JP3020640B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect, a hair loss-preventing effect, and an anti-dandruff effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of androgen. However, phenomena such as poor blood circulation, decreased hair mother cell activity, enlarged sebaceous glands, and scalp fibrosis are caused. It is presumed that it is caused by complicated intertwining.

[0005] Therefore, at present, simply using an androgen-suppressing component does not bring about hair growth. Furthermore, even if an antiandrogen is used as a hair restorer in order to suppress the hyperplasia of the sebaceous glands, which is said to be caused by the excessive action of androgen, the effect is not sufficient.

[0006] Heparin according to the present invention is a substance known to have a microangiogenic action. However, even when heparin alone is used as a hair restorer, the hair growth and hair restorer effects are not sufficient, as with conventional blood circulation promoting substances.

Further, Japanese Patent Application Laid-Open No. 01-9351 discloses that
A composition having a hair stimulating activity comprising a specific amount of a mixture of sulfomcopolysaccharides extracted from living organs, ie, heparin, hyaluronic acid, chondroitin sulfate, heparan sulfate, dermatan sulfate, etc., is disclosed.

However, the molecular weight of hyaluronic acid and the mixing ratio of heparin and hyaluronic acid are not described at all. Furthermore, the effect of this composition was clearly different from that of the hair growth cosmetic of the present invention as described below.

Accordingly, the present inventors have conducted various studies to obtain a scalp activation promoting substance which promotes peripheral blood flow of the scalp and activates hair cells. That is, an object of the present invention is to provide a hair restoration cosmetic composition that promotes peripheral blood flow of the scalp, activates hair matrix cells, and has excellent effects such as hair growth, hair loss prevention and dandruff prevention.

[0010]

The hair restoration cosmetic of the present invention for achieving the above object comprises (A) heparin and / or a salt thereof, and (B) oligomeric hyaluronic acid and / or a molecular weight of 400 to 5,000. Or a salt thereof is blended, and the blending ratio of (A) and (B) is 1: 9 to 9: 1.

That is, the present inventors have conducted various studies on promotion of peripheral blood flow of the scalp and activation of hair cells, and as a result, together with heparin having a normal molecular weight, a molecular weight of 400 to 5,000 was obtained.
It has been found that the use of the oligomer hyaluronic acid of the formula (1) exhibits excellent hair-growth and hair-growth effects.

The heparin according to the present invention is a known substance as described below. CAS RN: 9005-49-6 Generic name: Heparin or Heparinic acid Chemical formula: (C12O10NH19) n Molecular weight: 6,000-20,000

In the present invention, the molecular weight is 6,000 to 20,000.
It is possible to incorporate one of the commonly available heparins or salts thereof. Examples of the salts include salts with alkali metals such as sodium and potassium, salts with alkaline earth metals such as magnesium and calcium, and salts with basic amino acids such as lysine. In addition, the molecular weight is 200 to 5,000.
0 oligomer hyaluronic acid and / or a salt thereof (hereinafter, referred to as
Oligomer hyaluronic acids). Examples of the salts include salts with alkali metals such as sodium and potassium, and salts with alkaline earth metals such as magnesium and calcium.

As the heparin and / or a salt thereof (hereinafter abbreviated as heparins) used in the present invention, those derived from tissues such as lungs, liver, kidneys, skin, and thymus of animals can be used. As the oligomeric hyaluronic acids, those derived from hoods such as chickens, those derived from the skin of cattle and pigs, and those derived from streptococci such as Streptococcus zooepidamidids can be used. As a method for preparing the oligomeric hyaluronic acid used in the present invention, any oligomeric hyaluronic acid in this range can be used as it is, and if it is 5,000 or more, it can be used after being reduced in molecular weight by an enzyme such as hyaluronidase or chondroitinase. Further, it can be easily obtained by acid hydrolysis or alkali hydrolysis.

The compounding amount of the heparin of the present invention in the hair-growing cosmetic may be 0.01 to 5.0% by weight, more preferably 0.05 to 3.0% by weight, based on the total amount. is there. That is, if the amount is less than the lower limit, the desired effects of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected.

