JP2000016920A - Hair tonic cosmetic - Google Patents
Hair tonic cosmeticInfo
- Publication number
- JP2000016920A JP2000016920A JP10181990A JP18199098A JP2000016920A JP 2000016920 A JP2000016920 A JP 2000016920A JP 10181990 A JP10181990 A JP 10181990A JP 18199098 A JP18199098 A JP 18199098A JP 2000016920 A JP2000016920 A JP 2000016920A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- cosmetic
- acetyl
- carnitine
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、育毛効果、脱毛予
防効果に優れた養毛化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.
【０００２】[0002]
【従来の技術】従来より、トウガラシチンキおよびニコ
チン酸誘導体等の血行促進物質、また毛髪の栄養成分で
あるアミノ酸およびビタミン類を配合してなる養毛化粧
料が知られている。さらには、皮脂腺の肥大防止効果を
もつ成分や、男性ホルモンの抑制作用をもつ成分を配合
する医療用養毛剤や養毛化粧料も数多く提案されてい
る。2. Description of the Related Art Conventionally, hair restoration cosmetics are known which contain blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair. Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.
【０００３】しかし、従来より使用されている血行促進
物質は、皮膚刺激が強くその配合量に制限があったり、
血行促進の持続時間が短いという欠点がある。[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short.
【０００４】ところで、男性型脱毛症は男性ホルモンの
過剰作用が原因の一つと言われているが、血行の不良や
毛母細胞の活性低下、皮脂腺の肥大化、頭皮の線維化等
の現象が複雑に絡みあって生じていると推察されてい
る。[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.
【０００５】しかし、男性ホルモンの過剰作用が原因と
いわれる毛母細胞の活性低下や皮脂腺の肥大化を抑制す
るために、単に抗男性ホルモン剤等を育毛剤として用い
ても、育毛作用を発現するまでには至らないのが現状で
ある。また、毛母細胞賦活剤や血行促進剤を単独で用い
ても、良好な成績は得られない。[0005] However, even if an anti-androgen agent is simply used as a hair restorer to suppress hair matrix cell activity reduction and sebaceous gland hypertrophy, which are said to be caused by excessive action of androgen, the hair growth effect is exhibited. At present it does not reach. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.
【０００６】前記の問題点を解決する手段として、特開
平５−５８８５０号公報における奇数炭素数を有する脂
肪酸類、アルコール類と、ヒドロキシプロピルアルコー
ルと、低級アルコールを含有する育毛剤組成物、特開平
５−１３９９３６号公報におけるある種のカルボキシル
ベタインを含有する発毛剤、特開平５−１７０６２５号
公報における酸性ムコ多糖類とホップエキスを含有する
養毛化粧料等を始めとして数多くの養毛・育毛剤が提案
されているが、末梢血流を促進し、毛母細胞の賦活化を
する物質を単独で用いても格段の育毛作用については見
出せず、また組成物においても充分満足すべき効果を得
るまでには至らず、育毛効果、脱毛予防効果に改良の余
地があるのが実情であった。As a means for solving the above-mentioned problems, a hair restorer composition containing fatty acids and alcohols having an odd carbon number, hydroxypropyl alcohol and a lower alcohol disclosed in JP-A-5-58850 is disclosed. Numerous hair growth and hair growth, including a hair growth agent containing certain carboxyl betaines described in JP-A-5-139936, a hair growth cosmetic containing an acid mucopolysaccharide and a hop extract described in JP-A-5-170625, and the like. Agents have been proposed, but using a substance that promotes peripheral blood flow and activates hair matrix cells alone has not found any remarkable hair-growth effect, and has a satisfactory effect in the composition. In fact, there was room for improvement in the hair growth effect and the hair loss prevention effect.
