JP2787696B2 - Hair growth promoter - Google Patents

Description

The present invention relates to a novel hair growth promoter. More specifically, the general formula [I] R ¹ —OH [I] “wherein R ¹ represents an acyclic branched higher aliphatic hydrocarbon group having 20 carbon atoms which may be substituted with a hydroxyl group. And a salt thereof as an active ingredient.

[Prior Art] Conventionally, various active ingredients have been used in hair restorers, for example, amino acids such as serine and methionine; vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as salicylic acid and purple root extract; estradiol Hormones such as vitamin E; keratolytic agents; humectants; humectants; fragrances; antidandruff agents; cooling agents; herbal extracts;

JP-A-60-4113 describes an alcohol having an odd carbon chain length or a derivative thereof as an active ingredient of a hair restorer. Further, Japanese Patent Application Laid-Open No. 61-207321 describes higher aliphatic alcohols having 22 to 34 carbon atoms as active ingredients of hair growth materials.

[Problems to be Solved by the Invention] However, it has been the fact that none of the conventional hair tonics has a sufficient hair growth effect.

[Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventors have conducted intensive studies on a substance which does not show any side effects and exhibits an excellent hair growth effect against alopecia. ] The compound represented by the formula or a salt thereof exhibits an excellent hair growth effect,
The present invention has been completed.

An object of the present invention is to provide a hair growth promoter comprising a compound exhibiting an excellent hair growth effect as an active ingredient.

In the compound of the general formula [I], examples of the acyclic branched higher aliphatic hydrocarbon group having 20 carbon atoms which may be substituted by the hydroxyl group in R ¹ include a phytyl group (3,7,11, 15-tetramethyl-2-hexadecene-1-
Yl), isophytyl (3,7,11,15-tetramethyl-1-hexadecene-3-yl), geranyllinalyl (3,7,11,15-tetramethylhexadecane-1,6,10, 14
-Tetraen-3-yl group), 7-hydroxymethyl-
3,11,15-trimethylhexadecane-2,6,10,14-tetraen-1-yl group and 2,3-dihydroxy-3,7,11,15
And a group such as -tetramethylhexadecane-1-yl group.

Salts of the compound of the general formula [I] include salts with alkali metals such as sodium and potassium; and salts with alkaline earth metals such as magnesium and calcium.

Further, in the compound of the general formula [I] or a salt thereof,
When isomers exist (eg, optical isomers, geometric isomers, tautomers, and the like), the invention includes all such isomers and extends to all crystalline forms and solvates. is there.

The content of the compound of the general formula [I] in the hair growth-promoting agent (total weight) of the present invention is not particularly limited and can be selected in a wide range, but is usually 0.1 to 10% by weight, preferably 0.1 to 10% by weight. -5% by weight.

The hair growth-promoting agent of the present invention includes amino acids (serine, serine,
Methionine, etc.), hormonal agents (progesterone, estradiol, etc.), anti-inflammatory agents (purple root extract, glycyrrhizic acid, hydrocortisone acetate, etc.), vasodilators (nicotinic acid, minoxidil, etc.), herbal extracts (such as assembly extract, carrot extract, etc.) Dandruff (hinokitiol, sulfur, etc.), cooling agent (l-menthol, camphor, etc.), wetting agent (glycerin, mucopolysaccharide, pyrrolidone carboxylic acid, etc.), keratolytic agent (urea,
Resorcinol, etc.), perfume (lavender oil, neroli,
Bergamot), vitamin A, vitamin E or a vitamin E derivative, vitamin B ₆ , vitamin H, lecithin, and fatty acids.

As the base, for example, purified water, monohydric alcohols (ethanol, isopropyl alcohol, etc.),
Polyhydric alcohols (glycerin, propylene glycol, etc.), higher fatty acids (palmitic acid, linoleic acid, etc.), fats and oils (fatty acid glyceride, olive oil, squalene, beeswax, etc.), liquid paraffin, surfactants (polyoxyethylene cured castor) Oil, stearyltrimethylammonium chloride, distearyldimethylammonium chloride, sodium lauryl sulfate, etc.), emulsifiers (cetyl alcohol) and solubilizers can be used.

The hair growth promoter of the present invention can be prepared and used in various dosage forms such as a hair tonic, a hair cream, a hair lotion or a hair spray according to a conventional method.

 Next, the effects of the hair growth promoter of the present invention will be described.

Hair growth promoting effect test method 6 weeks old BDF ₁ , 5 male mice as a group, 1% (weight ratio) for the purpose of shaving the back from the back with a safety razor and suppressing hair growth from the next day 0.2 ml / mouse of ethanol solution containing testosterone was applied once a day for one week. From the 8th day of shaving, the same amount was applied twice a week for 3 weeks.

On the other hand, the test solution was applied at a rate of 0.2 ml / mouse once a day from the 8th day of shaving for 3 weeks (excluding Sunday). In the control group, 85.5 parts by weight of ethanol and glycerin 1 were added.
0.2 ml / mouse of 0.0 part by weight and 4.5 parts by weight of purified water (hereinafter abbreviated as “mixture A”) per mouse was shaved on day 8 from the 8th day.
It was applied once a day for 3 weeks (except Sunday).

The hair growth-promoting effect of the novel hair growth-promoting agent of the present invention was determined by visually observing the degree of hair growth daily with the naked eye, and by the number of mice that had developed hair on the entire surface of the shaved site.

In Table 1, 2 minutes after the administration of the test solution.
The hair growth promoting effects observed after a week and three weeks have passed, as shown below, Indicated by

Test solution: Example 1 3.0 parts by weight of phytol was added to 97.0 parts by weight of the mixed solution A and dissolved to obtain a solution.

Example 2 3.0 parts by weight of isophytol was added to 97.0 parts by weight of the mixed solution A and dissolved to obtain a liquid preparation.

Example 3 3.0 parts by weight of phytantriol was added to 97.0 parts by weight of the mixed solution A and dissolved to obtain a liquid preparation.

Example 4 3.0 parts by weight of 1-pentadecanoylglycerol was added to 97.0 parts by weight of the mixed solution A and dissolved to obtain a liquid preparation.

As is clear from these results, the hair growth promoter of the present invention exhibits an excellent hair growth promoting effect.

[Effect of the Invention] A compound represented by the general formula R ¹ -OH of the present invention, wherein R ¹ has the same meaning as described above, or a salt thereof can be used as a hair growth promoter.

[Examples] Next, as examples of the present invention, the dosage form of the hair growth promoter of the present invention is shown together with its composition (% by weight), but the present invention is not limited to this.

──────────────────────────────────────────────────続 き Continuation of front page (56) References Special Table Sho-59-500129 (JP, A) Japanese Patent Publication Sho-38-5050 (JP, B1) (58) Fields surveyed (Int. Cl. ⁶ , DB name) A61K 7/06-7/155

Claims (1)

(57) [Claims] 1. A compound represented by the general formula: R ¹ -OH, wherein R ¹ represents a noncyclic branched higher aliphatic hydrocarbon group having 20 carbon atoms which may be substituted with a hydroxyl group. Or a hair growth promoter containing a salt thereof as an active ingredient.