JP3534959B2 - Hair restoration cosmetics - Google Patents
Hair restoration cosmeticsInfo
- Publication number
- JP3534959B2 JP3534959B2 JP26918096A JP26918096A JP3534959B2 JP 3534959 B2 JP3534959 B2 JP 3534959B2 JP 26918096 A JP26918096 A JP 26918096A JP 26918096 A JP26918096 A JP 26918096A JP 3534959 B2 JP3534959 B2 JP 3534959B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- extract
- present
- growth
- acerola
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Cosmetics (AREA)
Description
【発明の詳細な説明】
【０００１】
【発明の属する技術分野】本発明は、育毛効果、脱毛予
防効果に優れた養毛化粧料に関する。
【０００２】
【従来の技術および発明が解決しようとする課題】従来
より、トウガラシチンキおよびニコチン酸誘導体等の血
行促進物質、また毛髪の栄養成分であるアミノ酸および
ビタミン類を配合してなる養毛化粧料が知られている。
さらには、皮脂腺の肥大防止効果をもつ成分や、男性ホ
ルモンの抑制作用をもつ成分を配合する医療用養毛剤や
養毛化粧料も数多く提案されている。
【０００３】しかし、従来より使用されている血行促進
物質は、皮膚刺激が強くその配合量に制限があったり、
血行促進の持続時間が短いという欠点がある。また、毛
髪の栄養成分も低濃度では皮膚への浸透性が低く、かつ
単独では効果が十分に発揮されないという問題点があ
る。
【０００４】ところで、男性型脱毛症は男性ホルモンの
過剰作用が原因の一つと言われているが、血行の不良や
毛母細胞の活性低下、皮脂腺の肥大化、頭皮の線維化等
の現象が複雑に絡みあって生じていると推察されてい
る。
【０００５】しかし、男性ホルモンの過剰作用が原因と
いわれる毛母細胞の活性低下や皮脂腺の肥大化を抑制す
るために、単に抗男性ホルモン剤等を育毛剤として用い
ても、育毛作用を発現するまでには至らないのが現状で
ある。また、毛母細胞賦活剤や血行促進剤を単独で用い
ても、良好な成績は得られない。
【０００６】前記の問題点を解決する手段として、特開
平５−５８８５０号公報における奇数炭素数を有する脂
肪酸類、アルコール類と、ヒドロキシプロピルアルコー
ルと、低級アルコールを含有する育毛剤組成物、特開平
５−１３９９３６号公報におけるある種のカルボキシベ
タインを含有する発毛剤、特開平５−１７０６２５号公
報における酸性ムコ多糖類とホップエキスを含有する養
毛化粧料等を始めとして数多くの養毛・育毛剤が提案さ
れているが、末梢血流を促進し、毛母細胞の賦活化をす
る物質を単独で用いても格段の育毛作用については見出
せず、また組成物においても充分満足すべき効果を得る
までには至らず、育毛効果、脱毛予防効果に改良の余地
があるのが実情であった。
【０００７】
【課題を解決するための手段】本発明者らは、このよう
な実情に鑑み、頭皮の末梢血流の促進および毛母細胞の
賦活作用のある物質について、鋭意研究を重ねた結果、
アセロラの果実より抽出したエキスと、デュークエキ
ス、ジイソプロピルアミンジクロロアセテート、γ−ア
ミノ酪酸及びγ−アミノ−β−ヒドロキシ酪酸からなる
群より選ばれる少なくとも一種以上の物質を含有した養
毛化粧料が、各成分の相乗効果により、本発明の目的で
ある優れた育毛効果、脱毛予防効果を発現することを見
いだし、本発明を完成した。
【０００８】すなわち、アセロラの果実より抽出したエ
キスと、デュークエキス、ジイソプロピルアミンジクロ
ロアセテート、γ−アミノ酪酸及びγ−アミノ−β−ヒ
ドロキシ酪酸からなる群より選ばれる少なくとも一種以
上の物質を含有する養毛化粧料によって本発明の目的が
達成される。
【０００９】
【発明の実施の形態】以下、本発明の実施の形態につい
て詳述する。
【００１０】アセロラ（Malpighia glabra Linne）は中
南米原産の常緑灌木であり、サクランボに似た小さな赤
い実をつける。この果実はＬ−アスコルビン酸を多量に
含有し、食品素材として利用されている。
【００１１】本発明に用いられるアセロラの果実より抽
出したエキスは、特開平２−２００６１０号公報等に開
示されている方法で製造され、Ｌ−アスコルビン酸の他
に、アミノ酸、有機酸、糖、ペクチン等の有用物質をも
含有する。このアセロラの果実より抽出したエキスを化
粧品に配合することはよく知られている（特開平２−２
００６１０号公報）。しかしながら、養毛化粧料におけ
る効果については現在のところ知られていない。
【００１２】以下に、アセロラの果実からのエキス抽出
方法例を示す。
＜抽出例１＞
アセロラの果実を水洗後、圧搾し、圧搾汁を得る。これ
をろ過、デカンテーション等により沈澱を除去し、必要
に応じて減圧下濃縮を行う。その後、必要に応じてエタ
ノール、プロピレングリコール等を加えた後、低温下静
置する。その後生じた沈澱を再度ろ過にて除去し、必要
に応じて孔径０．２２μｍのメンブレンフィルターを用
い、ろ過してエキスを得る。
【００１３】＜抽出例２＞
アセロラの果実を細かく粉砕し、グリセリン、１，３−
ブチレングリコール、プロピレングリコール、エタノー
ル、水などを抽出溶媒として単独で、又は混合して加え
攪拌後、低温下にて浸漬抽出する。抽出液を必要に応じ
て減圧下濃縮を行い、ろ過、デカンテーション等により
清澄化し、必要に応じて孔径０．２２μｍのメンブレン
フィルターを用い、ろ過してエキスを得る。
【００１４】＜抽出例３＞
抽出例１又は２にて得られたエキスを、更に他の溶媒に
て再抽出する。その後、必要に応じて孔径０．２２μｍ
のメンブレンフィルターを用い、ろ過してエキスを得
る。溶媒を選択することにより、一部の成分を除去する
ことも可能であり、また養毛化粧料に配合する際に適し
たエキスを得ることができる。
【００１５】本発明の目的である育毛効果、脱毛予防効