【０００７】[0007]
【発明が解決しようとする課題】かかる実情に鑑み、毛
成長促進、育毛、脱毛などの効果のある物質について鋭
意検討した結果、アセチルカルニチンおよびその塩の少
なくとも一種を配合した養毛化粧料が、育毛効果、脱毛
予防効果に優れていることを見いだし、本発明を完成す
るに至ったものであって、その目的とするところは、育
毛効果、脱毛予防効果に優れた養毛化粧料を提供するに
ある。In view of such circumstances, as a result of intensive studies on substances having an effect of promoting hair growth, hair growth, hair loss, etc., a hair restoration cosmetic containing at least one of acetylcarnitine and a salt thereof has been developed. The present invention has been found to be excellent in hair growth effect and hair loss prevention effect, and has led to the completion of the present invention. An object of the present invention is to provide a hair restoration cosmetic excellent in hair growth effect and hair loss prevention effect. It is in.
【０００８】[0008]
【課題を解決するための手段】上述の目的は、アセチル
カルニチンおよびその塩の少なくとも一種を配合した養
毛化粧料によって達成される。The above-mentioned object is achieved by a hair-growing cosmetic containing at least one of acetylcarnitine and a salt thereof.
【０００９】[0009]
【発明の実施の形態】以下、本発明の実施の形態につい
て詳述する。Embodiments of the present invention will be described below in detail.
【００１０】本発明に利用されるアセチルカルニチンと
は、下記一般式（１）で示されるものであり、具体的に
はアセチル−Ｌ−カルニチン酸などが挙げられる。Acetylcarnitine used in the present invention is represented by the following general formula (1), and specifically includes acetyl-L-carnitic acid and the like.
【００１１】[0011]
【化１】 （ＣＨ3)3 Ｎ+ ＣＨ2 ＣＨ（ＯＣＯＣＨ3 ）ＣＨ2 ＣＯＯ- （１）Embedded image (CH 3 ) 3 N + CH 2 CH (OCOCH 3 ) CH 2 COO − (1)
【００１２】アセチルカルニチンの塩とは、下記一般式
（２）で示されるものであり、The salt of acetylcarnitine is represented by the following general formula (2):
【００１３】[0013]
【化２】 （ＣＨ3)3 Ｎ+ ＣＨ2 ＣＨ（ＯＣＯＣＨ3 ）ＣＨ2 ＣＯＯＨ ・Ｘ- （２） （ただし、Ｘ- は各種のアニオンを示す。）## STR2 ## (CH 3) 3 N + CH 2 CH (OCOCH 3) CH 2 COOH · X - (2) ( provided that, X - represents various anions.)
【００１４】そのアニオン（Ｘ- ）としては、クロリ
ド、スルフォネート、ニトレート、アセテート、シトレ
ート、ニコチネート、サリチレートなどが挙げられ、具
体的にはアセチル−Ｌ−カルニチン塩酸塩、アセチル−
Ｌ−カルニチン硫酸塩、アセチル−Ｌ−カルニチン硝酸
塩、アセチル−Ｌ−カルニチンアセテート、アセチル−
Ｌ−カルニチンシトレート、アセチル−Ｌ−カルニチン
ニコチネート、アセチル−Ｌ−カルニチンサリチレート
などが挙げられる。[0014] The anion (X -) as the chloride, sulfonate, nitrate, acetate, citrate, nicotinate, and the like salicylates, specifically acetyl -L- carnitine hydrochloride, acetyl -
L-carnitine sulfate, acetyl-L-carnitine nitrate, acetyl-L-carnitine acetate, acetyl-
L-carnitine citrate, acetyl-L-carnitine nicotinate, acetyl-L-carnitine salicylate and the like can be mentioned.
