JPH05170625A - Hair tonic - Google Patents

Abstract

PURPOSE:To provide a hair tonic which can accelerate peripheral blood flow in scalp, activate hair mother cells and shows excellent hair-growing effect, and prevention of hair removal. CONSTITUTION:The hair tonic contains at least one selected from acidic muco polysaccharides of low molecular weight or their salts and an essence of hop leaves.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition which promotes peripheral blood flow in the scalp and activates hair matrix cells, and which is excellent in hair growth effect and hair loss prevention effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as capsicum tincture, nicotinic acid derivatives, etc., or scalp skin cell activating substances such as Senburi extract and Korean carrot extract have been blended. A hair nourishing cosmetic is known. Furthermore, recently, a number of hair nourishing cosmetics have been proposed in which a component having an effect of preventing sebaceous gland hypertrophy and a component having an inhibitory effect on male hormone are mixed.

However, the blood circulation-promoting substances that have been conventionally used have strong skin irritation and the amount of the mixture is limited,
It has a shortcoming that the duration of blood circulation promotion is short. Also, cell activating substances have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

[0004] By the way, male pattern baldness is said to be caused by an excessive action of male hormones, but phenomena such as poor blood circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp are caused. It is presumed that they are complicatedly intertwined.

Therefore, the hair-growth effect is not sufficient even if a male-hormone inhibitory component is used or a component that suppresses the sebaceous gland hypertrophy, which is said to be caused by the excessive action of androgen, is used.

The acidic mucopolysaccharide according to the present invention, such as heparin, has been applied in a composition for stimulating hair growth as disclosed in Japanese Patent Laid-Open No. 63-313715. It has not come out to the full. In addition, hops are a plant of the Moraceae family, which is used for medicinal or brewing pre-maturation female spikes, and is said to have a female hormone action, and is a suitable component of alopecia considered to be due to androgen excess type. Conceivable. For example, JP-A-61-1
It is applied as a medicinal component of hair nourishing cosmetics as seen in Japanese Patent No. 33123. However, even if hops are used alone, they have only the effect of appropriately improving the environment of the scalp, and do not show a positive hair growth effect.

As a result of various studies on promotion of peripheral blood flow in the scalp and activation of hair mother cells, the present inventors have found that at least one selected from the group of low molecular weight acidic mucopolysaccharides and salts thereof and hop extract. It was found that a hair nourishing cosmetic composition containing and exhibits excellent hair-growth and hair loss prevention effects, and completed the present invention.

[0008]

The present invention is a hair nourishing cosmetic composition containing at least one selected from the group of low molecular weight acidic mucopolysaccharides and salts thereof and a hop extract. ..

As the low-molecular-weight acidic mucopolysaccharide relating to the present invention, hyaluronic acid, dermatan sulfate, chondroitin sulfate, heparin, heparan sulfate and the like can be used, and they are all known substances, cartilage and joints. , Eyeball,
It becomes a matrix component in the skin and other connective tissues, binds to proteins, and is widely distributed in the animal body. As the molecular weight of the acidic mucopolysaccharide used in the present invention, hyaluronic acid is 1,0.
00 to 100,000, dermatan sulfate and chondroitin sulfate are preferably 1,000 to 10,000, and heparin and heparan sulfate are preferably 1,000 to 7,000. Examples of the salt of the acidic mucopolysaccharide used in the present invention include lithium salts of the mucopolysaccharide, sodium salts, alkali metal salts such as potassium salts, alkaline earth metal salts such as magnesium salts and calcium salts, ammonium salts, triethanol. Preferred are alkanolamine salts such as amine salts and diisopropanolamine salts, and basic amino acid salts such as lysine salts, arginine salts and histidine salts. Also,
These acidic mucopolysaccharides can also be used as a free acid. The low molecular weight acidic mucopolysaccharides and salts thereof used in the present invention can be easily obtained by a hydrochloric acid hydrolysis method or an enzymatic decomposition method as described in JP-A No. 64-22809. The average molecular weight of the acidic mucopolysaccharide obtained at each treatment time was measured according to the method of Motohashi et al. (Journal of Chromatography, Volumes 435, 335
Pp. 342, 1988) In addition, the hop extract used in the present invention can be obtained by extracting from female ears of the mulberry plant hop before its maturity. That is, the fruit ears are harvested in mid-August when they are greenish to slightly yellowish, dried in the shade and then thermally dried at 50 to 60 ° C. As a medicinal component, essential oils include humulone, cohumulone, adhumulone, lupron, colprone, adolpron, xantholmol and the like. In addition, it is said to include tannin, rutin, and quercetin glycoside. The extraction can be easily performed with cold water, hot water, ethyl alcohol, or hydrous alcohol.

