JPH064525B2 - Hair nourishing cosmetics - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a hair nourishing cosmetic composition containing nicotinic alcohol tartrate, and more specifically, it continuously promotes blood circulation in the scalp to promote hair growth, hair loss, and dandruff. The present invention relates to a hair nourishing cosmetic having an excellent preventive effect.

(Prior Art) Conventionally, a hair nourishing cosmetic composition containing a scalp blood circulation-promoting substance such as capsicum tincture, assembly extract, ginseng extract, nicotinic acid and methyl nicotinate has been known.

However, these blood circulation-promoting substances have strong skin irritation and have a restriction on the amount to be mixed, or have a weak blood circulation-promoting effect in a short time or have a weak blood circulation-promoting effect. It was not a substance that was effective enough to exert the effect of preventing dandruff.

DISCLOSURE OF THE INVENTION Therefore, as a result of diligent research on the blood circulation promoting substance that is effective when blended in a hair nourishing cosmetic composition, the present inventors have found that a hair nourishing cosmetic obtained by incorporating nicotinic alcohol tartrate, which is a related compound of nicotinic acid. The present invention has completed the present invention by discovering that the agent has low skin irritation and continuously promotes blood circulation in the scalp, and has excellent effects on hair growth, hair loss prevention, dandruff prevention, and the like.

(Object of the invention) That is, the object of the present invention is to promote blood circulation of the scalp continuously,
It is intended to provide a hair nourishing cosmetic excellent in effects such as hair growth, hair loss prevention and dandruff prevention.

(Structure of the Invention) The present invention is a hair nourishing cosmetic composition containing nicotinic alcohol tartrate.

(Detailed Description of Configuration) Nicotinic alcohol tartrate used in the present invention is a known substance, and is applied as a drug having an excellent peripheral blood flow increasing action to ameliorate Meniere's disease.

The chemical properties of nicotinic alcohol tartrate are as follows.

(1) Structure (2) chemical name: 3-pyridinemethanol d- Tatoreito (3-pyridinemethanol d-tartrate) (3) Molecular _{formula: C 6 H 7 NO · C} 4 H 6 O 6 (4) Molecular weight: 259.22 (5) melting point : 145 to 150 ° C. (decomposition) The nicotinic alcohol tartrate contained in the hair nourishing cosmetic composition of the present invention has an appropriate transdermal absorbability, and therefore maintains an effective concentration of the drug in the scalp. It has low skin irritation and produces a continuous blood circulation promoting action. It is speculated that this continuous blood circulation promoting action activates hair matrix cells to exert excellent hair growth and hair loss prevention effects, and further normalizes scalp metabolic function to enhance dandruff prevention effect.

The amount of nicotinic tartrate alcohol blended may be 0.05 to 0.5% by weight (hereinafter abbreviated as wt%) based on the total weight of the composition for hair nourishing cosmetics of the present invention, and is preferably 0. 0.1 to 0.3 wt%. If the blending amount is less than 0.05 wt%, the effect aimed at by the present invention is not sufficient.
Even if it exceeds 5 wt%, it is not possible to expect an improvement in the effect commensurate with the increase.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, and a hair cream according to a conventional method.

The hair nourishing cosmetic of the present invention may be appropriately blended with a dye, a fragrance, a bactericide, an antiseptic, a keratolytic agent, an antiandrogen agent, a hair nourishing agent, an antioxidant, etc. within a range to achieve the object of the present invention. it can.

(Example) Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples.

The skin blood flow test method, mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) Skin blood flow test method 3 New Zealand White rabbits were shaved on the abdomen,
After being fasted for 18 hours, pentabarbitol sodium salt is intravenously injected at a rate of 35 mg / kg for anesthesia. Fix the back of the rabbit, fix the plate type transducer on the sample application site (test site) on the abdomen with cellophane tape, and use a cross thermoelectric stack skin blood flow meter (Shinei Co., Ltd. type 201) The skin blood flow (μV) is measured.

Samples were uniformly coated with the 0.1g to the skin site of 3 × 2 cm, blood flow before sample application (C _B) and after the sample application after a certain period of time (0.5, 1.0, 2.0 hours After) blood flow (C
t) is measured and the blood flow increase rate (%) is calculated by the following formula.

The test results are shown by the average value of the blood flow increase rate of 3 birds.

