JPH0574566B2 - - Google Patents

Description

[Detailed description of the invention]

TECHNICAL FIELD The present invention relates to hair cosmetics containing hair-growth ingredients, particularly hair-growth products. Traditionally, various medicinal ingredients, such as vitamin E,
vitamins such as; amino acids such as serine and methionine; vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as purple root extract; female hormones such as elastodiol; skin function enhancers such as cephalantin; steel pantothenate, etc. Although hair nourishing agents containing melanin synthesis catalysts and keratolytic agents such as salicylic acid are known, satisfactory effects on promoting hair growth and hair growth have not been achieved. Alopecia can occur due to various causes, but in any case, the hair on the head is unable to undergo a normal hair cycle and reaches a telogen state. In order to improve hair loss and promote hair growth, it is necessary to bring hair follicles in the resting phase into a normal growth phase (Anagen). Therefore, the present inventors conducted extensive research on the conversion of telogen hair into anagen hair, and as a result, discovered that various organic acid glycerides have excellent hair-nourishing effects. Therefore, an object of the present invention is to provide a hair cosmetic having a high hair growth effect, and this hair cosmetic is characterized by containing 0.1 to 10% by weight of organic acid glyceride as a hair growth component. The organic acid glycerides used in the present invention include organic acid glycerides represented by the following general formulas [], [], [], [], or [].

【formula】

【formula】

【formula】

【formula】

[Formula] (However, R represents a fatty acid residue, and R ₁ represents an acid residue selected from polybasic carboxylic acids, oxyacids, and ketonic acids.) In the present invention, a preferred organic acid residue is succinic acid. , polybasic carboxylic acids such as fumaric acid; oxyacids such as citric acid, malic acid, and lactic acid; and ketonic acids such as pyruvic acid and oxalacetic acid; Preferred fatty acid residues have 2 to 24 carbon atoms, and include residues of saturated fatty acids such as acetic acid, lauric acid, palmitic acid, and stearic acid; and unsaturated fatty acids such as oleic acid. includes groups. In the present invention, the organic acid glyceride is not limited to a single type, and a plurality of types may be used in combination. The content of organic acid glyceride is 0.1 to 10% by weight of the entire hair cosmetic, more preferably 1.0 to 10% by weight.
It is. If the content is less than 0.1% by weight, the effect may not be apparent. In addition, the content is 10% by weight
If the amount is exceeded, it may not dissolve completely and it may not be possible to produce a transparent product. The reasons why organic acid glycerides exhibit excellent hair-nourishing effects are: firstly, because they are fat-soluble, they easily dissolve in the sebum that is secreted from the sebaceous glands and coexists with the hair follicles, and easily penetrate into the hair roots. , because it is not degraded and metabolized via phosphofructokinase.
It is considered that it is effective against alopecia caused by the action of hormones, that is, it is not directly affected by the action of hormones, and thirdly, that it has extremely high energy production efficiency. The hair cosmetic composition of the present invention can be used in various forms such as hair tonics, hair tonics, hair lotions, and hair creams according to conventional methods. Furthermore, it can also be used as a shampoo or hair rinse. Ingredients other than organic acid glycerides, such as distilled water, alcohols, polyhydric alcohols, surfactants, oils and fats as a base, may also be blended, and vitamins, etc. as other medicinal ingredients.
Hormones, amino acids, anti-inflammatory agents, vasodilators, skin function enhancers, keratolytic agents, etc. may also be added at the same time. In order to test the hair growth effect of organic acid glycerides, 14 types of samples shown in the table below were prepared and subjected to animal experiments. The results of the experiment are shown in the same table.
In addition, in the table, samples Nos. 1 to 10 used organic acid glycerides as test substances, and were prepared by dissolving them in ethanol. Sample No.11
-13 used succinic acid, malic acid, or lactic acid as test substances, and were prepared by dissolving each of these in ethanol. Sample No. 14 consists only of ethanol. Animal experiments were conducted as follows. A group of 6 to 8 New Zealand White male rabbits weighing approximately 2.5 kg were dehaired from the back.
Only those in the resting phase were subjected to experiments. Apply 0.2 ml of each sample to the back of the telogen but from which hair has been removed.
It was applied twice a week for 30 to 60 days, and the number of days required for telogen hair to convert to anagen hair was determined. In addition,
In the table, "Number of days for promotion" indicates how many days the conversion from telogen hair to anagen hair was promoted compared to when only ethanol was applied (sample No. 14).

【table】

[Table] As is clear from the above table, the compositions of the present invention containing organic acid glycerides (Samples Nos. 1 to 10) exhibit excellent hair growth effects. Next, various examples of the hair cosmetic of the present invention will be shown. In each example, the content of the components constituting the composition is expressed in weight %. Example 1 Hair nourishing agent 90% ethanol 92.5% glyceric acid oleic acid citric acid ester
5.0〃 Olive oil 1.0〃 Glycyrrhizin 1.0〃 Fragrance 0.5〃 Example 2 Hair nourishing agent 90% ethanol 89.5% Glycerin distearate malate ester
3.0〃 Liquid paraffin 5.0〃 Polyethylene glycol 2.0〃 Fragrance 0.5〃 Example 3 Hair cream Olive oil 5.0 Liquid paraffin 51.0 Beeswax 1.0 Sorbitan sesquiolate 3.0 Glycerin myristate pyruvate ester
10.0 Refined Water 30.0 Examples 4 Hair Tonitsuku Glycerinolauric acid Estel 3.0 Estel 3.0 Thagalashitinki 0.5 Hinokituru 0.1 α -Tokov Erotic 0.3 Warfish oil 10.0 Ethanol 86.1 Example 5 Shampoo Laurelirle Tel sodium Sodium 5.0 % α -α -α -α -α -α 10.0 % sodium luhonlate Ethanolamine 5.0% Glyceryl palmitate fumarate ester
1.5% Purified water 78.5% When the hair cosmetic of this invention was used on patients with alopecia, it was found to be effective against a wide range of alopecia, especially androgenetic alopecia such as juvenile alopecia and middle age alopecia, as well as circular alopecia. It has been revealed that it has an excellent hair growth effect on alopecia. Further, no side effects are observed when using the hair cosmetic of the present invention. When the hair cosmetic of the above-mentioned example was subjected to a skin irritation test using a closed patch test on 25 healthy people, all results were negative (positive rate 0).
%). As described above, all hair cosmetics according to the present invention are highly safe.

Claims (1)

[Scope of Claims] 1. A hair cosmetic containing 0.1 to 10% by weight of an organic acid glyceride represented by the following general formula [], [], [], [], or [] as a hair growth ingredient. . [Formula] [Formula] [Formula] [Formula] [Formula] (However, R represents a fatty acid residue, and R ₁ represents an acid residue selected from polybasic carboxylic acids, oxyacids, and ketonic acids.)