JPH08231353A - Hair tonic - Google Patents

Abstract

PURPOSE: To obtain a hair tonic effective for human and mammals, having preventing effect on falling off of hair and promoting effect on hair production, comprising an extract of a plant for a crude medicine as an active ingredient. CONSTITUTION: This hair tonic comprises an extract of a plant for a crude medicine from Peru, called Huito, Jagua or Chinchilcuma or its raw material plant, as an active ingredient. The plant is preferably Huito (or Jagua) derived from Genipaamericana L. of the family Rubiaceae or Chinchilcuma derived from Mutisiaacuminata R and P. of the family Asterceae. The amount of the extract blended is preferably 0.005-20wt.%, preferably 0.01-5wt.% calculated as a dried substance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. More specifically, the present invention relates to a hair nourishing agent comprising as an active ingredient an extract from a herb medicinal plant produced in Peru. The hair nourishing agent of the present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes.

For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as cembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, and female hormone agents such as estradiol. , Skin function enhancers such as cefarantin, etc. are mixed and used for the prevention and treatment of alopecia.

[0004]

However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effects. It was This is probably because there are various causes of hair loss and the mechanism of hair growth is very complicated. Considering such a variety of causes of hair loss, it would be desirable to provide further new hair nourishing agents.

Accordingly, an object of the present invention is to provide a hair nourishing agent having an excellent hair loss preventing effect and hair growth promoting effect in order to cope with the various causes of hair loss.

[0006]

[Means for Solving the Problems] From the above viewpoints, the present inventors have widely searched for effective substances in foreign countries and have conducted studies. As a result, they have found that an extract from a specific plant that has been used as a crude drug produced in Andes, Peru has excellent hair loss prevention effect and hair growth promoting effect.

Therefore, according to the present invention, there is provided the above object.
The solution is provided by providing a hair nourishing agent containing as an active ingredient an extract from a specific medicinal plant from Andes, Peru. As a specific herbal plant for the purpose of the present specification, there are locally used Huito (or Jagu).
a)) or those with the names Chinchilcuma and Chinchilcuma, as well as individual plants selected from their source plants, or mixtures thereof.

[0008] More specifically, Muteishia Akiyuminata Earl of Fuito of the plants (or Jiyagua) Geni path Americana El of Rubiaceae (Rubiaceae). To (Genipaamericana L.), and Chinchirukuma the Asteraceae (Asteraceae). Andpee. (Mutisia acuminata R. &
P.).

[0009] These plants may be derived from whole grass or any of their constituent parts as long as they do not adversely affect the object of the present invention and contain active ingredients.
However, whole plants can be advantageously used in the above plants. As the plant body of the present invention, the whole plant immediately after collection may be subjected to extraction as it is, but it is preferable to provide the whole plant dried after collection to extraction. It is convenient to use some of them that are dried, which are commercially available.

As a method for preparing an extract from a plant used in the present invention, the plant is used as a solvent, for example, hot water, a lower alcohol such as methanol or ethanol, a hydrous lower alcohol, propylene glycol, or 1-3 butylene glycol. It is possible to use the method of extraction with the above-mentioned polyhydric alcohol or hydrous alcohol such as hydrous polyhydric alcohol.

The amount of the extract from the plant used in the present invention is 0.005 to 2 as a dried product in the total amount of the hair restorer.
It is 0% by weight, preferably 0.01 to 5% by weight. 0.0
If it is less than 05% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation.

In addition to the above components, the hair nourishing agent according to the present invention contains
Various components commonly used in cosmetics, quasi drugs, pharmaceuticals, etc., such as oil, higher fatty acid, solid paraffin, liquid paraffin, silicone oil, squalane, etc .; moisturizers, such as hyaluronic acid, propylene glycol, maltitol, atelocollagen , Sodium lactate, etc .; thickeners, quince mucilages, carboxyvinyl polymers,
Xanthan gum, etc .; oil such as glyceryl monooleate, nicotinamide, benzyl nicotinate, vitamin E acetate, cembly extract, carpronium chloride,
Assembly extract, vasodilators such as acetylcholine derivatives, amino acids such as serine and methionine, vitamin B
6. Vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cefarantin, and female hormone agents such as estradiol May be mixed at the same time. Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and biothionol, refreshing agents such as menthol, salicylic acid, Zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, oils such as higher alcohols, glycerin, propylene Polyhydric alcohol such as glycol, fragrance, antioxidant, ultraviolet absorber, dye,
Ethanol, water, a moisturizer, a thickener, etc. can be appropriately added within a range that does not impair the effects of the present invention.

The hair nourishing agent of the present invention may be in any form as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment.

The hair nourishing agent of the present invention is applied by transdermal administration, which is applied or sprayed directly on the skin. Further, the optimum dose of the hair nourishing agent of the present invention cannot be clearly specified because it varies depending on age, individual differences, medical conditions, etc. However, in general, the dose for administration to humans is 1 kg of body weight and 1 kg of body weight. The daily dose is 0.01 to 100 mg, preferably 0.1 to 10 mg, and this amount can be administered once a day or divided into 2 to 4 times a day.

