JP2546813B2 - Hair nourishing cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention activates hair matrix cells,
The present invention relates to a hair nourishing cosmetic having excellent hair-growth effects, hair loss prevention effects, and dandruff prevention effects that are exhibited by promoting peripheral blood flow in the scalp, and also has good storage stability.

[0002]

BACKGROUND OF THE INVENTION Medicinal carrot extracts, such as ginseng ginseng, which have been conventionally used, have low permeability to skin at low concentrations,
Moreover, there is a problem that the cell activation effect is not sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of androgen, but there are phenomena such as poor blood circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp. It is presumed that they are complicatedly intertwined. Therefore, the present situation is that even if a male hormone inhibitory component is used, the hair-growth action is not achieved. Furthermore, in order to suppress the hypertrophy of the sebaceous glands, which is said to be caused by the excessive action of male hormones, the use of anti-androgen agents and the like as hair-growing agents is not sufficient.

Further, regarding the medical carrot extract typified by Panax ginseng and the like, as a compounding example, JP-A-53 is recommended.
-9328 (composition for skin and skin treatment method), JP-A-56-29021 (composition for lower limb care),
JP-A-60-181021 (flame-retardant adhesive paste)
The application is described in, but these are all natural medicinal carrot extracts (hereinafter referred to as natural carrot extracts).

It is difficult to obtain a natural carrot extract of a constant quality. On the other hand, the medicinal ginseng extract obtained by the culture of the present invention (hereinafter referred to as cultured ginseng extract), stable quality is obtained compared to natural ones, the content of vitamins is large, It has the advantage that there is little mud odor that is a peculiar odor. The production method of this cultured Panax ginseng extract has been disclosed so far (Japanese Patent Laid-Open No. 63-13 / 1988)
No. 9133), but there have been no examples of application to skin cosmetics and hair nourishing cosmetics.

On the other hand, the salts of succinic acid according to the present invention are
It is known to have the action of promoting cell respiration,
It was not known at all to have hair growth and hair-growth effects. Further, although skin cosmetics (Japanese Patent Laid-Open Nos. 63-77809 and 159304) have been disclosed as examples of blending salts of succinic acid, their application as a hair nourishing cosmetic has not been found.

The object of the present invention is to have excellent hair-growth effect, hair loss prevention effect, and dandruff prevention effect, which are exhibited by activating hair mother cells and promoting peripheral blood flow of the scalp, and have good storage stability. It is to provide hair nourishing cosmetics.

[0008]

In order to achieve the above object, the present inventors have promoted hair root activation by activating hair mother cells and hair growth by promoting peripheral blood flow of the scalp. As a result of diligent studies to obtain a substance that exerts an effect, it was revealed that by combining a cultured Panax ginseng extract and salts of succinic acid, an excellent hair-growth and hair-growth effect can be achieved by adding and further adding a vitamin E derivative. Heading The present invention has been completed.

The details of the configuration of the present invention will be described below. Since ancient times, ginseng has been prized as an all-purpose noble drug centering on tonic strength. In the pharmaceutical field, it is used as an extract, a flow extract, etc., and is also used as a carrot extract in cosmetics. The usefulness of these carrots is said to be due to Ginsenoside, which is one of the main saponins.

[0010] Culture Otaneninjinekisu of the present invention contain a saponin as a natural carrot, culture Ginseng suitable hydrophilic solvent (ethyl alcohol, water and / or ethyl alcohol, pro Pi Ren grayed recall, butylene glycol, By using an extract extracted with glycerin, low molecular weight polyethylene glycol, etc.), it is possible to obtain a hair nourishing cosmetic composition that is stable in quality, highly safe, and excellent in usefulness.

The cultured Panax ginseng extract according to the present invention can be produced, for example, by the production method disclosed in JP-A-63-139133. That is, a callus is generated from a tissue of natural Panax ginseng by a liquid culture by a conventional method. The callus obtained is filtered off and the collected callus is dried under warm air. Ethanol is added to this callus (1 Kg) for extraction and aging. Then, the extract was concentrated under reduced pressure so that the ethanol content of the extract was 50 V / V%, left in a cool place for 7 to 10 days, and then filtered.
Cultured Panax ginseng extract (41) is obtained. According to this method, a qualitatively stable extract can be obtained from natural ginseng. The stability of quality will be described below.

Reference Example: Cultured Panax ginseng extract produced by the production method of Japanese Patent Laid-Open No. 63-139133 and Panax ginseng extract obtained from nature (hereinafter referred to as natural Panax ginseng extract) were analyzed by thin layer chromatography per 1 ml of the extract. Gins, the active ingredient
Table 1 shows the results of separating the contents of enoside saponins, quantifying them with a TLC scanner, and comparing them. The ethanol content of the cultured Panax ginseng extract and the natural Panax ginseng extract is 50 V / V%.

[0013]

[Table 1] From this table, it can be seen that the saponin content of the cultured Panax ginseng extract shows less variation and the quality is stable as compared with the natural Panax ginseng extract.

The amount of the cultured Panax ginseng extract of the present invention incorporated into the hair nourishing cosmetic composition is from 0.01 to 0.01 based on the total amount.
It may be 10 wt%, more preferably 0.5 to 5.
It is 0 wt%. If the amount is less than the lower limit, the effect aimed at by the present invention is not sufficient, and if the amount exceeds the upper limit, the effect commensurate with the increase cannot be expected.

The salts of succinic acid according to the present invention include:
A mono or di salt of succinic acid and a base, for example, an alkali metal salt such as potassium salt or sodium salt, a basic amino acid salt such as lysine salt, ornithine salt or arginine salt, monoethanolamine salt or triethanolamine. Examples thereof include alkanolamine salts such as salts.