The blending amount of the oligomeric hyaluronic acid is appropriately adjusted depending on the dosage form of the hair growth cosmetic, etc., but may be 0.01 to 5.0 wt%, more preferably 0.1 wt%. The content is from 0.05 to 3.0 wt%. And the compounding ratio of heparin and oligomeric hyaluronic acid is 1:
When the ratio is 9 to 9: 1, the effect of the present invention can be obtained.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0019]

The present invention will be described below in detail with reference to examples and comparative examples. In the examples, heparin is abbreviated as HEPA, hyaluronic acid as HA, and sodium salt of hyaluronic acid having a molecular weight of 4,000 as HA-Na [MW 4,000].

The mouse hair growth promoting effect test method, human hair growth promotion effect test method and practical test methods described in the Examples are shown below.

(1) Mouse hair growth promoting effect test method The skin in the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric clipper, and completely depilated with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part twice daily in the morning and evening twice at 0.2 g per animal. A group of 10 animals was used for one sample.
In addition, a base alone was applied as a control group. 15 after the start of the experiment
On the day, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, a value obtained by dividing the average value of the examples or the comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Test Method for Promoting Human Hair Growth The hair of 10 test subjects who are male pattern baldness was shaved at a position 5 cm above the ears of the head at two places on the left and right at a circular shape having a diameter of 1 cm. About 3 ml of the sample of the example or the comparative example was applied on the left side twice a day every morning and evening to the hairy test site, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites and averaging the length of the 20 hairs on the left side (to which the example or the comparative example was applied) (B ) Was divided by the average value (A) of the lengths of the 20 hairs on the right side (untreated), and the judgment results were shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results show that the hair growth effect, the hair loss prevention effect, and the anti-dandruff effect are “hair has become bristle or hair has increased,” “hair loss has decreased,” and “hair loss has decreased. The number of respondents. "

Examples 1 to 5 and Comparative Examples 1 to 4 Oily hair tonic In the raw material composition shown in Table 1, samples were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out.

[0025]

[Table 1]

[0026]

[Table 2]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed with stirring, dispersed and stirred. Fill. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of conducting various tests on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 4 had low mouse and human hair growth promoting effects, and the results of practical tests were not good. Particularly in Comparative Example 1 containing pepper tincture, three persons complained of mild skin irritation in a practical test.

The hair growth cosmetics of Examples 1 to 5 of the present invention showed a high hair growth promoting effect, and showed clearly good results in all tests. In Examples 1 to 5, skin irritation did not occur in various tests on human skin.

Examples 6 to 10 and Comparative Examples 5 to 8 Hair cream In the raw material composition shown in Table 3, various tests were carried out by adjusting each hair cream in the same manner as in Example 1, and the results were shown in the right of Table 4. Column.

[0031]

[Table 3]

[0032]

[Table 4]

(1) Preparation method After dissolving the component (B) shown in Table 3 in the component (A) or (C), the components (A) and (C) are dissolved by heating to 80 ° C and mixed. did. Further, when cooled to 50 ° C. while stirring, the component (D) was added, and stirring was continued to 30 ° C. to prepare each hair cream.

(2) Characteristics As shown in Table 4, Examples 6 to 10 exhibited a high hair growth promoting effect and showed excellent results in all of the tests.

On the other hand, the hair cream containing heparin of Comparative Example 8 and hyaluronic acid having a molecular weight of 800,000 was clearly inferior in various properties as compared with the hair cream of the example of the present invention.

[0036]

As described above, the present invention improves peripheral blood flow of the scalp, activates hair matrix cells, and is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect,
It is clear to provide hair nourishing cosmetics without skin irritation.

Claims (1)

(57) [Claims] (A) heparin and / or a salt thereof,
(B) a mixture of oligomeric hyaluronic acid having a molecular weight of 400 to 5,000 and / or a salt thereof, wherein the mixing ratio of (A) and (B) is 1: 9 to 9: 1. Hair nourishing cosmetics.