JPH0640858A - Hair tonic - Google Patents

Hair tonic

Info

Publication number
JPH0640858A
JPH0640858A JP3276728A JP27672891A JPH0640858A JP H0640858 A JPH0640858 A JP H0640858A JP 3276728 A JP3276728 A JP 3276728A JP 27672891 A JP27672891 A JP 27672891A JP H0640858 A JPH0640858 A JP H0640858A
Authority
JP
Japan
Prior art keywords
hair
agent
growth factor
phase
hair tonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3276728A
Other languages
Japanese (ja)
Inventor
Chika Hanzawa
千加 榛沢
Akihiro Ishino
章博 石野
Makoto Uzuka
誠 宇塚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiseido Co Ltd
Original Assignee
Shiseido Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to JP3276728A priority Critical patent/JPH0640858A/en
Publication of JPH0640858A publication Critical patent/JPH0640858A/en
Pending legal-status Critical Current

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  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE:To obtain a hair tonic having excellent hair tonic effect such as hair- falling preventing effect and hair restoration effect by using a fibroblast growth factor as an active component. CONSTITUTION:A fibroblast growth factor, preferably a base-type fibroblast growth factor is used as an active component and compounded in an amount of 0.000001-0.1wt.% based on the total hair tonic. The hair tonic is properly compounded with other components such as vasodilator, amino acid, vitamin, dermatic function promoting agent, female hormone preparation, antibacterial agent, refreshing agent, oil, polyhydric alcohol, surfactant, perfumery and antioxidant. The agent is formed in a form applicable to the skin such as liquid, milky lotion or ointment and directly applied or scattered to the skin at a daily rate of 0.01-1,000mug/1kg body weight in 1-4 divided doses. It is applicable in the fields of pharmaceuticals, quasi-drugs and cosmetics.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、繊維芽細胞成長因子
(Fibroblast Growth Factor
以下FGFと記載する)を有効成分として配合する、
優れた脱毛防止、発毛効果等の養毛作用を持つ養毛料に
関する。本発明は、特に医薬品、医薬部外品、或は化粧
品分野において利用される。
FIELD OF THE INVENTION The present invention relates to a fibroblast growth factor (Fibroblast Growth Factor).
Hereinafter referred to as FGF) as an active ingredient.
The present invention relates to a hair nourishing agent having excellent hair loss prevention and hair growth effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

【0002】[0002]

【従来の技術】従来より、禿や脱毛の原因としては、毛
根、皮脂腺等の器官における男性ホルモンの活性化、毛
包への血流量の低下、皮脂の分泌過剰、過酸化物の生成
等による頭皮の異常等が考えられている。このため従来
の養毛料には、前記の原因を取り除いたり、または、軽
減する作用を持つ化合物が一般に配合されている。例え
ば、ビタミンB 、ビタミンE等のビタミン類、セリ
ン、メチオニン等のアミノ酸類、センブリエキス、アセ
チルコリン誘導体などの血管拡張剤、紫根エキス、ヒノ
キチオール等の抗炎症剤、エストラジオールなどの女性
ホルモン剤、セファランチンなどの皮膚機能亢進剤など
が配合され、脱毛症の予防および治療に用いられてい
る。
2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as cembly extract and acetylcholine derivative, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, cepharanthin, etc. , A skin function-enhancing agent, etc. are mixed and used for the prevention and treatment of alopecia.

【0003】[0003]

【発明が解決しようとする課題】しかしながら、前記の
ように種々の試みがなされているにもかかわらず、従来
の養毛料ではその脱毛防止、発毛効果等の養毛作用は必
ずしも充分なものではなかった。これらはおそらく、脱
毛の原因がさまざまであり、また発毛の機構も非常に複
雑であるためであると考えられている。
However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effect. There wasn't. It is believed that these are probably due to various causes of hair loss and the mechanism of hair growth is also very complicated.

