraction method may be a commonly used method, for example, a method in which eucalyptus leaves are immersed in an organic solvent for a long time, an extraction is carried out while heating and stirring at a temperature not higher than the boiling point of the organic solvent, and filtration is performed. To obtain an extract.

In order to obtain a eucalyptus extract having a higher hair growth promoting activity during the above-mentioned extraction operation, it is more preferable to dry the eucalyptus leaves than to extract the eucalyptus leaves directly with acetone, a lower alcohol or glycols. Degrease with solvent,
It is preferable to remove the essential oil and then extract with a lower alcohol or glycol. This operation can also be performed by removing essential oils by steam distillation, and then extracting by adding a lower alcohol or glycol to the residue.
Examples of the non-polar solvent include alkanes such as hexane, pentane and heptane.

Although the eucalyptus extract can be used as it is as an active ingredient of the hair restorer of the present invention, the extract may be further subjected to a suitable separation means, for example, partition extraction, gel filtration, silica gel chromatography, reverse phase or normal phase. Fractions having high activity can be fractionated and used by the high performance liquid chromatography method described above.

The eucalyptus extract thus obtained is preferably used by dissolving it in water or a solvent such as water-lower alcohol. The eucalyptus extract is 0.0001 to 10% by weight (hereinafter simply referred to as "%"), particularly 0.0005 to 1% by dry weight in the hair restorer of the present invention from the viewpoint of a synergistic effect and a feeling of irritation to the scalp. It is preferable to mix them.

The blood circulation promoter used in the present invention includes:
Ginkgo extract, kina extract, shobu root extract, assembly extract, clove extract, chimney extract, spruce extract, capsicum tincture, nicotinic acid and its derivatives,
Garlic extract, yuzu extract, acetylcholine, carpronium chloride, γ-oryzanol, cromakalim, circretin, cepharanthin, nicorandil, d, l acetate
Vitamin E such as -α-tocopherol, vitamin E derivatives such as vitamin E nicotinate, biotin, pinacidil, hinokitiol, minoxidil, and the like. Of these, ginkgo extract, assembly extract,
Clove extract, pepper tincture, garlic extract,
Carpronium chloride, cepharanthin, d, l-α acetate
-Tocopherol and minoxidil are more preferred, assembly extract and d, l-α-tocopherol acetate are particularly preferred.

The assembly extract is a seasonal plant belonging to the Gentianaceae [scientific name: Swertia japonica Mak]
ino ], and contains bitter glycosides such as suertimarin, suerthioside, gentiobicloside, and amarogentin as main components, and expands blood capillaries in the skin to promote blood circulation. D, l-α-Tocopherol acetate is a fatty acid ester of vitamin E and has an antioxidant effect in addition to dilating the capillaries of the skin to promote blood circulation.

The hair follicle activator used in the present invention includes:
Yeast extract, diatom extract, ginseng extract, ginseng extract, placenta extract, royal jelly extract, disodium adenosine triphosphate, potassium aspartate, photosensitive pigment 301, glyceride pentadecanoate, netakanaal, panthenol, ethyl pantothenate, etc. Among them, ginseng extract, ginseng extract, placenta extract, glyceride pentadecanoate, panthenol and ethyl pantothenate are more preferred, and panthenol and ethyl pantothenate are particularly preferred.

Panthenol and ethyl pantothenate are
A derivative of pantothenic acid, a type of vitamin B complex, that improves the function of hair cells in hair follicles.

When used as a hair restorer in combination with a eucalyptus extract, at least one or more selected from the above-mentioned blood circulation promoters and hair follicle activators are mixed and used. Particularly preferably, a blood circulation promoter and a hair follicle activator are used in combination.
Further, it is preferable to use it by dissolving it in water or a solvent such as water-lower alcohol.

It is preferable that the blood circulation promoting agent and the hair follicle activator are incorporated in the hair growth agent of the present invention in an amount of 0.0001 to 5%.
If it is less than 0.0001%, a sufficient effect cannot be obtained.
If it exceeds 5%, unpleasant irritation is given to the scalp, which is not preferable. A more preferable range is 0.0005 to 1%.

