JPH06219926A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic free from side effects and capable of exhibiting excellent trichogenous promotion effect on alopecia. CONSTITUTION:The hair tonic contains a vegetable oil as an active ingredient. Examples of the vegetable oil includes camellia oil, olive oil, sesame oil, soybean oil, safflower oil, rape oil or evening primrose oil. The blend amount of vegetable oil is preferably 1-100wt.%, further preferably 5-100wt.% based on total amount of hair tonic. This hair tonic is applicable to external preparations such as cosmetics, medicines and quasi-drugs.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair nourishing agent containing a vegetable oil as an active ingredient.

[0002]

2. Description of the Related Art Conventional hair nourishing agents include vasodilators (vitamin E and its derivatives, cembly extract, benzyl nicotinate, capsicum tincture, minoxidil and carpronium chloride), nutritional supplements (various vitamins and their derivatives, serine and methionine). Such as amino acids), antidandruff components (salicylic acid, resorcin, pyridoxine and its derivatives, hinokitiol, benzalkonium chloride and isopropylmethylphenol, etc.), female hormones (such as estradiol), anti-inflammatory components (purple root extract and glycyrrhetinic acid) And its derivatives), moisturizing ingredients (sodium hyaluronate, glycerin, water-soluble collagen, pyridonecarboxylic acid, lecithin, etc.), hair root metabolic function activating ingredients (pantothenic acid and Of derivatives, placenta extract,
Carrot extract and biotin, etc., refreshing ingredients (l-
Menthol), anti-androgens (such as spironolactone), fragrances (such as lavender oil, neroli and bergamot) and fatty acids. Among these, the vasodilator component, the nutritional supplement component and the hair root metabolic function activating component exhibit a hair nourishing effect by promoting energy supply to the hair root part, and are contained in most hair nourishing agents. However, the lack of energy in the hair root is due to Glucose-6-Phosphate Dehydrogenase (G6p
DH) activity is decreased [Journal of Cosmetics, No. 6
Vol. 1, No. 9, pp. 9-14, 1982], sufficient effects cannot be obtained unless an energy supply not through G6pDH is measured.

[0003]

As described above, it is the actual situation that none of the conventional hair nourishing agents have the sufficient effects.

[0004]

In view of the above circumstances, the present inventors have earnestly studied a component exhibiting an excellent hair growth effect on alopecia without causing side effects, and as a result, camellia oil has hair roots. There was an ATP content increasing action and a hair growth promoting action was recognized. It has been found that vegetable oils such as olive oil, sesame oil, soybean oil, safflower oil, rapeseed oil and evening primrose oil also have a hair growth promoting effect, and thus completed the present invention.

The present invention will be described in detail below. Examples of the vegetable oil of the present invention include camellia oil, olive oil, sesame oil, soybean oil, safflower oil, rapeseed oil and evening primrose oil. In the case of the hair nourishing agent of the present invention, the blending amount of the vegetable oil is
It is preferably 1 to 100% by weight, and more preferably 5 to 100% by weight, based on the total amount of the hair restorer. The hair nourishing agent of the present invention is applied to external use such as cosmetics, pharmaceuticals and quasi-drugs, and unless the effect is impaired, vasodilator components (vitamin E and its derivatives, cembly extract, which are conventionally used in hair nourishing agents, Benzyl nicotinate, capsicum tincture, minoxidil and carpronium chloride), nutritional supplements (various vitamins and their derivatives and amino acids such as serine and methionine), antidandruff (salicylic acid, resorcin, pyridoxine and its derivatives, hinokitiol, Benzalkonium chloride and isopropylmethylphenol, etc.), female hormones (such as estradiol), anti-inflammatory ingredients (purple root extract and glycyrrhizic acid and its derivatives, etc.), moisturizing ingredients (sodium hyaluronate, glycerin, water-soluble) Lagen, pyridonecarboxylic acid and lecithin, etc.), hair root metabolic function activating components (pantothenic acid and its derivatives, placenta extract, carrot extract and biotin, etc.), cooling components (1-menthol, etc.), antiandrogens components (such as spironolactone), One or more kinds of fragrances (lavender oil, neroli, bergamot, etc.) and fatty acids can be added and used. Examples of the base include purified water, monohydric alcohols (such as ethanol and isopropyl alcohol), polyhydric alcohols (such as glycerin and propylene glycol), higher fatty acids (such as palmitic acid and linoleic acid), and oils and fats. (Squalene, beeswax,
Cetyl alcohol, castor oil and liquid paraffin, etc., surfactants (polyoxyethylene hydrogenated castor oil,
Stearyl trimethyl ammonium chloride, disteryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride and sodium lauryl sulphate etc.) and
A pH adjuster (such as caustic soda and triethanolamine) can be used. Furthermore, more favorable results are obtained by adding vasodilator components such as tannic acid and vitamin E, which have not been conventionally used as hair nourishing agents. The hair nourishing agent of the present invention can be prepared and used in various dosage forms such as a hair tonic, a hair cream, a hair lotion or a hair spray according to a conventional method.