【0004】本発明者らは、上記のように養毛作用が不
充分であることにに鑑み、脱毛に対して有効であり、優
れた脱毛防止、発毛効果等の養毛作用を持つ物質を探求
した結果、FGFが優れた養毛作用を持つことを見出
し、本発明を完成するに至った。
In view of the insufficient hair-feeding effect as described above, the present inventors are effective for hair loss and have excellent hair-preventing effects such as hair loss prevention and hair growth effects. As a result of the search, the inventors have found that FGF has an excellent hair-feeding effect, and have completed the present invention.

【0005】[0005]

【課題を解決するための手段】すなわち、本発明はFG
Fを有効成分として配合することを特徴とする養毛料を
提供するものである。以下、本発明の構成について詳述
する。本発明で使用するFGFは一般にacid型(以
下a−FGFと記載する)とbasic型(以下b−F
GFと記載する)の2種類に分けられる。本発明におい
てはこれらのうちどちらを用いてもかまわないが、b−
FGFが好ましい。また本発明で使用するFGFは既に
ウシ由来のものが市場に試薬として出ている。本発明で
使用するFGFは上記のものでも良いし、さらにウマ、
ヒツジ、ウサギ、ラット等いずれの動物由来のものを用
いてももかまわない。
That is, the present invention provides FG
The present invention provides a hair nourishing agent containing F as an active ingredient. Hereinafter, the configuration of the present invention will be described in detail. The FGF used in the present invention is generally acid type (hereinafter referred to as a-FGF) and basic type (hereinafter referred to as b-F).
(Described as GF). In the present invention, either of these may be used, but b-
FGF is preferred. The FGF used in the present invention is already available on the market as a reagent derived from bovine. The FGF used in the present invention may be the one described above, or a horse,
Any animal-derived animal such as sheep, rabbit and rat may be used.

【0006】本発明のFGFの配合量は養毛料全量中、
0.01〜1000ppm (0.000001〜0.1 重量%)、好ましくは
0.1 〜100ppm(0.00001 〜0.01重量%)である。0.01pp
m 未満であると、本発明の効果が充分得られず、1000pp
m を超えると製剤上好ましくない。
[0006] The amount of FGF of the present invention is
0.01-1000ppm (0.000001-0.1wt%), preferably
It is 0.1 to 100 ppm (0.00001 to 0.01% by weight). 0.01pp
If it is less than m, the effect of the present invention cannot be sufficiently obtained, and 1000 pp
When it exceeds m, it is not preferable in terms of formulation.

【0007】本発明に係る養毛料には上記FGFのほ
か、塩化カルプロニウム、センブリエキス、アセチルコ
リン誘導体等の血管拡張剤、セリン、メチオニン等のア
ミノ酸類、ビタミンB6 、ビタミンE及びその誘導体、
ビオチン等のビタミン類、パントテン酸及びその誘導
体、グリチルレチン酸及びその誘導体、ニコチン酸ベン
ジルなどのニコチン酸エステル類、セファランチン等の
皮膚機能亢進剤、エストラジオール等の女性ホルモン剤
等を同時に配合してもよい。さらに、通常、養毛料に用
いられる添加剤、例えば、ヒノキチオール、ヘキサクロ
ロフェン、ベンザルコニウムクロリド、セチルピリジニ
ウムクロリド、ウンデシレン酸、トリクロロカルバニリ
ドおよびビチオノール等の抗菌剤、メントール等の清涼
剤、サリチル酸、亜鉛およびその誘導体、乳酸およびそ
のアルキルエステルなどの薬剤、クエン酸等の有機酸
類、アルギニン等のアミノ酸類、オリーブ油、スクワラ
ン、流動パラフィン、イソプロピルミリステート、高級
脂肪酸、高級アルコール等の油分、グリセリン、プロピ
レングリコール等の多価アルコール、その他界面活性
剤、香料、酸化防止剤、紫外線吸収剤、色素、エタノー
ル、水、保湿剤、増粘剤等が本発明の効果を損なわない
範囲で適宜配合することができる。
The hair nourishing agent according to the present invention includes, in addition to the above-mentioned FGF, vasodilators such as carpronium chloride, cembly extract and acetylcholine derivative, amino acids such as serine and methionine, vitamin B6, vitamin E and its derivatives,
Vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cepharanthin, and female hormone preparations such as estradiol may be mixed at the same time. . Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and antibacterial agents such as biothionol, a refreshing agent such as menthol, salicylic acid, Zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, oils such as higher fatty acids and higher alcohols, glycerin, propylene Polyhydric alcohol such as glycol, other surfactants, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, humectants, thickeners and the like may be appropriately blended within a range that does not impair the effects of the present invention. it can.

