JP2519184B2 - Hair nourishing cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to a hair nourishing cosmetic excellent in hair nourishing and hair-growth effects. More specifically, the present invention relates to a hair nourishing cosmetic that continuously promotes blood circulation in the scalp and is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect.

(Prior Art) Hair nourishing cosmetics containing a scalp blood circulation-promoting substance such as capsicum tincture, sea bream extract, Korean carrot extract, nicotinic acid, and methyl nicotinate have been well known.

However, these blood circulation promoting substances have strong skin irritation,
There is a restriction on the amount to be blended, the blood circulation promoting action is reduced in a short time, or the blood circulation promoting action is weak, and it is effective enough to exert effects such as hair growth, hair loss prevention, and dandruff prevention. It was not a substance.

DISCLOSURE OF THE INVENTION Therefore, the present inventor has conducted extensive studies on a natural extract, a blood circulation promoting substance, and a cell activating agent which are significantly effective when blended with a hair nourishing cosmetic, and as a result, the result is that Rangium domesticum jack. An extract obtained from the bark of Burduke or Randium domesticus Jack Burrsa, an assembly extract, and diisopropylamine dichloroacetate or γ
-A hair nourishing cosmetic composition characterized by containing aminobutyric acid has extremely weak skin irritation, continuously promotes blood circulation in the scalp, suppresses sebum secretion, and is excellent in hair growth, hair loss prevention and dandruff prevention, etc. The present invention has been completed by discovering that it has the above effect.

(Object of the Invention) An object of the present invention is to provide a hair nourishing cosmetic that continuously promotes blood circulation in the scalp, suppresses secretion of sebum, and has excellent effects such as hair growth, hair loss prevention, and dandruff prevention. .

(Structure of the Invention) The present invention provides an extract obtained from the skin of Randum domestica camouflage barduke or Randium domestica camouflage bar lancer, cembly extract, and diisopropylamine dichloroacetate or γ-aminobutyric acid. A hair nourishing cosmetic which is characterized by containing.

(Detailed Description of Structure) An extract obtained from the skin of Randum domesticus jack barduke or Randium domesticus jack bar lancer used in the present invention is described in JP-A-60-243020. It is a known 5α-reductase activity inhibitor and is a known substance. The production method is described in the same publication and is extracted with ethanol, hexane, ethyl acetate, etc. as in Reference Examples 1 to 4. Any other extraction solvent may be used as long as it is suitable for each operation, for example, pentane, hexane, heptane,
Aliphatic hydrocarbons such as cyclohexane, toluene, aromatic hydrocarbons such as xyleneno, halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, alcohols such as methanol and ethanol,
Water, diethyl ether, petroleum ether, ethyl acetate, acetone or a mixed solvent of two or more of these can be raised. Not all the components of these pericarps have been elucidated, but the major ones have been isolated and their structures have been determined. The main components are radisic acid and its glycoside, langioside A, B, C
Etc. are known.

All of these substances have physiological activity and can be used as an extract as in Reference Example 1 of JP-A-60-243020 or in a form in which each component is isolated as in Reference Examples 2 to 4. . Further, the main component, Langic acid, and its glycoside, Landeoside A, B, C, have physiological activity and can be used.

In addition, the outline of the method for producing the assembly extract, which is an extract of natural products, is described below.

[Method for producing assembly extract]

This is an extract obtained by digesting a dried and crushed whole plant of senburi (Swertia Japonica Makino) during flowering in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was used in the examples.

50 g of crushed assembly product with water-containing ethanol (ethanol 90 w
t%) was digested in 250 ml at a temperature of 40 to 50 ° C., and the residue was digested again in the same manner to obtain Extract 1.5. 100 ml of purified water was added to the residue which was concentrated under reduced pressure, the mixture was aged for 1 week, the insoluble part was filtered off and the extract was concentrated under reduced pressure, and then ethanol was added to bring the ethanol content of the extract to 40 wt%. Thus, 100 ml of the assembly extract was obtained.

As a result of earnest research on the above-mentioned constituents to be blended in the hair nourishing cosmetics, the present inventors have found that (i) the skin extract, (ii) the assembly extract, (iii) diisopropylamine dichloroacetate or γ- The hair nourishing cosmetics that are mixed with aminobutyric acid at the same time have an excellent hair growth effect (mouse hair growth promoting effect, human hair growth promoting effect), hair nourishing effect, antidandruff effect, etc. due to their synergistic effect. Was remarkably recognized.

That is, these three components (i), (ii) and (iii) act synergistically on the scalp to expand scalp peripheral blood vessels, normalize hair mother cell metabolic function and enhance antidandruff effect. It was possible to achieve the excellent effect of being able to.

Further, the mixing ratio of the components such as the skin extract of the hair nourishing cosmetic is appropriately adjusted depending on the action and effect of each component, the dosage form of the hair nourishing cosmetic, etc. i) is 0.01-10.0wt%, (ii) is 1.0-20.0w
t% and (iii) may be 0.01 to 0.5 wt%, and if the content is less than the lower limit of each content, the effect of the present invention is not sufficient. On the other hand, if the content exceeds the upper limit, the increase is commensurate. The improvement of the effect is not expected.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, etc. according to a conventional method. The hair nourishing cosmetics of the present invention include dyes, fragrances, bactericides, preservatives, keratolytic agents, antiandrogens,
A hair nourishing agent, an antioxidant and the like can be appropriately added within the range where the object of the present invention is achieved.

