JPS62190116A - Hair-tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair-tonic cosmetic effective in continuously promoting blood flow of scalp and having excellent hair-growing effect, falling-off preventing effect and dandruff preventing effect by using nicardipine hydrochloride as an active component. CONSTITUTION:A hair-tonic cosmetic effective in activating hair matrix cell, exhibiting excellent hair-growing and falling-off preventing effect, normalizing metabolic function of scalp and improving dandruff-preventing effect is produced by compounding the compound of formula (molecular weight, 515.99; melting point, 160-171 deg.C) to a hair-tonic cosmetic at an amount of 0.05-1.0wt%, preferably 0.1-0.7wt% based on the whole composition. It can be used in the form of hair-tonic, hair-lotion, hair-cream, etc. The cosmetic may be further compounded arbitrarily with colorant, perfumery, disinfectant, antiseptic, keratolytic agent, antiandrogen agent, hair-tonic, antioxidant, etc.

Description

Detailed Description of the Invention (Technical Field) The present invention relates to a hair nourishing cosmetic containing nicardipine hydrochloride, and more specifically, it has a hair growth effect, hair loss prevention effect, and hair loss prevention effect by continuously promoting blood circulation in the scalp. This article relates to highly effective hair nourishing cosmetics.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been known.

However, these blood circulation-promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added, or their blood circulation-promoting effects decrease in a short period of time, or their blood circulation-promoting effects are weak. The substance was not effective enough to exhibit sufficient effects such as preventing dandruff.

(Disclosure of the Invention) Therefore, as a result of intensive research into blood circulation promoting substances that are effective when incorporated into hair-growth cosmetics, the present inventors have found that hair-growth cosmetics containing nicardipine hydrochloride have low skin irritation and are effective against scalp irritation. The present inventors have discovered that it continuously promotes blood circulation, has excellent effects on hair growth, hair loss prevention, and dandruff prevention, etc., and has completed the present invention.

(Object of the invention) That is, the object of the present invention is to continuously promote blood circulation in the scalp,
To provide a hair nourishing cosmetic excellent in effects such as hair growth, hair loss prevention and dandruff prevention.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing nicardipine hydrochloride.

(Specific Description of Structure) Nicardipine hydrochloride used in the present invention is a known substance, and has been applied to improve hypertension as a drug having an excellent effect of increasing peripheral blood flow.

The chemical properties of nicardipine hydrochloride are as follows.

(2) Generic name Nicardipine hydrochloride
e) (3) Chemical name 2-(N-benzyl-N-methylaL))ethyl methyl 2,6-cymethyl-4-(m-
Nitrophenyl)-1,4-dihydropyridine-8,5
-dicarboxylate hydrochloride (2-(N
-benzyl-N-methylamino)
ethyl methyl12, 6-aimethy
l-4-(m-n1trophenyl)-1, 4
-dihydropyridine -8,5-dic
arboxylatehydrochloride) (4) Molecular formula: C25H29NaOa・HCI (5)
Molecular weight: 515.99 (6) Melting point: 167-171°C Since nicardipine hydrochloride incorporated into the hair-growth cosmetic of the present invention has appropriate transdermal absorbability, the effective concentration of the drug in the scalp is maintained. It has low skin irritation,
It produces a sustained effect of promoting blood circulation locally on the skin. It is presumed that this continuous blood circulation promoting effect activates hair matrix cells, exhibits excellent hair growth and hair loss prevention effects, and further normalizes the scalp metabolic function to enhance the dandruff preventive effect.

The blending amount of nicardipine hydrochloride is 0.05 to 1.0% by weight (hereinafter referred to as w) based on the total weight of the hair nourishing cosmetic composition of the present invention.
(abbreviated as t%), preferably 0.1 to 0
．． 7 wt%. If the blending amount is less than 0.06 wt%, it is not sufficient to achieve the desired effect of the present invention, and on the other hand, 1. O
Even if the amount exceeds wt%, an improvement in effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method.

The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test, mouse hair growth promoting effect test, human hair growth promoting effect test and practical test described in Examples are shown below.

(1) Skin blood flow test The abdomens of eight New Sealant White rabbits were separated,
After fasting for 18 hours, the rabbit is anesthetized by intravenously injecting sodium salt of bendoparbitol at a rate of 85 my/k (1:1). The skin blood flow m (μ
V) is measured.

