JP2000016922A - Hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a safe hair tonic derived from natural plant and presenting marked efficacy. SOLUTION: This hair tonic contains, as active ingredient, a squeezed product of a plant belonging to the genus Calanthe and/or an extract afforded by solvent extraction of the above squeezed product; wherein, more precisely, the active ingredient contains (i) calanthoside A and (ii) 2-hydroxyindole formed by the action of a β-glucosidase on calanthoside A.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an active ingredient obtained from a plant belonging to the genus Ebine belonging to the family Orchidaceae, and more particularly to hair growth and hair growth containing a pressed product and / or an extract of the pressed product as an active ingredient. Agent. In particular, the present invention relates to a hair growth and fostering agent that promotes hair growth and hair growth that is useful for those with severe hair loss, those whose heads are becoming thinner, or those whose hair has already fallen out. .

More specifically, the present invention is more excellent in hair growth and hair growth effects than a direct extract (hereinafter, also referred to as a direct extract) obtained by simply extracting a plant of the genus Ebine with a solvent such as alcohol. The present invention relates to a hair-growing / hair-growing agent comprising a pressed product of a plant of the genus Ebine or a pressed juice as an active ingredient.

[0003]

2. Description of the Related Art Conventionally, various hair growth and growth agents have been used for baldness,
It has been used for the prevention and treatment of physiological symptoms such as thinning hair, dandruff and fat. In general, as a compounding agent of a hair growth and hair growth agent, those mainly used for promoting blood circulation of the scalp, activating hair matrix cells, suppressing lipid secretion of the scalp, supplying nutrition to the hair, and the like are used.

[0004] For example, conventional hair growth and hair growth agents of this type include pentadecanoic acid glyceride, cepharanthin, assembly extract, soluble cystine, carrot extract, 1-menthol, isopropylmethylphenol, glycyrrhetinic acid, tocopherol acetate, and hinokitiol. , Tincture of tincture, licorice extract, nicotinamide, salicylic acid, tacanal and the like are known.

[0005] As described above, various hair growth and growth agents are known, but they are effective for promoting hair growth and hair growth, preventing hair loss, generating dandruff and itching. In addition, there is a demand for a highly safe product that has no skin irritation due to side effects even during long-term use.

However, in the conventional hair-growing / hair-growing agent having the above-mentioned components, the hair loss is temporarily cured, but the thin hair does not thicken. At present, it has not been effective.

[0007] Further, even if it is used for hair whose hair has already fallen off, it is only effective to produce hair even after about six months have passed, and it cannot be grown further.

[0008]

SUMMARY OF THE INVENTION In view of the above-mentioned limitations of the prior art, the present inventors have found that the conventional hair growth and hair growth stimulants cannot exert a satisfactory effect because they promote the activation of hair roots. It was thought that the cause was the lack of components and components that promote the erecting (that is, toughening) of the hair, and intensive research was conducted to develop more excellent hair growth and hair growth agents.

As a result, the present inventors have confirmed that the extract of the genus Ebine of the family Orchidaceae has the effect of erecting hair and promoting its growth, and these plant extracts are effective. It has been found that it can be used as a hair-growth / hair-growth agent, and has been proposed above (JP-A-5-294813).

[0010] The hair growth and fostering agent proposed by the present inventors (JP-A-5-294813) has a severe hair loss, a thinned head, or the hair has already fallen off. It can improve the head by using it for those who have it, and can reduce hair loss and promote hair growth in a short time. Having.

The present inventors have been working on further improvement research of hair growth and hair growth agents since then. The present inventors have been conducting research and development to utilize the extract of the genus Ebine in parallel with cosmetics, particularly whitening agents. It has been found that a whitening effect is stronger in a pressed product (typically, juice) of a plant of the genus Ebine than in an extract extracted by solvent extraction (typically, alcohol extraction).

In general, when extracting an active ingredient from a plant, a solvent extraction method is employed. However, the finding that simple squeezed products (juices) from the above-mentioned raw materials include a substance having a high activity,
It gives important directions in plant utilization technology.

