JPS62270514A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To provide a hair-tonic cosmetic containing ifenprodil tartrate, effective in continuously promoting the blood flow in scalp and having excellent hair-growing, falling-preventive and dandruff-preventive effects and low irritation to skin. CONSTITUTION:The objective hair-tonic cosmetic having the above effects can be produced by compounding a hair-tonic cosmetic such as hair tonic, hair lotion, hair cream, etc., with 0.05-1.0wt%, preferably 0.1-0.7wt% (based on the whole cosmetic composition) ifenprodil tartrate of formula. Since the ifenprodil tartrate has proper transcutaneous absorbability, it is effective in maintaining the active concentration of the above drug component in the scalp. It has low skin irritation and exhibits continuous effect to promote the blood flow in scalp. Furthermore, it is expected that the continuous blood flow- promoting effect activates the hair-matrix cell to develop excellent hair growing effect and falling-preventive effect and normalizes the metabolic function in scalp to improve the dandruff-preventive effect.

Description

Detailed Description of the Invention 8. Detailed Description of the Invention (Technical Field) The present invention relates to a hair-growth cosmetic containing ifenbrodil tartrate. , relates to a hair nourishing cosmetic with excellent anti-hair loss and anti-dandruff effects.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been known.

However, these blood circulation-promoting substances are highly irritating to the skin (there are restrictions on the amount that they can be added to), their blood circulation-promoting effects decrease in a short period of time, or their blood circulation-promoting effects are weak, and they have a negative effect on hair growth and hair loss. The substance was not effective enough to sufficiently exhibit effects such as prevention and prevention of sagging.

(Disclosure of the Invention) Therefore, as a result of intensive research into blood circulation promoting substances that are effective when incorporated into hair-growth cosmetics, the present inventor found that hair-growth cosmetics containing ifenbrodil tartrate have low skin irritation and are gentle on the scalp. We have completed the present invention by discovering that it continuously promotes blood circulation and has excellent effects on hair growth, hair loss prevention, and dandruff prevention.

(Objective of the invention) The object of the present invention is to continuously promote blood circulation in the scalp, promote hair growth,
To provide a hair nourishing cosmetic excellent in effects such as preventing hair loss and preventing dandruff.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing ifenprodil tartrate.

(Specific description of the structure) Ifenbrodil tartrate used in the present invention is a known substance, and as a substance having a vasodilatory effect, it is applied as a therapeutic agent for dizziness, headache, etc. associated with the sequelae of cerebral infarction. The chemical properties of ifenbrodil tartrate are as follows.

(1) Structure (2) Chemical name: dl-erythro 4-benzyl-a
-(4-hydroxyphenyl)-β-methyl-1-piperidineethanoltartaric acid (11-erythro -4-benzyl -a
-(4-hydroxy-phenyl)-β-me
tbyl-1-piperi, dine ethan
altartrate (3) Molecular formula: (Og+, HgyNOs+)g-04
H606(4) Molecular weight: sot, o.

(6) Melting point: Approximately 209°C Ifenprodil tartrate blended into the hair-growth cosmetic of the present invention has appropriate transdermal absorbability, so it maintains an effective concentration of the drug in the scalp and does not cause skin irritation. It has low potency and produces a continuous blood circulation promoting effect. It is presumed that this continuous blood circulation promoting effect activates hair matrix cells, exhibits excellent hair growth and hair loss prevention effects, and further normalizes the scalp metabolic function to enhance the dandruff preventive effect.

The blending amount of ifenprodil tartrate is 0.305 to 1.0% by weight based on the total weight of the hair nourishing cosmetic composition of the present invention.
(hereinafter abbreviated as wt%), preferably 0,
It is 1 to 0.7 wt%. If the blending amount is less than 0.05 wt%, it will not be sufficient to achieve the desired effect of the present invention;
．． Even if it exceeds Owt%, it is not possible to expect an improvement in the effect commensurate with the increase.

The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method.

The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test method The abdomen of 8 New Sealant White rabbits was
After 18 hours of administration, the sodium salt of pentabarbitol is intravenously injected at a rate of 85 my/Kf for anesthesia.

A plate-type transducer was fixed with cellophane tape on the sample application site (#A test site) on the abdomen, and a cross-thermoelectrode skin blood flow meter (Shinei Co., Ltd. Shincoder, 20
Skin blood flow (μV) is measured using a blood cell type (type 1).

