JPS62135408A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:A hair tonic cosmetic, obtained by blending citric acid nicametate with other ingredients, capable of sustainedly promoting the blood circulation of the scalp and having improved effect on hair growth and prevention of depilation and dandruff. CONSTITUTION:A hair tonic cosmetic containing 0.1-0.7wt% citric acid nicametate (2-diethylaminoethyl nicotinate citrate) expressed by the formula as an active ingredient. The compound expressed by the formula has moderate percutaneous absorbability and is capable of holding the effective concentration in the scalp, activating the hair-matrix cells by sustained blood circulation promoting action to produce effect on hair growth and prevention of depilation and normalizing the scalp metabolic function and enhancing dandruff preventing action. Hair tonic, hair lotion, hair cream, etc., may be adopted as the dosage form.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair-growth cosmetic containing citric acid nimethate, and more specifically, it continuously promotes blood circulation in the scalp and has a hair-growth effect, a hair loss prevention effect, and a dandruff prevention effect. This article relates to highly effective hair nourishing cosmetics.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been known.

However, these blood circulation-promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added, and their blood circulation-promoting effects are reduced to 1 [Table 3]. , -1O-face F promoting effect was weak, and the substance was not actionable enough to sufficiently exhibit effects such as preventing hair loss, hair loss, and dandruff.

(Disclosure of the Invention) The inventors of the present invention have conducted extensive research on blood circulation promoting substances that are effective when incorporated into hair-growth cosmetics, and have found a hair-growth cosmetic that contains citric acid nicamethate, a derivative of nicotinic acid. 9. It has low irritation to the skin, continuously promotes blood circulation in the scalp, and has excellent effects on hair growth, hair loss prevention, and dandruff prevention.
The present invention was completed based on this discovery.

(Object of the invention) That is, the object of the present invention is to continuously promote blood circulation in the scalp,
To provide a hair nourishing cosmetic with excellent effects such as hair growth, hair loss prevention and dandruff prevention.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing citric acid nimethate.

(Specific description of the structure) Nimethate citrate used in the present invention is a known substance, and has been applied to improve hypertension as a drug having an excellent effect of increasing peripheral blood flow.

The chemical properties of citric acid nimethate are as follows.

(1) Structure (2) Chemical name: 2-diethylaminoethyl nicotinate citrate (2-diethylantinoethyl n1coti
natecitrate ) (3) Molecular formula: (46H2606N2% formula %) Since the citric acid nicamethate blended into the hair-nourishing IM of the present invention has appropriate transdermal absorbability, the effectiveness of the drug in the scalp is sustained. It has low skin irritation and produces a continuous blood circulation promoting effect.This continuous blood circulation promoting effect activates the hair matrix and hair follicles, resulting in soaked hair growth and hair loss prevention effects. However, it is believed that it normalizes the scalp function and improves the anti-dandruff effect.

The amount of citric acid nimethate is 0.05 to 1.0 weight, i1%, based on the total 11 of the hair nourishing cosmetic composition of the present invention.
(hereinafter abbreviated as wt%), preferably 0
．． 1 to Q, 7 wt%. If the blended air is less than 0.05 wt%, it is not sufficient to achieve the desired effect of the present invention;
．． Even if the amount exceeds Qwt%, it cannot be expected that the effect will improve commensurately with the increase.

The hair nourishing cosmetic of the present invention can be made into a hair tonic, a hair lotion, or a hair cream according to a conventional method.

The hair-growth cosmetics of the present invention contain pigments, fragrances, bactericides, preservatives, keratin-R solubilizing agents, anti-androgens, hair-growth agents, antioxidants, etc. within the range that achieves the purpose of the present invention. can do.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test method The abdomen of three New Sealant White rabbits was
After fasting for 18 hours, the animals are anesthetized by intravenously injecting pentabarbitol sodium salt at a rate of 35 Mg/kg. Secure the rabbit's back, secure the plate-type transducer with cellophane tape over the sample application site (test site) on the abdomen, and perform cross-heating! The skin blood flow rate (μV
) to measure.

The sample was uniformly shaken at 0.12 on 3 x 21 skin sites, and the blood flow gQh (QB ) of sample application + 3i1 and the sample thickness (OF + -111-9nBH!IJ
&) The blood flow g(at) is measured, and the blood flow increase rate (%) is calculated using the following formula.