The present inventors have pursued the findings found in the development of cosmetics, especially whitening agents, using the above-mentioned plants of the genus Ebine. As a result, the squeezed product (juice) is one of the amino acids that constitute the protein of the skin. They found that there are substances that antagonize tyrosinase oxygen, which oxidizes certain tyrosine and produces melamine. It goes without saying that the melamine produced by the tyrosinase oxygen causes skin spots and darkening.

The present inventor has applied the above findings to an improvement study of a hair growth and hair growth agent utilizing a plant of the genus Ebine, and the mechanism thereof has not been completely elucidated. It has been found that antimetabolites in the juice have an excellent effect on hair growth and hair growth agents.

The present invention has been completed based on the above findings. According to the present invention, there is provided a hair-growing / hair-growing agent comprising a pressed product (juice) of a plant of the genus Ebine excellent as a hair-growing / hair-growing agent as an active ingredient.

[0016]

SUMMARY OF THE INVENTION In general, the present invention provides a hair growth method characterized by containing a pressed product of a plant of the genus Ebine itself and / or an extract of the pressed product as an active ingredient.・ It relates to hair growth agents.

More specifically, the present invention relates to a hair-growing / hair-restoring agent containing a pressed product of a plant of the genus Ebine and / or an extract of the pressed product as an active ingredient, wherein The extract of the pressed product contains (i) calanthoside A (calanthoside A), and (ii) 2-hydroxyindole produced by a β-glucosidase enzyme that degrades the currant site A. The present invention relates to a hair growth / growth agent.

Hereinafter, the technical configuration and embodiments of the present invention will be described in detail.

In the present invention, the reason why a pressed product of a plant of the genus Ebine and / or an extract extracted from the pressed product is employed as an active ingredient of the hair growth and growth agent is as described above.
Hereinafter, this point will be discussed again. As described above, the research and development of a hair growth and hair growth agent using the genus Ebine of the present invention is carried out in parallel with the research and development of cosmetics and whitening agents using the genus Ebine of the present inventors. Use the knowledge of

In the research and development of cosmetics, particularly whitening agents, using Ebine plants, the present inventors have found that, in an extract obtained by alcoholic extraction of Ebine plants, a currant site A (Calanthoside) represented by the following chemical formula 1 is used. It has been determined that A) is contained as an active ingredient.

[0021]

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The above-mentioned currant site A has a property (anti-tyrosinase activity) that weakens the activity of tyrosinase, a tyrosine oxidase that promotes skin spots and darkening. The tyrosinase oxidizes tyrosine, which is one of the amino acids constituting protein in the skin, as shown in the following chemical formula 2, and changes it to melanin (black pigment) via doper. This is the mechanism of skin blemishes and darkening.

[0023]

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In the subsequent research and development of the present inventors,
It has been found that squeezed juice of a plant of the genus Ebine has a greater whitening effect than an alcohol extract. Regarding this, the present inventors think as follows. (i). In the squeezed juice, enzymes that degrade glycosides such as currant side A, which are originally contained in plants (for example, β
-Glucosidase) is present. (ii) The decomposing enzyme decomposes currant side A as shown in the following chemical formula 3 to produce 2-hydroxyindole. (iii) The 2-hydroxyindole is a compound similar to melanin and suppresses the enzyme reaction of tyrosinase. That is, 2-hydroxyindole (antimetabolites)
This suppresses the enzyme reaction of tyrosinase. (iv) On the other hand, in the alcohol extract, the enzyme that decomposes currant side A during extraction with an alcohol solvent is not extracted, and therefore, no 2-hydroxyindole is produced.

[0025]

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As described above, the plant of the genus Ebine is directly extracted in order to extract all the active ingredients from the plant of the genus Ebine.
The method of extracting with an alcohol solvent and using the extracted extract as a cosmetic or whitening agent is a pressed product (juice) of a plant of the genus Ebine
Is less effective than the method using. The present inventors have already proposed cosmetics (whitening agents) based on these findings.