【0008】本発明の養毛料の性状は、液状、乳液、軟
膏など外皮に適用できる性状のものであればいずれでも
よい。本発明の養毛料は皮膚に直接に塗布または散布す
る経皮投与による投与方法をとる。また、本発明の養毛
料の投与量は、年齢、個人差、病状等により変化するの
で明確には確定できないが、一般に人に投与する場合の
投与量は体重1kgおよび1日当り0.01〜1000μg 、 好ま
しくは0.1 〜100 μg であり、 この量を1日1回または
2〜4回に分けて投与することができる。
The hair nourishing agent of the present invention may be in any form as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment. The hair nourishing agent of the present invention is administered by percutaneous administration by directly applying or spraying on the skin. Further, the dose of the hair nourishing agent of the present invention cannot be definitely determined because it varies depending on age, individual difference, medical condition, etc. However, in general, the dose for administration to humans is 1 kg of body weight and 0.01 to 1000 μg per day, preferably. Is 0.1 to 100 μg, and this amount can be administered once a day or in 2 to 4 divided doses.

【0009】[0009]

【実施例】次に実施例をあげて本発明の養毛料の製法お
よび養毛作用をさらに具体的に説明する。本発明はこれ
により限定されるものではない。配合量は重量%であ
る。
EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. The blending amount is% by weight.

【0010】(製造法)あらかじめ、b−FGFの100
μg/ml(ppm)の水溶液を調整した。95%エタノールにb
- FGF、および硬化ヒマシ油エチレンオキシド(40 モ
ル) 付加物を添加し、 攪拌溶解させ、 次いでイオン交換
水を添加、混合して実施例1の液状の養毛料を得た。実
施例2〜5並びに比較例1も実施例1と同様にして得
た。
(Manufacturing method) 100% of b-FGF was prepared in advance.
An aqueous solution of μg / ml (ppm) was prepared. B in 95% ethanol
-FGF and hydrogenated castor oil ethylene oxide (40 mol) adduct were added, dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 1. Examples 2 to 5 and Comparative Example 1 were also obtained in the same manner as in Example 1.

【0011】[0011]

【表1】 [Table 1]

【0012】[発毛試験]実施例1〜5 および比較例1
の発毛試験を毛周期の休止期にあるC3H/HeNCr
Jマウスを用い、小川らの方法(ノーマル アンド ア
ブノーマル エピダーマル ディファレンシェーション
[Normal and Abnormal Epidermal Differentiation] 、
M.Seiji およびI.A.Bernstein 編集、 第159 〜170 ペー
ジ、1982年、東大出版)により行なった。すなわち、マ
ウスを1群10匹とし、無塗布、実施例1〜5 および比較
例1の7群に分け、バリカンおよびシェーバーでマウス
の背部を剃毛し、それぞれのサンプルを1日1回、0.1
mlずつ塗布した。各サンプルの発毛効果はマウス背部の
発毛部分を測定して面積比によって比較した。各サンプ
ルによる50%発毛率に要する日数を表2に示した。
[Hair Growth Test] Examples 1 to 5 and Comparative Example 1
Hair growth test with C3H / HeNCr in the resting period of hair cycle
Using the J mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiation
[Normal and Abnormal Epidermal Differentiation],
Edited by M. Seiji and IA Bernstein, pp. 159-170, 1982, University of Tokyo. That is, the number of mice was 10 per group, and there was no application, and the mice were divided into 7 groups of Examples 1 to 5 and Comparative Example 1, the backs of the mice were shaved with a clipper and a shaver, and each sample was treated with 0.1 times a day.
Each ml was applied. The hair-growth effect of each sample was measured by measuring the hair-growth part on the back of the mouse and compared by the area ratio. Table 2 shows the number of days required for 50% hair growth rate for each sample.

