JPS62123108A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:A hair tonic cosmetic, obtained by blending hepronicate with other ingredients, having low skin irritancy and capable of sustainedly promoting the blood circulation of the scalp and exhibiting improved effect on hair growth, prevention of depilation and dandruff, etc. CONSTITUTION:A hair tonic cosmetic obtained by blending hepronicate (=2- hydroxymethyl-2-hexyl-1,3-propanediol trinicotinate), which is a well-known nicotinic acid derivative, having improved blood serum hypoliphemic action, applied to improvement in hyperlipemia and expressed by the formula with other ingredients. The amount of the above-mentioned compound to be blended is 0.05-1.0wt%, preferably 0.1-0.7wt% based on the total weight of the hair tonic cosmetic composition. The above-mentioned hair tonic cosmetic may be suitably blended with a dyestuff, perfume, germicide, preservative, keratolytic agent, antiandrogen agent, hair tonic, antioxidant, etc., in addition to the above- mentioned compound and used in a dosage form, e.g. hair tonic, hair lotion, hair cream, etc., according to a conventional method.

Description

Detailed Description of the Invention (Technical Field) The present invention relates to the production of hepronicate.
), and more specifically, it relates to a hair nourishing cosmetic that continuously promotes blood circulation in the scalp and has excellent hair growth, hair loss prevention, and dandruff prevention effects.

(Conventional technology) Conventional Yoshishi, Capsicum tincture, Jasminum extract.

Hair nourishing cosmetics containing scalp blood circulation promoting substances such as Korean ginseng extract, nicotinic acid, and methyl nicotinate are known.

However, these blood circulation-promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added.The blood circulation-promoting effect decreases in a short period of time or the blood circulation-promoting effect is weak. The substance was not effective enough to sufficiently exhibit effects such as prevention and prevention of dandruff.

(Disclosure of the Invention) As a result of intensive research into blood circulation promoting substances that are effective when incorporated into hair-nourishing cosmetics, the present inventors found that hair-nourishing cosmetics containing hepronicate, a derivative of nicotinic acid, are effective for skin care. We have completed the present invention by discovering that it has low irritation, continuously promotes blood circulation in the scalp, and has excellent effects on hair growth, hair loss prevention, and dandruff prevention.

(Object of the invention) That is, the object of the present invention is to continuously promote blood circulation in the scalp,
To provide a hair nourishing cosmetic excellent in effects such as hair growth, hair loss prevention and dandruff prevention.

(Structure of the Invention) The present invention is an R hair-forming material containing hebronicate.

(Specific explanation of the structure) Hebrodicate used in the present invention is a known substance,
It has been applied to improve hyperlipidemia as a drug that promotes blood circulation.

The chemical properties of hepronicate are as follows.

+1) Structure (2) Chemical name: 2-hydroxymethyl-2-hexyl-1,3-propanediol trinicotinate (2-
Hydroxymethyl-2-hexyl-1
,8-propandioltrinlcoti-n
(3) Molecular formula: 28H31N306 (・11 Molecular weight: 505.58 (5) Melting point: 96-100°C After being absorbed into the scalp, the hepronicate added to the hair-growth cosmetic of the present invention is Its action gradually produces free nicotinic acid, which causes no skin irritation and produces a continuous blood circulation promoting effect.This continuous blood circulation promoting effect activates hair matrix cells. excellent hair growth,
It is presumed that it exerts a hair loss preventive effect and further normalizes the scalp metabolic function to enhance the dandruff preventive effect. Hepronicate lt! Please understand the entire composition of the hair nourishing cosmetic of the present invention! It may be 0.05 to 1.0% by weight (hereinafter abbreviated as wt%) based on the amount, preferably 0.1 to 0.7W.
[%. If the blending amount is less than 0.05 wt%, it will not be sufficient to achieve the desired effect of the present invention, and on the other hand, 1. Even if it exceeds OW[%, it is not possible to expect an improvement in the effect commensurate with the increase.

The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method.

The hair nourishing cosmetic of the present invention includes a pigment, a fragrance, and a bactericide.

Preservatives, keratolytic agents, anti-androgens, hair nourishing agents.

Antioxidants and the like may be added as appropriate within the range that achieves the purpose of the present invention.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test method The abdomen of 8 New Sealant White rabbits was
After fasting for 18 hours, the animals are anesthetized by injecting the sodium salt of pentabarbitol into the elbow at a rate of 35~/Ky. The back of the rabbit was fixed, a plate-type transducer was fixed with cellophane tape over the sample application site (test site) on the abdomen, and a cross-heat-packed skin type 1 blood flow meter (Shinei Co., Ltd. Shincoder, model 201) was placed. skin blood flow (μV
) to measure.

