JPS62192311A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:A hair tonic cosmetic, obtained by blending pentoxifylline in a hair tonic cosmetic, capable of sustainedly promoting the blood circulation of scalp and having improved effect on hair growth, prevention of depilation and dandruff. CONSTITUTION:A hair tonic cosmetic, obtained by blending a compound expressed by the formula (278.31 molecular weight and 104-106 deg.C melting point) in an amount of 0.05-1.0wt% based on the total weight in a hair cosmetic, rapidly absorbable in the scalp when applied to the scalp, capable of sustaining the effective concentration of the drug in the scalp and having low skin irritancy. The compound is capable of preventing hemocytolysis, smoothly promoting microcirculation of blood in the scalp, activating the scalp tissue and preventing depilation and dandruff and further has metabolic improving effect of the skin by increasing adenosine triphosphate (ATP) and cyclic adenosine monophosphate (AMP) in scalp cells. The formulation form includes hair tonic, hair lotion, hair cream, etc. A dyestuff, perfume, germicide, preservative, keratolytic agent, etc., are suitably blended, as necessary.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair nourishing cosmetic containing pentoxifylline, and more specifically, it has a hair growth effect, a hair loss prevention effect, and a dandruff prevention effect by continuously promoting blood circulation in the scalp. This article relates to highly effective hair nourishing cosmetics.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been known.

However, these blood circulation-promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added, or their blood circulation-promoting effects decrease in a short period of time, or their blood circulation-promoting effects are weak. The substance was not effective enough to exhibit sufficient effects such as preventing dandruff.

(Disclosure of the Invention) Therefore, as a result of intensive research into blood circulation promoting substances that are effective when incorporated into hair-growth cosmetics, the present inventors found that hair-growth cosmetics containing pentoxifylline have low skin irritation. (We have completed the present invention by discovering that it continuously promotes blood circulation in the scalp and has excellent effects on hair growth, hair loss prevention, and dandruff prevention.)

(Objective of the Invention) That is, the object of the present invention is to provide a hair-growth cosmetic that continuously promotes blood circulation in the scalp and is excellent in effects such as hair growth, hair loss prevention, and dandruff prevention.

(Structure of the Invention) The present invention is a hair nourishing cosmetic containing pentoxifylline.

(Specific explanation of composition) Pentoxifylline is a known substance used in the present invention,
The chemical structure etc. are as follows.

(1) Structure: CH9 (2) Chemical name: 1-(5-oxohexyl)theobromine (3) Molecular formula: 018H18N40B (4) Molecular weight:
278.31 (5) Melting point = 104-106°C When pentoxifylline used in the present invention is blended into a hair-growth cosmetic and applied to the scalp, it is quickly absorbed into the skin,
It maintains the effective concentration of the drug in the scalp and has low skin irritation (1) prevents deformation of blood cells, (2) smoothly promotes microblood flow in the scalp, and (3) improves scalp It exerts pharmacological effects locally on the scalp, including revitalizing tissue, (4) preventing hair loss, and (5) preventing dandruff.

Furthermore, pentoxifylline used in the present invention also has the effect of improving skin metabolism by increasing MuTP and cyclic 8MP in scalp cells. It is presumed that this continuous blood circulation promotion effect inactivates hair matrix cells, exhibits excellent hair growth and hair loss prevention effects, and further normalizes scalp metabolic function to enhance dandruff prevention effects.

The blending amount of pentoxifylline may be 0.05 to 1.0% by weight (hereinafter abbreviated as wt%) based on the total weight of the hair nourishing cosmetic composition of the present invention, and preferably 0.05 to 1.0% by weight (hereinafter abbreviated as wt%). 1~
Q., 7wt%. If the blending amount is less than 0.05 wt%, it will not be sufficient to achieve the desired effect of the present invention, and on the other hand, 1. Q
Even if wt96 is exceeded, an improvement in effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be formulated into a hair tonic, hair lotion, hair cream, etc. according to a conventional method.

The hair nourishing cosmetic of the present invention may contain pigments, fragrances, bactericides, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc., as appropriate in order to achieve the purpose of the present invention. can.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.

The skin blood flow test method, the mouse hair growth promoting effect test method, the human hair growth promoting effect test method, and the practical test method described in the Examples are shown below.

(1) Skin blood flow test The abdomens of three New Sealant White rabbits were lined up and
After fasting for 18 hours, the animals are anesthetized by intravenously injecting the sodium salt of bendoparbitol at a rate of 35 m and 97 kg. Fix the rabbit's back, place the plate-type transducer on the sample application area 1 (test area) on the abdomen with cellophane tape, and place a cross-thermoelectrode skin blood flow meter (Shinei Co., Ltd. Shincoder, model 201). skin blood flow (μV
) to measure.

