JPH08231352A - Hair tonic - Google Patents

Abstract

PURPOSE: To obtain a hair tonic having excellent preventing effect on falling off of hair and promoting effect on hair production, comprising an extract of a plant for a crude medicine from Indonesia as an active ingredient. CONSTITUTION: This hair tonic contains 0.005-20wt.% of one or more selected from Orange aring derived from Eclipta alba L. of the family Asteraceae, Srigading derived from Nyctanthes arbor-tristis L. of the family Oleaceae, Jangkang derived from Sterculia foetida L of the family Sterculiaceae, Lempyang derived from Zingiber aromaticum Mal. of the family Zingiberaceae, Meniran derived from Phyllanthuss niruri L. of the family Euphorbiaceae, Mrico bolong derived from Melaleuca Leucadindra of the family Myrtaceae and Temu kunei derived from Boesenbergia pandurata of the family Zingiberaceae as an active ingredient. The plant is extracted with a solvent (e.g. methanol). The hair tonic is percutaneously administered by direct application or spraying to skin. Adose is 0.01-100mg/kg/day.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. More specifically, the present invention relates to a hair nourishing agent containing an extract from a herb medicinal plant produced in Indonesia as an active ingredient. The hair nourishing agent of the present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes.

For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as cembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, and female hormone agents such as estradiol. , Skin function enhancers such as cefarantin, etc. are mixed and used for the prevention and treatment of alopecia.

[0004]

However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effects. It was This is probably because there are various causes of hair loss and the mechanism of hair growth is very complicated. Considering such a variety of causes of hair loss, it would be desirable to provide further new hair nourishing agents.

Accordingly, an object of the present invention is to provide a hair nourishing agent having an excellent hair loss preventing effect and hair growth promoting effect in order to cope with the various causes of hair loss.

[0006]

[Means for Solving the Problems] From the above viewpoints, the present inventors have widely searched for effective substances in foreign countries and have conducted studies. As a result, they have found that an extract from a specific plant that has been used as a crude drug in Indonesia has excellent hair loss prevention effect and hair growth promoting effect.

Therefore, according to the present invention, there is provided the above object.
The solution is provided by providing a hair nourishing agent containing as an active ingredient an extract from a specific medicinal plant in Indonesia. As for the specific medicinal plants mentioned here, there are Orang aring and Srigadin in the field.
g), Jangkang, Lempyan
g), Meniran, Murico bol
ong) and Temu kunei, as well as individual plants selected from the group consisting of their raw plants, and mixtures of two or more thereof.

More specifically, [0008], Oran'arin of the plants Eshiriputa Alba El of the Asteraceae (Asteraceae).
To (Eclipta alba L.), Surigadjin is Mokuisei Department (O
Leaceae ) Nicatantes al boat list stake el.
To (Nyctanthes arbo-tristis L.), Jiyankan the star clear Fuoechidaeru of Sterculiaceae (Sterculiaceae). (Sterculia foetida L. ), Renpiyan the Jingiba Aromachikumu Mar Shiyouga family (Zingiberaceae). (Zingiba aromaticum Mal .), Meniran is Fuiransasu Niruri of Euphorbiaceae (Euphorbiaceae)
El. To (Phyllanthuss niruri L.), Muriko boron in Meraroika Roika de Indra of the myrtle family (Myrtaceae) (Melaleuca leucadindra), and Temu Kunei in Boesenberugia Pandourata (Boesenbergia pandurata) of Shiyouga family (Zingiberaceae), derived from each Is believed to be.

These plants may be derived from whole grass or any of their constituent parts, as long as they do not adversely affect the object of the present invention and contain active ingredients. However, whole plants can be advantageously used in the above plants. As the plant body of the present invention, the whole plant immediately after collection may be subjected to extraction as it is, but it is preferable to provide the whole plant dried after collection to extraction. It is convenient to use some of them that are dried, which are commercially available.

As a method for preparing an extract from a plant used in the present invention, the plant is used as a solvent, for example, hot water, a lower alcohol such as methanol or ethanol, a hydrous lower alcohol, propylene glycol, or 1-3 butylene glycol. It is possible to use the method of extraction with the above-mentioned polyhydric alcohol or hydrous alcohol such as hydrous polyhydric alcohol.

The amount of the extract from the plant used in the present invention is 0.005 to 2 as a dried product in the total amount of the hair restorer.
It is 0% by weight, preferably 0.01 to 5% by weight. 0.0
If it is less than 05% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation.