The inventor of the present invention has conceived to divert the above findings to the development of a hair growth and hair growth agent, which is a completely different field of application from the prevention of skin spots, and has proceeded with studies. As a result, it has been found that a hair growth and hair growth agent containing a squeezed product (juice) of an Ebine plant as an active ingredient has higher performance than an alcoholic extract of an Ebine plant.

The present inventor has sufficiently elucidated the reason why a hair growth / hair restorer containing a squeezed product (juice) of an Ebine plant as an active ingredient is more efficient than an alcohol extract of an Ebine plant. However, as described above, 2-hydroxyindole (antimetabolites) is produced in the squeezed product (juice) of the plant of the genus Ebine, which is the activity of tyrosinase, a tyrosine oxidase for tyrosine, which is a protein constituent amino acid of the skin. It is thought to reduce skin growth and activate the hair growth and hair growth effects of the skin.

In the present invention, the squeezed product (juice) of a plant of the genus Ebine is used as it is or as an active ingredient of a hair-growing and hair-growing agent after purification by filtration. Further, in the present invention, the pressed product (juice) of a plant of the genus Ebine is allowed to naturally decompose currant side A by a β-glucosidase enzyme in the pressed product (juice) to allow 2-hydroxyindole (antagonism of metabolism) After increasing the concentration of the substance (substance), a conventional solvent extraction method using alcohol, water, or hydrated alcohol may be applied, and the extracted extract may be used as an active ingredient of a hair growth and hair growth agent.

In the present invention, the above-mentioned method for increasing the concentration of 2-hydroxyindole (antimetabolites) in a pressed product (juice) of a plant of the genus Ebine comprises leaving the pressed product (juice) for a desired time. The method is not limited, and another method may be adopted. As another method described above, an enzyme or emulsin (β-glucosidase) present in almonds and seeds of various plants, for example, peach and almond, may be added to the squeezed juice at about 0.05%. In this way,
A large amount of 2-hydroxyindole can be produced in a short time.

In the hair-growing / hair-growing agent of the present invention, a plant of the genus Ebine which is a starting material, that is, Ebine of the family Orchidaceae (Cala)
As the nthe discolor, the following can be exemplified.

(1). Diebine type: diebine (C. di
color) and kieebine (C. sieboldi)
i), Kirishima shrimp (C. aristulifer)
a), C. amamiana, C. iz-insularis, C. tricarinara, C. tokunoshimaiensis, C. arisanhisa, and C. arisanenhisa (E., C. arisanenhisa). (C. plantaginea), chloronuka (C. chloroleuca), and C. caudatiabiella. (2). Tin flea vine type: tin flea vine (C. li
ukiensis), Tamazaki ebine (C. dens)
iflora), C. pulchra. (3). Taganelan type: Taganelan (C. bungoa)
na), Whiteana (C. whiteana). (4). Sakurajima shrimp type: Sakurajima shrimp (C.
oblanceolata), Mannii (C. mann)
i). (5). Kiso ebine type: Kiso ebine (C. shlech)
teri), C. alpina. (6). Kinseiran type: Kinseiran (C.nipp
onica). (7). Hirohanokaran type: Hirohanokaran (C. ja
ponica). (8). Asahyebine type: Asahyebine (C. hatt
orii). (9). Natsuebine type: Natsuebine (C. reflex
a). (10). Truran type: Turran (C. furcat
a), Long-tailed shrimp (C. longicarat)
a), Okinawa shrimp (C. okinawaensi)
s), masker (C. mascara), Madagascariensis, C. natalensis. (11). Toxalan type: Toxalan (C. venus)
ta), C. longipes, C. biloba. (12). Vesteta type: Vesteta (C. vesti
ta), rosea (C. rosea), Hermerie (C. e)
lmeri), C. rubens, C. cardilossa.

Among the above-mentioned plants belonging to the genus Ebine which are used as starting materials for the hair growth and growth agent of the present invention, in particular,
nthe discol Lindl), Kievine (C. sieboldii), Natsuebine (C. ref)
lexa) is effective.

