JP2955033B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic composition which improves peripheral blood flow of the scalp, activates hair matrix cells, and is excellent in hair growth, hair loss prevention and dandruff prevention.

[0002]

2. Description of the Related Art There have been known hair restoration cosmetics containing a blood circulation promoting substance such as pepper tincture and nicotinic acid derivative, or a substance which activates skin cells of the scalp such as assembly extract and Korean ginseng extract. ing. More recently,
Components and having the effect of prevention of enlargement of the sebaceous glands, have been proposed also hair tonic cosmetic formulation components act to suppress male hormones.

[0003]

However, the blood circulation promoting substances used hitherto have the drawbacks that they are highly irritating to the skin, have a limited amount, and have a short duration of blood circulation promotion. Also, there is a problem that the substance that activates cells has low permeability to the skin at a low concentration, and the effect is not sufficiently exerted by itself. On the other hand, androgenetic alopecia is said to be one of the causes of excessive action of male hormones.However, other factors such as poor blood circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, and fibrosis of the scalp are complicated. It is presumed to be involved. Therefore, at present, even if an inhibitory component of a male hormone is used, it does not reach the point where a hair-growth effect is exhibited. Further, a hair restorer containing an anti-androgen agent or the like is known to suppress the enlargement of the sebaceous gland, which is said to be caused by the excessive action of the androgen. However, the effect is not sufficient.

On the other hand, the occurrence of hirsutism is known as a side effect of minoxidil which is a hypotensive agent, and its application as a hair restorer has been carried out. However, even if minoxidil is used alone, the hair growth and hair growth effects are not sufficient, and the types of alopecia where the effects are expressed are limited, so that a hair growth agent with even higher effects is required at present. .

On the other hand, ketanserin according to the present invention is 5H
Known as T ₂ receptor inhibitor is a substance in the development as a therapeutic agent for hypertension. However, the effects of ketanserin and / or its salts on hair growth and hair growth are not known, and no application as a hair growth agent has been carried out.

The present inventors have promoted peripheral blood flow of the scalp,
Various studies were carried out to obtain a scalp activation promoting substance that activates hair matrix cells. However, an object of the present invention is to provide a hair restoration cosmetic composition which promotes peripheral blood flow of the scalp, activates hair matrix cells, and has excellent effects such as hair growth, hair loss prevention and dandruff prevention.

[0007]

Means for Solving the Problems The present inventors have conducted various studies on substances that promote peripheral blood flow in the scalp and activate hair matrix cells. As a result, ketanserin and / or a salt thereof enhance peripheral blood flow. It has been found that it promotes and activates hair mother cells, and exhibits excellent hair growth and hair growth effects.

[0008] Ketanserin according to the present invention is a known substance as described below. CAS RN: 74050-98-9 Generic name: 3- [2- [4- (4-Fluorobenzoyl) -1-piperidinyl]
ethyl] -2,4 [1H, 3H] -quinazolinedione Chemical formula: C ₂₂ H ₂₂ FN ₃ O ₃ Molecular weight: 395.43 In the present invention, ketanserin and / or a salt thereof can be blended. Examples of the salts include salts with carboxylic acids such as acetic acid and succinic acid, salts with oxycarboxylic acids such as lactic acid, citric acid, malic acid and tartaric acid, and salts with mineral acids such as hydrochloric acid and sulfuric acid.

The amount of the ketanserin and / or its salt of the present invention to be incorporated into the hair-growing cosmetic is 0.001 to 2.0 % by weight (hereinafter abbreviated as wt%) based on the total amount of the composition.
And more preferably 0.01 to 1.0 wt%.
It is. If the amount is less than the lower limit, the intended effect of the present invention is not sufficient, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected.

[0010] The hair nourishing cosmetic composition of the present invention can be formed into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam and the like according to a conventional method. is there. The hair restoration cosmetic of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded within a range that achieves the object of the present invention.

[0011]

EXAMPLES Hereinafter, the present invention will be described in detail based on examples. Prior to this, the mouse hair growth promoting effect test method, human hair growth promoting effect test method, and practical test methods described in the examples will be described.

(1) Mouse hair growth promoting effect test method The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric hair clipper, and completely depilated with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part twice daily in the morning and evening twice at 0.2 g per animal. A group of 10 animals was used for one sample.
In addition, a base alone was applied as a control group. 15 after the start of the experiment
On the day, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, the value obtained by dividing the average value of the examples or comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Test Method for Promoting Human Hair Growth The hair of a subject with male pattern baldness at a position 5 cm above the ears of the head of each of 10 test subjects was circular in shape with a diameter of 1 cm at two places on the left and right. Approximately 3 ml of the sample of the example or the comparative example was applied to the left side of the test site twice a day every morning and evening and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites and averaging the length of the 20 hairs on the left side (to which the example or the comparative example was applied) (B )
Was divided by the average value (A) of the lengths of the 20 hairs on the right side (untreated), and the judgment results were shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method The effect of applying the composition to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results show that the hair growth effect, the hair loss prevention effect, and the anti-dandruff effect are “hair has become bristle or hair has increased,” “hair loss has decreased,” and “hair loss has decreased. The number of respondents. "

Examples 1 to 5 and Comparative Examples 1 to 3 Oily hair tonic In the raw material composition shown in Table 1, a hair tonic was prepared by blending samples as described below, and the above-mentioned various tests were carried out.

(1) Composition

[Table 1]

(2) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed, stirred and dispersed to form a container. Fill. When used, the contents are shaken and dispersed uniformly.

(3) Characteristics Table 2 shows the results of various tests conducted on each oily hair art tonic. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good. Particularly in Comparative Example 1 containing pepper tincture, three persons complained of mild skin irritation in a practical test. The hair growth cosmetics of the present invention of Examples 1 to 5 showed a high hair growth promoting effect, and showed clearly good results over all of the tests. In Examples 1 to 5, skin irritation did not occur in various tests on human skin.

[Table 2]

[0019] Examples 6-10, Comparative Examples 4-6 Similarly to hair creams Examples 1-5, and, prepare each hair cream conducted various tests by the composition of Table 3, Table 4 and the results It was shown to.

(1) Composition

[Table 3]

(2) Preparation method After the component (B) shown in Table 3 is dissolved in the component (A) or (C), the components (A) and (C) are dissolved by heating to 80 ° C. and mixed. did. Furthermore, stirring and cooled to at became 50 ° C. The component (D) added with and, prepare the hair cream continued stirring until 30 ° C..

(3) Characteristics As shown in Table 4, Examples 6 to 10 exhibited a high hair growth promoting effect and exhibited excellent results over all of the tests.

[Table 4]

[0023]

As described above, the present invention improves peripheral blood flow of the scalp, activates hair matrix cells, has excellent hair growth, hair loss prevention and dandruff prevention effects, and has no skin irritation. Obviously, hair cosmetics are provided.

Claims (1)

(57) [Claims] 1. A hair-growing cosmetic comprising ketanserin and / or a salt thereof.