In addition to the above components, the hair nourishing agent according to the present invention contains
Various components commonly used in cosmetics, quasi drugs, pharmaceuticals, etc., such as oil, higher fatty acid, solid paraffin, liquid paraffin, silicone oil, squalane, etc .; moisturizers, such as hyaluronic acid, propylene glycol, maltitol, atelocollagen , Sodium lactate, etc .; thickeners, quince mucilages, carboxyvinyl polymers,
Xanthan gum, etc .; oil such as glyceryl monooleate, nicotinamide, benzyl nicotinate, vitamin E acetate, cembly extract, carpronium chloride,
Assembly extract, vasodilators such as acetylcholine derivatives, amino acids such as serine and methionine, vitamin B
6. Vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cefarantin, and female hormone agents such as estradiol May be mixed at the same time. Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and biothionol, refreshing agents such as menthol, salicylic acid, Zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, oils such as higher alcohols, glycerin, propylene Polyhydric alcohol such as glycol, fragrance, antioxidant, ultraviolet absorber, dye,
Ethanol, water, a moisturizer, a thickener, etc. can be appropriately added within a range that does not impair the effects of the present invention.

The hair nourishing agent of the present invention may be in any form as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment.

The hair nourishing agent of the present invention is applied by transdermal administration, which is applied or sprayed directly on the skin. Further, the optimum dose of the hair nourishing agent of the present invention cannot be clearly specified because it varies depending on age, individual differences, medical conditions, etc. However, in general, the dose for administration to humans is 1 kg of body weight and 1 kg of body weight. The daily dose is 0.01 to 100 mg, preferably 0.1 to 10 mg, and this amount can be administered once a day or divided into 2 to 4 times a day.

The thus-prepared hair nourishing agent of the present invention has an excellent hair-removing action as well as a hair-growing and hair-growing action, and is useful as a pharmaceutical or cosmetic for hair care.

[0016]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. Unless otherwise specified, the blending amount means% by weight.

Examples 1-7: Preparation of Extracts Oran Allin, Surigadin, Jiancan, Lempian, Meniran, Muricoboron and Temkunei (each dried whole grass, 500 g) were treated separately by the cold methanol extraction method. Specifically, the dried product was treated with 7.5 l of methanol for 5 days, and the dried product of methanol extract was 51.5 g (Example 1) of oranaline, 126.8 g (Example 2) of surigadin, and diyancan, respectively. For 108.1 g (example 3), Lempian for 24.9 g (example 4) and Meniran for 33.1 g
(Example 5), 34.5 g of mulicovoron (Example 6) and 30.9 g of Temkunay (Example 7) were obtained.

Examples 8 to 14: Preparation of hair nourishment 1% of each methanol extract dried product obtained in Examples 1 to 7 was separately added to 70% ethanol 90%, hydrogenated castor oil ethylene oxide (40 mol) adduct 1.0. % And ion-exchanged water (residual) after stirring to dissolve, ion-exchanged water ( adjusted to 100% ) is further added and mixed again to prepare liquid hair nourishing agents 1 to 7 corresponding to dried products. Obtained.

Examples 15 to 21: Preparation of Extract The same operation was repeated using 70% ethanol instead of methanol in Examples 1 to 7 to obtain 70% ethanol extract dried product in an amount of 41.2 g (Example 15). ), 101.4 g for Surigadin (Example 16), 86.1 g for Jijankan (Example 17), 2 for Lempian.
0.1 g (Example 18), 26.7 g of meniran (Example 1)
9), 27.7 g of mulicovoron (Example 20) and 24.1 g of temkuney (Example 21) were obtained.

Examples 22 to 28: Preparation of hair nourishment 0.1% of each 70% ethanol extract dried product obtained in Examples 15 to 21 was individually added to 70% ethanol 90%,
Sodium oleate 0.01%, dodecylbenzene sulfonic acid 0.49%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.5% and deionized water (residual)
Was mixed and stirred to dissolve. Ion-exchanged water (10%) was further added to and mixed with each of the solutions to prepare Examples 15 to 2, respectively.
Liquid hair nourishing agent 8 (from oran allin) corresponding to 1.
9 (from Surigajin), 10 (from Jiangcan), 11
(Derived from lempian), 12 (derived from meniran), 13 (derived from mulicovoron) and 14 (derived from temkuney).

Examples 29 to 35: Preparation of Extract The same operation was repeated by using ethyl acetate instead of methanol in Examples 1 to 7 to obtain a dried product of ethyl acetate extract in an amount of 38.2 g (Example 29) of oran allin. 94.0g for Surigajin (Example 30), 80.1 for Jyankan
g (Example 31), 18.3 g for Lempian (Example 3)
2), for Meniran 24.9 g (Example 33), Murico
25.8 g of boron (Example 34) and 22.5 g of Temkunay (Example 35) were obtained.

