JPH11302131A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic for scalp and hair, having excellent blood flow- promoting effect and excellent also in safety. SOLUTION: This cosmetic for scalp and hair comprises a blood flow- promoting agent (preferably one or more agents seleded from blood flow- promoting agents of a group comprising nicotinic acids and minoxidils) and Cuachalalate extract. Furthermore, the above blood flow-promoting agent is formulated in an amount of 0.001-5.0 wt.% and the above Cuachalalate extract is formulated in an amount of 0.0001-20.0 wt.% based on whole cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scalp hair cosmetic (hereinafter referred to as "hair cosmetic"). More specifically, the present invention relates to a cosmetic for hair which has an excellent blood flow promoting effect and is also excellent in safety. The cosmetic for hair of the present invention is used particularly in the field of pharmaceuticals, quasi-drugs or cosmetics.

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, by improving blood circulation in the scalp,
Products that can improve hair loss and the like have been developed. Various troubles on the scalp are increasing with the increase of social stress in today's aging society, and the demand for hair cosmetics corresponding to the trouble on the scalp is rapidly increasing. In general, causes of baldness and hair loss on the head include activation of androgens in organs such as the sebaceous glands above the hair follicles, insufficient supply of nutrients due to a decrease in blood flow to the hair papilla and hair follicles, and corneal epithelium. Excessive dandruff, excessive sebum secretion, production of lipid peroxide, stress, and the like due to malformation and the like. Also, in growing durable and beautiful hair,
It is important to provide sufficient nutrition to the nipples and hair follicles. A decrease in blood flow to the dermal papilla or hair follicle causes nutritional deficiency and a decrease in the function of excreting waste products, and causes fine hair and thin hair.

[0003] From such a viewpoint, improvement of at least a decrease in blood flow function in the scalp is an indispensable point in solving troubles in the scalp and hair. Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be causes of baldness, hair loss and the like as described above. For example, in order to improve blood circulation in the scalp, a blood flow enhancer such as assembly extract, vitamin E and its derivatives, an acetylcholine derivative, cepharanthin and the like, and a local stimulant such as pepper tincture are blended. Anti-inflammatory agents such as purple root extract are combined to suppress inflammation of the scalp that occurs, female hormones such as estradiol are combined to suppress male hormones, and antibacterial agents such as salicylic acid are used to prevent dandruff and itching. In addition, amino acids such as serine and methionine, vitamins, and the like are blended for nutritional supplementation to hair follicles and the like, and are used for prevention and treatment of baldness, hair loss, hair thinning, and the like.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into cosmetics for hair. There was a strong tendency to be accompanied by a tingling sensation and redness, and the blending amount was naturally limited.

The problem to be solved by the present invention is to provide a cosmetic for hair which has an excellent blood flow promoting effect and is also excellent in safety.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining and combining a blood flow enhancer conventionally used in hair cosmetics and quacharate extract,
The present inventors have found that a hair cosmetic composition having an excellent blood flow promoting effect, a hair growth effect, an effect of preventing hair thinning, and an excellent safety is provided, and completed the present invention.

[0007] That is, the present invention is an invention which provides a cosmetic for hair containing a blood flow enhancer and a quatcharate extract.

[0008] When the above-mentioned blood flow enhancer is one or more blood flow enhancers selected from the group consisting of nicotinic acids and minoxidil, particularly when the blood flow enhancer has a predetermined effect. It can be used effectively.

[0009]

Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exhibits a desired effect by being combined with a blood flow enhancer and an extract of quacharalate in combination.

[0010] The blood flow enhancer which can be incorporated into the hair cosmetic of the present invention, when applied on the skin, promotes blood flow,
And as long as there is no safety problem as a component of the external preparation,
It is not particularly limited, and its mechanism of action should not be questioned.

[0011] Specifically, nicotinic acid and its derivatives (this is defined as nicotinic acids in the present application),
Minoxidil and its derivatives and analogs thereof (this is defined as minoxidil in the present application), cepharanthin, vitamin E and its derivatives, γ-oryzanol, alkoxycarbonylpyridine N-oxide, capronium chloride, acetylcholine and its derivatives What has been conventionally blended as a blood flow promoter in hair cosmetics can be appropriately selected. These blood flow promoters can be used alone in the cosmetic for hair of the present invention, but can also be used in combination of two or more.

[0012] Among these blood flow enhancers, it is particularly preferable to select one or more of nicotinic acids and minoxidil and incorporate them in the cosmetic for hair of the present invention.