【0013】[0013]

【表2】 [Table 2]

【0014】表2から明らかなように、本発明に係わる
養毛料は、優れた発毛効果を有している。
As is clear from Table 2, the hair nourishing agent according to the present invention has an excellent hair growth effect.

【0015】[養毛作用試験]次に本発明の養毛料の脱
毛防止、発毛効果等の養毛作用を調べるために、人に対
して、トリコグラム試験を実施した。実施例1〜5 、比
較例1の養毛料について行なった。
[Hair nourishing test] Next, in order to examine the hair nourishing effects such as hair loss prevention and hair growth effects of the hair nourishing agent of the present invention, a trichogram test was conducted on humans. The hair nourishing agents of Examples 1 to 5 and Comparative Example 1 were used.

【0016】[トリコグラム試験]養毛料の使用前と使
用後の抜去毛髪の毛根を顕微鏡下で観察し、毛根の形態
から休止期毛根数を計数し、その割合の増減によって養
毛料の養毛作用を比較した。休止期毛根とは成長の止ま
った毛の毛根であり、脱毛を訴える人は正常な人よりも
この休止期毛根の割合が多いことが認められている。実
施例1〜5 および比較例1の各養毛料をそれぞれ男性被
験者10名の頭皮に1日2回、1回2mlずつ6カ月間連続
して塗布し、塗布直前および6カ月間塗布終了直後に被
験者1名につき100 本ずつ毛髪を抜去し、それぞれの毛
根を調べた。結果を表3に示した。
[Trichogram test] The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, and the number of resting hair roots is counted from the morphology of the hair nourishing agent. The effects were compared. Resting hair roots are hair roots that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each hair nourishment of Examples 1 to 5 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, immediately before and immediately after the application for 6 months. 100 hairs were removed from each subject, and each hair root was examined. The results are shown in Table 3.

【0017】[0017]

【表3】 [Table 3]

【0018】表3から明らかなように、本発明に係る養
毛料は、優れた養毛作用を有している。
As is clear from Table 3, the hair nourishing agent according to the present invention has an excellent hair nourishing action.

【0019】[0019]

【発明の効果】本発明の養毛料は脱毛防止、発毛効果等
の優れた養毛効果を持つ養毛料である。
The hair nourishing agent of the present invention has excellent hair nourishing effects such as hair loss prevention and hair growth effects.

【0020】 実施例6 O/W乳液型養毛料 (A 相) 重量% b- FGF水溶液 100 μg/ml(ppm) 1.0 ホ゜リオキシエチレン(60モル) 付加硬化ヒマシ 油 2.0 グリセリン 10.0 ジプロピレングリコール 10.0 1,3 −ブチレングリコール 5.0 ポリエチレングリコール1500 5.0 (B 相) セチルイソオクタネート 10.0 スクワラン 5.0 ワセリン 2.0 プロピルパラベン 2.0 (C 相) カルボキシビニルポリマー1%水溶液 30.0 ヘキサメタリン酸ソーダ 0.03 イオン交換水 8.35 (D 相) イオン交換水 4.5 (E 相) カセイカリ 0.12 イオン交換水 5.0 (製造法)A相、B相をそれぞれ60℃で加熱溶解し、混
合してホモミキサー処理しゲルを作る。これにD相を徐
々に添加しホモミキサーで分散する。次にこれに溶解し
たC相を加え、最後に溶解したE相を添加しホモミキサ
ーで乳化してO/W乳液型の養毛料を得た。この養毛料
を実施例1と同様に人に対して、実使用テストを行った
ところ、その養毛作用が優れていることが確認された。
Example 6 O / W emulsion type hair nourishing agent (phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 1.0 polyoxyethylene (60 mol) addition-hardened castor oil 2.0 glycerin 10.0 dipropylene glycol 10.0 1 , 3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) ion Exchanged water 4.5 (Phase E) Causticari 0.12 Ion exchanged water 5.0 (Production method) Phases A and B are melted by heating at 60 ° C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test to humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

