JP3014214B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic composition which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect and an effect of preventing hair loss.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of androgen. However, phenomena such as poor blood circulation, decreased hair mother cell activity, enlarged sebaceous glands, and scalp fibrosis are caused. It is presumed that it is caused by complicated intertwining.

[0005] Therefore, at present, simply using an androgen-suppressing component does not bring about hair growth. Even if a component that suppresses sebaceous gland hypertrophy is used as a hair restorer, its effect is not sufficient.

[0006] The Sadako used in the present invention is the fruit of the locust beetle, as described in "Shin-no-Nori-Honkei" as "supplementing inside, relieving the gut, nourishing the spirit, and excluding a hundred diseases"
It has been used as a nourishing tonic for the symptoms of lower back and knee pain, twilight, tinnitus, insomnia, and constipation. In addition, since there is a description that "it is also effective to change white hair to black", application of a formulation formulated alone or in combination with other components as a hair restorer (Japanese Patent Application Laid-Open Nos. 62-99318 and 62) −3801
No. 3, JP-A-1-230512, etc.), but even if Mesadako is used alone in cosmetics and used externally, the percutaneous penetration of the active ingredient is poor and a sufficient hair-growth effect can be obtained. There is no present. In addition, even if it is combined with other components, the hair-growing effect is not sufficient. Forsythia is detoxified, drained,
It is a crude drug that has been used as an anti-inflammatory and diuretic. However, it was not known that the forsythia extract had hair growth and hair growth effects. Examples of the composition of the forsythia extract include oral compositions (JP-A-63-60918), deodorants (JP-A-63-5754) and deodorants (JP-A-63-5754).
No. 21059) has been published, but no application as a hair growth cosmetic has been found.

[0007] An object of the present invention is to provide a hair nourishing cosmetic composition which promotes peripheral blood flow of the scalp, activates hair matrix cells, and has excellent hair growth and hair loss preventing effects.

[0008]

DISCLOSURE OF THE INVENTION The present invention provides a hair-growing cosmetic containing an extract of Mesadako and an extract of forsythia, and a mixed extract of Mesadako and forsythia. It is a hair nourishing cosmetic characterized by the following.

[0009] The Sadako according to the present invention is a dried product of the fruit of the plant of the family Oleaceae, Sap. In addition, the forsythia is a dried or crushed fruit of the forsythia, Chinese forsythia native to China of the Oleaceae family, or the Chinese Forsythia native to the Korean Peninsula. And the extracts are 5 to 30 volumes
Extract with a double volume of extraction solvent. As the extraction solvent,
Water, hydrated alcohol, alcohols, acetone, ethyl acetate, benzene, chloroform and the like can be used, and the extraction is carried out at warm temperature or preferably under reflux. Among them 10
A 90% aqueous ethanol solution is preferred as the extraction solvent. Ursolic acid,
Oleanoic acid, mannitol, glucose, palmitic acid, stearic acid, oleic acid, linoleic acid, and the like are known. Components extracted from the forsythia include oleanolic acid, lignan, and lignan glycosides such as fililine, pinoresinol, matiresinol, and matiresinoside, flavonoid rutin, and caffeic acid derivative forsitoside A. Here, what should be particularly noted in the present invention may be a hair nourishing cosmetic in which a single extract of each of Mesadako and the forsythia is combined, or an extract of a mixture of Mesadako and the forsythia is combined. It may be used as a hair nourishing cosmetic. Above all, it was found that the hair-growth cosmetic containing the extract of the mixture was more excellent in hair-growth effect as described later. In the extract of the mixture of Mesadako and forsythia, the fruit of Mesadako and forsythia is preferably in the range of 1: 0.1 to 1: 1.

In the following text, the compounding amount is indicated on the basis of the pure content (converted to the dry residue) of the extract obtained by extraction with water or an aqueous ethanol solution.