The amount of the low-molecular-weight acidic mucopolysaccharide and its salts to be blended is 0. 1 based on the total amount of the hair nourishing cosmetic (composition).
The range of 01 to 3.0% by weight (hereinafter abbreviated as Wt%) is preferable. The amount of hop extract is preferably 0.01 to 3.0 Wt% based on the total amount of the hair nourishing cosmetic. Here, the blending amount of both components is 0.0
If less than 1 Wt%, the effect is not sufficiently achieved, while 3.
Even if it exceeds 0 Wt%, the improvement of the effect commensurate with the increase cannot be expected. Further, the compounding ratio of both components is appropriately in the range of low molecular weight mucopolysaccharide / hop extract = 0.05 to 10.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., by a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes dyes, fragrances, bactericides, antiseptics, keratolytic agents, antiandrogens,
Antioxidants and the like can be appropriately added within a range that achieves the object of the present invention.

[0013]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In the examples, hyaluronic acid is HA,
Heparin is abbreviated as HP, chondroitin sulfate as CS, dermatan sulfate as DS, and heparan sulfate as HS. In addition, hyaluronic acid sodium salt with a molecular weight of 1,000 is HA-N
It is abbreviated as a [MW.1,000].

The mouse hair growth promoting effect test method, human hair hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) Test method for mouse hair growth promoting effect: The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely removed with a depilatory cream. From the next day, 0.2 g per animal of each sample of Example and Comparative Example was applied twice daily in the morning and evening to the skin of the test area. For each sample, 10 animals were used per group.
The base alone was applied as a control group. 15 after the start of the experiment
The animals were sacrificed on the day, 20 hairs were randomly extracted from the sample application site, each length was measured, and the average value of each group was calculated. Next, the value obtained by dividing the average value of the examples or comparative examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Human hair growth promoting effect test method 10 male hair loss patients to be tested were shaving the hair at a position 5 cm above the ears of the head in a circular shape with a diameter of 1 cm at two positions on the left and right. About 3 ml of the sample of the Example or Comparative Example was applied to the left side of the hair on the left side twice a day twice a day in the morning and evening, and compared with the untreated right side. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value of the lengths of 20 hairs on the left side (applied Example or Comparative Example) (B ) Was divided by the average value (A) of the lengths of 20 hairs on the right side (untreated), and the judgment result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical Test Method 20 heads of male pattern baldness were applied to the heads twice daily in the morning and in the evening for 6 consecutive times.
The effect after applying the sample for a month was evaluated. The test result shows that “hairy hair has become bristles or bristles have increased” for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect.
The number of respondents who answered "less hair loss" and "less dandruff" was shown.

Examples 1 to 12 and Comparative Examples 1 to 14 Oily Heartonics In the raw material compositions shown in Table 1, active ingredients were blended as shown in Tables 2 and 3 to prepare haironics. Carried out.

[0019]

[Table 1]

[0020]

[Table 2]

[0021]

[Table 3]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the component (A) and the component (B) are mixed and dispersed by stirring to obtain a container. To fill. At the time of use, the contents should be evenly dispersed by shaking.

(2) Properties The results of various tests of each oily hair artic are shown in the right columns of Tables 2 and 3. As shown in Table 2, Comparative Example 1
Nos. 14 to 14 had low mouse and human hair growth promoting effects, and the results of practical tests were also not good.

The hair nourishing cosmetics of the present invention of Examples 1 to 12 are
It showed a high hair growth-promoting effect and clearly good results in all the tests. In addition, in Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0025]

INDUSTRIAL APPLICABILITY As described above, the present invention improves peripheral blood flow in the scalp, activates hair matrix cells, is excellent in hair growth effect, hair loss prevention effect, dandruff prevention effect, and has no skin irritation. It is obvious to provide a hair nourishing cosmetic.

Claims (2)

[Claims] 1. A hair nourishing cosmetic composition comprising at least one selected from the group of low molecular weight acidic mucopolysaccharides and salts thereof, and hop extract. 2. A low molecular weight acidic mucopolysaccharide comprises hyaluronic acid having an average molecular weight of 1,000 to 100,000, chondroitin sulfate and dermatan sulfate having an average molecular weight of 1,000 to 10,000, and an average molecular weight of 1,000 to 7. 1,000
The hair nourishing cosmetic composition according to claim 1, which is heparin and heparan sulfate.