【００１５】本発明の養毛化粧料には、公知のビタミン
Ｅ、ビタミンＥアセテート、ビタミンＥニコチネートな
どのビタミンＥ誘導体、パントテニルアルコール、パン
トテン酸カルシウムなどのパントテン酸誘導体、ニコチ
ン酸ベンジル、ニコチン酸アミドなどのニコチン酸誘導
体、グリチルリチン酸、グリチルリチン酸ジカリウム、
グリチルリチン酸モノアンモニウムなどのグリチルリチ
ン酸誘導体、グリチルレチン酸、グリチルレチン酸ステ
アリルなどのグリチルレチン酸誘導体、抗アンドロゲン
剤、センブリエキス、朝鮮ニンジンエキス、デュークエ
キス、トウガラシチンキ、ジイソプロピルアミンジクロ
ロアセテート、γ−アミノ酪酸誘導体などを本発明の目
的を達成する範囲で適宜組み合わせて配合できる。The hair restoration cosmetic of the present invention includes known vitamin E derivatives such as vitamin E, vitamin E acetate and vitamin E nicotinate, pantothenic acid derivatives such as pantothenyl alcohol and calcium pantothenate, benzyl nicotinate and nicotinic acid. Nicotinic acid derivatives such as amides, glycyrrhizic acid, dipotassium glycyrrhizinate,
Glycyrrhizic acid derivatives such as monoammonium glycyrrhizinate, glycyrrhetinic acid, glycyrrhetinic acid derivatives such as stearyl glycyrrhetic acid, antiandrogens, assembly extracts, Korean ginseng extracts, Duke extracts, red pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, etc. May be appropriately combined and compounded within a range that achieves the object of the present invention.
【００１６】本発明に利用されるアセチルカルニチンお
よびその塩の配合量としては、化粧料の処方成分全量を
基準として０．０１〜２０重量％（以下、ｗｔ％と略記
する）の範囲、好ましくは０．０５〜１０ｗｔ％の範
囲、最も好ましくは０．１〜５ｗｔ％の範囲である。The amount of acetylcarnitine and its salt used in the present invention is in the range of 0.01 to 20% by weight (hereinafter abbreviated as wt%), preferably based on the total amount of the cosmetic ingredients. It is in the range of 0.05 to 10 wt%, most preferably in the range of 0.1 to 5 wt%.
【００１７】本発明の養毛化粧料は、常法に従って、た
とえばヘアートニック、ヘアーローション、ヘアートリ
ートメント、ヘアークリーム、ヘアーコンディショナ
ー、シャンプー、リンス、ヘアージェル、ヘアーミス
ト、ヘアーフォーム等の剤型に製造し、使用することが
可能である。The hair nourishing cosmetic composition of the present invention is manufactured in a usual manner into dosage forms such as hair tonic, hair lotion, hair treatment, hair cream, hair conditioner, shampoo, rinse, hair gel, hair mist, hair foam and the like. And can be used.
【００１８】本発明の養毛化粧料は、養毛、育毛および
／または脱毛予防のために、それを目的とする局所（頭
皮）に、その剤型に従って塗布または噴霧して適用され
る。The hair restoration cosmetic composition of the present invention is applied or sprayed on a topical (scalp) intended for the purpose of hair restoration, hair growth and / or hair loss prevention according to the dosage form.
【００１９】なお、本発明の養毛化粧料には、色素、香
料、殺菌剤、防腐剤、界面活性剤、顔料、角質溶解剤、
抗酸化剤等を適宜配合することができる。The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a surfactant, a pigment, a keratolytic agent,
An antioxidant and the like can be appropriately compounded.
【００２０】[0020]
【実施例】以下、実施例および比較例により本発明を詳
細に説明するが、本発明はこれらに限定されるものでは
ない。なお、本発明に使用した試験方法は下記の通りで
ある。The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows.
【００２１】（１）マウス毛成長促進効果試験法 Ｃ３Ｈ系マウス（雄・８週齢・平均体重３５ｇ）の背部
中央の皮膚を電気バリカンで刈った後、シェーバーによ
り完全に除毛した。翌日より実施例および比較例の各試
料を被験部皮膚に毎日１回、一匹当り０．２ｍｌ塗布し
た。一試料に対して動物は一群１０匹を使用した。な
お、対照群として有効成分を除外した基剤単独を塗布し
た。実験開始後１４日目に動物を屠殺し、被験部皮膚の
写真撮影を行なった。つぎに、写真を画像解析装置に取
り込み、最初に毛刈りした面積（Ａ）と、発毛面積
（Ｂ）を求め、さらに 発毛率（％）＝〔（Ｂ）／（Ａ）〕×１００ を個々の動物について算出した。最後に、実施例または
比較例の各群の平均値を対照群の平均値により除した値
を毛成長促進効果として判定に用いた。(1) Mouse Hair Growth Promoting Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. In addition, as a control group, the base alone excluding the active ingredient was applied. On the 14th day after the start of the experiment, the animals were sacrificed and photographs of the skin of the test area were taken. Next, the photograph was taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) were determined. Further, the hair growth rate (%) = [(B) / (A)] × 100 Was calculated for each animal. Finally, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.