The amount of the extract to be used in the present invention is as follows: (1) The amount of each extract of Mesadako and forsythia in a hair-growing cosmetic is as follows: Sadako: 0.0
01-5.0wt%, Forsythia: 0.001-3.0wt%
And more preferably, Sadako: 0.005 to
2.0 wt%, forsythia: 0.001 to 1.0 wt%. That is, if the amount is less than the lower limit, the desired effects of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected. (2) The amount of the extract of the mixture of Mesadako and forsythia in the hair growth cosmetic was 0.001 in terms of dry residue based on the total amount.
It is sufficient if it is ~ 5.0 wt%, more preferably 0.00
5 to 2.0 wt%. That is, if the amount is less than the lower limit, the desired effects of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0014]

The present invention will be described below in detail with reference to examples and comparative examples. The percentages shown in the examples are percentages by weight.

The test methods of ddY mouse hair growth promoting effect, C3H mouse hair growth promoting effect test method, human head hair growth promoting effect test method and practical test methods described in the Examples are shown below.

(1) Test Method for Promoting Hair Growth of ddY Mouse Hair The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric clipper, and completely depilated with a depilatory cream. From the next day, the samples of the examples and the comparative examples were applied to the skin of the test portion twice daily in the morning and evening at 0.2 g per animal. A group of 10 animals was used for one sample.
In addition, a base alone was applied as a control group. 15 after the start of the experiment
On the day, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, a value obtained by dividing the average value of the examples or the comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Test Method for Promoting Hair Growth of C3H Mice The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. Once daily of each sample day from Examples and Comparative Examples to the subject unit skin was 0.2 g applied Ri one animal person other. A group of 10 animals was used for one sample. still,
Base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed, and the skin of the test area was photographed. Next, the photograph is taken into an image analyzer, and the area (A) of initial shaving and the area of hair growth (B) are obtained. Further, the hair growth rate (%) = (B) / (A) × 100 is individually calculated. Of animals. Lastly, the value obtained by dividing the average value of each group of the examples or comparative examples by the average value of the control group was used as a hair growth promoting effect in the determination.

(3) Human hair growth promoting effect test method Male test subject 1 in her 30s and 40s with decline in hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm.
One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 125
Volume, page 123, 1991), the hair growth rate was determined for the hair (about 30 to 40 hairs) at the target site, and the average value was calculated (A). Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice daily in the morning and evening around the test site, and massaged well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

(3) Practical test method Twice in the morning and evening twice a day on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results showed hair growth effect, against sections of hair loss prevention effect, "raw hair is one you want to the bristles of the bristle has increased", in the number of people who answered "hair loss is low."

Examples 1 to 12, Comparative Examples 1 and 2 Oily hair tonic In the raw material compositions shown in Table 1, active ingredients were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out.

[0021]

[Table 1]

[0022]

[Table 2]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed with stirring, dispersed and placed in a container. Fill. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests conducted on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 and 2 had low mouse and human hair growth promoting effects, and the results of practical tests were not good.

The hair growth cosmetics of the present invention of Examples 1 to 12 show a high hair growth promoting effect in a mouse hair growth test and a human hair growth promoting effect test, and clearly show good results in all tests. Indicated. In Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0026]

As described above, the present invention promotes the peripheral blood flow of the scalp, activates hair matrix cells, is excellent in hair growth and hair loss prevention effects, and has no skin irritation. It is obvious to provide.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-2-20723 (JP, A) JP-A-1-230512 (JP, A) JP-A-1-1932111 (JP, A) JP-A-62 99318 (JP, A) JP-A-64-38013 (JP, A) JP-A-63-60918 (JP, A) JP-A-63-21059 (JP, A) (58) Fields investigated (Int. ⁷ , DB name) A61K 7/06

Claims (2)

(57) [Claims] 1. A hair restoration cosmetic comprising an extract of Mesadako and an extract of forsythia. 2. A hair-growing cosmetic, comprising a mixed extract of virgin and forsythia.