JP2955055B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect, a hair loss-preventing effect, and an anti-dandruff effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of androgen. However, phenomena such as poor blood circulation, decreased hair mother cell activity, enlarged sebaceous glands, and scalp fibrosis are caused. It is presumed that it is caused by complicated intertwining. Therefore, at present, simply using an androgen-suppressing component does not lead to the expression of a hair-growth effect. Furthermore, even if an anti-androgen agent or the like is used as a hair restorer to suppress the enlargement of the sebaceous gland, which is said to be caused by the excessive action of androgen, the effect is not sufficient.

[0005] The melilot extract according to the present invention is a substance that has been used as a therapeutic agent for thrombosis, an antifungal agent, a therapeutic agent for hemorrhoids, a therapeutic agent for trauma, and the like. However, it was not known at all that the melilot extract had hair growth and hair growth effects. In addition, oral compositions (Japanese Patent Application Laid-Open No. 58-134012) and galenical patch preparations (Japanese Patent Application Laid-Open No. 02-282332) have been disclosed as examples of blending the melilot extract. I didn't see it.

An object of the present invention is to provide a hair restoration cosmetic composition which promotes peripheral blood flow of the scalp, activates hair matrix cells, and has excellent effects such as hair growth, hair loss prevention and dandruff prevention.

[0007]

Means for Solving the Problems The present inventors have conducted various studies on promotion of peripheral blood flow of the scalp and activation of hair matrix cells. It has been found that a hair growth effect is exhibited.

[0008] The melilot extract according to the present invention is a component extracted from the stem, leaf, whole plant, or root of the Japanese lobster belonging to the subfamily Jacuzzi subfamily of the legume family. Examples of components to be extracted include coumarin and its related substances, and glycosides such as melilotside and melilotic acid. As the extraction solvent, hot water, hydrous alcohol, alcohols, acetone, ethyl acetate, chloroform and the like can be used. In particular, a 10-90% aqueous ethanol solution is preferred as the extraction solvent.

[0009] In the following text, the pure content of the extract obtained by extraction with a 50% aqueous ethanol solution (converted to the dry residue)
The blending amount is indicated based on

The amount of the melilot extract of the present invention to be added to the hair-growing cosmetic is 0.001 to 2.0 based on the total amount.
wt%, more preferably 0.005 to 1.
0 wt%. That is, if the amount is less than the lower limit, the desired effects of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

[0012] The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0013]

The present invention will be described below in detail with reference to examples and comparative examples. The mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are described below.

(1) Mouse Hair Growth Promotion Effect Test Method The skin in the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric hair clipper, and completely depilated with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part twice daily in the morning and evening twice at 0.2 g per animal. A group of 10 animals was used for one sample.
In addition, a base alone was applied as a control group.

On the 15th day after the start of the experiment, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, a value obtained by dividing the average value of the examples or the comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Human hair growth promoting effect test method The hair of 5 subjects above the ears of the heads of 10 test subjects with male pattern baldness was formed into a circular shape having a diameter of 1 cm at two places on the left and right. Approximately 3 ml of the sample of the example or the comparative example was applied on the left side twice daily in the morning and evening to the test site which had been shaved, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites and averaging the length of the 20 hairs on the left side (to which the example or the comparative example was applied) (B ) Is divided by the average value (A) of the length of the 20 right hairs (untreated),
The judgment results were shown as the average of (B) / (A) of 10 test subjects.

(3) Practical test method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results show that the hair growth effect, the hair loss prevention effect, and the anti-dandruff effect are “hair has become bristle or hair has increased,” “hair loss has decreased,” and “hair loss has decreased. The number of respondents. "

Examples 1 to 6, Comparative Examples 1 to 3 Oily hair tonic In the raw material composition shown in Table 1, samples were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out.

[0019]

[Table 1]

[0020]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A), the components (A) and (C) are mixed with stirring, dispersed and filled into a container. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests conducted on each oily hair art tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good. Particularly in Comparative Example 1 containing pepper tincture, three persons complained of mild skin irritation in a practical test.

On the other hand, the hair restoration cosmetics of the present invention of Examples 1 to 6 exhibited a high hair growth promoting effect, and showed clearly good results in all of the tests. In Examples 1 to 6, skin irritation did not occur in various tests on human skin.

Examples 7 to 12 and Comparative Examples 4 to 6 Hair cream
Were prepared and subjected to various tests. The results are shown in the right column of Table 4.

[0025]

[Table 3]

[0026]

[Table 4]

(1) Preparation method After the component (B) shown in Table 3 is dissolved in the component (A) or (C), the components (A) and (C) are dissolved by heating to 80 ° C. and mixed. did. Further, when cooled to 50 ° C. while stirring, the component (D) was added, and stirring was continued to 30 ° C. to prepare each hair cream.

(2) Characteristics As shown in Table 4, Examples 7 to 12 exhibited a high hair growth promoting effect and showed excellent results in all of the tests.

[0029]

As described above, the present invention improves peripheral blood flow of the scalp, activates hair matrix cells, is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect, and has a skin irritation effect. It is clear that there is no hair growth cosmetic.

Claims (1)

(57) [Claims] 1. A hair restoration cosmetic comprising a melilot extract.