JPH05286835A - Hair-raising cosmetic - Google Patents

Abstract

PURPOSE:To provide the hair-raising cosmetic stimulating the peripheral blood flows in scalps, activating hair mother cells, excellent in hair-growing effect, alopecia-preventing effect and dander-preventing effect, and free from the irritation of skins. Ursolic acid, oleanolic acid, mannite, glucose, palmitic acid, stearic acid, oleic acid, linoleic acid, etc., are known as the ingredients contained in NYOTEISHI (the fruit of Ligustrum japonicum), and the ingredients extracted from Forsythia suspensa include oleanolic acid, lignan, lignan derivatives such as phillyrin, pinoresinol, matairesinol and matairesinoside, rutin as a flavonoid, and caffeic acid derivatives such as forsythoside A. CONSTITUTION:The hair-raising cosmetic comprises the extract of the NYOTEISHI and the extract of the Forsythia suspensa, and another hair-raising cosmetic comprises the mixed extracts of the NYOTEISHI and the Forsythia suspensa.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition which promotes peripheral blood flow in the scalp and activates hair matrix cells, and which is excellent in hair growth effect and hair loss prevention effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as capsicum tincture, nicotinic acid derivatives, etc., or scalp skin cell activating substances such as Senburi extract and Korean carrot extract have been blended. A hair nourishing cosmetic is known. Furthermore, recently, a number of hair nourishing cosmetics have been proposed in which a component having an effect of preventing sebaceous gland hypertrophy and a component having an inhibitory effect on male hormone are mixed.

However, the blood circulation-promoting substances that have been conventionally used have strong skin irritation and the amount of the mixture is limited,
It has a shortcoming that the duration of blood circulation promotion is short. Also, cell activating substances have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

[0004] On the other hand, androgenetic alopecia is said to be caused by an excessive action of androgen, but such phenomena as poor blood circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp are caused. It is presumed that they are complicatedly intertwined.

Therefore, the present situation is that even if a male hormone inhibitory component is used, a hair-growth action is not achieved. Further, even if a component that suppresses hypertrophy of the sebaceous glands is used as a hair-growing agent, the effect is not sufficient.

[0006] The female Sadako used in the present invention is a fruit of the squirrel mochi, but as described in Shenno Honkyo, "supplementing the inside, calming the five organs, nourishing the spirit, and excluding a hundred diseases",
It has been used as a nutritional tonic for symptoms such as lower back and knee pain, dizziness, tinnitus, insomnia and constipation. In addition, since it is described that "white hair can be effectively changed to black", the application as a hair nourishing agent of the formula of Sadako alone or in combination with other components (Japanese Patent Laid-Open Nos. 62-99318 and 64). -3801
No. 3, JP-A-1-230512, etc.) is disclosed, but even when Sadako alone is compounded in a cosmetic and applied externally, the percutaneous penetration of the active ingredient is poor and a sufficient hair-feeding effect is obtained. The current situation is that there are none. Similarly, even if it is combined with other components, the hair nourishing effect is not sufficient. Renja, detoxification, drainage,
It is a crude drug that has been used as an anti-inflammatory and diuretic drug. However, it has not been known that the extract of Ginseng has hair growth and hair growth effects. In addition, as an example of blending the extract of Ginseng, oral composition (JP-A 63-60918), deodorant (JP-A 63-5754), deodorant (JP-A 63-
No. 21059 gazette) has been published, but its application as a hair nourishing cosmetic has not been found.

An object of the present invention is to provide a hair nourishing cosmetic composition which promotes peripheral blood flow in the scalp, activates hair matrix cells, and has effects such as hair growth and hair loss prevention.

[0008]

Means for Solving the Problems The present invention provides a hair nourishing cosmetic which is characterized by containing an extract of Sadako and an extract of Rensetsu, and a mixed extract of Sadako and Rensei. It is a characteristic hair nourishing cosmetic.

[0009] The female Sadako according to the present invention is a dried product or a crushed product of the fruits of the plant of the family Oleaceae, Sciurus vulgaris or S. Rensai is a dried product or a crushed product of the fruits of Chinese forsythia, Chinese forsythia, or Korean forsythia native to the Korean Peninsula, which are native to the Chinese pearl oyster family. And those extracts are 5 volumes to 30
Extract with a double volume of extraction solvent. As the extraction solvent,
Water, water-containing alcohol, alcohols, acetone, ethyl acetate, benzene, chloroform and the like can be used, and extraction is carried out at a warm temperature or preferably under reflux. Above all 10
A 90% aqueous solution of ethanol is preferred as the extraction solvent. Ursolic acid is a component extracted from Sadako,
Oleanophosphoric acid, mannitol, glucose, palmitic acid, stearic acid, oleic acid, linoleic acid, etc. are known. In addition, examples of the components extracted from the continuous ginseng include oleanoic acid, lignans, and lignan glycosides such as fililin, pinoresinol, matairesinol, and matairesinoside, flavonoid rutin, and caffeic acid derivative forsitoside A. Here, it should be noted that in the present invention, a hair nourishing cosmetic composition in which a single extract of each of Sadako and Rensei is mixed may be used, or an extract of the mixture of Sadako and Rensengai is mixed. It may be used as a hair nourishing cosmetic. Above all, it has been found that the hair nourishing cosmetic containing the extract of the mixture is more excellent in the hair nourishing effect as described later. In the extract of a mixture of Sadako and Rensetsu, it is preferable that the fruits of Sadako and Rensetsu be in the range of 1: 0.1 to 1: 1.