Examples 36 to 42: Preparation of hair nourishing agent 0.05 dry product of each ethyl acetate extract obtained in Examples 29 to 35
%, 70% ethanol 90%, lauryl dimethylamine oxide 0.1%, hydrogenated castor oil ethylene oxide (60 mol) adduct 0.9%, and ion-exchanged water (remainder) were mixed and stirred to be dissolved. . Ion-exchanged water (10%) was further added and mixed to each solution to obtain liquid hair nourishing agents 15 to 21.

The hair nourishing agent 15 is derived from oranaline,
The same 16 is derived from Surigadin, the same 17 is derived from Jyankan, the same 18 is derived from Lempian, the same 19 is derived from Meniran, the same 20 is derived from Muricovoron, and the same 21 is derived from Temkuney. .

Examples 43 to 49: Preparation of Extract The same operation was repeated using acetone instead of methanol in Examples 1 to 7. Acetone extract dried product obtained from each whole plant dried product was 33.
1 g (Example 43), 81.9 g of Surigajin (Example 4)
4), 70.0 g for diyancan (example 45), 16.3 g for lempyan (example 46), 21.6 g for meniran (example 47), 22 for muricoboron.
0 g (Example 48) and 11.0 g (Example 49) for temukney.

Examples 50 to 56: Preparation of hair nourishment 0.1% of each acetone extract dry product obtained in Examples 43 to 49
Was mixed with 70% ethanol 90%, sorbitan sesquioleate 0.4%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.6% and ion-exchanged water (residual), and dissolved by stirring. Ion-exchanged water (10%) was added to and mixed with each of these solutions to form a liquid hair nourishing agent 22
~ 28 were obtained (in turn, from the dried acetone extract of Examples 43-49).

Examples 57 to 63: Preparation of Extract The same operation was repeated using 40% aqueous ethanol solution instead of methanol in Examples 1 to 7. The 40% ethanol extract dried product obtained from each whole plant dried product was 28.1 g for oranaline (Example 57), 69.3 g for surigadin (Example 58), and 59.
4 g (Example 59), for Lempian (Example 60), 13.8 g for Meniran (Example 61), 18.9 g for Muricoboron (Example 62) and 1 for Temkunay.
It was 6.9 g (Example 63).

Examples 64-70: Preparation of hair nourishing agent 0.3% of each 40% ethanol extract dry matter obtained in Examples 57-63 was separately added to 70% ethanol 90%.
%, Lauroyl taurine 0.1%, cetylpyridinium chloride 0.01%, hydrogenated castor oil ethylene oxide (40 mol) adduct 0.89%, and ion-exchanged water (residual) were mixed and stirred to dissolve. Ion-exchanged water (10%) was added to these solutions separately to obtain liquid hair nourishments 29 to 35 (in order, derived from the dried 40% ethanol extract of Examples 57 to 63).

Hair Growth Test Example Using the 70% ethanol as a control sample, the following hair growth test was conducted on the liquid hair nourishing agents 1 to 35 of the present invention.

C3 as an experimental animal in the resting phase of the hair cycle
Using the H / HeNCrJ mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differen
tiation], edited by M. Seiji and IA Bernstein, pp. 159-170, 1982, The Univ. of Tokyo).

That is, each group of 10 mice was divided into 6 groups for the test sample and the control sample, and the backs of the mice were shaved with a clipper and a shaver, and each sample was treated once a day for 0. 1 ml each was applied. The results of measuring the hair regeneration area after 25 days are shown in Table 1 below (numerical values are average values).

[0031]

[Table 1]

As is clear from Table 1, the hair nourishing agent of the present invention has a significant effect in the hair growth test in mice.

Example of hair nourishing action test In order to investigate the hair nourishing action such as hair loss prevention and hair growth effect of the hair nourishing agent of the present invention, a trichogram test was conducted on humans by the following method. The test sample and the control sample are the same as the hair nourishing agents 1, 2, 3, 4, 5, 6, 7 and 70% ethanol used in the above hair growth test example.

The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, the number of resting hair roots is counted from the morphology of the hair roots, and the hair nourishing effect of the hair nourishing agent is compared by increasing or decreasing the ratio. did. Resting hair roots are hair roots of hairs that have stopped growing,
It has been found that people who complain of hair loss have a higher proportion of this telogen root than normal people.

The hair nourishment of the test sample and the control sample was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, and immediately before the application and immediately after the application for 6 months. 100 hairs were removed from each person, each hair root was examined, and a practical use test was conducted. Table 2 shows the results.

Table 2 Proportion hair growth effects of the specimen telogen hair roots (control and 20% less than the decrease ± 20% 20% or more increase assessments hair tonic charge number) (%) (%) (%) Control 10 50 40 Invalid 1 60 30 10 Effective 2 60 30 10 Effective 3 60 30 10 Effective 4 60 30 10 Effective 5 60 30 10 Effective 6 60 30 10 Effective 7 − − − − As is clear from Table 2, the present invention The hair restorer has a significant hair restorer effect in the human trichogram test.

