JP3045613B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic which promotes peripheral blood flow of the scalp, activates hair matrix cells, and has an excellent hair-growth effect and a hair loss-preventing effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives, or activators of hair matrix cells of the scalp such as assembly extract and Korean ginseng extract have been blended. Known hair-growth cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an inhibitory effect on sebaceous gland hypertrophy and a component having an androgen-inhibiting effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

Therefore, simply using an anti-androgen as a hair restorer to suppress the enlargement of the sebaceous glands, which is said to be caused by the excessive action of the androgen, does not bring about the hair growth effect. Is the current situation. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

The hyaluronic acid according to the present invention comprises a skin-friendly cosmetic composition (JP-A-61-129106),
It is incorporated into cosmetics as a component having a therapeutic effect on alopecia in hair restorer (JP-A-61-43104) or a skin treatment composition (JP-A-64-13008). However, hyaluronic acid is a component having a moisturizing effect by nature, and has a weak penetrating power into the skin. Therefore, hyaluronic acid only exerts a moisturizing effect on the skin and does not reach a hair-growing effect. Also, hair growth cosmetics have been filed for assembly extract and Korean carrot extract, but they have not yet achieved hair growth effects by themselves, and are currently used in combination with other active ingredients. is there.

[0007] An object of the present inventors is to provide a hair growth cosmetic composition having excellent hair growth and hair loss preventing effects by promoting peripheral blood flow of the scalp and activating hair matrix cells.
The present inventors have conducted various studies on promotion of peripheral blood flow of the scalp and activation of hair matrix cells. As a result, hair growth cosmetics containing hyaluronic acid and a hybrid extract and / or a panax ginseng extract have excellent hair growth, It has been found that a hair growth effect is exhibited.

[0008]

Means for Solving the Problems The present invention is a hair restoration cosmetic comprising a hyaluronic acid and an extract of Japanese cabbage or a ginseng extract.

The hyaluronic acid according to the present invention is a known substance and is abundantly present in connective tissues such as bovine and porcine animal skin, umbilicus, cartilage, eyeballs, etc., as well as in the stomach cavity of chicken squirrel and silkworm. It is also present on membranes, capsular cells of streptococci and resident bacteria. In order to isolate hyaluronic acid, it is obtained by preparing a homogenate of these tissues according to a conventional method, decomposing the protein with a protease, and further performing a dialysis operation and an ethanol precipitation operation. The assembly extract is an extract obtained by digesting a dried and crushed assembly in ethanol or hydrous ethanol and filtering off. Furthermore, the Korean ginseng extract is an extract obtained by cold-immersing a dried and ground root of ginseng for 5 to 6 years in ethanol or hydrous ethanol and filtering off. Here, the molecular weight of the hyaluronic acid used in the present invention may be in the range of usual 500,000 to 2,000,000, or may be a low molecular weight of 500,000 or less, and especially those of 100,000 or less. Shows good hair-growing effect.

The amount of hyaluronic acid to be added to the hair-growing cosmetic should be 0.001 to 5.0% by weight, more preferably 0.01 to 3.0% by weight, based on the total amount. That is, the desired effect can not be obtained sufficiently in the present invention is less than the lower limit of this amount, also be exceeded the upper limit, but can not be expected improvement of effect corresponding to the increase. The blending amount of the assembly extract or the Korean ginseng extract is preferably 0.001 to 2.0 wt%, more preferably 0.1 to 1.0 wt%, in terms of the dry residue. Further, the desired effect can not be obtained sufficiently in the present invention is less than the lower limit of this amount, also be exceeded the upper limit can not be expected the improvement of the effect commensurate with the increase.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

[0012] The hair nourishing cosmetic of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0013]

The present invention will be described below in detail with reference to examples and comparative examples. The percentages shown in the examples are percentages by weight.

The mouse hair growth promoting effect test method, the human hair growth promotion effect test method and the practical test methods described in the Examples are shown below.