【００２２】（２）ヒト頭髪毛成長促進効果試験法 ３０〜４０代の毛成長に衰えの認められる男性被験者１
０名の頭頂部の頭髪を直径約７ｍｍの円形状に剃毛し
た。更に、毛刈り１日後及び３日後に林らの方法（ブリ
ティッシュ・ジャーナル・オブ・デルマトロジー、１２
５巻、１２３頁、１９９１年）により毛成長速度を対象
部位の毛髪（約３０〜４０本）について求めて、平均値
（Ａ）を計算した。次に各被験者に被験部位を中心とし
て、実施例又は比較例の試料を毎日朝夕２回、約３ｍｌ
塗布し、よくマッサージさせた。試験開始３ケ月目に同
様にして同一部位の毛成長速度の測定を行い、平均値
（Ｂ)を計算した。効果の判定は、各養毛化粧料使用前
後の比（Ｂ）／（Ａ）を比較することにより行った。(2) Human hair growth promoting effect test method Male test subject 1 in her 30s and 40s with reduced hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm. One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 12
5, p. 123, 1991), the hair growth rate was determined for the hair at the target site (about 30 to 40 hairs), and the average value (A) was calculated. Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice a day every morning and evening around the test site.
Apply and massage well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.
【００２３】（３）実用試験法 男性型脱毛症患者２０名の頭部に毎日朝夕２回、連続６
ケ月間試料を塗布した後の効果を評価した。試験結果
は、育毛効果、および脱毛予防効果の各項に対して、
「生毛が剛毛化した、或いは剛毛が増加した」、「脱毛
が少なくなった」と各々回答した人数で示した。(3) Practical test method Twice in the morning and evening, 6 consecutive times on the heads of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who answered, "Regrowth of raw hair or increase of bristle" and "Reduction of hair loss" were indicated.
【００２４】実施例１〜６、比較例１〜３（ヘアートニ
ック） 表１の原料組成において、表２に記載の如く有効成分を
配合してヘアートニックを調製し、前記の諸試験を実施
した。尚、Ｌ−カルニチン酸はＣＡＲと、Ｌ−カルニチ
ン塩酸塩はＣＡＲＣＬと略記する。またアセチル−Ｌ−
カルニチン酸はＡＬＣＲ、アセチル−Ｌ−カルニチン塩
酸塩はＡＬＣＲ・ＨＣｌのごとく略記する。Examples 1 to 6 and Comparative Examples 1 to 3 (Heart Tonic) Hair tonics were prepared by mixing active ingredients as shown in Table 2 in the raw material composition shown in Table 1, and the above-mentioned various tests were carried out. . In addition, L-carnitine acid is abbreviated as CAR and L-carnitine hydrochloride is abbreviated as CARCL. Acetyl-L-
Carnitine acid is abbreviated as ALCR, and acetyl-L-carnitine hydrochloride is abbreviated as ALCR.HCl.
【００２５】[0025]
【表１】 [Table 1]
【００２６】[0026]
【表２】 [Table 2]
【００２７】（１）調製法 表１に記載の予め溶解しておいた（Ａ）に属する油溶性
成分に、別に均一溶解した（Ｃ）成分に（Ｂ）成分を徐
々にを加えて均一に混合攪拌して溶解した水溶性成分を
添加し、均一に再混合攪拌して製造した。(1) Preparation method The component (B) is gradually added to the component (C), which has been separately dissolved, in the oil-soluble component belonging to the component (A), which has been dissolved in advance as shown in Table 1, and then uniformly added. A water-soluble component dissolved by mixing and stirring was added, and the mixture was uniformly remixed and stirred to manufacture.