The amount of the succinic acid salt compounded may be 0.005 to 5.0 wt%, more preferably 0.05 to 2.0 wt%, based on the total amount. If the amount is less than the lower limit, the effect of the present invention is not sufficient,
Further, even if the upper limit is exceeded, it is impossible to expect an improvement in the effect commensurate with the increase.

The mixing ratio of cultured Panax ginseng and salts of succinic acid is suitably 50: 1 to 1:20, and preferably 10: 1 to 1: 5. That is, when outside the range of this is because the effect obtained is not sufficient.

Vitamin E derivatives include vitamin E acetate, vitamin E nicotinate, vitamin E succinate and the like, and the blending amount thereof is 0.
The range of 001 to 2.0 wt% is preferable. If the blending amount is less than 0.001 wt%, the effect cannot be sufficiently achieved, while if it exceeds 2.0 wt%, the improvement of the effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., according to a conventional method. is there. Further, the hair nourishing cosmetic of the present invention can be appropriately blended with a dye, a fragrance, a bactericide, an antiseptic, a keratolytic agent, an antiandrogen, an antioxidant, etc. within a range to achieve the object of the present invention. .

[0020]

EXAMPLES The present invention will be described in detail below based on examples.
The mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below. The mouse hair growth promoting effect test method and human hair hair growth promoting effect test method were used to examine the effect of activating hair mother cells and promoting peripheral blood flow of the scalp.

(1) Test method for mouse hair growth promoting effect: The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely removed with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied to the skin of the test site twice daily in the morning and evening, 0.2 g per animal. For each sample, 10 animals were used per group.
The base alone was applied as a control group. 15 after the start of the experiment
The animals were sacrificed on the day, 20 hairs were randomly extracted from the sample application site, each length was measured, and the average value of each group was calculated. Next, the value obtained by dividing the average value of the examples or comparative examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Human hair growth promoting effect test method 10 hair test subjects who are male pattern baldness have circular hairs with a diameter of 1 cm at 5 cm above the ears of the head. About 3 ml of the sample of the Example or Comparative Example was applied to the left side twice daily in the morning and evening on the test site shaved in the above, and compared with the untreated right side. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value of the lengths of 20 hairs on the left side (applied Example or Comparative Example) (B ) Is divided by the average value (A) of the length of 20 hairs on the right side (untreated),
The determination result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method 20 heads of male pattern baldness test subjects were evaluated for their effects after being applied twice daily in the morning and evening twice a day for 6 consecutive months. The test results show that, for each item of hair-growth effect, hair loss prevention effect, and dandruff prevention effect, "hair bristling or increased hair loss", "less hair loss", "less hair loss" The number of people who answered

Examples 1 to 6 and Comparative Examples 1 to 2 Oily Heartonic In the raw material composition of Table 2, the component (B) was blended as shown in Tables 3 and 4 to prepare the hairtonic. Various tests were carried out.

[0025]

[Table 2]

(2) Preparation Method After dissolving the component (B) shown in Table 2 in the component (A), the component (A) and the component (C) are mixed and stirred to be dispersed in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Characteristics The results of various tests of each oily hair artic are shown in the right columns of Tables 3 and 4. Comparative Examples 1 and 2 had a relatively low mouse and human hair growth promoting effect, and the results of practical tests were not so good. In comparison, Examples 1 to 6
The hair nourishing cosmetic of the present invention showed a high hair growth promoting effect, and clearly showed good results in all the tests. still,
Examples 1-6 did not cause skin irritation in the tests on human skin. In addition, Examples 5 and 6 to which the vitamin E derivative was added showed little change in appearance, color tone and odor characteristics when stored in a 45 ° C constant temperature bath for 2 months, as compared with other Examples.

[0028]

[Table 3]

[0029]

[Table 4]

Examples 7 to 12 and Comparative Examples 3 to 4 Hair Cream In the same manner as in Example 1, each hair cream shown in Table 5 was prepared and various tests were carried out, and the results are shown in Table 6 and Table. 7
In the right column.

[0031]

[Table 5]

(2) Preparation Method After dissolving the component (B) shown in Table 5 in the component (A) or the component (C), the components (A) and (C) are dissolved by heating at 80 ° C. and mixed. did. Further, when cooled to 50 ° C. with stirring, the component (D) was added, and stirring was continued up to 30 ° C. to prepare each hair cream.

(3) Characteristics As shown in the right columns of Tables 6 and 7, in comparison with Comparative Examples 3 and 4, Examples 7 to 12 show a high hair growth promoting effect and all the tests. It showed an excellent effect. In addition, in Examples 7 to 12, skin irritation did not occur in various tests on human skin. Example 11 in which a vitamin E derivative was added
Compared to the other examples, Nos. 12 and 12 showed little change in appearance, color tone, and odor characteristics when stored in a 45 ° C. thermostat for 2 months.

[0034]

[Table 6]

[0035]

[Table 7]

[0036]

Industrial Applicability As described above, the present invention is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect that are activated by activating hair mother cells and improving peripheral blood flow of the scalp, and has good storage stability. However, it is obvious to provide a hair nourishing cosmetic composition that is free of skin irritation.

Claims (2)

(57) [Claims] 1. A hair nourishing cosmetic comprising a mixture of cultured Panax ginseng extract and salts of succinic acid. 2. The hair nourishing cosmetic according to claim 1, wherein a vitamin E derivative is added and blended.