JP3014215B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic composition which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect and an effect of preventing hair loss.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives, or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of androgen. However, phenomena such as poor blood circulation, decreased hair mother cell activity, enlarged sebaceous glands, and scalp fibrosis are caused. It is presumed that it is caused by complicated intertwining.

[0005] Therefore, at present, simply using an androgen-suppressing component does not bring about hair growth. Furthermore, even if a hair matrix activator, a blood circulation promoter, or a component for suppressing sebaceous gland hypertrophy, which is commonly used, is used, its hair growth effect is not sufficient.

The fir extract of the present invention according to the present invention is characterized by
It is a substance that has been used as sweating and antispasmodic. As a folk medicine, raw juice of foliage is bitten by insect bites and used for trauma such as eczema, and in China, it is used for allergic rhinitis. Onamomi is a naturalized plant that is considered to have come to Japan from the continent for a long time, and is produced as a wild product in Tokushima, Osaka, Aichi and Niigata. However, it was not known that the Onami fir extract had a hair growth and hair growth effect. Further, an external preparation for skin (JP-A-03-190809) has been disclosed as an example of the formulation of a fir extract, but no application as a hair nourishing cosmetic was found.

[0007] It is an object of the present invention to provide an excellent hair growth cosmetic which promotes peripheral blood flow of the scalp, activates hair matrix cells, and prevents hair growth and hair loss.

[0008]

Means for Solving the Problems The present invention is a hair-growth cosmetic containing a fir extract.

[0009] engagement Waru cocklebur in the present invention is a Asteraceae plant scientific name is Kisanchiumu Sutorumariumu Linnaeus
(Xanthium Strumarium L), an annual plant. In addition, the fruit portion of the onamimomi is called somiko in Chinese medicine. The component extracted from these, key Santos tourmaline glycoside, a resin-like substance Kin Santos Torr Min, fatty oils, stigmasterol, beta-sitosterol, and the like. As the extraction solvent, aqueous alcohol, alcohols, acetone, ethyl acetate, hexane and the like can be used. Particularly, preferred is 10% to 90% aqueous ethanol or 100% methanol extraction solvent.

[0010] In the following text, the blending amount is indicated on the basis of the pure content (converted by the dry residue) of the extract obtained by extraction with each extract.

The amount of the fir extract of the present invention in the hair-growing cosmetic is 0.001 to 5.0 w on the basis of the total amount.
t%, more preferably 0.005 to 2.0
wt%. That is, the desired effect can not be obtained sufficiently in the present invention is less than the lower limit of this amount, also be exceeded the upper limit, but can not be expected improvement of effect corresponding to the increase.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0014]

The present invention will be described below in detail with reference to examples and comparative examples. The percentages shown in the examples are percentages by weight.

The test methods for promoting mouse hair growth, the test methods for promoting human hair growth, and the practical test methods described in the Examples are shown below.

(1) Test Method for Promoting Hair Growth of C3H Mice The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 g per animal.
A group of 10 animals was used for one sample. In addition, a base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed, and the skin of the test area was photographed. Next, the photograph is taken into an image analysis device, and the area (A) of initial shaving and the area of hair growth (B) are obtained, and the hair growth rate (%) =
(B) / (A) × 100 was calculated for each animal. Lastly, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination. (2) Human hair growth promoting effect test method Male subject 1 in whom hair growth in 30s-40s is weakened
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm.
One day and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 125,
123, 1991), the hair growth rate was determined for the hair (about 30 to 40 hairs) at the target site, and the average value was calculated (A). Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice a day every morning and evening around the test site,
Massaged well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results were expressed in terms of the number of persons who answered, "Regrowth of hair was increased or hair was increased" and "Reduction of hair loss" for each item of hair growth effect and hair loss prevention effect.

Production Example 1 1 kg of sea fir was extracted three times with 1 L of an 80% aqueous ethanol solution, and the extracted solution was concentrated to dryness with a rotary evaporator to obtain about 80 g of a muddy extract, which was extracted with an 80% ethanol extract. did. An extract obtained by extracting with a 50% aqueous ethanol solution to obtain an extract was used as a 50% ethanol extract. Production Example 2 Blue ears were extracted with a 50% aqueous ethanol solution and made into an extract to obtain a 50% ethanol extract.

Examples 1 to 7, Comparative Examples 1 to 3 Oily hair tonic In the raw material composition shown in Table 1, active ingredients were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out. In addition, the pepper tincture used in the comparative example was the one described in the Japanese Pharmacopoeia.

[0020]

[Table 1]

[0021]

[Table 2]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed, stirred and dispersed. Fill. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests performed on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good. Particularly in Comparative Example 1 containing pepper tincture, three persons complained of mild skin irritation in a practical test.

The hair growth cosmetics of the present invention of Examples 1 to 7 exhibited a high hair growth promoting effect, and showed clearly good results in all of the tests. In Examples 1 to 7, no skin irritation occurred in various tests on human skin.

[0025]

As described above, the present invention improves the peripheral blood flow of the scalp, activates hair matrix cells, is excellent in hair growth effect and hair loss preventing effect, and has no hair irritation without skin irritation. Obviously providing cosmetics.

Claims (1)

(57) [Claims] 1. A hair-growth cosmetic comprising a fir extract.