Examples of the nicotinic acid derivative include benzyl nicotinate, tocopherol nicotinate, β-butoxyethyl nicotinate, nicotinamide and the like. These nicotinic acids are currently commercially available, and can be produced by a generally known method.

Minoxidil has a peripheral vasodilatory effect and has been used for the treatment of intractable hypertension.
Since hirsutism was recognized as a side effect thereof, it is a substance that has been used as a topical preparation (US Pat. Nos. 4,139,619 and 4,596,812), and its chemical name is 6- (1-pimelidinyl) -2,4-pyrimidineamine-3-oxide.

As the minoxidil derivative, a salt of the minoxidil can be mentioned, and as the minoxidil analog, a conjugate of the minoxidil can be mentioned.

These minoxidils are currently commercially available, and can be produced by a generally known method.

In the hair cosmetic of the present invention, the above-mentioned blood flow enhancer is used in an amount of 0.001 to 0.001 to the total amount of the hair cosmetic.
It is preferred to be added in the range of 5.0% by weight.
It is particularly preferred to be added in the range of 01 to 2.0% by weight. If the amount of the blood flow promoting agent is less than 0.001% by weight based on the total amount of the cosmetic for hair, a sufficient blood flow promoting effect cannot be obtained, which is not preferable. On the other hand, if the content exceeds 5.0% by weight based on the total amount of the cosmetic for hair, there is a possibility that a problem may occur from the aspect of safety such as skin irritation and the like, which is not preferable.

The quacharalate extract, which is incorporated in the hair cosmetic composition of the present invention together with the above blood flow enhancer, is particularly suitable for the quacharalate (Cuachalalate, scientific name: Juliania adstr) which grows in the Acapulco region on the Pacific coast of southern Mexico.
Ingens), which is an extract obtained from a plant and is already known to be effective for wound healing, burning, gingival toughness, digestive system cancer, hair loss, etc. (JP-A-4-18131)
No. 3) and further have been found to have a protease inhibitory action. The quacharate extract can be obtained by, for example, immersing the quatcharate leaves, stems, flowers, bark, seeds, fruits, whole plants and the like in a solvent or refluxing with heating with a solvent, followed by filtration and concentration. In addition, the concentrate thus obtained can be further used in the hair cosmetics of the present invention by further subjecting the concentrate to purification, such as fractionation and chromatography, using a solvent. As the solvent, any solvent can be used as long as it is a solvent generally used for plant extraction. For example, alcohols such as methanol and ethanol, hydroalcohols, organic solvents such as acetone and ethyl acetate, alone or They can be used in combination.

The amount of the quacharate extract in the hair cosmetic composition of the present invention is preferably 0.0001% by weight to 20.0% by weight, and more preferably 0.05% by weight to 5.0% by weight, based on the total weight of the hair cosmetic composition. 0% by weight is particularly preferred.

If the amount is less than 0.0001% by weight based on the total amount of the cosmetic for hair, a sufficient blood flow promoting effect cannot be obtained, which is not preferable. This is not preferable in that it tends to cause skin irritation and causes skin irritation.

Thus, the combination of the above-mentioned blood flow promoter and the above-mentioned quacharate extract is combined, whereby the cosmetic for hair of the present invention has an excellent blood flow promoting effect and is also excellent in safety. Is provided.

In the hair cosmetic composition of the present invention, the medicinal component usually incorporated in the hair cosmetic composition is used in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.

[0023] For example, capsicum tincture, cantharides extract, camphor, topical stimulants such as nonyl acid vanillamide; pyridoxine or derivatives thereof, sulfur, anti-seborrhoeic agents such as vitamin B _6; benzalkonium chloride, isopropyl methyl phenol, resorcinol , Zinc pyrithione, photosensitizer 101, photosensitizer 102, antibacterial agents such as salicylic acid, sodium salicylate, orthopyrox, hinokitiol; metabolic activators such as photosensitizer 301, placenta extract, biotin; glycyrrhizic acid, glycyrrhetinic acid, or their derivatives, lithospermi radix extract, anti-inflammatory agents such as menthol; estradiol, female hormones such as estrone; amino acids serine, methionine, tryptophan, etc., vitamins _{a, B 2, B 12,} D, pantothenic acid or a derivative thereof Vitamins and the like can also be incorporated into the present invention for hair cosmetics.

In addition, plant extracts, such as Altea extract, yoquinin extract, and the like, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tanjin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary The extract of the present invention focuses on extracts other than blood flow-promoting effects, such as extracts, pheasant extracts and mallow extracts. It can be incorporated into the cosmetic.