In the present invention, the whole plant and rhizome of flowers, roots, stems, leaves and the like of the above-mentioned plant of the genus Ebine (hereinafter sometimes simply referred to as “epine”) are effectively used.

The hair-growing / hair-growing agent of the present invention comprises a pressed product (juice) prepared from the above-mentioned shrimp and / or the aforementioned pressed product (juice).
And an extract obtained by aging and then solvent extraction after the aging as an active ingredient.

In order to produce a pressed product from shrimp, the collected shrimp are washed with water, drained, roughly cut, and then squeezed with a pressing machine (for example, MI type manufactured by Komagata Seisakusho Co., Ltd.). ) Can be obtained. From the 1 kg shrimp, about 120
ml of pressed juice (liquid) can be obtained. The press compression pressure may be set as desired, for example, 500 to
It may be set to about 5,000 kg / cm ² .

Further, in order to produce the above-mentioned extract from shrimp, the conventional solvent extraction method may be used. In order to produce an extract from shrimp, a common solvent extraction method may be used. As the extraction solvent, water, hydrous alcohol, alcohol and the like can be used. The alcohol is
Lower alkyl alcohols, particularly ethyl alcohol, are desirable from the viewpoint of safety. Ethyl alcohol may be pure ethyl alcohol, but industrially, hydrated ethyl alcohol is preferred. Also, sake brewing such as distilled liquor can be used. In the above-mentioned hydrous ethyl alcohol, the alcohol concentration is not particularly limited, but is practically about 30 to 90%, preferably about 40 to 70%.

The hair-growing / hair-growing agent of the present invention comprises a pressed product of a plant of the genus Ebine obtained according to the above-described embodiment and / or a solvent-extracted extract obtained after aging the pressed product (hereinafter, these are referred to simply as a pressed product of Ebine). ), Benzoic acid as a preservative used in ordinary cosmetics, vitamin E as an antioxidant, vitamin C as an example of adjusting the pH value, and the like. It is prepared by diluting with alcohol or the like so that it can withstand long-term storage. In this case, the dilution ratio of the pressed prawn is not particularly limited, but is preferably 5 to 40%, preferably 10 to 30% in the whole solution. Specifically, it is preferable to use 100 to 200 cc of squeezed shrimp and use it as a 1000 cc solution as a whole.

The hair-growing / hair-restoring agent of the present invention contains squeezed shrimp as an active ingredient. As other ingredients, those conventionally used as hair-restoring ingredients are appropriately added and added. can do. Examples of the other compounding components include vitamins, amino acids, animal and vegetable oils, and sodium chloride. Examples of the vitamins in this case include vitamin A, vitamin B ₁ , vitamin B ₂ , niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, and biotin H (vitamin H). Also,
Amino acids include dopa (β-3,4-dihydroxyphenylalanine). Examples of animal and vegetable oils include horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, and germ oil.

Here, the general actions and effects of these components which may be added to or blended with the squeezed shrimp of the present invention, which is an active ingredient of the hair growth and growth agent of the present invention, are as follows.
That is, the vitamin A is useful for protecting mucous membranes and nerves and has been found to have an excellent effect on keratosis keratosis. Vitamin B ₁ , vitamin B ₂ , and vitamin Bs such as niacin are used in the skin, Stabilizes the mucous membrane nerves,
It activates the scalp and has an effect on cell respiration. Vitamin C promotes metabolism of the scalp, and sodium pantothenate and potassium pantothenate have an effect of improving hair and preventing gray hair. Vitamin E has a blood circulation promoting action or a hair cell activating action, and biotin H (vitamin H) has an action of activating hair roots by mixing with vegetable oil to prevent hair loss.

The dopa (β-3,4-dihydroxyphenylalanine) is decomposed in the body by oxygen and becomes a precursor of melanin pigment required for new skin and hair. Also, horse oil, olive oil, camellia oil, rapeseed oil, sesame oil,
Animal and vegetable oils such as germ oil soften the scalp, and particularly in sesame oil, activate the hair roots by mixing with biotin to prevent hair loss.