The thus-prepared hair nourishing agent of the present invention has an excellent hair-removing action as well as a hair-growing and hair-growing action, and is useful as a pharmaceutical or cosmetic for hair care.

[0016]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. Unless otherwise specified, the blending amount means% by weight.

Examples 1-2: Preparation of Extracts White dais (or Jiagua) and Chintil bear (each dried whole grass) were separately treated by the methanol cold soak extraction method. Specifically, the dried product (500 g) was treated with 7.5 l of methanol for 5 days, respectively, and the dried product of methanol extract was 138.4 g from the former and 10 from the latter.
Obtained 3.6 g.

Examples 3-4: Preparation of hair nourishing agent 1.0% of each methanol extract dried product obtained in Examples 1-2 was
Each was individually mixed with 70% ethanol 90%, hydrogenated castor oil ethylene oxide (40 mol) adduct 1.0%, and ion-exchanged water (residual), and dissolved by stirring. Further, ion-exchanged water (10%) was added to each solution, and the mixture was again mixed and stirred to obtain a liquid hair nourishing agent 1 [derived from Phuit (or Jiagua)] and a liquid hair nourishing agent 2 (derived from tintil bear).

Examples 5-6: Preparation of Extract The same operation was repeated using 70% ethanol instead of methanol in Examples 1-2. Thus, 103.5 g of a dry product of 70% ethanol extract was obtained for phyto (or diyagua) and 72.5 g of tintil bear.

Examples 7-8: Preparation of hair nourishment 0.1% dry product of each 70% ethanol extract obtained in Examples 1-2
%, 70% ethanol 90%, sodium oleate 0.01%, dodecylbenzene sulfonic acid 0.49%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.5% and deionized water (residual) Was mixed and stirred to dissolve. Ion-exchanged water (10%) was further added to each solution, and the mixture was again mixed and stirred to give a liquid hair nourishing agent 3
[Fight (or Jiagua) origin] and liquid hair nourishing agent 4
(From Chinchyl bear) was obtained.

Examples 9 to 10: Preparation of Extract The ethyl acetate extract dried product was obtained by repeating the same procedure using ethyl acetate instead of methanol in Examples 1 and 2. Yield is 8 for huito (or yagua)
30.4 g and 62.1 g for Chinchyl bear.

Examples 11 to 12: Preparation of hair nourishing agent 0.05% of each ethyl acetate extract dried product obtained in Examples 9 to 10
Were separately mixed with 70% ethanol 90%, lauryl dimethylamine oxide 0.1%, hydrogenated castor oil ethylene oxide (60 mol) adduct 0.9% and ion-exchanged water (residual), and dissolved by stirring. Ion-exchanged water (10%) was further added to each solution and mixed to form a liquid hair nourishing agent 5 [from Phyto (or Jigua)],
A liquid hair nourishing agent 6 (derived from Chinchyl bear) was obtained.

Examples 13 to 14: Preparation of extract The same operation was repeated using acetone instead of methanol in Examples 1 and 2. In this way, 89.9 g of dried acetone extract was added to the weight (or yagua).
675.3 g was obtained for Chinchyl bear.

Examples 15 to 16: Preparation of hair nourishment 0.1% of each acetone extract dry product obtained in Examples 13 to 14
Was mixed with 70% ethanol 90%, sorbitan sesquioleate 0.4%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.6% and ion-exchanged water (residual), and dissolved by stirring. Further, ion-exchanged water (10%) was added to the obtained solution and stirred to prepare a liquid hair nourishing agent 7
[Fight (or Jiagua) origin], liquid hair nourishing agent 8
(From Chinchyl bear) was obtained.

Examples 17 to 18: Preparation of extract The same operation was repeated using 40% aqueous ethanol solution instead of methanol in Examples 1 and 2. In this way, 40% ethanol extract dried product
And 56.6 g of tintil bear.

Examples 19 to 20: Preparation of hair nourishing agent 0.3% of each 40% ethanol extract dried product obtained in Examples 17 to 18 was individually added to 70% ethanol 90%.
%, Lauroyl taurine 0.1%, cetylpyridinium chloride 0.01%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.89%, and ion-exchanged water (residual) were mixed and stirred to dissolve. Ion-exchanged water (10%) was further added to and mixed with each of these solutions to prepare a liquid hair nourishing agent 9 [derived from Phyto (or digua)] and a liquid hair nourishing agent 10
(From Chinchyl bear) was obtained.

Hair Growth Test Example Using the 70% ethanol as a control sample, the following hair growth test was conducted on the liquid hair nourishing agents 1 to 10 of the present invention.

C3 as an experimental animal in the resting phase of the hair cycle
Using the H / HeNCrJ mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differen
tiation], edited by M. Seiji and IA Bernstein, pp. 159-170, 1982, The Univ. of Tokyo).

That is, each group of 10 mice was divided into 6 groups for the test sample and the control sample, and the back of each mouse was shaved with a clipper and a shiver, and each sample was treated with 0.1 times a day. 1 ml each was applied. The results of measuring the hair regeneration area after 25 days are shown in Table 1 below (numerical values are average values).