果を示す範囲を検討した。その結果、上記方法により得
られた本発明に係るアセロラの果実より抽出したエキス
の配合量は、抽出に用いる果実と得られるエキスの質量
比を１とした場合、養毛化粧料の０．００１〜２０質量
％（以下、ｗｔ％と略する）であればよく、より好まし
くは０．０１〜１０ｗｔ％である。
【００１６】本発明に用いるγ−アミノ酪酸及びγ−ア
ミノ−β−ヒドロキシ酪酸は公知の化合物である。
【００１７】そして、デュークエキス、ジイソプロピル
アミンジクロロアセテート、γ−アミノ酪酸及びγ−ア
ミノ−β−ヒドロキシ酪酸は、本発明の目的である育毛
効果、脱毛予防効果を示す範囲を検討した結果、養毛化
粧料の総量を基準として、０．００１〜２０．０ｗｔ％
であればよく、より好ましくは０．０１〜５．０ｗｔ％
である。
【００１８】本発明においてアセロラの果実より抽出し
たエキスと併用する物質としては、ジイソプロピルアミ
ンジクロロアセテートが、特に好ましい結果を与える。
【００１９】本発明に係る養毛化粧料は、常法に従っ
て、たとえばヘアートニック、ヘアーローション、ヘア
ークリーム、ヘアーコンディショナー、シャンプー、リ
ンス、ヘアージェル、ヘアーミスト、ヘアーフォーム等
の剤型に製造し、使用することが可能である。
【００２０】本発明に係る養毛化粧料は、養毛、育毛お
よび／または脱毛予防のために、それを目的とする局所
（頭皮）に、その剤型に従って塗布または噴霧して適用
される。
【００２１】なお、本発明に係る養毛化粧料には、色
素、香料、殺菌剤、防腐剤、界面活性剤、顔料、角質溶
解剤、抗アンドロゲン剤等を本発明の目的を達成する範
囲で適宜配合することができる。
【００２２】
【実施例】以下、実施例および比較例により本発明を詳
細に説明するが、本発明はこれらに限定されるものでは
ない。なお、本発明に使用した試験方法は下記の通りで
ある。
【００２３】実用試験法
男性型脱毛症患者２０名の頭部に毎日朝夕２回、連続６
ケ月間試料を塗布した後の効果を評価した。試験結果
は、育毛効果、および脱毛予防効果の各項に対して、
「生毛が剛毛化した、あるいは剛毛が増加した」、「脱
毛が少なくなった」と各々回答した人数で示した。
【００２４】実施例１〜４、比較例１〜６（ヘアートニ
ック）
表１の原料組成において、表２に記載の如く有効成分を
配合してヘアートニックを調製し、前記の試験を実施し
た。
【００２５】なお、以下の実施例、比較例にて配合した
アセロラの果実より抽出したエキスの調製方法は前述し
た抽出例１に該当し、具体的に下記に示す。
【００２５】アセロラの果実よりのエキスの調製方法
（抽出方法）
アセロラの果実（１０ｋｇ）を圧搾し、圧搾汁を得た。
これを減圧下濃縮後ろ過し、ろ液（約２ｋｇ）を得た。
ろ液にプロピレングリコール３０ｗｔ％水溶液（１８ｋ
ｇ）を加え、冷所に７日間静置した。その後、ろ過して
エキス（約２０ｋｇ）を得た。
【００２６】
【表１】
【００２７】（１）調製法
表１に記載の（Ｂ）成分を（Ａ）成分中に溶解させた
後、（Ｃ）成分を添加し、混合攪拌分散して容器に充填
した。
【００２８】（２）特性
【００２９】
【表２】【００３０】各ヘアートニックの試験を実施した結果を
表２に示した。表２の通り、実施例１〜４の本発明に係
る養毛化粧料は、実用試験の結果は良好であり、アセロ
ラの果実より抽出したエキスによる、育毛効果及び脱毛
予防効果の促進が見られた。一方、比較例１〜６は実用
試験の結果は良好ではなかった。
【００３１】なお、いずれの実施例の養毛化粧料を用い
た場合にも、ヒトに炎症、その他副作用と考えられる症
状は発現せず、本発明に係る養毛化粧料は安全性にも優
れることが明らかであった。
【００３２】
【発明の効果】本発明に係る養毛化粧料は、毛母細胞の
賦活化作用を有し、育毛効果、脱毛予防効果および安全
性に優れる。Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and a hair-loss preventing effect. 2. Description of the Related Art A hair restoration cosmetic comprising a blood circulation promoting substance such as pepper tincture and a nicotinic acid derivative, as well as amino acids and vitamins which are nutritional components of hair. The fee is known.
Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed. [0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and their amounts are limited.
The disadvantage is that the duration of blood circulation promotion is short. In addition, there is a problem in that the nutritional component of the hair also has a low permeability to the skin at a low concentration, and the effect is not sufficiently exerted by itself. [0004] By the way, male pattern baldness is said to be one of the causes of the excessive action of male hormones. However, phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands and fibrosis of the scalp, etc. It is presumed that this is caused by complicated intertwining. [0005] However, in order to suppress the decrease in hair matrix activity and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male hormones, the hair growth action is exhibited even if an anti-androgen agent is simply used as a hair restorer. It is not the case at present. