JPH09110645A - Hair nourishing cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair nourishing cosmetic excellent in hair nourishing effect, depilation preventing effect and safety, containing a pantetheine-S-sulfonic acid and a nonionic surfactant. SOLUTION: This hair nourishing cosmetic contains 0.01-10wt.% of a pantetheine-S-sulfonic acid and a nonionic surfactant or its salt and 0.01-20wt.% of a nonionic surfactant having 12-17HLB value (e.g. polyoxyethylene sorbitan monostearate). The cosmetic is properly mixed with a coloring matter, perfume, germicide, antiseptic, keratin, antiandrogen, antioxidant, etc., and can be prepared into a dosage form such as hair tonic, hair lotion, hair cream, hair conditioner, shampoo, rinse, hair jell, hair mist, hair foam, etc. The cosmetic has activating action on hair matrix, is useful for hair nourishing, hair growing and depilation and is applied to an affected part (scalp) by coating or spraying.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.

[0002]

2. Description of the Related Art Conventionally, hair nourishing cosmetics are known which contain blood circulation promoting substances such as capsicum tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair. Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003]

However, the conventionally used blood circulation promoting substances have drawbacks such as strong skin irritation, a limited amount of the mixture, and a short duration of blood circulation promotion. In addition, there is also a problem that the hair nutrient has low permeability to the skin at a low concentration, and its effect is not sufficiently exhibited by itself.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

However, in order to suppress the decrease in the activity of hair mother cells and the enlargement of the sebaceous glands, which are said to be caused by the excessive action of male hormones, even when an androgen inhibitor is simply used as a hair-growing agent, the hair-growing action is exhibited. The current situation is that it does not reach this level. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

As means for solving the above-mentioned problems, Japanese Patent Publication No. 2-27965, Japanese Patent Application Laid-Open No. 5-58850, Japanese Patent Application Laid-Open No. 5-1399336, and Japanese Patent Application Laid-Open No. 5-17.
A large number of hair nourishing and hair-growth agents have been proposed, including No. 0625, etc.
Japanese Patent No. 965 discloses that pantetheine-S-sulfonic acid and / or a salt thereof has a hair-growth and hair-growth effect, and also has a feature of expressing a moisturizing effect and a tissue activating effect. However, even if this substance was used alone, no satisfactory hair-growth action was found.

In view of such circumstances, the inventors of the present invention have conducted extensive studies on a substance having an action of promoting peripheral blood flow in the scalp and activating hair matrix cells, and as a result, the above-mentioned pantetheine-S-sulfonic acid or Focusing on the salt, pantetheine-S-sulfonic acid or a salt thereof, and an HLB value of 12 to 17
The present invention was completed by discovering that the hair nourishing cosmetic composition containing the nonionic surfactant of (1) simultaneously expresses the excellent hair nourishing and hair-growth effects, which are the objects of the present invention, due to the synergistic effect of each component.

[0008]

That is, pantetheine-S-sulfonic acid or a salt thereof and an HLB value of 12 to 17
The object of the present invention is achieved by the hair nourishing cosmetic composition containing the nonionic surfactant.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail. The nonionic surfactant used in the present invention is a nonionic surfactant having an HLB value of 12 to 17, and if the HLB value is out of the range of 12 to 17, the hair-growth effect and the hair loss prevention effect are inferior. It is necessary to appropriately select and use a nonionic surfactant having an HLB value of 12 to 17. Examples of these nonionic surfactants include:
Polyoxyethylene sorbitan monostearate (20
E. FIG. O. ), Polyoxyethylene sorbitan monooleate (20 EO) and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit tetraoleate (40 EO), polyoxyethylene sorbit tetrastearate (60 EO). ) Etc., polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glyceryl monooleate (15 EO),
Polyoxyethylene glycerin vegetable oil fatty acid ester (15 EO) and other polyoxyethylene glycerin fatty acid ester, polyoxyethylene monostearate (25 EO) and polyoxyethylene monooleate (12 EO) and other polyethylene glycols Fatty acid ester, polyoxyethylene lauryl ether (9E.
O. ), Polyoxyethylene oleyl ether (10
E. FIG. O. ) Such as polyoxyethylene alkyl ether,
Polyoxyethylene nonyl phenyl ether (7.5
E. FIG. O. ), Polyoxyethylene octyl phenyl ether (30 EO) and other polyoxyethylene alkyl phenyl ethers, polyoxyethylene hydrogenated castor oil (60 EO), polyoxyethylene castor oil (40
E. FIG. O. ) Such as polyoxyethylene castor oil, hydrogenated castor oil, polyoxyethylene lanolin (20EO),
Polyoxyethylene lanolin alcohol (20E.
O. ) And other polyoxyethylene lanolin derivatives. Among them, polyoxyethylene sorbitan monostearate (20E.
O. ), Polyoxyethylene hydrogenated castor oil (60E.
O. ) Etc. are particularly preferable.

