JP3133532B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention suppresses inflammation of the scalp, promotes peripheral blood flow, and activates hair matrix cells.
The present invention relates to a hair nourishing cosmetic having an excellent hair loss preventing effect.

[0002]

2. Description of the Related Art Conventionally, hair restoration cosmetics containing a blood circulation promoting substance such as pepper tincture and nicotinic acid derivatives, or amino acids and vitamins, which are nutritional components of hair, have been known. Are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also,
At a low concentration, the nutritional components of the hair also have a problem that the permeability to the skin is low and the active effect on the hair alone is not sufficient.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

[0005] Therefore, even if a male hormone-inhibiting component or a component that inhibits sebaceous gland hypertrophy is used alone to suppress the excessive action of male hormones, the hair-growth effect is not sufficient.

[0006] The Artemisia mugwort extract according to the present invention is a substance that has been used as a therapeutic agent for anti-inflammatory, antipyretic, diuretic, jaundice and the like. However, it was not known that the Japanese sagebrush extract had hair growth and hair growth effects. As for diisopropylamine dichloroacetate, a cosmetic (Japanese Patent Publication No. 18523/1987) has been filed,
There is a description that the growth of hair roots is promoted, but it is not enough to achieve a sufficient hair growth effect by itself, and at present it is used in combination with other active ingredients.

As a result of various studies on the promotion of peripheral blood flow of the scalp and the activation of hair matrix cells, the present inventors have found that a hair nourishing cosmetic composition containing an extract of pearl mugwort and diisopropylamine dichloroacetate has excellent hair growth, The present invention has been found to exhibit a hair-growth effect, and the present invention has been completed. The purpose of the invention is to promote peripheral blood flow of the scalp and activate hair matrix cells to promote hair growth and hair loss. An object of the present invention is to provide a hair nourishing cosmetic having an excellent preventive effect.

[0008] The present invention exhibits excellent hair growth and hair growth effects as described above, because the anti-inflammatory effect of the Japanese sagebrush extract improves the environment of the scalp and further enhances the permeability of diisopropylamine dichloroacetate. It can be considered that the activation of hair mother cells is promoted and the hair growth and hair growth effects are remarkably improved.

[0009]

Means for Solving the Problems The present invention is a hair restoration cosmetic comprising an extract of sagebrush and diisopropylamine dichloroacetate.

[0010] The extract of the sagebrush according to the present invention can be obtained by extracting from the whole plant of a young sagebrush of the Asteraceae family. The medicinal ingredients are
It contains 6,7-dimethoxy-coumarin, chlorogenic acid, caffeic acid and the like, and β-pinene, capilone, capylene, capilin, folic acid, capillarin and the like in essential oils. As a solvent to be extracted, cold water, hot water, aqueous alcohol, alcohols such as ethanol and methanol, acetone, ethyl acetate, chloroform, propylene glycol, butylene glycol and the like can be used. More preferably, it is hot water or a 30 to 70% aqueous ethanol solution.

In the following text, the compounding amount is indicated on the basis of the pure content (converted by the dry residue) of the extract obtained by extraction with hot water or a 50% aqueous ethanol solution.

The diisopropylamine dichloroacetate according to the present invention is a known substance known as a skin cell activator, can be chemically synthesized, and has a molecular weight of 230.15.

[0013] The amount of the extract of Kawataya mugi is calculated based on the total amount of the hair-growing cosmetic composition (composition) as a dry residue.
0.001 to 1.0% by weight (hereinafter abbreviated as wt%)
Is more preferable, more preferably 0.01 to 0.5 w
t%.

The compounding amount of diisopropylamine dichloroacetate is preferably 0.001 to 5.0% by weight, more preferably 0.01 to 2.0% by weight.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0017]

The present invention will be described below in detail with reference to examples and comparative examples. The mouse hair growth promoting effect test method, human hair growth promotion effect test method, and practical test methods described in the Examples are shown below.

(1) Mouse Hair Growth-Promoting Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal.
A group of 10 animals was used for one sample. The base alone was applied as a control. On the 14th day after the start of the experiment, the animals were sacrificed, and the skin of the test area was photographed. next,
The photograph is taken into an image analyzer, and the area (A) of first shaving and the area of hair growth (B) are determined, and the hair growth rate (%) =
(B) / (A) × 100 was calculated for each animal. Finally, a value obtained by dividing the average value of each group of the examples or the comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(2) Human hair growth promotion effect test method Male test subject 1 in which hair growth in 30's and 40's has declined
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm.
One day and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 125,
123, 1991), the hair growth rate was determined for the hair (about 30 to 40 hairs) at the target site, and the average value was calculated (A). Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice a day every morning and evening around the test site,
Massaged well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method Twice in the morning and evening twice daily for 20 male and female alopecia patients
The effect after applying the sample for a month was evaluated. The test results are shown by the number of persons who answered, "Regrowth of hair or increased bristles" and "Reduction of hair loss" for each item of hair growth effect and hair loss prevention effect.

In the following text, the blending amount is indicated based on the pure content (converted by the dry residue) of the extract obtained by extraction with the 50% aqueous ethanol solution as described above.

Examples 1 to 8 and Comparative Examples 1 to 3 (oily hair tonics) In the raw material composition shown in Table 1, active ingredients were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out. did. In addition, the pepper tincture used in the comparative example was the one described in the Japanese Pharmacopoeia.

[0023]

[Table 1]

[0024]

[Table 2]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) is added, and the mixture is stirred, dispersed and filled into a container. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests conducted on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good.

The hair growth cosmetics of the present invention of Examples 1 to 8 exhibited a high hair growth promoting effect, and showed clearly good results in all of the tests. In Examples 1 to 8, no skin irritation occurred in various tests on human skin.

[0028]

As described above, the present invention suppresses inflammation of the scalp, improves peripheral blood flow, activates hair matrix cells, has an excellent hair-growth effect and a preventive effect on hair loss, and has an effect on skin irritation. It is clear that there is no hair growth cosmetic.

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-53-136528 (JP, A) JP-A-62-145009 (JP, A) JP-A-62-1103006 (JP, A) JP-A-1- 96125 (JP, A) JP-A-3-188013 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 CA (STN) MEDLINE (STN)

Claims (1)

(57) [Claims] 1. A hair-growing cosmetic comprising: a mugwort extract and diisopropylamine dichloroacetate.