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone. As means for solving the above-mentioned problems, a hair restorer composition containing fatty acids and alcohols having an odd number of carbon atoms, hydroxypropyl alcohol and a lower alcohol disclosed in JP-A-5-58850 is disclosed. Numerous hair growth and hair growth, including a hair growth agent containing a certain carboxybetaine in JP-A-5-139936, a hair growth cosmetic containing an acidic mucopolysaccharide and a hop extract in JP-A-5-170625, etc. Agents have been proposed, but the use of a substance that promotes peripheral blood flow and activates hair matrix cells alone does not show any remarkable hair-growth effect, and also shows a satisfactory effect in the composition. In fact, there was room for improvement in the hair growth effect and the hair loss prevention effect. [0007] In view of such circumstances, the present inventors have conducted intensive studies on substances that promote peripheral blood flow of the scalp and activate hair matrix cells. ,
Extract extracted from the fruit of acerola, Duke extract, diisopropylamine dichloroacetate, hair restoration cosmetics containing at least one or more substances selected from the group consisting of γ -aminobutyric acid and γ-amino-β-hydroxybutyric acid , It has been found that the synergistic effects of the respective components exhibit excellent hair-growth effects and hair-loss preventing effects, which are the objects of the present invention, and have completed the present invention. That is, an extract extracted from the fruit of acerola, a duke extract, diisopropylamine dichloroacetate, γ-aminobutyric acid and γ-amino-β-hi
The object of the present invention is achieved by a hair growth cosmetic containing at least one or more substances selected from the group consisting of droxybutyric acid . Embodiments of the present invention will be described below in detail. [0010] Acerola (Malpighia glabra Linne) is an evergreen shrub native to Latin America and bears small red berries similar to cherries. This fruit contains a large amount of L-ascorbic acid and is used as a food material. The extract extracted from the fruit of acerola used in the present invention is produced by the method disclosed in JP-A-2-200610 and the like. In addition to L-ascorbic acid, amino acids, organic acids, sugars, It also contains useful substances such as pectin. It is well known that an extract extracted from the fruit of acerola is incorporated into cosmetics (Japanese Patent Laid-Open No. 2-2 / 1990).