Pantetheine-S-used in the present invention
Examples of the sulfonic acid salt include alkali metals such as calcium, sodium and magnesium. Of these, calcium salts are most preferable in order to obtain the effects of the present invention.

Pantethein-S-used in the present invention
The amount of sulfonic acid or a salt thereof to be blended is 0.01 to 10% based on the total amount of the hair nourishing cosmetic, as a result of examining the range showing the hair growth effect and hair loss prevention effect, which is the object of the present invention.
0 wt% (hereinafter abbreviated as wt%) is preferable, and 0.1 to 5.0 wt% is more preferable.

The amount of the nonionic surfactant used in the present invention is preferably 0.01 to 20.0 wt% based on the total amount of the hair nourishing cosmetic composition from the viewpoints of hair growth effect and hair loss prevention effect. More preferably, it is 0.05 to 10.0 wt%.

The hair nourishing cosmetic composition of the present invention can be prepared according to a conventional method, for example, a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner.
It can be manufactured and used in dosage forms such as hair gel, hair mist, and hair foam.

The hair nourishing cosmetic composition of the present invention is applied or sprayed to a desired topical region (scalp) according to its dosage form for the purpose of preventing hair nourishment, hair growth and / or hair loss.

The hair nourishing cosmetic composition of the present invention includes dyes, fragrances, germicides, antiseptics, keratolytic agents, antiandrogens,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0016]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows.

(1) Test method for mouse hair growth promoting effect C3H mice (male, 8 weeks old, average weight 35 g) were shaved at the center of the back with electric clippers, and then completely shaved by a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. The base alone was applied as a control. 14 after the start of the experiment
On the day, the animals were sacrificed and the skin of the test area was photographed. Next, the photograph was taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) were determined. Further, the hair growth rate (%) = [(B) / (A)] × 100 Was calculated for each animal. Finally, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Test method for human hair growth promoting effect Male subject 1 in the thirties and forties with a decline in hair growth
The hair of the 0 head of the head was shaved into a circular shape having a diameter of about 7 mm.
Furthermore, the method of Hayashi et al. (British Journal of Dermatology, 12
Volume 5, p. 123, 1991), the hair growth rate was determined for the hair (about 30-40 hairs) at the target site, and the average value was calculated (A). Next, for each subject, the sample of the Example or Comparative Example was administered twice daily in the morning and evening, centering on the test site, about 3 times.
ml was applied and massaged well. The hair growth rate at the same site was measured in the same manner 3 months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method 20 heads of male pattern baldness were applied to the heads twice daily in the morning and evening, and continuously 6 times.
The effect after applying the sample for a month was evaluated. The test results are shown by the number of respondents who responded that "hairy hair became bristles or bristles increased" and "hair loss decreased" for each item of hair growth effect and hair loss prevention effect.

Examples 1 to 16 and Comparative Examples 1 to 5 (Heartonic) In the raw material composition shown in Table 1, the active ingredients were blended as shown in Tables 2 and 3 to prepare a hairnic, and the various tests described above were conducted. Was carried out.

[0021]

[Table 1]

[0022]

[Table 2]

[0023]

[Table 3]

(1) Preparation Method The components (B) shown in Table 1 are dissolved alone (comparative example) or mixed (example) in the component (A), and then (C).
The ingredients were added, and the mixture was stirred, dispersed and filled in a container. At the time of use, the contents were uniformly shaken and used.

(2) Characteristics Tables 2 and 3 show the results of various tests conducted on each hairnic.
Are also shown. As shown in Tables 2 and 3, Comparative Examples 1 to 5 were low in the mouse hair growth promoting effect and the human hair growth promoting effect, and the results of the practical test were also not good.

On the other hand, the hair nourishing cosmetics of the present invention of Examples 1 to 16 show a high mouse hair growth promoting effect and human hair growth promoting effect, and the results of practical tests are also good,
Clearly good results were obtained over all of the tests.
In addition, when using the hair restoration cosmetics of any of the examples,
No inflammation or other symptoms considered to be side effects occurred in mice and humans, and it was clear that the hair restoration cosmetic of the present invention was also excellent in safety.

[0027]

EFFECTS OF THE INVENTION The hair nourishing cosmetic composition of the present invention has an activity of activating hair mother cells, and is excellent in hair growth effect, hair loss prevention effect and safety.

Claims (1)

[Claims] 1. A hair nourishing cosmetic comprising pantetheine-S-sulfonic acid or a salt thereof and a nonionic surfactant having an HLB value of 12 to 17.