The increase in blood flow is found to be about 5 to 20% even when the cream base is applied as a sample, but when a sample containing a component with a remarkable blood circulation promoting effect is applied,
The rate of increase is as high as 40 to 80%.

(2) Mouse hair growth promoting effect test method The back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight: 35 g) was shaved with an electric clipper, and then completely removed with a depilatory cream. Each sample of Examples and Comparative Examples was applied to the skin of the test site twice daily in the morning and evening, and the amount of each animal was 0.
1 ml was applied. For each sample, 10 animals were used per group.

The hair nourishing effect was judged by comparing the macroscopic evaluation points with the judgment criteria shown in the table below, and the hair length and hair weight with the control group.

On the 15th day after the start of the experiment, the animals were sacrificed and visually evaluated according to the criteria, and the evaluation points were totaled to obtain an average evaluation point per animal. Furthermore, the skin of the test area was excised, a certain area of the skin was punched and dried with a punch having a diameter of 12 mm, the weight of the hair was measured, and the length of 20 hairs therein was also measured, and the average value was calculated. It was calculated.

(3) Human hair growth promoting effect test method 10 test subjects who are androgenetic alopecia are shaved at 5 cm above the ears of their heads in a circular shape with a diameter of 1 cm at two left and right locations. About 3 ml of the sample of Example or Comparative Example was applied to the left side of the test site on the left side twice daily in the morning and evening, and compared with the untreated right side. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value of the lengths of 20 hairs on the left side (applied Example or Comparative Example) (B ) Was divided by the average value (A) of the lengths of 20 hairs on the right side (untreated), and evaluated.

The judgment results are shown by the average value of (B) / (A) of 10 test subjects.

(4) Practical test method The effect of 20 male subjects with alopecia was applied to the head of the subject twice a day twice a day for 6 consecutive months. The test results show that the hair growth effect, the hair loss prevention effect, and the dandruff prevention effect are "brushed or increased raw hair", "less hair loss", "less dandruff". The number of people who answered

Examples 1 to 4 and Comparative Examples 1 to 4 [Oily Hearthonic] In the following raw material compositions, nicotinic acid and its related compounds were blended as shown in Table 1 to prepare respective hearthnics. Various tests were carried out.

In the skin blood flow rate test, sample application 0.5, 1.0, 2.
The blood flow rate of increase after 0 hours was measured.

(1) Composition (2) Preparation method (A) component of nicotinic alcohol tartrate was dissolved in component (C), other components were dissolved in component (B), and components (A) and (B) were uniformly dissolved. . Then, the component (A) and the component (B) are mixed, stirred and dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Characteristics The results of various tests of each oily hair artic are shown in the right column of Table 1.

As shown in Table 1, in Comparative Examples 1 to 4, the blood flow volume increase rate was low or the blood flow volume increase rate decreased with time. Further, Comparative Examples 2 and 3 have skin irritation,
Testing on human skin was not possible.

The hair nourishing cosmetics of the present invention of Examples 1 to 4 showed clearly good results in all the tests.

In Examples 1 to 4, skin irritation did not occur in various tests on human skin.

Examples 5-7, Comparative Examples 5-7 [Hair Cream] Each hair cream was prepared and various tests were carried out in the same manner as in Example 1, and the results are shown in the right column of Table 1.

(1) Composition (2) Preparation method The component (B) was dissolved in the same manner as in Example 1 and Comparative Examples 2 and 3,
After mixing components (A) and (C) that were heated and dissolved at a temperature of 80 ° C, cool the mixture with stirring and when the temperature reaches 50 ° C, add component (D) and stir to a temperature of 30 ° C. Then, each hair cream was prepared.

(3) Properties As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are the hair nourishing cosmetics of the present invention, show a sustained blood flow increase rate as compared with Comparative Examples 5 to 7. In addition, it showed an excellent effect in various tests, and the compounding amount of nicotinic alcohol tartrate was 0.
The object of the present invention can be achieved in the range of 05 to 0.5 wt%.

(Effects of the Invention) As described above, the present invention provides a hair nourishing cosmetic that continuously promotes blood circulation in the scalp, is excellent in hair growth, hair loss prevention, dandruff prevention, and the like, and has no skin irritation. Is clear.

Claims (1)

[Claims] 1. A hair nourishing cosmetic composition containing nicotinic alcohol tartrate.