JP3045590B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic composition which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect and a hair loss-preventing effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

[0005] Therefore, simply using an androgen-suppressing component or using a component that suppresses sebaceous gland hypertrophy, which is said to be caused by excessive action of androgen, does not provide a sufficient hair-growth effect.

The acidic mucopolysaccharides of the present invention, for example, heparin, have been applied to compositions for stimulating hair growth as disclosed in Japanese Patent Application Laid-Open No. 63-313715. Has not yet been demonstrated. In addition, hops are used for medicinal or brewing of pre-mature female ears in mulberry plants, and are also said to have an effect on female hormones. Conceivable. For example, JP-A-61-
No. 33123, it is applied as a medicinal component of a hair nourishing cosmetic. However, the use of hops alone has only an effect of appropriately improving the environment of the scalp, and does not bring about a positive hair growth effect.

The present inventors have conducted various studies on promoting peripheral blood flow of the scalp and activating hair matrix cells. As a result, the hop extract and at least one selected from the group consisting of low-molecular-weight acidic mucopolysaccharides and salts thereof are disclosed. The present inventors have found that a hair-growing cosmetic composition containing the formula (1) exhibits excellent hair-growth and hair-loss-preventing effects, and completed the present invention.

[0008]

DISCLOSURE OF THE INVENTION The present invention is a hair restoration cosmetic comprising at least one selected from the group of low molecular weight acidic mucopolysaccharides and salts thereof and a hop extract. .

As the low-molecular-weight acidic mucopolysaccharide according to the present invention, hyaluronic acid, dermatan sulfate, chondroitin sulfate, heparin, heparan sulfate and the like can be used, all of which are known substances and include cartilage and joints. , Eyeball,
It becomes a matrix component in the skin and other connective tissues, binds to proteins, and is widely distributed in animals. As the molecular weight of the acidic mucopolysaccharide used in the present invention, hyaluronic acid is 1,0
It is preferably from 100 to 100,000, dermatan sulfate and chondroitin sulfate from 1,000 to 10,000, and heparin and heparan sulfate from 1,000 to 7,000. Examples of the salt of the acidic mucopolysaccharide used in the present invention include an alkali metal salt such as a lithium salt, a sodium salt, and a potassium salt of the mucopolysaccharide, an alkaline earth metal salt such as a magnesium salt and a calcium salt, an ammonium salt, and triethanol. Alkanolamine salts such as amine salts and diisopropanolamine salts, and basic amino acid salts such as lysine salts, arginine salts and histidine salts are preferred. Also,
These acidic mucopolysaccharides can also be used as free acids. The low-molecular-weight acidic mucopolysaccharides and salts thereof used in the present invention can be easily obtained by a hydrochloric acid hydrolysis method or an enzymatic decomposition method as described in JP-A-64-22809. The average molecular weight of the acidic mucopolysaccharide obtained by each treatment time was measured according to the method of Motohashi et al. (Journal of Chromatography, Vol. 435, 335
３４ 342, 1988) The hop extract used in the present invention can be obtained by extracting the mulberry plant hops from the unripened female spikes. That is, in mid-August, when the ears turn green to slightly yellow, they are harvested, shaded, and then thermally dried at 50 to 60 ° C. Pharmaceutical components include humulone, cohumulone, adhumulone, lupulone, colupulone, adolpron, xantholmol, etc. in essential oils. In addition, tannin, rutin, and quercetin glycosides are said to be included. Extraction can be easily performed with cold water, hot water, ethyl alcohol, or hydrous alcohol.

The amount of the low-molecular-weight acidic mucopolysaccharide and salts thereof is 0.1% based on the total amount of the hair restoration cosmetic composition (composition).
The range of 01 to 3.0% by weight (hereinafter abbreviated as Wt%) is preferable. The amount of the hop extract is preferably in the range of 0.01 to 3.0 Wt% based on the total amount of the hair nourishing cosmetic. Here, the amount of each component is 0.0
If the content is less than 1 Wt%, the effect is not sufficiently achieved, while 3.
Even if it exceeds 0 Wt%, the improvement of the effect corresponding to the increase cannot be expected. The mixing ratio of the two components is suitably in the range of low molecular weight mucopolysaccharide / hop extract = 0.05 to 10.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there.

[0012] The hair nourishing cosmetic of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0013]

The present invention will be described below in detail with reference to examples and comparative examples. In the examples, hyaluronic acid is HA,
Heparin was abbreviated as HP, chondroitin sulfate as CS, dermatan sulfate as DS, and heparan sulfate as HS. Also, sodium hyaluronate having a molecular weight of 1,000 is HA-N
Abbreviated as a [MW.1,000].

The mouse hair growth promoting effect test method, the human hair growth promotion effect test method and the practical test methods described in the Examples are shown below.

(1) Mouse Hair Growth Promotion Effect Test Method The skin in the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric hair clipper, and the hair was completely removed with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part twice daily in the morning and evening twice at 0.2 g per animal. A group of 10 animals was used for one sample.
In addition, a base alone was applied as a control group. 15 after the start of the experiment
On the day, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, a value obtained by dividing the average value of the examples or the comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Human hair growth promotion effect test method The hair of 5 test subjects who are male pattern baldness at the position of 5 cm above the ears of the heads is shaved into a circular shape with a diameter of 1 cm at two places on the left and right. About 3 ml of the sample of the example or the comparative example was applied on the left side twice a day every morning and evening to the hairy test site, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites and averaging the length of the 20 hairs on the left side (to which the example or the comparative example was applied) (B ) Was divided by the average value (A) of the lengths of the 20 hairs on the right side (untreated), and the judgment results were shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method Twice in the morning and evening twice a day on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results show that the hair growth effect, the hair loss prevention effect, and the anti-dandruff effect are each term "grown hair or increased bristles",
The number of respondents who answered "reduction of hair loss" and "reduction of dandruff" was indicated.

Examples 1 to 12 and Comparative Examples 1 to 14 Oily hair tonic In the raw material composition shown in Table 1, active ingredients were blended as shown in Tables 2 and 3 to prepare hair tonics. Carried out.

[0019]

[Table 1]

[0020]

[Table 2]

[0021]

[Table 3]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed, stirred and dispersed. Fill. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests conducted on each oily hair tonic are shown in Table 2 and Table 3, right column. As shown in Table 2, Comparative Example 1
No. 14 had a low mouse and human hair growth promoting effect, and the results of practical tests were not good.

The hair growth cosmetics of the present invention of Examples 1 to 12
It showed a high hair growth promoting effect and showed clearly good results over all the tests. In Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0025]

As described above, the present invention improves peripheral blood flow of the scalp, activates hair matrix cells, is excellent in hair growth effect, hair loss prevention effect, dandruff prevention effect, and has no skin irritation. It is clear that hair restoration cosmetics are provided.

Claims (2)

(57) [Claims] 1. A hair restoration cosmetic comprising at least one selected from the group consisting of low molecular weight acidic mucopolysaccharides and salts thereof and a hop extract. 2. A low-molecular-weight acidic mucopolysaccharide comprising hyaluronic acid having an average molecular weight of 1,000 to 100,000, chondroitin sulfate and dermatan sulfate having an average molecular weight of 1,000 to 10,000, and an average molecular weight of 1,000 to 7 000
The hair restoration cosmetic according to claim 1, which is heparin and heparan sulfate.