0.1 g of the sample was applied uniformly to a 3 x 2 cm skin area, and the blood flow rate (ON) before sample application and after a certain period of time after sample application (0, 5, 1, 0, 2, 0 hours later) were measured. blood flow (
Ot) is measured, and the blood flow rate increase rate (stop) is calculated using the following formula.

The test results were shown as the average value of the blood flow increase rate of the three birds.

5-209 even when cream base is applied as a sample
An increase rate of blood flow of about 6% was observed, but when a sample containing ingredients with a remarkable blood circulation promoting effect was applied, the rate of increase was 40% to 8%.
The increase rate will be high, such as 0%.

(2) Mouse hair growth promotion effect test After cutting the dorsal skin from the tail of ddY white mice (male I, 6 weeks old, average weight 35 g) with electric clippers, the hair was completely removed with hair removal cream, and the test was carried out from the next day. and comparison 1
Apply each sample to the affected skin twice a day in the morning and evening.
1 mA+ was applied. - A group of 10 animals were used for each sample.

The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group according to the criteria shown in the table below.

On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, and a diameter of 12 m was removed.
After punching out a certain area of the skin with a punch of 500 mm and drying it, the weight of the hair was measured, and the length of 20 hairs among them was also measured, and the average value of each hair was measured.

Judgment criteria for hair growth effect evaluation score (3) Human hair growth promotion effect test The hair of 10 test subjects who were patients with androgenetic alopecia was placed in two places on the left and right, 5 cm above the ears. Approximately 3 ml of the sample of Example or Comparative Example was applied to the left side of the test site, which was shaved in a circular shape with a diameter of 1 am, twice a day in the morning and evening, and compared with the untreated right side.

The effectiveness was determined by shaving 20 hairs each on the left and right test sites on the 28th day after the start of the test, and calculating the average length of the 20 hairs on the left side (where Example or Comparative Example was applied). ) to the right (
Evaluation was performed by dividing the length of 20 untreated hairs by the average value (2).

The judgment results were shown as the average value of @/ (A) of 10 test subjects.

(4) Practical test 6 consecutive treatments were applied to the heads of 20 test subjects suffering from androgenetic alopecia twice a day in the morning and evening. The effects after application during injury were evaluated. The test results showed that hair growth effect, hair loss prevention effect, and dandruff prevention effect showed that ``grown hair became bristly or increased,'' ``hair loss decreased,'' and ``dandruff decreased.'' ” indicated by the number of people who answered.

Examples 1 to 4, Comparative Examples 1 to 4 (Oily Hair Tonic) Each hair tonic was prepared by blending various scalp blood circulation promoting substances as listed in Table 1 with the following raw material composition. The various tests described above were conducted.

In addition, in the skin blood flow test, the sample application was 0.5.1. o.

(1) Composition (2) Preparation method Among the (2) ingredients, chili pepper tincture is dissolved in the working ingredient, the other ingredients are dissolved in the (6) ingredient, and (6) and (O ingredients are each uniformly mixed). Then, the ω) component and the (0) component are mixed, stirred and dispersed, and then filled into a container. When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various Artonic tests conducted on each oily are listed in the right column of Table 1.

As shown in Table 1, in Comparative Examples 1 to 4, the rate of increase in blood flow was low, or the rate of increase in blood flow decreased over time. In addition, Comparative Examples 2 to 4 caused skin irritation,
Testing on human skin was not possible.

The hair nourishing cosmetics of Examples 1 to 4 of the present invention clearly showed good results in all of the various tests.

In Examples 1 to 4, no skin irritation occurred in various tests on human skin.

Examples 5 to 7, Comparative Examples 5 to 7 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 1.

(1) Composition (2) Preparation method Among the (4) components, chili pepper tincture is dissolved in the (O component), and the other components are dissolved or dispersed in the (6) component.
6), (Each component Q was heated and dissolved at a temperature of 80 ° C. Next, after mixing the components (6) and (0, it was cooled with stirring, and when the temperature reached 50 ° C., the component (2) was added, and Each hair cream was prepared with continued stirring until the temperature reached 30°C.

(3) Properties As shown in Table 1, the hair nourishing cosmetics of Examples 5 to 7, which are the hair nourishing cosmetics of the present invention, exhibit a sustained increase in blood flow rate compared to Comparative Examples 5 to 7. It also showed excellent effects in various tests, and the blending amount of pentoxifylline was 0.05 to 1.
The present invention within the range of 9 wt% (effects of the invention) As described above, the present invention continuously promotes blood circulation in the scalp, has excellent effects such as hair growth, hair loss prevention, and dandruff prevention, and provides nourishing products that do not irritate the skin. It is clear that hair cosmetics are provided.

Claims (1)

[Claims] A hair nourishing cosmetic containing pentoxifylline.