A sample of 0.12 was applied uniformly to an 8x2- skin area, and the blood flow 1 t (CB) before the sample application and after a certain period of time after the sample application (e.g. 0.5, 1.0, 2.0 hours) were measured. After that, the blood flow 1 (Ct) is measured, and the blood flow increase rate (%) is calculated using the following formula.

The test results were shown as the average value of the blood flow increase rate of 8 birds.

Ct-CB Blood flow increase rate (%); , --x t o.

An increase in blood flow of about 5 to 20% was observed even when a cream base of skin cosmetics was applied as a sample, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied, The increase rate is high (40-80%).

(2) Mouse hair growth promotion effect test method The skin on the back of the tail of a ddY white mouse (male, 6 weeks old, average weight 85 years) was shaved with electric clippers, and then the hair was completely removed using a hair removal cream. The next day, each sample of the Example and Comparative Example was applied to the skin of the test subject twice daily, in the morning and evening, for -fi 0.1 d per animal.

- A group of 10 animals were used for each sample.

The hair-restoring effect was determined by comparing the visual evaluation score based on the criteria shown in the table below and the hair length and hair weight with the control group.

On the 15th day after the start of the experiment, the marked animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score for -animals. Furthermore, the skin of the test area was excised, a certain area of skin was punched with a punch with a diameter of 12 mm, and after drying, the weight of the hair was measured, and the length of 20 hairs among them was also measured, and the average value was and the standard deviation was calculated.

(3) Human hair growth promotion effect test method The hair of 10 test subjects who are androgenetic alopecia patients at a position 50 m above the ears was shaved into a circular shape with a diameter of ICII at two locations on the left and right sides. Approximately 8 ml of the sample of Example or Comparative Example was applied to the test site on the left side twice a day in the morning and evening! and compared with the untreated right side. To judge the effectiveness, 28 days after the start of the test, 20 hairs each on the left and right test sites were shaved, and the average length of the 20 hairs on the left side (where Example or Comparative Example was applied) (B ) divided by the average length of 20 hairs on the right side (untreated) (a).

The judgment results were expressed as the average value of (B)/(A) for the 10 test subjects.

(4) Practical test method The effect was evaluated after applying moss to the heads of 20 test subjects, who were patients with androgenetic alopecia, twice a day in the morning and evening for six consecutive months.

The test results showed that ``grown hair became brushy or the amount of raw hair increased'', ``hair loss decreased'', and ``dandruff decreased'' for each of the hair growth effect, hair loss prevention effect, and dandruff prevention effect. It is shown by the number of people who did the same thing.

Examples 1-4. Comparative Examples 1 to 4 [Oitsu He Artonic] Using the following raw material composition, nicotinic acid and its derivatives were blended as shown in Table 1 to prepare each hair artonic, and the various tests described above were conducted. did.

In addition, in the skin blood flow test, the sample application was 0.5 and 1.0.

The rate of increase in blood flow was measured after 2.0 hours.

fll Composition (2) Preparation method After each of the components (A) and (B) is uniformly dissolved, the components (5) and (5) are mixed and dispersed, and then filled into a container.

When using, shake and disperse the contents uniformly.

+3+ 'l'! The results of various Artonic tests conducted on each gender are listed in the right column of Table 1.

As shown in Table 1, in Comparative Examples 1 to 4, the rate of increase in blood flow was low or decreased as the time passed. In addition, Comparative Example 2゜8 had skin JtV stimulation,
Testing on human skin was not possible.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, skin 1a was tested in various tests on human skin.
MIJ Geki did not occur.

Examples 5-7. Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 1.

(1) Composition (2) Preparation method (5) Components (B) were each heated and dissolved at a temperature of 80°C, and then mixed, cooled while stirring, and when the temperature reached 50°C, (C) Each hair cream was prepared by adding the ingredients and continuing stirring until the temperature reached 30°C.

(3) Characteristics As shown in Table 1, the hair nourishing cosmetic of Example 5-7, which is the skin cosmetic of the present invention, exhibits a sustained increase rate in blood flow shortening compared to Comparative Example 5-7. It also showed excellent effects in various tests, and the blending amount of hepronicate was 0.05 to 1. O
Within the wt% range (effects of the invention) As described above, the present invention continuously promotes blood circulation in the scalp, has excellent effects such as hair growth, hair loss prevention, and dandruff prevention, and also reduces wear irritation. It is clear that it provides a cosmetic with low hair growth.

Pa F1

Claims (1)

[Claims] A hair nourishing cosmetic containing hepronicate.