In the following text, the compounding amount is shown based on the pure content of the extract obtained by extraction with water or an aqueous solution of ethanol (calculated as the dry residue).

The blending amount of the extract used in the present invention is (1) the blending amount of each of the individual extracts of Sadako and Renzoku in the hair nourishing cosmetic composition is calculated on the basis of the total amount as dry residue and Sadako: 0.0
01-5.0 wt%, continuous vinegar: 0.001-3.0 wt%
It is good, and more preferably, Sadako: 0.005-
2.0 wt%, continuous vinegar: 0.001-1.0 wt%. That is, if the amount is less than the lower limit, the desired effect of the present invention cannot be sufficiently obtained, and if the amount is more than the upper limit, the improvement of the effect commensurate with the increase cannot be expected. (2) The blended amount of the mixture extract of Sadako and Renzoku in the hair nourishing cosmetic is 0.001 in terms of dry residue based on the total amount.
˜5.0 wt%, more preferably 0.00
5 to 2.0 wt%. That is, if the amount is less than the lower limit, the desired effect of the present invention cannot be sufficiently obtained, and if the amount is more than the upper limit, the improvement of the effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be prepared into a dosage form such as a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner, a hair gel, a hair mist, a hair foam, etc. according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes dyes, fragrances, bactericides, antiseptics, keratolytic agents, antiandrogens,
Antioxidants and the like can be appropriately added within a range that achieves the object of the present invention.

[0014]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In addition,% shown in the examples means% by weight.

The ddY mouse hair growth promoting effect test method, the C3H mouse hair growth promoting effect test method, the human hair growth promoting effect test method and the practical test method described in Examples are shown below.

(1) Test method for hair growth promoting effect on ddY mouse White skin of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely removed with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied twice a day in the morning and evening on the skin of the test area, 0.2 g per animal. For each sample, 10 animals were used per group.
The base alone was applied as a control group. 15 after the start of the experiment
The animals were sacrificed on the day, 20 hairs were randomly extracted from the sample application site, each length was measured, and the average value of each group was calculated. Next, the value obtained by dividing the average value of the examples or comparative examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Method for testing hair growth promoting effect of C3H mouse C3H mouse (male, 8 weeks old, average weight 35 g) was shaved at the center of the back with an electric clipper, and then completely shaved by a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test site once daily, at 0.2.
For each sample, 10 animals were used per group. The base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed and the skin of the test area was photographed. Next, the photograph was taken into the image analysis device, the area (A) where the hair was first shaved and the hair-growth area (B) were calculated, and the hair-growth rate (%) =
(B) / (A) × 100 was calculated for individual animals. Finally, a value obtained by dividing the average value of each group of Examples or Comparative Examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(3) Test method for human hair growth promoting effect Male subject 1 in the thirties and forties with a decline in hair growth
The hair of the 0 head of the head was shaved into a circular shape having a diameter of about 7 mm.
Furthermore, the method of Hayashi et al. (British Journal of Dermatology, 125
Vol. 123, 1991), the hair growth rate was determined for the hair (about 30-40 hairs) at the target site, and the average value was calculated (A). Then, about 3 ml of the sample of Example or Comparative Example was applied to each test subject twice daily in the morning and evening, and the mass was thoroughly massaged. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after the use of each hair nourishing cosmetic.

(3) Practical test method The heads of 20 male pattern baldness patients were exposed to the head twice daily in the morning and evening for 6 consecutive times.
The effect after applying the sample for a month was evaluated. The test result shows that “hairy hair has become bristles or bristles have increased” for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect.
The number of respondents who answered that "hair loss has decreased" is shown.

Examples 1 to 12 and Comparative Examples 1 and 2 Oily Heartonics In the raw material compositions shown in Table 1, active ingredients were blended as shown in Table 2 to prepare haironics, and the above-mentioned tests were carried out.

[0021]

[Table 1]

[0022]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the component (A) and the component (B) are mixed and dispersed by stirring to form a container. To fill. At the time of use, the contents should be evenly dispersed by shaking.

(2) Characteristics The results of various tests of each oily hair artic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 and 2 had a low mouse and human hair growth promoting effect, and the results of the practical tests were also not good.

The hair nourishing cosmetics of the present invention of Examples 1 to 12 showed a high hair growth promoting effect in a mouse hair growth test and a human hair growth promoting effect test, and clearly show good results in all the tests. Indicated. In addition, in Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0026]

INDUSTRIAL APPLICABILITY As described above, the present invention promotes peripheral blood flow in the scalp, activates hair matrix cells, is excellent in hair growth effect and hair loss prevention effect, and has no skin irritation. It is clear to provide.

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Tatsu Miyamoto 5-328, Kotobuki-cho, Odawara-shi, Kanagawa Kanebo Co., Ltd.

Claims (2)

[Claims] 1. A hair nourishing cosmetic comprising an extract of Sadako and an extract of Rensai. 2. A hair nourishing cosmetic composition containing a mixed extract of Sadako and Rensetsu.