Also, zinc or a derivative thereof; lactic acid or an alkyl ester thereof; organic acids such as succinic acid, malic acid and citric acid; protease inhibitors such as tranexamic acid; olive oil, squalane, liquid paraffin, isopropyl myristate, Oils such as fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; other surfactants, humectants, thickeners, antioxidants, ultraviolet absorbers, fresheners, fragrances, pigments, ethanol, water, etc. It can be appropriately compounded within a range that does not impair the desired effect of the present invention.

The form of the cosmetic for hair of the present invention is not limited as long as it has a property applicable to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, an aerosol, and the like. By blending the components and the like, it is possible to prepare the cosmetic for hair of the present invention in a desired product form. Also,
The cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The cosmetic for hair of the present invention can be used for treating or preventing problems that can be solved by promoting blood flow in the scalp, for example, hair loss, dandruff, itching, etc.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. However, the objects shown here are examples, and the diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0029]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. In addition, the compounding amount in these Examples and the like is a percentage by weight based on the entire system in which the component is compounded, unless otherwise specified. First, prior to disclosure of each embodiment, a test for examining the blood flow promoting effect and the like of each embodiment will be described.

1. Blood flow test by laser Doppler method
Experimental laser Doppler method, ie, ALF-2100
(Advance Co., Ltd.), a laser was applied to the skin, and the change in blood flow before and after application of the test article was measured by a method of measuring the change in blood flow using the shift in reflected light (Doppler effect). . That is, in Examples 1 to 8 and Comparative Examples 1 to 4 below, blood flow was measured inside the forearm using panels of six persons each. Then, 1 mL of each of these samples was applied to a 2 cm × 2 cm square inside the forearm. Thirty minutes after the application, the blood flow was measured again, and the blood flow promoting effect was evaluated based on the degree of the change.

Each measurement was performed five times for each panel, and the following evaluation was made based on the average value of six persons. <Evaluation Criteria> +++: The blood flow increased three times or more, and an extremely remarkable blood flow promoting effect was recognized. ++: The blood flow increased twice or more, and a remarkable blood flow promoting effect was observed. +: The blood flow increased 1.5 times or more, and a considerable blood flow promoting effect was recognized. ±: The blood flow increased by 1.0 times or more and less than 1.5 times, and a slight blood flow promoting effect was observed. -: No increase in blood flow was observed, and no blood flow promoting effect was observed.

2. Hair growth test For the samples of Examples 1 to 8 and Comparative Examples 1 to 4 below, the hair growth test was performed in the quiescent period of the hair cycle in C3H / HeN.
Ogawa et al.'S method (Normal &
Normal and Abnormal Epidermal Differentiation,
Edited by M. Seiji and IA Bernstein, pp. 159-170,
1982, published by the University of Tokyo).

That is, one group of mice was divided into 10 groups, each of which was uncoated, each of Examples 1 to 8 and Comparative Examples 1 to 4, and the back of the mouse was shaved with a hair clipper and a shaver. Once a day, 1 mL was applied. The hair growth effect of each sample was determined by the hair growth rate (%) on the back of each mouse after 30 days (= area of hair growth area / area of shaved area × 100).
The average was evaluated.

[Examples 1 to 8, Comparative Examples 1 to 4] Lotions of the components shown in Table 1 (Examples 1 to 8) and Table 2 (Comparative Examples 1 to 4) were prepared according to the production method described later. And
The blood flow test and the hair growth test were performed. These results are also shown in Tables 1 and 2.

[0035]

[Table 1]

[0036]

[Table 2]

<Preparation Method> Each drug (quacharate extract, nicotinamide and / or minoxidil), glycerin, hydrogenated castor oil ethylene oxide (20 mol) adduct, and perfume were dissolved in 95% ethanol. (Ethanol phase). Next, lactic acid, sodium lactate and a dye were added to purified water, dissolved, added to the ethanol phase, and stirred to obtain a clear liquid lotion.

From the results shown in Tables 1 and 2, it can be seen that the lotion of Example in which one or both of nicotinamide and minoxidil was combined with the extract of quacharate increased blood flow after use. Although the effect of promoting blood flow and the effect of growing hair were remarkably observed, the lotion of Comparative Example containing any of these blood flow promoters and the quacharate extract had a significant effect on blood even if these components were added in a considerable amount. Both the flow promoting effect and the hair growth effect were significantly inferior to the results of the above examples.