In the hair restorer of the present invention, by combining the eucalyptus extract with a component selected from a blood circulation enhancer and a hair follicle activator, a superior hair growth promoting effect can be obtained due to the synergistic effect. A further excellent hair growth promoting effect can be obtained by adding a moisturizing agent, an antibacterial agent, a keratolytic agent, a local stimulant, an anti-inflammatory agent, an antiseborrheic agent, an anti-androgen agent and the like.

The moisturizing agents used herein include life-extending grass extract, Hypericum perforatum extract, barley extract, orange extract, seaweed extract, cucumber extract, burdock extract, shiitake extract, jiou extract, duke extract, cordyceps extract, loquat extract and grape leaf extract. , Prune extract, loofah extract, Maikai extract, lily extract, apple extract, soluble collagen, glycerin,
Chondroitin sulfate, tuberose polysaccharide, trisaccharide, urea, hyaluronic acid, vitamin C phosphate calcium salt, sodium pyrrolidone carboxylate and propylene glycol. Also, as antibacterial agents, isopropyl methylphenol,
Examples include edetoacetic acid, benzalkonium chloride, octopirox, photosensitive dyes 101 and 201, chlorohexidine, salicylic acid, zinc pyrithione, potassium sorbate, paraben, biosol, and phenol. Examples of the keratolytic agent include aspirin, salicylic acid and resorcinol. Examples of the local stimulant include Dutch mustard extract, cantharis tincture, sansho extract, ginger tincture, peppermint oil, wasabi radish extract, 1-
Menthol and nonyl acid vanillyl amide are mentioned.
As anti-inflammatory agents, gongon extract, chamomile extract,
Kawamurai extract, Kikyo extract, Kyounin extract, Gardenia extract, Kumasa extract, Gentian extract,
Comfrey extract, hawthorn extract, birch extract,
Anti-histamines such as Achillea millefolium extract, mallow extract, tonin extract, loquat leaf extract, azulene, guaiazulene, glycyrrhetinic acid, diphenhydramine chloride, hydrocortisone acetate and prednisolone. Antiseborrheic agents include cashew extract, sulfur, thioxolone, banside, polysorbates, lecithin and the like. Examples of antiandrogens include ethinyl estradiol, chlormadinone acetate, cycloten acetate, progesterone, oxendrone, androstenedione, deoxycorticosterone, and the like.

In addition to the above-mentioned components, the hair restorer of the present invention may contain quasi-drugs, pharmaceuticals, and the like within a range not to impair the effects of the present invention.
Various components generally used in cosmetics, gelling agents, emulsifiers such as polyoxyethylene hydrogenated castor oil, thickeners, preservatives, antioxidants such as parahydroxybenzoate, coloring agents such as fragrances and dyes Can be added and blended.

[0025] The dosage form of the hair restorer is arbitrary, and for example, any liquid form such as a hair restorer, a hair tonic, a hair cream or the like that can be applied externally may be used. The dosage form when used as a component of a drug is also arbitrary, for example, transdermal, intravenous injection, etc.
It can be administered in various ways and can be formulated into appropriate dosage forms such as ointments, lotions, liniments and ampoules.

[0026]

The present invention will be described below in detail with reference to examples and comparative examples. The present invention is not limited by this. In addition, the outline of the preparation method of the plant extract described in the examples, the preparation method of the applied sample, and the test of the hair growth effect are shown below.

<Method for Preparing Plant Extract> To 100 g of dried and ground Eucalyptus globulus leaves, 2 liters of a 90% ethanol aqueous solution was added and immersed at room temperature. Two days later, the extract was filtered, and the solvent was distilled off from the obtained extract by an evaporator and vacuum centrifugation to obtain about 7.5 g of an ethanol extract. Furthermore, after adjusting to a final concentration of 0.5% with 50% ethanol, the filtered solution was used as a eucalyptus extract. In addition, the assembly extract was similarly obtained from the dried powder assembly, and the solution prepared to a final concentration of 1.0% and filtered was used as the assembly extract.

<Preparation of Coated Sample> A coated sample was prepared as follows. Ethanol in which polyoxyethylene hydrogenated castor oil as an emulsifier was dissolved to a final concentration of 0.2% was used. At the time of mixing the eucalyptus extract and the assembly extract, an appropriate amount of purified water in which the extract was previously dissolved was mixed and mixed with ethanol to make the final ethanol concentration 50%. In addition, when d, l-α-tocopherol acetate, panthenol and ethyl pantothenate were added, the solution was completely dissolved in ethanol at room temperature in advance, and then purified water was mixed to make the final ethanol concentration 50%.

