JPH0543429A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic cosmetic, capable of activating hair-matrix cells and excellent in hair growing and hair tonic effects and preventive effects on alopecia, dandruff, etc. CONSTITUTION:A hair tonic cosmetic is obtained by blending gamma-aminobutyric acid capable of activating hair-matrix cells of the scalp, exhibiting excellent hair tonic effects and preventive effects on alopecia, etc., further normalizing scalp metabolic function and enhancing antidandruff effects with diisopropylamine dichloroacetate having promoting action on blood circulation, activation of metabolism in hair roots in the scalp and promoting the growth of the hair roots in respective amounts within the range of 0.05-2.0wt.% at 1:(0.1-1) weight ratio of the former:latter. The hair-matrix cell activating and blood circulation promoting actions of both ingredients are synergistically exerted on the scalp to dilate scalp peripheral blood vessels, normalize the scalp metabolic function and further enhance antidandruff effects.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a hair nourishing cosmetic composition containing γ-aminobutyric acid (hereinafter abbreviated as GABA) and diisopropylamine dichloroacetate (hereinafter abbreviated as DADA). More specifically, the present invention relates to a hair nourishing cosmetic which activates hair matrix cells and is excellent in hair growth and hair nourishing effects, hair loss prevention, dandruff prevention, and the like.

[0002]

2. Description of the Related Art Conventionally, a hair nourishing cosmetic composition containing various components having a hair mother cell activating action or a blood circulation promoting action has been proposed. Further, in recent years, it has become popular to promote blood circulation by massaging or putting on the scalp by using a brush (putting brush) together with the application of a hair-growth cosmetic, because the desired hair-growth effect can be obtained.

However, it has been difficult to obtain a hair nourishing agent that is excellent enough to positively exert a hair-growth effect or a hair-growth effect. In addition, the present inventor
As described in Japanese Patent No. 6726, there has been proposed a cosmetic composition containing γ-aminobutyric acid and a derivative thereof, but in practical use, a hair nourishing cosmetic composition which is significantly effective in the effects of hair nourishment, hair loss prevention, dandruff prevention, etc. As a result, no product that was sufficiently satisfactory was obtained.

Therefore, as a result of intensive studies on activation of hair mother cells, the present inventors have found that a hair nourishing cosmetic composition containing GABA and DADA has a hair growth effect (mouse hair growth promoting effect,
Human hair growth promotion effect), hair nourishment effect, hair loss prevention effect,
The inventors have found that the anti-dandruff effect and the like are significantly effective, and have completed the present invention.

[0005]

The present invention relates to a hair nourishing cosmetic composition containing γ-aminobutyric acid (GABA) and diisopropylamine dichloroacetate (DADA).

GABA used in the present invention is a known substance and is applied as a brain metabolism promoter, and its chemical formula is as follows. Chemical formula: NH ₂ CH ₂ CH ₂ CH ₂ COOH This GABA activates hair matrix cells of the scalp to exert excellent hair nourishing effect, hair loss prevention effect, etc., and further normalizes scalp metabolic function to prevent dandruff. It can enhance the effect, and can be particularly effective when applied to androgenetic alopecia.

Further, the DADA according to the present invention is a known substance, and it includes liver damage such as acute and chronic hepatitis, fatty liver and cerebral hemorrhage,
It is applied as a therapeutic agent for cerebral thrombosis, hypertension, etc., and its chemical properties are as follows. Chemical name: Diisopropylamine dichloroacetate Chemical formula: C ₈ H ₁₇ Cl ₂ NO ₂ molecular weight; 230.14 Melting point; 118-122 ° C. This DADA has a blood circulation promoting action and therefore activates hair root metabolism in the scalp. And has an action of promoting the growth of hair roots.

The inventors of the present invention have studied the above constituents to be incorporated into the hair nourishing cosmetic composition, and have found that GABA and DAD
The hair nourishing cosmetic containing A and A has excellent hair growth effects (mouse hair growth promoting effect, human scalp hair growth promoting effect), hair nourishing effects, hair loss preventing effects, and antidandruff effects due to these synergistic effects. Was remarkably recognized.

In addition, as a result of exploring the blending ratio that maximizes the synergistic effect of the above-mentioned constituents to be blended in the hair nourishing cosmetic composition, the ratio (weight) of each of (i) GABA and (ii) DADA Ratio) is (i) :( ii) =
It is preferable that the ratio is 1: 0.1 to 1, and the excellent effect aimed at by the present invention was recognized. That is, the hair mother cell activating action and blood circulation promoting action of both (i) and (ii) act synergistically on the scalp to expand the scalp peripheral blood vessels, normalize the scalp metabolic function and enhance the antidandruff effect. It had the excellent effect of being able to.

