JP3080767B2 - Hair restoration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restoration excellent in effects such as hair growth, hair restoration, hair loss prevention and dandruff prevention.

[0002]

2. Description of the Related Art Alopecia is thought to be caused by various factors intricately intertwined with each other, and at present, its mechanism has not yet been sufficiently elucidated. Conventionally, hair restorations containing components having various hair matrix activation or blood circulation promoting actions have been used for prevention and treatment of hair loss,
It is not effective enough to suppress hair loss and promote hair growth and hair growth.

[0003] Fuzi used as a raw material for the hair restorer of the present invention has been described in ancient times in China as a herbal sutra, and is known as an important crude drug widely used in various Chinese herbal prescriptions in Chinese herbal medicine, and it is known as Ranunculaceae. ) Of Aconitum species (Aconitum specie)
prepared from tuberous roots of s). Japanese Unexamined Patent Publication (Kokai) No. 3-271213 proposes a hair-growing and hair-restoring agent characterized by containing an extract of the root, stem or leaf of the aconite, which is the original plant, but using an extract of aconite alone The hair growth and hair growth effects were insufficient.

[0004]

SUMMARY OF THE INVENTION In view of the above circumstances, the present inventors have conducted intensive studies and as a result, have found that the extract of Fuzi and a component having a blood circulation promoting action and / or a component having a hair mother cell activating action are obtained. By blending, safety is high,
The present invention has been found to show excellent effects on mouse hair growth promotion and human hair growth promotion, and also has a remarkable effect on dandruff prevention effect, thereby completing the present invention. That is, an object of the present invention is to provide a hair restorer having excellent effects such as hair growth, hair restoration, hair loss prevention, and dandruff prevention.

[0005]

SUMMARY OF THE INVENTION The present invention relates to an extract of Fuzi, an extract of purple cassava, an extract of bamboo ginseng, and an extract of vitamins.
E, vitamin E acetate, vitamin E nicotine
G, diisopropylamine dichloroacetate, potassium chloride
Lupronium, cepharanthin, D-pantothenyl al
Cole, D-pantothenyl ethyl ether, biotin,
From the group consisting of nicotinamide and benzyl nicotinate
A hair restorer comprising at least one selected substance .

The raw crude drug used as a raw material for the hair restorer according to the present invention is attached to a Ranunculaceae family.
e) Aconitum plant (Aconitum spec)
It may be prepared from the tuberous root of ises), and the origin and place of production are not limited. Also, in general,
Aconitum plants contain highly toxic aconitine alkaloids, and use of them requires caution, so it is more preferable to use what is called a processed appendix that has been prepared by detoxification such as heat treatment. Good.

[0007] As a base plant of Fuzi, for example, a cultivated species of Aconitum c.
armichaeli Debx. ), Wild species (Aconitum kusnezoffii Re)
ichb. ) And other honey beetles from Korea (Aco
Nitum triphyllum Nakai, Aconitum coreanum
Rap. ), Japanese Aconitum (Aconit)
um japonicum Thumb. ), Aconitum beetle (Aconitum chinense Pax)
t. ). In particular, Chinese beetle from China's Sichuan province is preferable in terms of quality stability and supply with a certain cultivation method.

[0008] As a detoxification processing method, Japanese Patent Publication No. 37
No. -18498, tuber root is autoclaved at 100-130 ° C., pressure 1.0-1.5 kg / c.
m2, a method of preparing by pressurizing and heat-treating for 20 to 40 minutes is a particularly preferable method because a simple, effective and safe crude drug can be stably produced. As an example prepared by this method, the product name of “Non-Japanese Pharmacopoeia”
Is mentioned. In addition, as a method mainly performed in China, the tubers washed with water are immersed in bitter solution for several days and dried, or further steamed, a method of preparing by drying after repeating such treatments as boiling, or There is a method in which the tuberous root is washed with water, divided vertically, buried in ash at the time of freshness, dried by heating, pressurizing and the like. As an example prepared by this method, the one sold in Shikoku, China as a Japanese stick (called Japanese gun stick in Japan) is preferable because it is sufficiently detoxified with a certain quality.

