JPS62138413A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:A hair tonic cosmetic that is obtained by adding a tartaric acid nicotinic alcohol ester, thus continuously accelerating scalp blood circulation to develop good effect of hair growth, depilation prevention and dandruff prevention. CONSTITUTION:The objective hair tonic cosmetic contains 0.1-0.3wt% tartaric acid nicotinic alcohol ester of the formula. The compound of the formula has high action to increase peripheral blood flow and is appropriately absorbed through skin so that its concentration can be kept at an effective concentration in scalp tissues. Further, skin irritation is reduced and it can activate the hair matrix to develop hair growth and depilation inhibition effects. Further, the scalp metabolism is normalized to increase dandruff prevention. The cosmettic can be combined with colorants, perfumes, fungicides, preservative, corneum solubilizer, antiandrogen and antioxidants and prepared into hair tonic lotion, solution, cream or such.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair-growth cosmetic containing nicotinic alcohol tartrate, and more specifically, it continuously promotes blood circulation in the scalp and has a hair-growth effect, a hair loss prevention effect, and a dandruff-fighting effect. This invention relates to a hair nourishing cosmetic with excellent preventive effects.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been known.

However, these blood circulation-promoting substances have strong skin irritation resistance, which places restrictions on their blending amount, or their blood circulation-promoting effect decreases in a short period of time, or their blood circulation-promoting effect is weak, resulting in poor hair growth and hair loss. It was not a product that was effective enough to fully exhibit the effects of prevention and prevention of dandruff.

(Disclosure of the Invention) Therefore, as a result of intensive research on blood circulation promoting substances that are effective when added to hair nourishing ↑1r ingredients, the present inventors have discovered that a hair nourishing agent containing nicotinic alcohol tartrate, which is a related compound of nicotinic acid, has been developed. The present inventors have discovered that hair cosmetics have low skin irritation, continuously promote blood circulation in the scalp, and have excellent effects on hair growth, hair loss prevention, and dandruff prevention.

(Object of the invention) That is, the object of the present invention is to continuously promote blood circulation in the scalp,
To provide a hair-nourishing cosmetic that is excellent in effects such as hair growth, hair loss prevention, and dandruff prevention.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing dicotinic alcohol tartrate.

(Specific description of the structure) Nicotinisoc tartrate alcohol used in the present invention is a known substance and has been applied to several seconds of Meniere's disease as a drug that has an excellent effect of increasing peripheral blood flow.

The chemical properties of nicotinic tartrate alcohol are as follows.

(1) Structure oon (2) Chemical name: 3-pyridinemethanol d-tartrate (3-pyridinemethanol-
tartrate) (3) Molecular formula: 0aIIyNO@0411eOe(4
) Molecular weight: 25'3.22 (5) Melting point: 145-150°C (decomposition) Since dicotinic alcohol tartrate to be incorporated into the hair-growth cosmetic of the present invention has suitable transdermal absorption, The drug maintains its effectiveness in the scalp, has low skin irritation, and produces a sustained blood circulation promoting effect.

This continuous blood circulation promotion effect activates hair matrix cells, promotes hair growth and prevents hair loss, and also improves scalp metabolism.
It is presumed that the anti-dandruff effect is enhanced by normalizing the dandruff function.

The amount of nicotinic alcohol tartrate may be 0.05 to 0.5% by weight (hereinafter abbreviated as wt%) based on the total weight of the hair nourishing cosmetic composition of the present invention, preferably 0. .1 to Q, 3wt%. The blending amount is o, oswt
If it is less than 0.5 wt %, it is not sufficient to achieve the desired effect of the present invention, and on the other hand, even if it exceeds 0.5 wt %, the effect cannot be improved commensurately with the increase.

The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method.

The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test method The abdomens of three New Sealant White rabbits were separated,
After fasting for 18 hours, the animals are anesthetized by intravenously injecting the sodium salt of pentaparbitol at a ratio of 9 to 35Q.

The back of the rabbit was fixed, a plate-type transducer was fixed with cellophane tape over the sample application site (test site) on the abdomen, and a cross-thermoelectrode skin blood flow meter (Shinei Co., Ltd. Shincoder, model 201) was used. Measure the skin q blood flow (μ■).

