JP3229503B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to carnitine chloride (hereinafter referred to as C).
H) and diisopropylamine dichloroacetate (hereinafter abbreviated as DADA).
The present invention relates to a hair restoration cosmetic having excellent hair growth and hair growth effects, as well as hair loss prevention and dandruff prevention.

[0002]

2. Description of the Related Art There have been proposed hair nourishing cosmetics comprising various components having a hair cell activating action or a blood circulation promoting action. In recent years, it has been widely used to promote blood circulation by massaging or putting on the scalp using a brush (patting brush) together with the application of a hair restoration cosmetic, as the desired hair restoration effect can be obtained.

[0003] However, it has been difficult to obtain a hair restoration excellent enough to be able to positively exert a hair-growth effect or a hair-growth effect. Further, the present inventor has disclosed in
As described in JP-A-48042, a skin cosmetic comprising carnitine and a derivative thereof has been proposed.
A hair satisfactorily satisfactory cosmetic composition having remarkable effects on hair growth, hair loss prevention, dandruff prevention and the like has not been obtained.

The present inventors have conducted intensive studies on the activation of hair matrix cells. As a result, among the carnitine and its derivatives, a hair-growing cosmetic comprising carnitine chloride (CH) and DADA in particular has a hair-growth effect ( The present invention has been found to exhibit remarkable effects in mouse hair growth promoting effect, human hair growth promoting effect), hair nourishing effect, hair loss preventing effect, particularly, hair loss preventing effect and dandruff preventing effect, and the present invention has been completed.

[0005]

SUMMARY OF THE INVENTION The present invention is a hair tonic cosmetic characterized by being blended with carnitine chloride (C H) and di-isopropyl Bill amine dichloroacetate (DADA).

[0006] CH used in the present invention is a known substance and is applied as a gastric secretion promoter, and its chemical formula is as follows. This CH can enhance the hair loss preventing effect, dandruff preventing effect and hair loss preventing effect.

[0007] DADA according to the present invention is a known substance, and can be used for acute / chronic hepatitis, liver damage such as fatty liver, cerebral hemorrhage, etc.
It has been applied as a therapeutic agent for cerebral thrombosis, hypertension, etc., and its chemical properties are as follows. Chemical name: diisopropylamine dichloroacetate Chemical formula: C ₈ H ₁₇ CI ₂ NO ₂ Molecular weight: 230.14 Melting point: 118-122 ° C. Since DADA has a blood circulation promoting action, it activates the metabolism of hair roots in the scalp. Has the effect of promoting hair root growth.

The present inventors have studied the above-mentioned constituents to be incorporated in the hair growth cosmetic composition. As a result, the hair growth cosmetic composition containing CH and DADA has an excellent hair growth effect ( Mouse hair growth promoting effect, human scalp hair growth promoting effect), hair nourishing effect, hair loss preventing effect, and dandruff preventing effect, in particular, hair loss preventing effect.

[0009] Further, as a result of exploring the compounding ratio which maximizes the synergistic effect of the above-mentioned constituents to be compounded in the hair nourishing cosmetic, the ratio (weight) of each compounding amount of (i) CH and (ii) DADA was determined. Ratio) is (i) :( ii) = 1:
It is preferably from 0.1 to 1, and excellent effects aimed at by the present invention have been recognized. That is, (i) and (i)
The superior effect that both the hair matrix activation activity and the blood circulation promotion activity of i) act synergistically on the scalp to expand the peripheral blood vessels of the scalp, normalize the scalp metabolic function and enhance the anti-dandruff effect. I was able to do it.

[0010] Further, CH and DAD in the hair nourishing cosmetic.
The amount of A is 0.05 to 2.CH based on the total amount.
0 Wt% and DADA may be 0.05 to 2.0 Wt%, and if the amounts are less than the lower limits of the respective compounding amounts, the intended effects of the present invention cannot be sufficiently obtained. It is not possible to expect an improvement in the effect corresponding to the above.

[0011] In addition, in addition to the above, various hair oils, wetting agents, pigments, fragrances, preservatives, surfactants,
Pigments, antioxidants and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0012]

The present invention will be described below in detail based on examples and comparative examples. The mouse hair growth promotion effect test, human hair growth promotion effect test, and practical test in this example are shown below.