[0009] The extract of the seaweed of the present invention refers to a component which has migrated from the seaweed to the solvent when the seaweed is extracted with a solvent, and this extract can be used in the form of a dried product after the solvent is removed. It can also be used in the state of being dissolved in a solvent. In the latter case, the extraction solvent constitutes a part of the base in the hair restoration of the present invention.

Solvents include water, alcohols such as methanol, ethanol, butanol, ethers such as ethyl ether, dioxane, ketones such as acetone, aliphatic hydrocarbons such as pentane and hexane.
Cyclohexane, esters, such as ethyl acetate, can be used. When the extract is used as a dried product after removing the solvent, any of the above-mentioned solvents can be used alone or in combination. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

At the time of extraction, the sticks can be used as they are, or they can be crushed or pulverized to improve contact with a solvent. The ratio between the attachment and the solvent is not particularly limited, but from the viewpoint of extraction efficiency and convenience, the attachment 1
It is preferred to use 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time varies depending on the extraction temperature, the presence or absence of stirring, and the like, but is preferably in the range of 30 minutes to 2 weeks.

[0012] component with a blood line promoting action and / or hair matrix cell-activating action, assembly extract has been conventionally used, purple assembly extract, ginseng extract, Takefushi ginseng extract, vitamin E, vitamin E Acetate, vitamin E nicotinate, diisopropylamine dichloroacetate, carpronium chloride, cepharanthin, D
-Pantothenyl alcohol, D-pantothenyl ethyl ether, acetyl pantothenyl ethyl ether, calcium pantothenate, sodium mononitroguaiacol, biotin, photosensitizer No. 301, capsicum tincture, canthalis tincture, ginger tincture, nicotinamide, nicotine Although benzyl, and the like, contact the present invention
Are used as purple extract, bamboo
Ginseng extract, Vitamin E, Vitamin E acetate, Vita
Min E nicotinate, diisopropylamine dichloroa
Acetate, carpronium chloride, cepharanthin, D-
Pantothenyl alcohol, D-pantothenyl ethyl A
Ter, biotin, nicotinamide, benzyl nicotinate
It is .

[0013] During each of the components of the above, and what is particularly identified as a blood circulation promoter, or alternatively the hair matrix cell activators, further to that combination effects of blood lines facilitate and Mohaha cell activation but also those Izu Re <br/> can be used in the present invention.

[0014] Here, in the present invention, the object of the present invention can be further enhanced by blending both the above-mentioned blood circulation promoter and hair matrix activator. Of the above-mentioned components, the extract of natural products, the extract of Japanese cabbage, the extract of purple crenata, the extract of ginseng, the extract of ginseng, the extract of bamboo ginseng are not specified, but the outline of each production method is described. It is described below.

[Method for producing assembly extract] Assembly (S
It is an extract obtained by drying or pulverizing a dried and ground product of the whole flowering plant of C. vertia japonica Makino) in ethanol or hydrous ethanol, and then filtering it off. In Examples, an extract obtained by the following method was used. 50 g of the crushed assembly was digested in 250 ml of 90 v / v% ethanol (hereinafter, v / v% is abbreviated as%) at a temperature of 40 to 50 ° C., filtered, and the residue was extracted again. 0.5 l were obtained. This was concentrated under reduced pressure, 100 ml of purified water was added to the concentrate, and after aging for one week, the extract obtained by filtering off insolubles was concentrated under reduced pressure, and then ethanol was added to reduce the ethanol concentration of the extract to 50%. Was adjusted to obtain a 100 ml assembly extract.