The sample was applied uniformly to a skin area of 3 x 2 cm at a concentration of 0.19, and the blood flow J'ik (Cn) applied to the sample was measured.
and blood flow ff1lt) after a certain period of time (0, 5, 1, 0, 2, 0 hours) after application of the sample, and calculate the blood flow M increase rate (%) using the following formula.

The test results were shown as the average value of the blood flow increase rate of the three birds.

Regarding the increase in blood flow, an increase rate of about 5 to 20% was observed even when a cream base was applied as a sample, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied,
The rate of increase is as high as 40-80%.

(2) Mouse hair growth promotion effect test method After cutting the dorsal skin from the tail of ddY white mice (male, 6-year-old, average weight 35 g) with electric clippers, hair growth promotion effect test method was performed using hair removal cream.
The hair was completely removed, and from the next day, each sample of Examples and Comparative Examples was applied to the skin of the test site twice a day in the morning and evening at a dose of 0.1 ytl per animal. - A group of 10 animals were used for each sample.

The hair-restoring effect was determined by comparing the visual evaluation score, hair length, and hairball 1 according to the criteria shown in the table below with the control group.

On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, a certain area of skin was punched with a punch with a diameter of 12 holes, and after drying, the weight of the hair was measured, and the length of 20 hairs among them was also measured, and the average value was was calculated.

Judgment criteria for hair growth effect evaluation score (3) Human hair growth promotion effect test method The hair of 10 test subjects who are patients with androgenetic alopecia was placed on the head at a position 5 cm above the ear in two places on the left and right. Approximately 3 ml of the sample of Example or Comparative Example was applied to the left side of the test site, which was shaved into a circular shape with a diameter of I cm, twice a day in the morning and evening, and compared with the untreated right side. The effectiveness was determined by shaving 20 hairs each on the left and right test sites on the 28th day after the start of the test, and calculating the average length of the 20 hairs on the left side (where Example or Comparative Example was applied) (B ) divided by the average length (mu) of 20 hairs on the right side (untreated) for evaluation.

The judgment results were shown as the average value of (B)/(A) of 10 test subjects.

(4) Practical test method The effect was evaluated after applying the product to the heads of 20 test subjects who were patients with androgenetic alopecia twice a day in the morning and evening for six consecutive months. The test results showed that hair growth effect, hair loss prevention effect, and dandruff prevention effect were shown as follows: ``The growth of hair became bristly or the growth of hair increased,'' ``There was less hair loss,'' and ``There was less dandruff. ”
It is shown by the number of people who answered.

Examples 1 to 4, Comparative Examples 1 to 4 [Oilly Hair Tonic] Each hair tonic was prepared by blending nicotinic acid and its related compounds with the following raw material composition as shown in Table 1. Then, the various tests described above were conducted.

In addition, in the skin blood flow test, the sample application was 0.5.1.012.
The rate of increase in blood flow was measured after 0 hours.

(1) Composition (2) Preparation method (4) Of the ingredients, nicotinic alcohol tartrate is (C)
(4),0
3) Each component was uniformly dissolved. Next, component (4) and (
B) The ingredients are mixed, stirred and dispersed and then filled into a container. When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests conducted on each oily hair tonic are listed in the right column of Table 1.

As shown in Table 1, in Comparative Examples 1 to 4, the rate of increase in blood flow was low, or the rate of increase in blood flow decreased over time. In addition, Comparative Example 2°3 caused skin irritation, making it impossible to test on human skin.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results were recorded in the right column of Table @1.

(1) Composition (2) Preparation method As in Example 1 and Comparative Examples 2 and 3,
4), (After heating and melting each component (0) to a temperature of 80°C and mixing them, cool while stirring, and when the temperature reaches 50°C, add component (2) and further raise the temperature to 30°C. Stirring was continued to make each hair cream.

(3) Characteristics As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are the hair nourishing cosmetics of the present invention, showed a sustained increase in blood flow rate compared to Comparative Examples 5 to 7. It also showed excellent effects in various tests, and the amount of dicotinic alcohol tartrate was 0.
The object of the present invention could be achieved within the range of 0.05 to 0.5 wt%.

(Hereinafter, the plan) (Effects of the invention) As described above, the present invention continuously promotes blood circulation in the scalp, has excellent effects such as hair growth, hair loss prevention, and dandruff prevention, and has no skin irritation. It is clear that hair nourishing cosmetics are provided.

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Claims (1)

[Claims] A hair nourishing cosmetic containing nicotinic alcohol tartrate.