The test results were shown as the average value of the blood flow increase rate of the three birds.

An increase in blood flow of about 5 to 20% was observed even when a cream base was applied as a sample, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied,
The rate of increase is as high as 40-80%.

(2) Mouse hair growth promotion effect test method After cutting the back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight 35 f) with hair clippers, hair was completely removed using hair removal cream. From the next day, each sample of the Example and Comparative Example was applied to the skin of the chin: 4 times twice a day in the morning and evening, - 0 per animal.
．． 1 ml was applied. - For each sample, 10 animals were used for each group.

The hair-restoring effect was determined by comparing the visual evaluation points, hair length, and hair electric power with the control fermentation according to the criteria shown in the table below.

On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, a certain area of the skin was punched out with a punch with a diameter of 12H, and after drying, one part of the hair was removed.
1, and the lengths of 20 of them were also measured, and the average value was calculated.

Judgment criteria for hair growth effect evaluation score (3) Human hair growth promotion effect test method The hair of 10 test subjects who are patients with androgenetic alopecia was placed on the head at position 51 above the ear in two places on the left and right. Approximately 3 ml of the sample of Example or Comparative Example was applied to the left side of the test site, which had been shaved into a circular shape with a diameter of 1cIII, twice daily in the morning and evening, and compared with the untreated right side. To judge the effectiveness, on the 28th day after the start of the test, 20 furs each on the left and right test sites were shaved, and the average length of the 20 hairs on the left side (where Example or Comparative Example was applied) ) divided by the average length (4) of 20 hairs on the right side (untreated) for evaluation.

The judgment results were shown as the average value of (B)/(4) for 10 test subjects.

(4) Practical Test Method The effect was evaluated after applying the product to the heads of 20 test subjects who were androgenetic alopecia patients twice daily in the morning and evening for 6 consecutive months.

The test results showed that hair growth effect, hair loss prevention effect, and dandruff prevention effect were shown as follows: ``The growth of hair became bristly or the growth of hair increased,'' ``There was less hair loss,'' and ``There was less dandruff. ” indicated by the number of people who answered.

Examples 1 to 4, Comparative Examples 1 to 4 [Tonic for oily hair] Each hair tonic was prepared by blending nicotinic acid and its derivatives as shown in Table 1 in the following raw material composition. Various tests were conducted.

In addition, in the skin blood flow test, the sample application was 0.5.1. o12.
The rate of increase in blood flow was measured after 0 hours.

(1) Composition (2) Preparation method (4) Dissolve citric acid nicamethate in component (0), HOH the other components in (seasonal component), (B), (
One portion of each O component was uniformly dissolved. next) component and (O
After mixing, stirring and dispersing the ingredients, fill the container 1 to 4 times. When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests conducted on each oily hair tonic are listed in the right column of Table 1.

As shown in Table 1, in Comparative Examples 1 to 4, the rate of increase in blood flow ii was low or the rate of increase in blood flow decreased over time. In addition, Comparative Example 2.3 caused skin irritation and could not be tested on human skin.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 [Hair Cream] In the same manner as in Example 1, each hair cream was strained and subjected to various tests, and the results are listed in the right column of Table 1.

(1) Composition (2) Preparation method Among the components (A), citric acid nicamethate is dissolved in the (O component), the other components are dissolved in the (8) component, and (6),
(The O components were each dissolved by heating at a temperature of 80°C. Then, (
B), (After mixing the O ingredients, the mixture was cooled while stirring, and when the temperature reached 8 degrees and 50 degrees Celsius, component (6) was added, and each hair cream was prepared by continuing to stir until the temperature reached 30 degrees Celsius. .

(3) Characteristics As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are hair cosmetics 4 of the present invention, showed a sustained increase in blood flow rate compared to Comparative Examples 5 to 7. It also showed poor effects in various tests, and the blending amount of citric acid nimethate was 0.05~
As described above, the present invention continuously promotes blood circulation in the scalp, has excellent effects on hair growth, hair loss prevention, and dandruff prevention, and improves skin! It is clear that a hair-nourishing cosmetic that does not cause skin irritation is provided.

Claims (1)

[Claims] A hair nourishing cosmetic containing citric acid nimethate.