(1) Mouse hair growth promoting effect test ddy white mouse (male: 6 weeks old, average weight: 35 g)
After cutting the back skin near the tail with an electric hair clipper, the hair was completely depilated with a depilatory cream, and from the next day, the samples of the examples and comparative examples were applied to the skin of the test portion twice daily in the morning and evening at 0.
1 ml was applied. A group of 10 animals was used for one sample. The evaluation of the hair growth effect was performed by comparing the evaluation points of the naked eye judgment based on the following judgment criteria, and the hair length and hair weight with the control group. On the 15th day after the start of the experiment, the animals were sacrificed, visually evaluated according to the following criteria, and their evaluation points were summed to obtain an average evaluation point per animal. Furthermore, after the skin of the test portion was punched out and dried, the weight of the hair was determined, and the length of the 20 hairs was also determined, and the average value was shown for each. [Judgment Criteria for Evaluation Point of Hair Growth Effect] Evaluation Point 5: Boundary with surrounding non-hair removal part is unknown 〃 4: Hair growth intensity ３ 3: Medium hair growth 〃 2: Hair growth mild 〃 1: Hair growth extremely mild 〃 0: Hair growth is not recognized

(2) Test of Human Hair Growth Promotion Effect A test was conducted by shaving a 10 cm subject with male pattern baldness at a position 5 cm above the ears of the head at two places on the left and right at a circular shape having a diameter of 1 cm. As a test site, about 3 ml of the sample of the example or the comparative example was applied to the test site on the left twice daily in the morning and evening and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites,
The value obtained by dividing the average value (B) of the lengths of the 20 hairs on the left side (to which the example or the comparative example is applied) by the average value (A) of the lengths of the 20 hairs on the right side (untreated) was evaluated. did. The judgment results were shown as the average of (B) / (A) of 10 test subjects.

(3) Practical test The efficacy was evaluated by applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months. The test results show that for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect, "hair has become bristle or hair has increased", "hair loss has decreased", "hair loss has decreased. No. "and" Reduced hair loss ".

Examples 1 to 3 and Comparative Examples 1 to 4 Oily hair tonic As shown in Table 1, CH
And DADA to prepare each hair tonic,
The above tests were performed.

[0017]

[Table 1]

(2) Preparation method After blending the component (C) with the component (B) and dissolving the components (A) and (B) uniformly, the components (A) and (B) are mixed and stirred. Disperse and subsequently fill the container. In use,
The container is used by uniformly shaking and dispersing. (3) Characteristics Table 2 shows the results of various tests performed on each oily hair tonic.

[Table 2] As shown, the hair tonic obtained by blending the hair tonic base of Comparative Example 1 and CH of Comparative Example 2, and Comparative Example 3
Examples 1 to 3, which are the hair restoration cosmetics of the present invention, clearly exhibited excellent properties in various tests, as compared with hair tonics in which DADA was independently blended.

Examples 4 to 6 and Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared with the composition shown in Table 3 in the same manner as in Example 1, and various tests were carried out. The results are shown in Table 4. Described. (1) Composition

[0020]

[Table 3]

(2) Preparation method The component (C) is blended into the component (B), and the components (A) and (B), each of which is heated and dissolved at a temperature of 80 ° C., are mixed.
When cooled to 50 ° C. while stirring, the component (D) was added, and stirring was continued to a temperature of 30 ° C. to prepare each hair cream.

[Table 4] (3) Properties As shown in Table 4, the hair-growth cosmetics of the present invention were used in Examples 4 to 4.
The hair cream of No. 6 was clearly recognized to be superior in various properties as compared with Comparative Examples 4 to 6.

[Table 2]

[0022]

As described above, it is apparent that the present invention provides a hair restoration cosmetic having extremely excellent effects such as hair growth, hair restoration, hair loss prevention, and dandruff prevention.

Continuation of front page (56) References JP-A-1-199905 (JP, A) JP-A-53-136528 (JP, A) JP-A-3-77808 (JP, A) JP-A-6-9348 (JP) JP-A-5-43429 (JP, A) JP-A-63-196507 (JP, A) JP-A-4-234804 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB Name) A61K 7/06

Claims (1)

(57) [Claims] 1. A hair restoration cosmetic comprising a mixture of carnitine chloride and diisopropylamine dichloroacetate.