Further, sodium chloride has an osmotic effect of promoting the absorption of the active ingredient derived from the genus Ebine from the scalp by adjusting the concentration of the added sodium chloride. It can penetrate deep into the hair to activate the hair roots, and in particular to promote the erecting of the hair (that is, toughening), so that hair loss can be reduced and the hair can be grown in a short period of time. is there.

In the hair growth and fostering agent of the present invention, an effective hair growth and fostering agent can be obtained by appropriately combining the above-mentioned added components with the squeezed shrimp (juice). For example, especially for those with severe hair loss and those whose heads are becoming thinner, biotin H, sesame oil, and sodium chloride can be added in addition to the active ingredient derived from the genus Ebine, and already added. For those who have lost their hair, dopa can be added in addition to this, and in order to further shorten the recovery period of the hair, germ oil is further added in addition to the above-mentioned components. You can also. The aforementioned dopa, biotin H,
The mixing ratio of sesame oil, germ oil and sodium chloride is not particularly limited, but each ratio is 0.05 to 1.0% by weight, preferably 0.1 to 0. 3% by weight, 0.05 to biotin H
0.5% by weight, preferably 0.1-0.5% by weight, 0.1-3.0% by weight per sesame oil, preferably 0.5-0.5%
1.5% by weight, 0.1-3.0% by weight, preferably 0.5-1.5% by weight, per germ oil, 0.5-5% by weight, preferably 1-2% by weight, of sodium chloride Within each range.

In the hair growth and hair growth agent of the present invention, the above-mentioned components and the mixing ratio are to be understood as illustrative, and the hair growth and hair growth effects are synergistically promoted by changing them according to the target symptoms. It goes without saying that you get it.
For example, as examples of preferred formulations for more effectively expressing the hair growth and hair growth effects and obtaining the hair growth and hair growth effects in a short period of time, biotin H,
It has been found that a mixture of sodium pantothenate, niacin, sodium chloride, sesame oil as a vegetable oil, germ oil, and horse oil as an animal oil is preferable. However, in any case, the hair growth and fostering agent of the present invention only needs to contain a shrimp squeezed product (juice) as an essential active ingredient, and is limited to the combination of the above-mentioned blending and addition components. It goes without saying that it is not done.

As a more preferred embodiment of the hair growth and fostering agent containing the above-mentioned pressed shrimp (juice) of the present invention as an active ingredient, preferably at least biotin H, sesame oil,
It contains sodium chloride, each percentage being 0.1-1.5% by weight for biotin H, 0.5-1.5% by weight for sesame oil and 1 for sodium chloride, based on the total weight.
To 2% by weight of the mixture in each range.
100 to 20 cc of the shrimp squeezed product (juice)
One compounded in the range of 0 cc can be exemplified. The hair growth and fostering agent of the present invention of the above-described embodiment is used for those with severe hair loss or those whose heads are becoming thinner, so that sesame oil and biotin H can be deeply penetrated by the osmotic action of sodium chloride. The hair root can be activated by infiltrating it into the skin, and the squeezed prawn (juice), which is the active ingredient, can promote the erecting of the hair (that is, toughening), so that hair loss can be reduced, There is an excellent effect that hair can be grown in a short period of time.

In another preferred embodiment of the hair-growing / hair-growing agent of the present invention, it preferably contains at least dopa, biotin H, sesame oil, and sodium chloride, and the ratio of each is 0 to dopa per total weight. 0.1-0.5% by weight, 0.1-0.5% by weight for biotin H, 0.5-1.5% by weight for sesame oil, 1-0.3% for sodium chloride
2% by weight of the mixture in each range, 100% of the mixture
0 to 100 cc of the shrimp squeezed product (juice)
Examples which are blended within the range of cc can be given.
The hair growth and fostering agent of the present invention of the above-mentioned embodiment is necessary for new skin and hair because DOPA is decomposed by oxygen in the body by using this hair fostering / hair fostering agent for a person whose hair has already fallen. Since it is a melanin pigment, it has an excellent effect that hair can be recovered in a short period of time.