【0021】 実施例7 クリーム状養毛料 (A 相) 重量% b- FGF水溶液 100μg/ml(ppm) 5.0 流動パラフィン 5.0 セトステアリルアルコール 5.5 グリセリルモノステアレート 3.0 EO(20モル)-2- オクチルドデシルエーテル 3.0 プロピルパラベン 0.3 香料 0.1 (B 相) グリセリン 8.0 ジプロピレングリコール 20.0 ポリエチレングリコール4000 5.0 ヘキサメタリン酸ソーダ 0.005 イオン交換水 45.095 (製造法)A相、B相をそれぞれ加熱溶解して混合し、
ホモミキサーで乳化してクリーム状養毛料を得た。この
養毛料を実施例1と同様に人に対して、実使用テストを
行ったところ、その養毛効果が優れていることが確認さ
れた。
Example 7 Creamy hair nourishing agent (phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 5.0 liquid paraffin 5.0 cetostearyl alcohol 5.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Production method) Phases A and B are dissolved by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

【0022】 実施例8 クリーム状養毛料 (A 相) 重量% b- FGF水溶液 100μg/ml(ppm) 0.5 流動パラフィン 10.5 グリセリルモノステアレート 3.0 EO(20モル)-2- オクチルドデシルエーテル 3.0 プロピルパラベン 0.3 香料 0.1 (B 相) グリセリン 10.0 ジプロピレングリコール 18.0 ポリエチレングリコール4000 5.0 ヘキサメタリン酸ソーダ 0.005 イオン交換水 54.595 (製造法)A相、B相をそれぞれ加熱溶解して混合し、
ホモミキサーで乳化してクリーム状養毛料を得た。この
養毛料を実施例1と同様に人に対して、実使用テストを
行ったところ、その養毛効果が優れていることが確認さ
れた。
Example 8 Cream hair nourishing agent (Phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 0.5 liquid paraffin 10.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 propylparaben 0.3 Fragrance 0.1 (Phase B) Glycerin 10.0 Dipropylene glycol 18.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 54.595 (Manufacturing method) Phases A and B are melted by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

【0023】 実施例9 O/W乳液型養毛料 (A 相) 重量% b- FGF水溶液 100 μg/ml(ppm) 10.0 ホ゜リオキシエチレン(60モル) 付加硬化ヒマシ 油 2.0 グリセリン 10.0 1,3 −ブチレングリコール 5.0 ポリエチレングリコール1500 5.0 (B 相) セチルイソオクタネート 10.0 ワセリン 8.0 プロピルパラベン 2.0 (C 相) カルボキシビニルポリマー1%水溶液 30.0 ヘキサメタリン酸ソーダ 0.03 イオン交換水 8.35 (D 相) イオン交換水 4.5 (E 相) カセイカリ 0.12 イオン交換水 5.0 (製造法)A相、B相をそれぞれ60℃で加熱溶解し、混
合してホモミキサー処理しゲルを作る。これにD相を徐
々に添加しホモミキサーで分散する。次にこれに溶解し
たC相を加え、最後に溶解したE相を添加しホモミキサ
ーで乳化してO/W乳液型の養毛料を得た。この養毛料
を実施例1と同様に人に対して、実使用テストを行った
ところ、その養毛作用が優れていることが確認された。
Example 9 O / W emulsion type hair nourishing agent (Phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 10.0 Polyoxyethylene (60 mol) Addition hydrogenated castor oil 2.0 Glycerin 10.0 1,3-butylene Glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Vaseline 8.0 Propylparaben 2.0 (Phase C) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion exchanged water 8.35 (D phase) Ion exchanged water 4.5 (E phase) ) KASEIKARI 0.12 Ion-exchanged water 5.0 (Production method) Phases A and B are dissolved by heating at 60 ° C, mixed, and homogenized to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test to humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