【００２８】（２）特性 各ヘアートニックの諸試験を実施した結果を表２に示し
た。表２の通り、比較例１、２および３はマウス毛成長
促進効果およびヒト頭髪毛成長促進効果が低く、実用試
験の結果も良好ではなかった。(2) Characteristics Table 2 shows the results of various tests performed on each hair tonic. As shown in Table 2, Comparative Examples 1, 2 and 3 had low mouse hair growth promoting effects and human hair growth promoting effects, and the results of practical tests were not good.
【００２９】一方、実施例１〜６に示した様にアセチル
カルニチンを配合した本発明の養毛化粧料は、マウス毛
成長促進効果およびヒト頭髪毛成長促進効果に優れ、実
用試験の結果も良好であり、諸試験の全てにわたって明
らかに良好な結果を示した。なお、いずれの実施例の養
毛化粧料を用いた場合にも、マウスおよびヒトに炎症、
その他副作用と考えられる症状は発現せず、本発明の養
毛化粧料は安全性にも優れる。On the other hand, the hair-growing cosmetic composition of the present invention containing acetylcarnitine as shown in Examples 1 to 6 is excellent in mouse hair growth promoting effect and human hair growth promoting effect, and has good results in practical tests. And clearly good results over all of the tests. In addition, in the case of using the hair nourishing cosmetic of any of the examples, inflammation,
No other symptoms considered to be side effects are exhibited, and the hair restoration cosmetic of the present invention is excellent in safety.
【００３０】実施例７〜１２、比較例４（オイリーヘア
ートニック） 表３の原料組成において、表４に記載の如く有効成分を
配合してオイリーヘアートニックを調製し、前記の諸試
験を実施した。尚、アセチル−Ｌ−カルニチン酸はＡＬ
ＣＲ、アセチル−Ｌ−カルニチン塩酸塩はＡＬＣＲ・Ｈ
Ｃｌ、アセチル−Ｌ−カルニチンスルフォネートはＡＬ
ＣＲＳ、アセチル−Ｌ−カルニチンアセテートはＡＬＣ
ＲＡＣ、アセチル−Ｌ−カルニチンシトレートはＡＬＣ
ＲＣＩ、アセチル−Ｌ−カルニチンニコチネートはＡＬ
ＣＲＮのごとく略記する。Examples 7 to 12 and Comparative Example 4 (oily hair tonic) Oily hair tonic was prepared by mixing active ingredients as shown in Table 4 in the raw material composition shown in Table 3, and the above-mentioned tests were carried out. . In addition, acetyl-L-carnitic acid is AL
CR, acetyl-L-carnitine hydrochloride is ALCR.H
Cl, acetyl-L-carnitine sulfonate is AL
CRS, acetyl-L-carnitine acetate is ALC
RAC, acetyl-L-carnitine citrate is ALC
RCI, acetyl-L-carnitine nicotinate is AL
Abbreviated as CRN.
【００３１】[0031]
【表３】 [Table 3]
【００３２】[0032]
【表４】 [Table 4]
【００３３】（１）調製法 表３に記載の予め溶解しておいた（Ａ）に属する油溶性
成分に、別に均一溶解した（Ｃ）成分に（Ｂ）成分を徐
々にを加えて均一に混合攪拌して溶解した水溶性成分を
添加し、均一に再混合攪拌して製造した。(1) Preparation method The component (B) was gradually added to the component (C), which was separately and uniformly dissolved, in the oil-soluble component belonging to the component (A), which was previously dissolved as shown in Table 3, and was uniformly added. A water-soluble component dissolved by mixing and stirring was added, and the mixture was uniformly remixed and stirred to manufacture.
【００３４】（２）特性 各オイリーヘアートニックの諸試験を実施した結果を表
４に示した。表４の通り、比較例４はマウス毛成長促進
効果およびヒト頭髪毛成長促進効果が低く、実用試験の
結果も良好ではなかった。(2) Characteristics Table 4 shows the results of conducting various tests on each oily hair tonic. As shown in Table 4, Comparative Example 4 had a low mouse hair growth promoting effect and a low human hair growth promoting effect, and the results of practical tests were not good.