[0037] Formulation Example Example 8-14, Example 22-28, Example 36-42, Example 50-5
6, formulation examples according to the present invention other than those described in Examples 64-70 are described below.

As shown in Tables 1 and 2, Examples 1-7, Examples 15-21, Examples 29-35, Examples 43-49, Examples 57-6.
The dried extract of 3 can be used interchangeably for the preparation of formulations. Therefore, the dried extracts in the following examples are Examples 1 to 7, Examples 15 to 21, Examples 29 to 35, and Example 43.
~ 49, any one according to Examples 57-63. It has been confirmed that any of the dried extracts has the same effects as those shown in Tables 1 and 2.

Example 71 (Phase A) Extract Dried Product 1.0 Polyoxyethylene (60 mol) Addition Hardened Castor Oil 2.0 Glycerin 10.0 Dipropylene Glycol 10.0 1,3-Butylene Glycol 5.0 Polyethylene Glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) Ion-exchanged water 4.5 (E-phase) KASEIKARI 0.12 Ion-exchanged water 5.0 (Production method) Phases A and B are heated and melted at 60 ° C, respectively,
Mix and homogenize to make a gel. Phase D is gradually added to this and dispersed by a homomixer.

Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent.

Example 72 (Phase A) Liquid Paraffin 5.0 Cetostearyl Alcohol 5.5 Glyceryl Monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Dried extract 5.0 Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium dodecyl sulfate 0.1 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Production method) Phase A , Phase B is melted by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent.

Example 73 Dry extract 0.5 Stearyl dimethylamine oxide 0.5 Hydrogenated castor oil Ethylene oxide (40 mol) adduct 1.0 95% ethanol 54.0 Ion-exchanged water balance (preparation) Ion to 95% ethanol Exchanged water was added, hydrogenated castor oil ethylene oxide (40 mol) adduct and stearyl dimethylamine oxide were added thereto, and then dried products of each extract were added and dissolved by stirring.

Example 74 N-coconut lauryl-β-aminopropionate 0.2 Dry extract 1.0 Sodium dodecylbenzene sulfonate 0.5 Hardened castor oil Ethylene oxide (40 mol) adduct 1.0 95% Ethanol 54. 0 ion-exchanged water balance (production method) Ion-exchanged water was added to 95% ethanol, and hydrogenated castor oil ethylene oxide (40 mol) adduct, sodium dodecylbenzene sulfonate and N-
After adding coconut lauryl-β-aminopropionate soda, each extract dried product is added and dissolved by stirring.

[0044]

The present invention provides hair nourishing agents obtained from various plant sources. All of these hair nourishing agents have excellent hair loss prevention effect and hair growth promoting effect in mammals including humans.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 35/78 ADA A61K 35/78 ADAT

Claims (8)

[Claims] 1. A hair nourishing agent comprising, as an active ingredient, an extract from an Indonesian herb medicinal plant, wherein the herb medicinal plants are each orang arin (Orang ari).
ng), Srigading, Jangkan
g), Lempyang, Meniran,
Mrico bolong and Temu
hair nourishing agent which is one or more kinds selected from the group consisting of those having the name of kunei) and their raw plants. 2. The herb medicinal plant is Asteraceae ( Asteraceae).
The hair nourishing agent according to claim 1, which is oranallin derived from Eclipta alba L. of ae ). 3. The herb medicinal plant is an oleaceae ( Olea
ceae ) Nictantes al boat stays El. ( N
Yctanthes arbor-tristis L.) derived surigadin, The hair restorer according to claim 1. 4. The method of claim 1, wherein herbal plants body, Sterculiaceae (Ster
culiaceae ) of Star Clear Fouetida El. ( Stercu
The hair nourishing agent according to claim 1, which is a janyan derived from lia foetida L.). 5. The herb medicinal plant is Zingidae ( Zing
iberaceae ) Jingivar Aroma Chikum Mar. ( Zing
The hair nourishing agent according to claim 1, which is Lempian derived from iber aromaticum Mal.). Wherein said herbal plants body, Fuiransasu Niruri El Euphorbiaceae (Euphorbiaceae). (Phyl
The hair nourishing agent according to claim 1, which is a meniran derived from Lanthus niruri L.). 7. The herb medicinal plant is Myrtaceae ( Myrt
Meraroika of aceae) Roika de Indra (Melaleuca le
The hair nourishing agent according to claim 1, which is mulicovoron derived from ucadindra ). 8. The herb medicinal plant is Zingidae ( Zing
iberaceae) of Boesenberugia Pandourata (Boesen
bergia pandurata ) -derived tem kunei.
Stated hair nourishment.