Table 1 Fuito (or Jiagua) Chintil bear Hair nourishment Hair regrowth area Hair nourishment Hair regrowth area (No.) (%) (No.) (%) 1 96.5 2 95.5 3 91.0 4 92.0 5 85.0 6 81.0 7 81.5 8 90.5 9 90.0 10 81.0 Control 5.0 As is clear from Table 1, the hair nourishing agent of the present invention has a significant effect in the hair growth test of mice.

Example of hair nourishment test In order to examine the hair nourishing action such as hair loss prevention and hair growth effect of the hair nourishing agent of the present invention, a trichogram test was conducted on humans by the following method. The test sample and the control sample were the hair nourishing agents 1 and 2 used in the above hair growth test example, and 7 as a control.
It is 0% ethanol.

The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, and the number of resting hair roots is counted from the morphology of the hair root, and the hair nourishing effect of the hair nourishing agent is compared by increasing or decreasing the ratio. did. Resting hair roots are hair roots of hairs that have stopped growing,
It has been found that people who complain of hair loss have a higher proportion of this telogen root than normal people.

Each of the hair nourishments of the test sample and the control sample was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, immediately before the application and immediately after the application for 6 months. 100 hairs were removed from each person, each hair root was examined, and a practical use test was conducted. Table 2 shows the results.

Table 2 Proportion hair growth effects of the specimen telogen hair roots (control and 20% less than the decrease ± 20% 20% or more increase assessments hair tonic charge number) (%) (%) (%) Control 10 50 40 Ineffective 1 65 33 12 Effective 2 60 30 10 Effective As is clear from Table 2, the hair nourishing agent of the present invention has a significant hair nourishing effect in the human trichogram test.

Examples 3-4, Examples 7-8, Examples 11-12, Example 1
In addition to 5-16 and Examples 19-20, the preparation of another embodiment of the formulation according to the invention is illustrated below. In the example below,
As the dried extract, any one obtained in Examples 1-2, Examples 5-6, Examples 9-10, Examples 13-14, and Examples 17-18 was selected. For all of these, the liquid hair nourishing agent 1 to
The hair loss prevention effect and the hair nourishing effect similar to those of No. 9 are obtained. Therefore, it should be understood that the dried extracts in the following examples represent compatible use cases.

Example 21 (Phase A) Dried extract 1.0 Polyoxyethylene (60 mol) Addition hydrogenated castor oil 2.0 Glycerin 10.0 Dipropylene glycol 10.0 1,3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) Ion-exchanged water 4.5 (E-phase) KASEIKARI 0.12 Ion-exchanged water 5.0 (Production method) Phases A and B are heated and melted at 60 ° C, respectively,
Mix and homogenize to make a gel. Phase D is gradually added to this and dispersed by a homomixer.

Next, dissolved phase C was added thereto, and finally dissolved phase E was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent.

Example 22 (Phase A) Liquid Paraffin 5.0 Cetostearyl Alcohol 5.5 Glyceryl Monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Dried extract 5.0 Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium dodecyl sulfate 0.1 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Production method) Phase A , Phase B is melted by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent.

Example 23 Dry extract 0.5 Stearyl dimethylamine oxide 0.5 Hardened castor oil Ethylene oxide (40 mol) adduct 1.0 95% ethanol 54.0 Ion-exchanged water balance (preparation) Ions in 95% ethanol Exchanged water was added, hydrogenated castor oil ethylene oxide (40 mol) adduct and stearyl dimethylamine oxide were added thereto, and then dried products of each extract were added and dissolved by stirring.

Example 24 N-coconut lauryl-β-aminopropionate sodium 0.2 dried extract 1.0 sodium dodecylbenzene sulfonate 0.5 hydrogenated castor oil ethylene oxide (40 mole) adduct 1.0 95% ethanol 54. 0 ion-exchanged water balance (production method) Ion-exchanged water was added to 95% ethanol, and hydrogenated castor oil ethylene oxide (40 mol) adduct, sodium dodecylbenzene sulfonate and N-
After adding coconut lauryl-β-aminopropionate soda, each extract dried product is added and dissolved by stirring.

[0041]

The present invention provides hair nourishing agents obtained from various plant sources. All of these hair nourishing agents have excellent hair loss prevention effect and hair growth promoting effect in mammals including humans.

Claims (3)

[Claims] 1. A hair nourishing agent comprising, as an active ingredient, an extract from a medicinal plant from Andes, Peru.
A hair nourishing agent in which the herb medicinal plant has a name of Huito (or Jagua) or Chinchilcuma or a raw material plant thereof. 2. The herb medicinal plant is Rubiacaceae ( Rubiac
eae ) of Genipaamericana el. ( Genipaamericana
L.)-Derived white (or diagua).
Stated hair nourishment. 3. The herb medicinal plant is Asteraceae ( Asteraceae).
ae ) Muteicia Akiyu Minata Earl and P. ( M
The hair nourishing agent according to claim 1, which is a chinchyl bear derived from utisia acuminata R. & P.).