【0024】 実施例10 O/W乳液型養毛料 (A 相) 重量% a- FGF水溶液 100 μg/ml(ppm) 1.0 ホ゜リオキシエチレン(60モル) 付加硬化ヒマシ 油 2.0 グリセリン 10.0 ジプロピレングリコール 10.0 1,3 −ブチレングリコール 5.0 ポリエチレングリコール1500 5.0 (B 相) セチルイソオクタネート 10.0 スクワラン 5.0 ワセリン 2.0 プロピルパラベン 2.0 (C 相) カルボキシビニルポリマー1%水溶液 30.0 ヘキサメタリン酸ソーダ 0.03 イオン交換水 8.35 (D 相) イオン交換水 4.5 (E 相) カセイカリ 0.12 イオン交換水 5.0 (製造法)A相、B相をそれぞれ60℃で加熱溶解し、混
合してホモミキサー処理しゲルを作る。これにD相を徐
々に添加しホモミキサーで分散する。次にこれに溶解し
たC相を加え、最後に溶解したE相を添加しホモミキサ
ーで乳化してO/W乳液型の養毛料を得た。
Example 10 O / W emulsion type hair nourishing agent (A phase) wt% a-FGF aqueous solution 100 μg / ml (ppm) 1.0 polyoxyethylene (60 mol) addition-hardened castor oil 2.0 glycerin 10.0 dipropylene glycol 10.0 1 , 3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) ion Exchanged water 4.5 (Phase E) Causticari 0.12 Ion exchanged water 5.0 (Production method) Phases A and B are melted by heating at 60 ° C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent.

Claims (2)

【特許請求の範囲】[Claims] 【請求項1】繊維芽細胞成長因子(Fibroblas
t GrowthFactor)を有効成分として配合
することを特徴とする養毛料。
1. A fibroblast growth factor (Fibroblas)
t Growth Factor) as an active ingredient.
【請求項2】繊維芽細胞成長因子が塩基型繊維芽細胞成
長因子(basic型−Fibroblast Gro
wth Factor)である請求項1記載の養毛料。
2. The fibroblast growth factor is a basic fibroblast growth factor (basic type-Fibroblast Gro).
The hair nourishing agent according to claim 1, which is a Wth Factor).
JP3276728A 1991-09-27 1991-09-27 Hair tonic Pending JPH0640858A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3276728A JPH0640858A (en) 1991-09-27 1991-09-27 Hair tonic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3276728A JPH0640858A (en) 1991-09-27 1991-09-27 Hair tonic

Publications (1)

Publication Number Publication Date
JPH0640858A true JPH0640858A (en) 1994-02-15

Family

ID=17573515

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3276728A Pending JPH0640858A (en) 1991-09-27 1991-09-27 Hair tonic

Country Status (1)

Country Link
JP (1) JPH0640858A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038708A1 (en) * 1996-04-18 1997-10-23 The General Hospital Corporation Modulating epithelial-mesenchymal interactions
JPH11130636A (en) * 1997-10-28 1999-05-18 Noevir Co Ltd Hair cosmetic
US6248779B1 (en) 1995-04-21 2001-06-19 Sekisui Kagaku Kogyo Kabushiki Kaisha External preparations for treating dermatoses
KR20070000005A (en) * 2005-06-24 2007-01-02 주식회사 아디포랩 Cosmetic composition containing fibroblast growth factor
JP2008127313A (en) * 2006-11-20 2008-06-05 Japan Natural Laboratory Co Ltd Cosmetic and hair cosmetic obtained by blending egf (epidermal growth factor)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248779B1 (en) 1995-04-21 2001-06-19 Sekisui Kagaku Kogyo Kabushiki Kaisha External preparations for treating dermatoses
US6306898B1 (en) 1995-04-21 2001-10-23 Sekisui Kaisha Kogyo Kabushiki Kaisha External preparations for the treatment of dermatoses
WO1997038708A1 (en) * 1996-04-18 1997-10-23 The General Hospital Corporation Modulating epithelial-mesenchymal interactions
JPH11130636A (en) * 1997-10-28 1999-05-18 Noevir Co Ltd Hair cosmetic
KR20070000005A (en) * 2005-06-24 2007-01-02 주식회사 아디포랩 Cosmetic composition containing fibroblast growth factor
JP2008127313A (en) * 2006-11-20 2008-06-05 Japan Natural Laboratory Co Ltd Cosmetic and hair cosmetic obtained by blending egf (epidermal growth factor)

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