No. 6010). However, the effect on hair-growth cosmetics is not known at present. The following is an example of a method for extracting an extract from acerola fruit. <Extraction Example 1> Acerola fruits are washed with water and then pressed to obtain a pressed juice. The precipitate is removed by filtration, decantation or the like, and concentrated under reduced pressure if necessary. Thereafter, if necessary, ethanol, propylene glycol and the like are added, and the mixture is allowed to stand at a low temperature. Thereafter, the resulting precipitate is removed by filtration again, and if necessary, an extract is obtained by filtration using a membrane filter having a pore size of 0.22 μm. <Extraction Example 2> Acerola fruit was finely ground and glycerin, 1,3-
Butylene glycol, propylene glycol, ethanol, water, or the like is used alone or as a mixture as an extraction solvent. The extract is concentrated if necessary under reduced pressure, clarified by filtration, decantation, or the like, and optionally filtered using a membrane filter having a pore size of 0.22 μm to obtain an extract. <Extraction Example 3> The extract obtained in Extraction Example 1 or 2 is re-extracted with another solvent. Thereafter, if necessary, the pore size is 0.22 μm.
The extract is obtained by filtration using a membrane filter. By selecting a solvent, it is possible to remove some components, and it is possible to obtain an extract suitable for blending into a hair nourishing cosmetic. The scope of the present invention, which shows the hair-growth effect and the hair loss-preventing effect, was examined. 0 Consequently, the amount of extract extracted from acerola fruit according to the present invention obtained by the above method, the extract obtained with the fruit used for extraction if the mass ratio was 1, the hair tonic cosmetics. 001-20 mass <br/>% may be a (hereinafter, abbreviated as wt%), more preferably 0.01-10 wt%. Γ-aminobutyric acid and γ-a used in the present invention
Mino -β- hydroxybutyrate Ru der known compounds. Then, Duke extract, diisopropylamine dichloroacetate, γ-aminobutyric acid and γ-
Mino-β-hydroxybutyric acid was examined for the range of hair growth and hair loss prevention effects that are the objects of the present invention, and as a result, 0.001 to 20.0 wt% based on the total amount of the hair growth cosmetic.
And more preferably 0.01 to 5.0 wt%.
It is. In the present invention, diisopropylamine dichloroacetate gives a particularly preferable result as a substance to be used in combination with the extract extracted from the fruit of acerola. The hair nourishing cosmetic composition according to the present invention is manufactured in a usual manner into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, and the like. It is possible to use. The hair-growing cosmetic composition according to the present invention is applied or sprayed to a topical area (scalp) for the purpose of hair-growing, hair-growth and / or hair loss prevention according to the dosage form. The hair nourishing cosmetics according to the present invention include a pigment, a fragrance, a bactericide, a preservative, a surfactant, a pigment, a keratolytic agent, an antiandrogen, etc. within a range in which the object of the present invention is achieved. It can be appropriately blended. The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows. Practical test method Twice in the morning and evening twice a day on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who indicated that "hair had become bristle or bristles had increased" and "hair loss had decreased", respectively. Examples 1 to 4 and Comparative Examples 1 to 6 (Heart Tonic) Hair tonics were prepared by mixing active ingredients as shown in Table 2 in the raw material compositions shown in Table 1, and the above test was carried out. [0025] In the following examples, the method made tone extract extracted from acerola fruit blended in Comparative Example corresponds to the extracted example 1 described above, specifically shown below. [0025] The method made control of the extract from the fruit of acerola fruit (extraction method) acerola (10kg) squeezing to give a squeezed juice.