[Production method of purple squirrel extract] Purple squirrel (Swartia pseudochin)
Ensis Hara) is an extract obtained by subjecting a dry and pulverized material of the whole plant at the flowering stage of Ensis Hara to cold or hot digestion in ethanol or hydrous ethanol, and filtering off. In Examples, an extract obtained by the following method was used. Extraction of 50 g of the purple crushed green plant with 750 ml of 90% ethanol at room temperature for 2 days, filtration, and extraction of the residue again were repeated three times to obtain 2.25 l of an extract. This was concentrated under reduced pressure, and ethanol and purified water were added to the concentrate to adjust the ethanol concentration of the extract to 70%. After aging for one week, the insoluble matter was filtered off, and 50 ml of purple extract was collected. Obtained.

[Production Method of Ginseng Extract] Panax ginseng CA Meye
This extract is obtained by cold soaking the dried and ground product of r) for 5 to 6 years in ethanol or water-containing ethanol, and filtering. In Examples, an extract obtained by the following method was used. Panax ginseng 5 to 6 years Root dry pulverized product 50g 90
% Ethanol in 200 ml for one week, the ethanol of the extract obtained by filtration was distilled off under reduced pressure, and purified water was added to adjust the ethanol concentration of the extract to 50%.
After this was aged in a cool place for 7 to 10 weeks, insolubles were filtered off to obtain 100 ml of a ginseng extract.

[Method for producing bamboo ginseng extract] Panax japonicum CA Mey
er) is an extract obtained by cold soaking the dried and ground product of root in ethanol or hydrous ethanol and filtering off. In Examples, an extract obtained by the following method was used. 50 g of dried and ground ginseng root is mixed with 90% ethanol 2
Then, the ethanol in the extract obtained by filtration was distilled off under reduced pressure, and purified water was added to adjust the ethanol concentration of the extract to 50%.
After aging in a cool place for a week, insolubles were filtered off to obtain 100 ml of a bamboo ginseng extract.

The present inventor has conducted intensive studies on the above-mentioned constituent components to be incorporated into the hair nourishing agent. As a result, at least one member selected from the group consisting of the extract of the sticks of the present invention and a blood circulation promoting agent or a hair cell activator is used. It has been found that a hair nourishing agent combined with the above has excellent effects such as an excellent hair restoring effect, a hair restoring effect, a hair loss preventing effect, and an anti-dandruff effect by its synergistic action.

In addition, the amount of the extract of the tufted hair-filling agent is 0.1% based on the total amount of the hair-growing agent.
0001 to 20 Wt% (in terms of dry matter), the total amount of the blood circulation promoting agent or the hair matrix activator may be the amount shown below, and if the amount is less than the lower limit of each compounding amount, the effect intended by the present invention is not sufficient. On the other hand, even if the value exceeds the upper limit, improvement of the effect corresponding to the increase cannot be expected.

That is, the amount of the blood circulation promoting agent or hair matrix activator used in the present invention is appropriately adjusted depending on the respective effects and the form of the hair restorer. Are preferred. In addition, the compounding amount was based on the total amount of the hair restoration. The extract was obtained by the extraction method described above. ─────────────────────────────────── Component content (wt%) ─────── ──────────────────────────── Assembly extract 0.5 to 20 Purple ginseng extract 0.5 to 10 Ginseng extract 0 0.1 to 10 Bamboo ginseng extract 0.1 to 10 Vitamin E 0.001 to 0.5 Diisopropylamine dichloroacetate 0.01 to 5.0 Carpronium chloride 0.01 to 5.0 Cepharanthin 0.01 to 5.0 0 Pantothenyl alcohols 0.01-2.0 Pepper tinctures 0.1-1.0 Nicotinic acids 0.1-1.0 Biotin 0.001-0.1 Mononitroglycol sodium 0.1-5. 0 Photosensitive element 301 0.001-0.1 ─────── ───────────────────────────

The hair restorer of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a shampoo, a rinse, a hair foam, a hair gel and the like according to a conventional method.