【００３５】一方、実施例７〜１２に示した様にアセチ
ルカルニチンを配合した本発明の養毛化粧料は、マウス
毛成長促進効果およびヒト頭髪毛成長促進効果に優れ、
実用試験の結果も良好であり、諸試験の全てにわたって
明らかに良好な結果を示した。尚、いずれの実施例の養
毛化粧料を用いた場合にも、マウスおよびヒトに炎症、
その他副作用と考えられる症状は発現せず、安全性にも
優れる。On the other hand, the hair-growing cosmetic composition of the present invention containing acetylcarnitine as shown in Examples 7 to 12 is excellent in mouse hair growth promoting effect and human hair growth promoting effect,
The results of the practical tests were also good, and all of the tests showed clearly good results. In addition, in the case of using the hair nourishing cosmetic composition of any of the examples, inflammation,
No other side effects are expected and safety is excellent.
【００３６】実施例１３〜１８、比較例５（ヘアートニ
ック） 表５の原料組成において、表６に記載の如く有効成分を
配合してヘアートニックを調製し、前記の諸試験を実施
した。Examples 13 to 18, Comparative Example 5 (Heart Tonic) Hair tonics were prepared by mixing active ingredients as shown in Table 6 in the raw material compositions shown in Table 5, and the above-mentioned various tests were carried out.
【００３７】尚、アセチル−Ｌ−カルニチン酸はＡＬＣ
Ｒ、アセチル−Ｌ−カルニチン塩酸塩はＡＬＣＲ・ＨＣ
ｌ、アセチル−Ｌ−カルニチンスルフォネートはＡＬＣ
ＲＳ、アセチル−Ｌ−カルニチンアセテートはＡＬＣＲ
ＡＣ、アセチル−Ｌ−カルニチンシトレートはＡＬＣＲ
ＣＩ、アセチル−Ｌ−カルニチンニコチネートはＡＬＣ
ＲＮのごとく略記する。Acetyl-L-carnitine acid is ALC
R, acetyl-L-carnitine hydrochloride is ALCR HC
l, Acetyl-L-carnitine sulfonate is ALC
RS, acetyl-L-carnitine acetate is ALCR
AC, acetyl-L-carnitine citrate is ALCR
CI, acetyl-L-carnitine nicotinate is ALC
Abbreviated as RN.
【００３８】[0038]
【表５】 [Table 5]
【００３９】[0039]
【表６】 [Table 6]
【００４０】（１）調製法 表５に記載の予め溶解しておいた（Ａ）に属する油溶性
成分に、別に均一溶解した（Ｃ）成分に（Ｂ）成分を徐
々にを加えて均一に混合攪拌して溶解した水溶性成分を
添加し、均一に再混合攪拌して製造した。(1) Preparation method The component (B) was gradually added to the component (C), which had been separately dissolved, to the oil-soluble component belonging to (A), which had been previously dissolved, as shown in Table 5, and was uniformly added. A water-soluble component dissolved by mixing and stirring was added, and the mixture was uniformly remixed and stirred to manufacture.
【００４１】（２）特性 各ヘアートニックの諸試験を実施した結果を表６に示し
た。表６の通り、比較例５はマウス毛成長促進効果およ
びヒト頭髪毛成長促進効果が低く、実用試験の結果も良
好ではなかった。それに対し、本発明の実施例１３〜１
８を配合したヘアートニックは諸特性において顕著な効
果が認められた。(2) Characteristics Table 6 shows the results of various tests of each hair tonic. As shown in Table 6, Comparative Example 5 had a low mouse hair growth promoting effect and a low human hair growth promoting effect, and the results of the practical test were not good. In contrast, Examples 13 to 1 of the present invention
The hair tonic containing 8 had a remarkable effect on various properties.
【００４２】[0042]
【発明の効果】以上の如く、本発明により、育毛効果、
脱毛予防効果に優れた養毛化粧料を提供できることは明
らかである。As described above, according to the present invention, a hair growth effect,
It is clear that a hair nourishing cosmetic having an excellent hair loss preventing effect can be provided.