GABA and D in the hair nourishing cosmetic composition
GABA is 0.0 based on the total amount of ADA.
5 to 2.0 wt%, DADA is 0.05 to 2.0 wt%
If the amount is less than the lower limit of each blending amount, the effect aimed at by the present invention cannot be sufficiently obtained, while if it exceeds the upper limit, the effect corresponding to the increase cannot be expected to be improved.

In addition to the above, the hair nourishing cosmetic of the present invention contains various oils, wetting agents, dyes, fragrances, preservatives, surfactants,
Pigments, antioxidants and the like can be appropriately added within the range where the object of the present invention is achieved.

[0012]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The mouse hair growth promoting effect test, human hair growth promoting effect test, and practical test in this example are shown below.

(1) Mouse hair growth promoting effect test ddy white mouse (male: 6 weeks old, average body weight: 35 g)
After cutting the back skin near the tail with an electric clipper, the hair was completely removed with a depilatory cream, and from the next day, each sample of the Examples and Comparative Examples was applied to the skin of the test site twice daily in the morning and evening, at a rate of 0.
1 ml was applied. For each sample, 10 animals were used per group. The hair-growth effect was evaluated by comparing the evaluation points of the macroscopic evaluation according to the following criteria with the hair length and hair weight with the control group. On the 15th day after the start of the experiment, the animals were sacrificed and visually evaluated according to the following criteria, and the evaluation points were totaled to obtain an average evaluation point per animal. Furthermore, after the skin of the test area was punched out and dried, the weight of the hair was measured, and the length of 20 hairs therein was also measured, and the average value was shown. [Judgment Criteria for Evaluation Points of Hair Growth Effect] Evaluation Point 5: Unknown Boundary with Surrounding Non-Extracted Hair 〃 4: Hair Growth Strength 〃 3: Medium Hair Growth 〃 2: Mild Hair Growth 〃 1: Extremely Mild Hair Growth 〃 0: No hair growth

(2) Human Hair Growth Promoting Effect Test 10 heads of 10 test subjects who are male pattern baldness were shaved into a circular shape with a diameter of 1 cm at 5 cm above the ears of the head. As a test site, about 3 ml of the sample of the Example or Comparative Example was applied to the test site on the left side twice daily in the morning and evening and compared with the untreated right side. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved,
The value obtained by dividing the average value (B) of the lengths of 20 hairs on the left side (applied in the Examples or Comparative Examples) by the average value (A) of the lengths of 20 hairs on the right side (untreated) was evaluated. did. The determination result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test 20 heads of androgenetic alopecia patients were evaluated by the effect after applying the sample to the head twice a day twice a day for 6 consecutive months. The test results show that hair loss effect, hair loss prevention effect, and dandruff prevention effect are “brush bristle or increased hair loss”, “less hair loss”, “less dandruff” The number of people who answered

Examples 1 to 3 and Comparative Examples 1 to 3 [Oily Hearth Nickel] As shown in Table 1, GA
BA and DADA were blended to prepare respective hair nicks, and the above-mentioned various tests were carried out.

[0017]

[Table 1]

(2) Preparation method Component (C) is blended with component (B) to uniformly dissolve components (A) and (B), and then component (A) and component (B) are mixed and stirred. Disperse and subsequently fill the container. When using,
Use the container by evenly shaking and dispersing. (3) Properties Table 2 shows the results of various tests of each oily hair art. As shown in Table 2, the present invention is compared with the hair artic acid containing the base of the articulation of Comparative Example 1 and the GABA of Comparative Example 2 and the hair articulation of Comparative Example 3 in which DADA is added alone. In Examples 1 to 3, which are hair nourishing cosmetics, excellent properties were clearly recognized in various tests.

[Table 2]

Examples 4 to 6 and Comparative Examples 4 to 6 [Hair Cream] Each hair cream having the composition shown in Table 3 was prepared in the same manner as in Example 1 and various tests were carried out. The results are shown in Table 4. Described. (1) Composition

[0020]

[Table 3]

(2) Preparation method The component (C) is blended with the component (B), the components (A) and (B) are heated and dissolved at a temperature of 80 ° C., and the mixture is mixed.
The component (D) was added when cooled to 50 ° C. with stirring and further stirred to a temperature of 30 ° C. to prepare each hair cream. (3) Properties As shown in Table 4, Examples 4 to 6 which are hair nourishing cosmetics of the present invention
It was clearly recognized that the hair cream of No. 6 was excellent in various properties as compared with Comparative Examples 4 to 6.

[Table 2]

[0022]

As described above, it is apparent that the present invention provides a hair nourishing cosmetic composition which is extremely excellent in effects such as hair growth, hair nourishment, hair loss prevention, and dandruff prevention.

[Table 4]

Claims (1)

[Claims] 1. A hair nourishing cosmetic composition comprising γ-aminobutyric acid and diisopropylamine dichloroacetate.