In another preferred embodiment of the hair-growing / hair-restoring agent of the present invention, it preferably contains at least dopa, biotin H, sesame oil, germ oil and sodium chloride, and the ratio of each to the total weight of dopa, biotin H, germ oil and sodium chloride. 0.1 to 0.
3% by weight, 0.1-0.5% by weight per biotin H, 0.5-1.5% by weight per sesame oil, 0.5% per germ oil
A mixture obtained by mixing the above-mentioned plant extract in a range of 100 to 200 cc with respect to 1000 cc of the mixture in a range of from 1.5 to 1.5% by weight and from 1 to 2% by weight of sodium chloride. be able to. The hair-growing / hair-growing agent of the present invention in the above-described embodiment can soften the scalp with germ oil, and thus has an excellent effect that the recovery period of the hair can be further shortened.

[0048]

The present invention will be described below in more detail with reference to examples. It goes without saying that the present invention is not limited to the embodiment.

(Example 1) (i) Preparation of Ebine squeezed liquid 2 kg of rhizome of Ebine (collection place: Miyazaki Prefecture) was washed with water, drained, then roughly cut, and then pressed with a pressing machine (Komagata Seisakusho MI).
Mold) to prepare 150 cc of pressed juice. The shrimp squeezed juice was sealed, left in the air at room temperature for 2 days, and aged.

(Ii) Preparation of Ebine Alcohol Extract for Control Ebine (collection site: Miyazaki Prefecture) 0.3 kg of rhizome was finely chopped and immersed in 100 cc of 35 ° alcohol.
After 10 days or more, insolubles were filtered to prepare 120 cc of an alcohol extract.

(Iii). Preparation of mixed solution for hair growth and hair growth agent (1). Nisin (nicotinic acid) 3 g, vitamin B ₁₃
g, 3 g of sodium pantothenate, 2 g of potassium pantothenate, and 2 g of benzoic acid are dissolved in 50 cc of hot water. (2) Dissolve 14 g of vitamin C in 330 cc of hot water. (3). 1 g of vitamin A, 40 cc of ethanol, 7 g of sesame oil, 60 cc of ethanol, and 5 g of vitamin E
Are dissolved in 25 cc of ethanol, respectively. (4) Add 10 cc of 92% glycerin to 10 g of horse oil and dissolve in 30 cc of ethanol. (5) Add 30 cc of 92% glycerin to 1 g of biotin H and dissolve it with 70 cc of ethanol and 50 cc of water while applying heat. (6) Dissolve 20 g of sodium chloride in 105 cc of water. (7) Mix the above solutions (1) to (6) and add vitamin B ₂
(Sigma) 0.01 g was mixed to prepare a mixed solution for a hair growth and hair growth agent.

(Iv). Preparation for a hair growth and hair growth agent (1). The product of the present invention: 1 cc of the above-mentioned Ebine pressed juice and a mixed solution 8c
c was mixed to obtain a hair growth and hair growth agent of the present invention. (2) Conventional product ... 1 cc of the alcohol extract and 8 cc of the mixed solution were mixed to obtain a conventional hair growth and hair growth agent. Note that this conventional product is disclosed in Japanese Patent Application Laid-Open
These are the same as those disclosed in US Pat. (3) Control product: A coating solution consisting only of 50% ethanol was used.

(V). Hair Restoration Test for Hair Growth and Hair Restoration Agent (Mouse Test) The hair restoring effect of the present invention and the conventional product was tested.
The test for the hair growth effect was evaluated by a basic evaluation system widely used to demonstrate the hair growth effect, ie, a hair growth experiment using C ₃ H mice. The contents of the hair growth test method described above are as follows. (1) as. Mice, 57 days old after birth, it was used to select only male C ₃ H / HeNCγ mice weighing 23～28G. In addition, the 57-day-old mouse is in a hair-resting period. (2). The hair on the back of the mouse was clipped with a clipper and shaved, and the hair growth / hair restorer was applied to the shaved portion daily at 100 μl from the 61st day of age. (3). Two weeks after the start of application, the hair growth area of the shaved part was measured with a plan meter and compared with the control group (the one using the 50% ethanol coating solution).