(1) Mouse Hair Growth Promotion Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. still,
Base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed, and the skin of the test area was photographed. Next, the photograph is taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) are obtained. Further, the hair growth rate (%) = (B) / (A) × 100 is individually calculated. Of animals. Lastly, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Human hair growth promoting effect test method Male test subject 1 in her 30s and 40s with reduced hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm.
One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 125
Volume, page 123, 1991), the hair growth rate was determined for the hair (about 30 to 40 hairs) at the target site, and the average value was calculated (A). Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice daily in the morning and evening around the test site, and massaged well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method Male subject 2 whose hair growth in her 30s and 40s is declining
The effect of applying the sample to the heads of 0 subjects twice daily in the morning and evening for six consecutive months was evaluated. The test results were expressed by the number of persons who answered, "Regrowth of hair was increased or hair was increased" and "Reduction of hair was reduced" for each item of hair growth effect and hair loss prevention effect.

(4) Method for producing assembly extract or Korean ginseng extract The method for producing the assembly extract or Korean ginseng extract used in the examples is not specified, but the outline of each production method is described below.

[Method for Producing Assembly Extract] This is an extract obtained by digesting a dried pulverized whole plant of a swallow (Swertia Japonica Makino) in ethanol or water-containing ethanol and filtering off. In Examples, an extract obtained by the following method was used. After 50 g of the milled assembly was digested in 250 ml of aqueous ethanol (50 wt% of ethanol) at a temperature of 40 to 50 ° C., the residue was repeatedly digested again to obtain 1.5 liter of extract. 100 ml of purified water was added to the residue obtained by concentration under reduced pressure, and after aging for one week, the extract obtained by filtering off the insoluble portion was concentrated under reduced pressure.
Then, ethanol was added to the extract to adjust the ethanol content to 50 wt%, thereby obtaining 100 ml of assembly extract.

[Production Method of Korean Ginseng Extract] Dry and ground roots of Panax ginseng CAMeyer for 5 to 6 years are cold-immersed in ethanol or hydrous ethanol.
It is an extract obtained by filtration. In Examples, an extract obtained by the following method was used. Panax ginseng 5
Sixty-year-old root milled material (50 g) was cold-immersed in 200 ml of water-containing ethanol (ethanol 50 wt%) for 1 week, the ethanol of the extract obtained by filtration was distilled off, purified water was added, and the ethanol content of the extract was 50 wt%. The resulting mixture was aged in a cool place for 7 to 10 weeks, and then filtered to obtain 100 ml of a carrot extract.

In the following text, the blending amount is indicated based on the pure content (converted by the dry residue) of the extract obtained by extraction with the 50% aqueous ethanol solution as described above.

Examples 1 to 8, Comparative Examples 1 to 3 Oily Hair Tonic In the raw material composition shown in Table 1, an active ingredient was blended as shown in Table 2 to prepare a hair tonic, and the above-described various tests were carried out. In addition, the pepper tincture used in the comparative example was the one described in the Japanese Pharmacopoeia.

[0023]

[Table 1]

[0024]

[Table 2]

(1) Preparation method After the component (B) shown in Table 1 is dissolved in the component (C), the components (A) and (B) are mixed with stirring, dispersed and filled into a container. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests conducted on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good.

The hair growth cosmetics of the present invention of Examples 1 to 8 exhibited a high hair growth promoting effect, and showed clearly good results in all of the tests. In Examples 1 to 8, no skin irritation occurred in various tests on human skin.

[0028]

Industrial Applicability As described above, the present invention improves the peripheral blood flow of the scalp, activates hair matrix cells, is excellent in hair growth effect and hair loss prevention effect, and has no skin irritation. It is obvious to provide.

──────────────────────────────────────────────────続 き Continuation of the front page (51) Int.Cl. ⁷ identification code FI A61P 43/00 105 A61K 31/73 (58) Investigated field (Int.Cl. ⁷ , DB name) A61K 7/06 A61K 31 / 715 A61K 35/78

Claims (1)

(57) [Claims] 1. A hair-growing cosmetic (but not containing a placenta extract) , characterized by containing hyaluronic acid and a carrot extract or a Korean ginseng extract.