Next, the effect of the hair nourishing agent of the present invention will be described. (Test for increasing ATP content in hair roots) 6-week-old BDF
₁ system, the test liquid on the back of male mice 0.2 ml / mouse once a day, was applied 3 days, withdrawn back hair final coating about 1.5 cm ² after 24 hours, measured ATP content in hair root by luciferin-luciferase method did. To the control group, a mixed solution of ethanol: glycerin: water = 80: 5: 15 was applied and treated in the same manner as the test solution. The ATP content in the hair root was shown as a percentage, with the value of the mixed liquid application group being 100.

ATP content in hair root ────────────────── Test liquid ATP content (%) ────────────────── Camellia oil (undiluted solution) 524 〃 (25% liquid ^* ) 144 ─────────────────── Commercial hair nourishing agent A ^** 394 ────────────── ─────Mixed liquid 100 ────────────────── (n = 6-8) ^* Weight ratio to the mixed liquid ^** Quasi-drugs Furubayashi Active (Shiseido )

(Hair growth promoting effect test) ( ₁ ) A group of 6-week-old BDF ₁ strain and 4 male mice
The hair from the back to the hips is shaved with an electric razor, and the test solution is applied for 4 weeks (excluding Saturday and Sunday) from the next day.
0.2 ml / mouse was applied to the cut part. On the other hand, to the control group, a mixed solution of ethanol: glycerin: water = 80: 5: 15 was applied in the same manner as the test solution. The effect of promoting hair growth in this test was determined by the number of animals in which hair growth was observed in 50% or more of the hair-cut portion.

Hair growth effect of vegetable oil ───────────────── Test solution Hair growth performance ^* ───────────────── Tsubaki oil 2 / 4 Safflower oil 1/4 Olive oil 2/4 Sesame oil 1/4 Soybean oil 2/4 Rapeseed oil 2/4 Evening primrose oil 2/4 ───────────────── Commercial hair restorer A ^** 0/4 ───────────────── Commercial hair nourishing agent B ^*** 0/4 ───────────────── Mixed Liquid 0/4 ───────────────── ^* Number of hairs raised / number used ^** Non-medicinal products Furubayashi Active (Shiseido) ^*** Non-prescription drug Kaloyan Apojica (Daiichi Pharmaceutical)

( ₂ ) Testosterone 1 g / kg was subcutaneously administered to the back of 6-week-old BDF ₁ strain male mice twice every two days, and two days after the final administration, the hair from the back to the hips was shaved with a razor. The hair was shaved, and 0.2 ml / mouse of the test solution was applied to the shaved part for 4 weeks (excluding Saturday and Sunday) from the next day. On the other hand, in the control group, ethanol: glycerin: water = 80: 5: 1
The mixed solution consisting of 5 was applied in the same manner as the test solution. 1
The group consisted of 4 animals. The effect of promoting hair growth in this test is 50% of that of the shaving area.
Based on the above, the number of animals in which hair growth was recognized was determined.

[0011]

[0012]

EXAMPLES The present invention will be described in detail with reference to the following examples, but the present invention is not limited thereto.
The blending amount is% by weight. Example 1 (Cream 1) Amount A Cetyl alcohol 5 Camellia oil 50 Propylene glycol monostearate 3 Polyoxyethylene cetyl ether (20EO) 1 B Sodium hyaluronate 0.1 Propylene glycol 4 Glycerin 2 Perfume, preservative, antioxidant Appropriate amount Purified water so that the total amount is 100% (Production method) The raw material of the oil phase part belonging to A and the raw material of the water phase part belonging to B are respectively heated to 70 ° C and completely dissolved, and then the oil phase part is removed. The mixture was mixed with the aqueous phase and emulsified with an emulsifying machine. The emulsion was cooled to a final temperature of 30 ° C. with a heat exchanger and then filled to obtain a cream.