───────────────────────────────────────────────────── フロントページの続き Ｆターム(参考） 4C083 AA122 AC102 AC122 AC182 AC352 AC432 AC472 AC482 AD042 AD631 AD632 CC37 DD23 DD38 EE05 EE10 EE22 FF05 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA122 AC102 AC122 AC182 AC352 AC432 AC472 AC482 AD042 AD631 AD632 CC37 DD23 DD38 EE05 EE10 EE22 FF05
Claims (1)
くとも一種を配合することを特徴とする養毛化粧料。1. A hair restoration cosmetic comprising at least one of acetylcarnitine and a salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10181990A JP2000016920A (en) | 1998-06-29 | 1998-06-29 | Hair tonic cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10181990A JP2000016920A (en) | 1998-06-29 | 1998-06-29 | Hair tonic cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000016920A true JP2000016920A (en) | 2000-01-18 |
Family
ID=16110403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10181990A Pending JP2000016920A (en) | 1998-06-29 | 1998-06-29 | Hair tonic cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000016920A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002074265A1 (en) * | 2001-03-19 | 2002-09-26 | Hans Schwarzkopf Gmbh & Co. Kg | Hair treatment agent comprising betains |
| EP1800654A3 (en) * | 2005-12-23 | 2007-11-28 | Henkel Kommanditgesellschaft auf Aktien | Reduction of ageing of hair |
| WO2009099167A1 (en) | 2008-02-06 | 2009-08-13 | Showa Denko K.K. | Hair growing cosmetic |
| JP2014221749A (en) * | 2013-05-14 | 2014-11-27 | 昭和電工株式会社 | Hair growth-related factor activator |
-
1998
- 1998-06-29 JP JP10181990A patent/JP2000016920A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002074265A1 (en) * | 2001-03-19 | 2002-09-26 | Hans Schwarzkopf Gmbh & Co. Kg | Hair treatment agent comprising betains |
| EP1709956A1 (en) * | 2001-03-19 | 2006-10-11 | Henkel Kommanditgesellschaft auf Aktien | Hair treatment composition comprising betains |
| EP1800654A3 (en) * | 2005-12-23 | 2007-11-28 | Henkel Kommanditgesellschaft auf Aktien | Reduction of ageing of hair |
| WO2009099167A1 (en) | 2008-02-06 | 2009-08-13 | Showa Denko K.K. | Hair growing cosmetic |
| JP2014221749A (en) * | 2013-05-14 | 2014-11-27 | 昭和電工株式会社 | Hair growth-related factor activator |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3464591B2 (en) | Hair restoration cosmetics | |
| JP4162823B2 (en) | Hair cosmetics | |
| JP3045590B2 (en) | Hair restoration cosmetics | |
| JP2000016920A (en) | Hair tonic cosmetic | |
| JPH0853327A (en) | Hair tonic composed of allantoin or its derivative | |
| JP3020640B2 (en) | Hair restoration cosmetics | |
| JP3133532B2 (en) | Hair restoration cosmetics | |
| JP2546813B2 (en) | Hair nourishing cosmetics | |
| JPS61171413A (en) | Hair tonic | |
| JP3202135B2 (en) | Hair cosmetics | |
| JP3229503B2 (en) | Hair restoration cosmetics | |
| JP3205601B2 (en) | Hair restorer | |
| JP2774071B2 (en) | Hair restoration cosmetics | |
| JPH1077216A (en) | Hair-restoring cosmetic material | |
| JP3522388B2 (en) | Hair growth agent | |
| JPH07304634A (en) | Hair tonic | |
| JP2793646B2 (en) | Hair restoration cosmetics | |
| JPH09110645A (en) | Hair nourishing cosmetic | |
| JP3624318B2 (en) | Hair nourishing agent | |
| JP2000281537A (en) | Hair tonic cosmetic | |
| JP3193544B2 (en) | Hair restoration cosmetics | |
| JP3717676B2 (en) | Hair nourishing | |
| JP2955033B2 (en) | Hair restoration cosmetics | |
| JPH069348A (en) | Hair growing cosmetic | |
| JP4327989B2 (en) | Hair cosmetics |