For the sample, 0.1 F was applied uniformly to a skin area of BX2 cm, and the blood flow rate (On) before sample application and after a certain period of time after sample application (for example, 0.5, 1.0, 2.0 hours later) were measured. The blood flow rate c, Ot) is measured, and the blood flow increase rate (%) is calculated using the following formula.

The test results were shown as the average value of the blood flow increase rate of 8 birds.

t - OB Blood flow increase rate (%) = oBX 100 The increase in blood flow was 5 even when a cream base was applied as a sample.
An increase rate of about 20% is observed, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied, the increase rate was 40 to 8%.
The increase rate will be high, such as 0%.

(2) Mouse hair growth promotion effect test method After cutting the back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight 86 g) with electric clippers, the hair was completely removed with hair removal cream, and the hair was removed from the next day. Apply each sample of Examples and Comparative Examples to the skin of the test subject twice daily in the morning and evening - 0.1 ml per animal! Coated. - A group of 10 animals were used for each sample.

The hair-restoring effect was determined by comparing the visual evaluation score based on the criteria shown in the table below and the hair weight in 2 hair lengths with the control group.

On the 16th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, and a diameter of 12 m was removed.
Punch out a certain area of the skin with a punch, dry it, and then
The weight of the hair was measured, and the lengths of 20 of the hairs were also measured, and the average value of each was calculated.

Judgment criteria for hair growth effect evaluation score (3) Human hair growth promotion effect test method The hair of 10 test subjects who are patients with androgenetic alopecia was placed on the head at 5 rams above the ear in two places on the left and right. Approximately B ml of the sample of Example or Comparative Example was applied to the left side of the test site, which was shaved into a circular shape with a diameter of 1 cm, twice a day in the morning and evening, and compared with the untreated right side. The effectiveness was determined by shaving 20 hairs each on the left and right test sites on the 28th day after the start of the test, and averaging the length of the 20 hairs on the left side (where Example or Comparative Example was applied).
was divided by the average length (4) of 20 hairs on the right side (untreated) for evaluation.

The judgment results were shown as the average value of Q3)/(4) of 10 test subjects.

(4) Practical test method The effect was evaluated after applying the product to the heads of 20 test subjects who were patients with androgenetic alopecia twice a day in the morning and evening for six consecutive months. The test results showed that hair growth effect, hair loss prevention effect, and in humans, for each of the preventive effects, ``hair became bristly or the number of hair increased,'' ``hair loss decreased,'' and ``dandruff decreased.'' It is shown by the number of people who answered "Yes."

Examples 1 to 4, Comparative Examples 1 to 4 [Oily hair tonic] Each hair tonic was prepared by blending various scalp blood circulation promoting substances with the following raw material composition as shown in Table 1. The various tests described above were conducted.

In addition, in the skin blood flow test, the sample application was 0.5, 1.0°2.
The rate of increase in blood flow was measured after 0 hours.

(2) Preparation method ■Among the ingredients, nicotinic acid and methyl nicotinate are added to ingredient (4), and capsicum tincture and ifenprodil tartrate are added to (O
After each of the components (2) and Q3) is uniformly dissolved, the components (4) and (4) are mixed and dispersed with stirring, and then filled into a container. When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests conducted on each oily hair tonic are listed in the right column of Table 1.

As shown in Table 1 (Comparative Examples 1 to 4 had a low blood flow increase rate or the blood flow increase rate decreased over time. Also, Comparative Examples 2 and 8゜4 had skin irritation. There is,
Testing on human skin was not possible.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 1.

(1) Composition (2) Preparation method CB) Among the ingredients, nicotinic acid and methyl nicotinate are (5)
As for the ingredients, capsicum tincture and ifenbrodil tartrate are dissolved in the active ingredients, and the (A) and (0) ingredients are each heated at a temperature of 80".
What was heated and dissolved in C was mixed. Next, the mixture was cooled while stirring, and when the temperature reached 50°C, component (9) was added, and stirring was continued until the temperature reached 80°C to prepare each hair cream.

(3) Characteristics As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are skin cosmetics of the present invention, exhibit a sustained increase in blood flow rate compared to Comparative Examples 5 to 7. As described above, the present invention shows excellent effects in various tests and can achieve the purpose of the present invention within the range of 0.05 to 1 Owt% (effects of the invention). It is clear that a hair-nourishing cosmetic that continuously promotes blood circulation, has excellent effects such as hair growth, hair loss prevention, and dandruff prevention, and has low skin irritation is provided.

Claims (1)

[Claims] A hair nourishing cosmetic containing ifenprodil tartrate.