(Example) Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples.

The mouse hair growth promotion test, human hair growth promotion test and practical test are shown below.

(1) Mouse Hair Growth Acceleration Test After cutting the back skin from the tail of ddy white mice (male, 6 weeks old, average weight: 30 g) with an electric clipper, the hair was completely removed with a depilatory cream, and the test was carried out from the next day. Each sample of Comparative Example was applied to the skin of the test site twice a day in the morning and in the evening at 0.1 ml per animal. For each sample, 10 animals were used per group.

The hair-growth effect was determined by comparing the hair length of the sample application part with that of the control group.

After 15 days from the start of the experiment, the animals were slaughtered, the skin at the test site was punched out and dried, and the length of 20 hairs therein was measured, and the average value of each was shown.

(2) Human hair growth promotion test On the ears of the heads of 10 test subjects who are male pattern baldness patients
The head of 5 cm position was shaved in a circular shape with a diameter of 1 cm in two left and right places, and about 3 ml of the sample of Example or Comparative Example was applied twice daily in the morning and evening, and compared with the untreated right side. did.
On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved and the average value of the lengths of 20 hairs on the left side (applied Example or Comparative Example) was measured (B). On the right (unprocessed)
The value was divided by the average value (A) of the lengths of 20 hairs of each of the above, and evaluated.

The result of the judgment is (B) / (A) for each of the 10 test subjects.
The average value of

(3) Practical test 20 heads of male pattern baldness test subjects were evaluated by the effect after applying the sample to the head twice a day twice a day for 6 consecutive months. The test results show that “hairy hair became bristle or increased virgin hair”, “less hair loss”, “less dandruff” for each item of hair nourishing effect, hair loss preventing effect, and dandruff preventing effect. The number of people who answered

Examples 1 to 12 and Comparative Examples 1 to 11 [Oily Hearthonic] In the following raw material composition, a radicic acid (hereinafter, abbreviated as LA) was obtained according to the description of Reference Example 2 of JP-A-60-243020. A mixture of Landiosides A, B and C (hereinafter abbreviated as LS, Reference Example 2), ethanol extract of fruit skin (hereinafter abbreviated as LAEE, Reference Example 1), hexane extract (hereinafter referred to as LAHE). Abbreviated, Reference Example 3), assembly extract, diisopropylamine dichloroacetate (hereinafter abbreviated as DADA), γ-aminobutyric acid (hereinafter GA
(Abbreviated as BA) was blended to prepare each hair nick, and the above-mentioned various tests were carried out.

(1) Composition (2) Preparation method The component (B) is dissolved in the component (A), the component (D) is dissolved in the component (C), and each is heated to 80 ° C. to be uniformly dissolved.
After cooling to 0 ° C., the components (A) and (C) are mixed and dispersed by stirring, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Properties Tables 1 and 2 show the results of various tests of each oily hair art.

As shown in Table 1, when the base of Comparative Example 1 was used alone. The hair growth promoting effect was low, and no hair nourishing or dandruff preventing effect was observed. In addition, LA, which is the main component of the peel extract of the present invention,
In Comparative Examples 2 to 7 in which LAEE, LAHE or assembly extract, DADA, and GABA were individually blended, and Comparative Examples 8 to 11 in which these three components were blended in two components, hair growth promoting effect was slightly higher than that in Comparative Example 1. , Hair growth and dandruff prevention were improved. On the other hand, the peel extract of the present invention, the assembly extract,
Examples 1 to 12 in which three components of DADA or GABA were simultaneously mixed
As shown in Table 2, the hair nourishing cosmetic of the present invention showed clearly good results in all of the tests. In addition, Example 1
-12 did not cause skin irritation in the tests on human skin.

Examples 13 to 24 Comparative Examples 12 to 22 [Sculp Treatment] Each scalp treatment was prepared and various tests were carried out in the same manner as in the example of Oily Heartnik, and the results are shown in Tables 3 and 4. did.

(1) Composition (2) Preparation method The component (B) is dissolved in the component (A), the component (D) is dissolved in the component (C), and the components are uniformly dissolved, and then each of the component (A) and the component (C) is heated to 80 ° C. The melts were mixed. Then, each scalp treatment was prepared by cooling to 30 ° C. with stirring.

(3) Properties As shown in Table 3, when the base of Comparative Example 1 alone was used, the hair growth promoting effect was low, and no hair nourishing or dandruff preventing effect was observed. In addition, LAE which is the main component of the peel extract of the present invention
Comparative Examples 13 to 17 in which E, LAHE or assembly extract, DADA, and GABA were blended alone, and Comparative Examples 19 to 22 in which these three components were blended in two parts, had a slightly hair growth promoting effect compared to Comparative Example 1. , Hair growth and dandruff prevention were improved. On the other hand, the peel extract of the present invention, the assembly extract, DA
The hair nourishing cosmetics of the present invention of Examples 13 to 24, in which the three components of DA or GABA were blended at the same time, clearly showed good results over all the tests carried out as shown in Table 4.

(Effects of the Invention) As described above, the present invention provides hair growth, hair growth, hair loss prevention,
It is obvious to provide a hair nourishing cosmetic excellent in the effect of preventing dandruff.

Claims (1)

(57) [Claims] 1. An extract obtained from the skin of Randum domesticacum jack barduke or Randium domesticacum jack bar lancer, an assembly extract, and diisopropylamine dichloroacetate or γ-aminobutyric acid. Characterizing hair nourishing cosmetics.