A sample of 0.11 was applied uniformly to a skin area of B After) blood flow ff1 (Ot) is measured, and the blood flow increase rate (%) is calculated using the following formula.

The test results were shown as the average value of the blood flow increase rate of the three birds.

5-20% even when cream base is applied as a sample
A moderate increase in blood flow rate was observed, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied, the rate of increase in blood flow was 40 to 80%.
%, the increase rate will be high.

(2) Mouse hair growth promotion effect test After cutting the back skin from the tail of daY white mice (male, 6 weeks old, average weight 85F) with hair clippers, the hair was completely removed with hair removal cream, and the hair was removed from the next day. Each sample of Examples and Comparative Examples was applied to the skin of the subject twice daily in the morning and evening, - o, 1 per animal.
ml was applied. - A group of 10 animals were used for each sample.

The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group according to the criteria shown in the table below.

On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, and a diameter of 12 m was removed.
After punching out a certain area of the skin with a punch of size m and drying it, the weight of the hair was measured, and the lengths of 20 of the hairs were also measured, and the average value was calculated.

Judgment criteria for hair growth effect evaluation score (3) Human @ Tsubo Hair Growth Promotion Test Test The hair of 10 test subjects who are androgenetic alopecia patients was measured 5 cm above the ears on the left and right sides. Apply 8 ml of the sample of Example or Comparative Example to the left side twice a day in the morning and evening on the test site where hair was shaved in a circular shape with a diameter of I cm. and compared with the untreated right side. The effectiveness was determined by shaving 20 hairs each on the left and right test sites on the 28th day after the start of the test, and averaging the length of the 20 hairs on the left side (where Example or Comparative Example was applied). was divided by the average length of 20 hairs on the right side (before treatment) and evaluated.

The judgment results were shown as the average value of )/(A) of the 10 test subjects.

(4) Practical test The effect was evaluated after applying the product to the heads of 20 test participants who were patients with androgenetic alopecia twice a day in the morning and evening for six consecutive months. The test results showed that hair growth effect, hair loss prevention effect, and dandruff prevention effect were shown as follows: ``The growth of hair became bristly or the growth of hair increased,'' ``There was less hair loss,'' and ``There was less dandruff. ”
It is shown by the number of people who answered.

Examples 1 to 4, Comparative Examples 1 to 4 [Oily hair tonic] Each hair tonic was prepared by blending various scalp blood circulation promoting substances as listed in Table 1 in the following raw material composition, and Various tests were conducted.

In addition, in the skin blood flow test, the sample application was 0.5.1.0.2.
The rate of increase in blood flow was measured after 0 hours.

(1) Composition (2) Preparation method Among the ingredients, nicardipine hydrochloride and capsicum tincture are dissolved in the active ingredient, the other ingredients are dissolved in the CB) ingredient,
) and (C) components were each uniformly dissolved. then CB)
After mixing and stirring the ingredients and (0) ingredients, fill them into a container.When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests on 7-tonic for each oily are listed in the right column of Table 1.

As shown in Table @1, in Comparative Examples 1 to 4, the rate of increase in blood flow was low, or the rate of increase in blood flow decreased over time. In addition, Comparative Examples 2 to 4 caused skin irritation,
Testing on human skin was not possible.

Examples 1 to 40 The hair nourishing cosmetic composition of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 1.

(1) Composition (2) Preparation method (4) Among the components, the chili pepper tincture is dissolved in the component (ω), the other components are dissolved or dispersed in the component (ω), and the (I)
3) Component (0) was heated to a temperature of 80°C. Next, after mixing the component (03) and (0), the mixture was cooled while stirring and when the temperature reached 50°C, the component (c) was added. Stirring was continued until the temperature reached 30°C to prepare each hair cream.

(3) Properties As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are the hair nourishing cosmetics of the present invention, showed a sustained increase in blood flow rate compared to Comparative Examples 5 to 7. It also showed excellent effects in various tests, and the blending amount of nicardipine hydrochloride was 0.06 to 1.
Owt% range (Effects of the invention) As described above, the present invention continuously promotes blood circulation in the scalp, has excellent effects exclusively on hair growth, hair loss prevention, and dandruff prevention, and also reduces skin irritation. It is clear that a hair-nourishing cosmetic product free of hair loss can be provided.

Claims (1)

[Claims] A hair nourishing cosmetic containing nicardipine hydrochloride.