Example 2 (Cream 2) Compounding amount A Tannin acid 3 Cetyl alcohol 5 Camellia oil 20 Vitamin E 2 Propylene glycol monostearate 3 Polyoxyethylene cetyl ether (20EO) 1 B Sodium hyaluronate 0.1 Propylene glycol 4 Glycerin 2 Triethanolamine 1 Fragrance, preservative, antioxidant Suitable amount Purified water Total amount of 100% (Production method) A cream was obtained in the same manner as in Example 1.

Example 3 (Hair liquid) Compounding amount A Camellia oil 20 Tannic acid 3 Vitamin E 2 Fragrance, moisturizer Proper amount 99.5% Ethanol Total amount 100% (manufacturing method) Mix all phase A, two layers Got a type of hair liquid.

Example 4 (Emulsion Lotion 1) Compounding amount A Camellia oil 5 Tannic acid 1 Vitamin E 0.3 Pantothenyl ethyl ether 1 Lecithin 1 Biotin 0.05 Hinokitiol 0.05 Propylene glycol monostearate 3 Polyoxyethylene cetyl Ether (20EO) 1 B Glycerin 3 Purified water 3 Assembly extract 1 Perfume, moisturizer Suitable amount 99.5% Ethanol Total amount 100% (Production method) An emulsion lotion was obtained in the same manner as in Example 1.

Example 5 (Emulsion Lotion 2) Amount A Camellia oil 10 Tannic acid 1 Vitamin E 0.3 Pantothenyethyl ether 1 Lecithin 1 Biotin 0.05 Hinokitiol 0.05 Propylene glycol monostearate 5 Polyoxyethylene cetyl Ether (20EO) 2 B Glycerin 5 Purified water 3 Assembly extract 1 Perfume, humectant Suitable amount 99.5% Ethanol Total amount 100% (Production method) An emulsion lotion was obtained in the same manner as in Example 1.

Example 6 (Emulsion Lotion 3) Compounding amount A Rape seed oil 5 Tannic acid 1 Vitamin E 0.3 Pantothenyl ethyl ether 1 Lecithin 1 Biotin 0.05 Hinokitiol 0.05 Propylene glycol monostearate 3 Polyoxyethylene cetyl Ether (20EO) 1 B Glycerin 3 Purified water 3 Assembly extract 1 Perfume, moisturizer Suitable amount 99.5% Ethanol Total amount 100% (Production method) An emulsion lotion was obtained in the same manner as in Example 1.

Example 7 (Emulsion Lotion 4) Amount A Olive oil 5 Tannic acid 1 Vitamin E 0.3 Pantothenyl ethyl ether 1 Lecithin 1 Biotin 0.05 Hinokitiol 0.05 Propylene glycol monostearate 3 Polyoxyethylene cetyl Ether (20EO) 1 B Glycerin 3 Purified water 3 Assembly extract 1 Perfume, moisturizer Suitable amount 99.5% Ethanol Total amount 100% (Production method) An emulsion lotion was obtained in the same manner as in Example 1.

Example 8 (Lotion) Compounding amount A Camellia oil 5 Castor oil 5 Tannic acid 1 Vitamin E 0.3 Pantothenyl ethyl ether 1 Lecithin 1 Biotin 0.05 Hinokitiol 0.05 Propylene glycol monostearate 3 Polyoxyethylene cetyl Ether (20EO) 1 assembly extract 1 fragrance, moisturizer proper amount 99.5% ethanol total amount 100% (manufacturing method) All phase A was mixed to obtain lotion.

[0020]

The vegetable oil of the present invention has a hair growth promoting effect and is useful as a hair nourishing agent.

Claims (2)

[Claims] 1. A hair nourishing agent containing a vegetable oil as an active ingredient. 2. The hair nourishing agent according to claim 1, wherein the vegetable oil is camellia oil, olive oil, sesame oil, soybean oil, safflower oil, rapeseed oil or evening primrose oil.