That is, it has been clarified that the hair cosmetic composition of the present invention in which a blood flow promoting agent and a quacharate extract solution are combined is remarkably exhibited a synergistic blood flow promoting effect and a hair growth effect. . This is because the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and the application part and its surroundings caused by blending these components in a large amount can be obtained. This indicates that it has become possible to prevent unpleasant irritation and redness of the part.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 9] Medicinal tonic (blending component) blending amount (% by weight) 95% ethanol 60.0 quacharate extract 8.0 β-butoxyethyl nicotinate 0.03 tocopherol acetate 1.0 propylene glycol 3.0 succinic acid Suitable amount Perfume and pigment Suitable amount Hardened castor oil ethylene oxide (5 mol) adduct 1.5 Purified water balance

<Production Method> Quacharate extract, β-butoxyethyl nicotinate, tocopherol acetate, propylene glycol, hydrogenated castor oil ethylene oxide (5 mol) adduct and a flavor were dissolved in 95% ethanol. (Ethanol phase). Next, succinic acid and a dye were added to purified water, dissolved, added to the ethanol phase, and stirred to obtain a transparent liquid medicated tonic.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a remarkable increase in blood flow was observed in the blood flow test, and a hair growth rate of 85% was obtained in the hair growth test.

Example 10 Hair Nourishing Lotion (Ingredients) Ingredient (wt%) 95% ethanol 70.0 Quacharate extract 4.0 Minoxidil 1.0 Cepharanthin 0.5 Pepper tincture 0.5 Sorbitol 10.0 Phosphoric acid 0.1 Sodium phosphate 0.2 Perfume and pigment Suitable amount Sodium lauryl sulfate 2.0 Purified water balance

<Production Method> Quacharate extract, minoxidil, cepharanthin, pepper tincture, and flavor were dissolved in 95% ethanol. (Ethanol phase).
Then, after adding phosphoric acid, sodium phosphate, sorbitol, sodium lauryl sulfate and a dye to purified water,
After dissolving and adding this to the ethanol phase, the mixture was stirred to obtain a clear liquid hair growth lotion.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a remarkable increase in blood flow was observed in the blood flow test, and a hair growth rate of 95% was obtained in the hair growth test.

Example 11 Hair Nourishing Lotion (Components) Component (% by weight) 95% Ethanol 45.0 Quacharate Extract 10.0 Caffeine 0.15 Benzyl Nicotinate 0.05 Aspartic Acid 0.05 Para Butylene glycol 2.0 Maltitol 8.0 Polyethylene glycol 400 2.0 Propyl paraben 0.05 Sodium hexametaphosphate Appropriate amount Sodium palmitate 0.3 Perfume and pigment Appropriate amount Purified water balance

<Preparation method> Quacharate extract, caffeine, benzyl nicotinate, parabutylene glycol, polyethylene glycol 400 in 95% ethanol
Propylparaben and perfume were dissolved (ethanol phase). Next, purified water is added with aspartic acid, maltitol, sodium hexametaphosphate, sodium palmitate, and a dye, and then dissolved, and the resulting solution is added to the ethanol phase and stirred to obtain a clear liquid hair nourishing lotion. Was.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a remarkable increase in blood flow was observed in the blood flow test, and a hair growth rate of 90% was obtained in the hair growth test.

Example 12 Scalp Massage Agent (Blending Components) Blending Amount (Weight%) 95% Ethanol 45.0 Quacharate Extract 1.0 Nicotinamide 0.8 Benzyl Nicotinate 0.05 Dynamite Glycerin 5.0 1,3-butylene glycol 8.0 dipropylene glycol 4.5 thickener 3.0 methyl paraben 0.2 perfume and dyes appropriate amount purified water balance

<Production method> A thickener was added to a part of purified water to dissolve and thicken, and then a dye dissolved in the remaining purified water was separately added (aqueous phase). To this aqueous phase, dynamite glycerin, 1,3-butylene glycol, and dipropylene glycol were added and mixed, and quatararate extract dissolved in 95% ethanol, nicotinamide, benzyl nicotinate, methylparaben and flavor were added. Then, the mixture was stirred to obtain a gel-like scalp massage agent.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a remarkable increase in blood flow was observed in the blood flow test, and a hair growth rate of 90% was obtained in the hair growth test.

[0052]

According to the present invention, there is provided a cosmetic for hair having an excellent blood flow promoting effect and excellent safety.

Claims (2)

[Claims] 1. A scalp / hair cosmetic containing a blood flow enhancer and quacharate extract. 2. The cosmetic for scalp hair according to claim 1, wherein the blood flow enhancer is one or more blood flow enhancers selected from the group consisting of nicotinic acids and minoxidil. .