FIG. 1 shows the test results of the hair growth effect using the mice. As shown in FIG. 1, the group using the shrimp squeezed juice of the present invention showed a more remarkable effect than the conventional product during the entire observation period. That is, the product of the present invention increased the hair growth effect by about 30 to 35% as compared with the conventional product.

(Example 2) The hair growth / hair restoration agent of the present invention (the product of the present invention) and a conventional product (as disclosed in Japanese Patent Application Laid-Open No. 5-294913) were used to reduce the thickness of the person or the head with severe hair loss. It was used on a visitor to test its effect. The effect of using the conventional product every day is as follows. (i) Use effect for severely hair-lossed persons: Hair loss was reduced after 4 to 5 days, and hair growth was observed after 6 months until the scalp disappeared. (ii). Use effect for persons with thin head: 2-
Three months later, hair began to grow on the spot where it fell off.
Years later, the hair grew by the time the scalp disappeared.

On the other hand, in the product of the present invention,
(Mouse test) It was confirmed that an effect that is in agreement with the result of the mouse test, that is, an effect significantly exceeding the use effect of the above-described conventional product was obtained.

[0057]

Industrial Applicability The present invention provides a hair-growing and / or hair-growing method which comprises, as an active ingredient, an extract from a plant of the genus Echinacea of the family Orchidaceae, and / or an extract obtained by aging the compressed product for a desired period of time and then extracting the extract with a desired solvent. It relates to a hair restorer. Hair growth of the present invention
The hair restorer is derived from the same plant of the genus Ebine in comparison with the hair restorer and hair restorer previously proposed by the present inventors (JP-A-5-294813), but has an excellent effect. .

It is considered that this is due to the following reasons. The hair growth and fostering agents proposed earlier by the present inventors use a solvent-extracted extract obtained by immersing a plant of the genus Ebine directly in an extraction solvent as an active ingredient. On the other hand, the present invention squeezes a plant of the genus Ebine and pressurizes tyrosinase (tyrosine oxidase), which oxidizes tyrosine, which is a kind of protein protein amino acid, in a pressed product (juice). This is because the content of hydroxyindole is increased and this is used as an active ingredient.

The hair-growing / hair-restoring agent of the present invention promotes erection of hair (toughening of hair) and reduces hair loss by using the above-mentioned squeezed product (juice) of the genus Ebine as an active ingredient. And an excellent effect that hair can be grown in a short period of time.

[Brief description of the drawings]

FIG. 1 is a graph showing test results of a hair growth effect.

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Claims (5)

[Claims] 1. A hair-growing / hair-growing agent comprising a pressed product of a plant of the genus Ebine and / or an extract of the pressed product as an active ingredient. 2. The hair growth and fostering agent according to claim 1, wherein the pressed product of the genus Ebine is a squeezed juice obtained by squeezing a plant of the genus Ebine. 3. An extract of a pressed product of a plant of the genus Ebine,
The hair-growing / hair-restoring agent according to claim 1, which is prepared by squeezing a plant of the genus Ebine and taking in the squeezed juice, and then extracting with an alcohol solvent. 4. A pressed product of a plant of the genus Ebine and / or an extract of the pressed product, comprising: (i) a calanthoside A; and (ii) a β-glucosidase that degrades the currant side A. The hair growth and fostering agent according to claim 1, which comprises 2-hydroxyindole produced by an enzyme. 5. An extract of a pressed product of a plant belonging to the genus Ebine,
The hair growth and cultivation according to claim 4, wherein the crushed product is left for a desired period of time to increase the concentration of 2-hydroxyindole produced in the crushed product by a β-glucosidase enzyme that degrades currant side A, and then extracted with alcohol. Hair restorer.