This was concentrated under reduced pressure and filtered to obtain a filtrate (about 2 kg).
A 30 wt% aqueous solution of propylene glycol (18 k
g) was added, and the mixture was allowed to stand in a cool place for 7 days. Thereafter, the mixture was filtered to obtain an extract (about 20 kg). [Table 1] (1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) was added, and the mixture was stirred, dispersed and filled into a container. (2) Characteristics [Table 2] Table 2 shows the results of the tests for each hair tonic. As shown in Table 2, the hair restoration cosmetics according to the present invention of Examples 1 to 4 showed good results in practical tests, and the extracts extracted from the fruits of acerola promoted the hair growth effect and the hair loss prevention effect. Was. On the other hand, Comparative Examples 1 to 6 did not show good results in practical tests. It should be noted that, when any of the hair-growth cosmetics of any of the examples is used, no inflammation or other symptoms considered to be side effects occur in humans, and the hair-growth cosmetic according to the present invention is also excellent in safety. It was clear. The hair restoration cosmetic composition of the present invention has an effect of activating hair matrix cells, and is excellent in hair growth effect, hair loss preventing effect and safety.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭63−303913（ＪＰ，Ａ) 特開 平３−77808（ＪＰ，Ａ) 特開 平５−43429（ＪＰ，Ａ) 特開 平８−48616（ＪＰ，Ａ) 特開 平２−200610（ＪＰ，Ａ) 特開 平５−17321（ＪＰ，Ａ) 特開 昭62−142108（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 A61K 35/78 ──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-63-303913 (JP, A) JP-A-3-77808 (JP, A) JP-A-5-43429 (JP, A) JP-A 8- 48616 (JP, A) JP-A-2-200610 (JP, A) JP-A-5-17321 (JP, A) JP-A-62-142108 (JP, A) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 7/ 00-7/50 A61K 35/78
Claims (1)
デュークエキス、ジイソプロピルアミンジクロロアセテ
ート、γ−アミノ酪酸及びγ−アミノ−β−ヒドロキシ
酪酸からなる群より選ばれる少なくとも一種以上の物質
を含有することを特徴とする養毛化粧料。(57) [Claim 1] An extract extracted from acerola fruit,
Duke extract, diisopropylamine dichloroacetate, γ-aminobutyric acid and γ-amino-β-hydroxy
A hair restoration cosmetic comprising at least one substance selected from the group consisting of butyric acid .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26918096A JP3534959B2 (en) | 1996-09-18 | 1996-09-18 | Hair restoration cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26918096A JP3534959B2 (en) | 1996-09-18 | 1996-09-18 | Hair restoration cosmetics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001091949A Division JP2001253808A (en) | 2001-03-28 | 2001-03-28 | Hair growing cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH1087440A JPH1087440A (en) | 1998-04-07 |
| JP3534959B2 true JP3534959B2 (en) | 2004-06-07 |
Family
ID=17468802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26918096A Expired - Lifetime JP3534959B2 (en) | 1996-09-18 | 1996-09-18 | Hair restoration cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3534959B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000016922A (en) * | 1998-06-26 | 2000-01-18 | Nomura:Kk | Hair tonic |
| GB9923023D0 (en) * | 1999-09-30 | 1999-12-01 | Boots Co Plc | Hair care composition |
| KR20040049068A (en) * | 2002-12-03 | 2004-06-11 | 주식회사 엘지생활건강 | Hair growth promotion composition |
| JP2005200357A (en) * | 2004-01-16 | 2005-07-28 | Kanebo Cosmetics Inc | Hair-fostering cosmetic |
| JP2009179611A (en) * | 2008-01-31 | 2009-08-13 | Kao Corp | Hair cosmetic |
-
1996
- 1996-09-18 JP JP26918096A patent/JP3534959B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1087440A (en) | 1998-04-07 |
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