The hair nourishes of the present invention include pigments, fragrances, bactericides, preservatives, keratolytic agents, anti-inflammatory agents, anti-androgens,
Hair restorers, antioxidants, cooling agents, other crude drug extracts and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0024]

The present invention will be described below in detail based on examples and comparative examples. The mouse hair growth promotion effect test method, the human hair growth promotion effect test method, and the practical test method described in the Examples are shown below.

(1) Mouse Hair Growth Promoting Effect Test The hair at the center of the back of a C3H mouse (male, 7 weeks old) was shaved with a clipper and a shaver, etc., and the sample was placed on the shaved site once a day, per mouse. 0.2 ml was applied. A group of 10 animals was used for one sample. On the 15th day after the start of the experiment, a photograph of the back of the mouse was taken, the shaved area and the hair growth area were calculated, the hair growth rate (%) was determined, and the hair growth promoting effect was determined by the average value of 10 cases.

(2) Test Method for Promoting Human Hair Growth The hair of a subject, who is a male pattern baldness, at a position 5 cm above the ears of the heads of the 10 test subjects was formed into a circular shape having a diameter of 1 cm at two places on the left and right. About 3 ml of the sample of the example or the comparative example was applied to the shaved test site on the left side twice daily in the morning and evening, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test.
Twenty hairs on each of the left and right test sites were shaved, and the average value (B) of the lengths of the 20 hairs on the left side (to which the example or the comparative example was applied) was calculated as the length of the 20 right hairs (untreated). The value divided by the average value (A) of the height was obtained and evaluated. The judgment results were shown as the average of (B) / (A) of 10 test subjects.

(3) Practical Test Method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results showed that for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect, "hair was bristle or hair was increased", "hair loss was reduced", and "hair loss was reduced" And the number of respondents.

Production Example 1 (Preparation of Bushi Extract) (1) A crushed dried tuber of Bushi (produced as Kawa Ozu or Hoshibushi) from Shikoku, China, is autoclaved at 100-130 ° C. Pressure 1.0-1.5kg / cm2,
Pressurize and heat for 40 minutes. Processed attachment 100
g in 1500 ml of 70% ethanol at room temperature (20 to
(25 ° C.) for 16 hours, and the supernatant is collected by filtration.
The mixture was concentrated under reduced pressure at 3 ° C. for 3 hours, and the solvent was distilled off to obtain 11.7 g of a brown extract.

(2) 100 g of Fuchu produced in Sichuan Province, China, which was processed in the same manner as in Production Example 1 (1), was immersed in 1500 ml of 40% ethanol at room temperature (20 to 25 ° C.) for 16 hours.
The supernatant was collected by filtration, concentrated at 45 ° C. under reduced pressure for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

(3) 50 g of a gun stick (produced as a stick valve) from Sichuan Province, China, is immersed in 500 ml of 70% ethanol at room temperature (20 to 25 ° C.) for 16 hours, and the supernatant is filtered. The extract was concentrated at 45 ° C. under reduced pressure for 2 hours, and after evaporating the solvent, 5.3 g of a brown extract was obtained.

(4) Non-Japanese Pharmacopoeia standard processed bush powder 50
g in 500 ml of 40% ethanol at room temperature (20 to 2).
(5 ° C.) for 10 hours, and the supernatant was collected by filtration, concentrated at 45 ° C. under reduced pressure for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

Examples 1 to 12 and Comparative Examples 1 to 12 (oily hair tonics) Each of the hair tonics was prepared by blending an extract of Fuzi with a blood circulation promoting agent or a hair cell activator in the following composition. Was prepared and the above-described tests were performed.

(1) Composition Ingredients Blended amount (wt%) オ リ ー ブ Olive oil 5.0 (A) Isopropyl myristate 5.0 Isopropyl methyl phenol 0.05 Polyoxyethylene nonyl phenyl ether 0.5 ──────────── (B) Extract of Fuzi See Tables 1 and 2 ────────────────────────残 量 Methylparaben 0.1 (C) Ethanol 60.0 Glycerin 5.0 Purified water 100.0 残 量──────────────────── (D) Blood circulation enhancer or hair matrix activator described in Tables 1 and 2 ────────── ────────────────────────

(2) Preparation Method The water-soluble components in the components (B) and (D) are dissolved in the component (C), and the other components (D) are dissolved in the component (A). , (A) and (C) are mixed, stirred and dispersed, and then charged into a container. When used, the contents are shaken and dispersed uniformly.