<Mouse Hair Growth Effect Test> C3H mice (male, 5 weeks old) were purchased and reared for 7 days. 5 per group
As a mouse, an area of about 2 cm × 4 cm of mouse back hair was shaved with an electric hair clipper and then treated with a depilatory. Three days later (4
5 days old), apply 100 μl of sample to shaved back skin
Was applied once daily. On the 12th day after the start of the application, the regenerated hair area ratio [%, (regenerated hair area / shaved area) × 100] was measured, and the average value in each group was determined.

<Examples 1, 2, Comparative Examples 1 to 3, Control Example>
A coating sample having the composition shown in Table 1 below was prepared,
A mouse hair growth effect test was performed. That is, eucalyptus extract and blood circulation promoter, assembly extract or d, l-α acetate
-Examples 1 and 2 and Comparative Examples 1 to 3 using tocopherol
I got In the control example, a solvent (50% ethanol) was used.

[0031]

[Table 1]

As is apparent from the average of the area ratio of the regenerated hair in Table 1, the hair regenerating agent of the present invention in which the eucalyptus extract and the blood circulation promoting agent are combined is remarkably regenerated in comparison with the comparative example.

<Examples 3 and 4, Comparative Examples 4 and 5> Table 2 below
A coated sample having the composition shown in Table 1 above was prepared, and a mouse hair growth effect test was performed. That is, Examples 3 and 4 and Comparative Examples 4 and 5 were obtained using a eucalyptus extract and a hair follicle activator, panthenol or ethyl pantothenate.

[0034]

[Table 2]

As is clear from the average of the area ratio of the regenerated hair in Table 2, the hair restorer of the present invention in which the eucalyptus extract and the hair follicle activator were combined was remarkably regenerated in comparison with the comparative example.

<Examples 5 to 8, Comparative Examples 6 to 9> Table 3 below
A coated sample having the composition shown in Table 1 above was prepared, and a mouse hair growth effect test was performed. That is, Eucalyptus extract, a blood circulation enhancer, assembly extract, d, l-α-tocopherol acetate, a hair follicle activator, and panthenol were blended to obtain Examples 5 to 8 and Comparative Examples 6 to 9.

[0037]

[Table 3]

As is apparent from the average of the area ratio of the regenerated hair in Table 3, the hair restorer of the present invention in which the eucalyptus extract is combined with a blood circulation promoter and a hair follicle activator has a further remarkable effect. Understand. In Examples 5 to 8, no side effects such as inflammation of the back skin were observed during the application period of 12 days and for one month after the application was completed. This suggests high safety of the eucalyptus extract, the blood circulation promoter and the hair follicle activator.

Table 4 shows examples of the preparation of a hair restorer containing the eucalyptus extract, a blood circulation promoter and a hair follicle activator used in the present invention.

<Embodiment 9>

[Table 4]

The components belonging to a of Table 4 are dissolved. Separately,
Dissolve the components belonging to b. a was added to b and uniformly stirred and mixed to produce a hair restorer.

[0042]

The hair restorer obtained by the present invention has an excellent hair growth-promoting action and a hair loss-inhibiting action by synergistic action of eucalyptus extract and other medicinal ingredients, and is useful for improving and treating male pattern baldness. It is valid.

Continued on front page F-term (reference) 4C083 AA111 AA112 AC102 AC122 AC432 AC641 AC642 AD661 AD662 CC37 DD23 EE10 EE22 FF01 FF05 4C086 BA09 MA63 NA14 ZA92 4C088 AB57 AB67 BA08 CA03 CA04 MA02 MA08 MA63 NA13 ZA92

Claims (2)

[Claims] 1. A hair restorer comprising at least one component selected from a blood circulation enhancer and a hair follicle activator, and a polar solvent extract of eucalyptus. 2. The hair restorer according to claim 1, wherein the blood circulation promoting agent is assembly extract or tocopherol acetate, and the hair follicle activator is panthenol or ethyl pantothenate.