(3) Characteristics As shown in Table 1, Comparative Examples 1 to 4 in which the extract of the seaweed of the present invention was used alone and Comparative Examples 5 to 12 in which only the substance promoting blood circulation or the activator of hair matrix cells were used were promoted. The effect was low, and no hair growth and dandruff preventing effects were observed. In contrast, the hair restorations of Examples 1 to 12 of the present invention, in which the extract of the bean paste of the present invention and a blood circulation promoting or hair matrix activator were simultaneously added,
As shown in Table 2, all the tests showed clearly good results. In Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0036]

[Table 1]

[0037]

[Table 2]

Examples 13 to 28 and Comparative Examples 13 to 20 (Scalp Treatment) In the following component composition, an extract of Fuzi and a blood circulation enhancer or a hair cell activator were blended to perform each scalp treatment. Prepared and performed the tests described above. (1) Composition Ingredients Compounding amount (wt%) ─────────────────────────────────── Liquid paraffin 0 Stearic acid 5.0 (A) Cetanol 5.0 Sorbitan monooleate 3.0 Polyoxyethylene sorbitan monooleate 3.0 Isopropylmethylphenol 0.1% ─────────────────── (B) Extract of Fuzi See Tables 3 and 4 ───────────────── ────────────────── Methylparaben 0.2 (C) glycerin 5.0 Perfume 0.2 Purified water Remaining amount when the total amount is 100.0 ────── ───────────────────────────── (D) Blood circulation promoting or hair matrix activator ───────────────────────────────────

(2) Preparation Method The water-soluble components in the components (B) and (D) are added to the component (C), and the other component (D) is added to the component (A). After heating and dissolving, component (A) and component (C)
The components were uniformly stirred and mixed. Then, the mixture was cooled to room temperature with stirring to prepare each scalp treatment.

(3) Characteristics As shown in Tables 3 and 4, Comparative Examples 13 and 14 in which the extract of the appendix of the present invention was used alone and Comparative Examples 15 to 20 in which the blood circulation promoting or hair matrix activator was used alone were used. The effect of promoting hair growth was low, and no effect of preventing hair growth and dandruff was observed. On the other hand, the hair restorer of the present invention of Examples 13 to 28 in which the extract of the beech paste of the present invention and the blood circulation promoting or hair matrix activator were simultaneously formulated showed clearly good results over all the tests. Indicated. In Examples 13 to 28, no skin irritation occurred in various tests on human skin.

[0041]

[Table 3]

[0042]

[Table 4]

[0043]

As described above, it is apparent that the present invention provides a hair growth preparation which exhibits a remarkable hair growth promoting effect and is excellent in effects such as hair growth, hair growth, prevention of hair loss, and prevention of dandruff.

Continuation of front page (56) References JP-A-3-66606 (JP, A) JP-A-1-199904 (JP, A) JP-A-3-123722 (JP, A) JP-A-3-271213 (JP) JP-A-63-303914 (JP, A) JP-A-62-103006 (JP, A) JP-A-1-216912 (JP, A) JP-A-60-178805 (JP, A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 7/06

Claims (1)

(57) [Claims] 1. Extraction of Bushi and extraction of purple mushroom
Liquid, bamboo ginseng extract, vitamin E, vitamin E acetate
G, vitamin E nicotinate, diisopropylamine di
Chloroacetate, carpronium chloride, cephalanch
, D-pantothenyl alcohol, D-pantothenyl
Tyl ether, biotin, nicotinamide, nicotine
At least one of the substances selected from the group consisting of benzyl acid
Hair restorer that combines one with the other.