JP2977648B2 - Hair restoration cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth cosmetic which promotes peripheral blood flow of the scalp and activates hair matrix cells, and has an excellent hair-growth effect, a hair loss-preventing effect, and an anti-dandruff effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as pepper tincture and nicotinic acid derivatives or activators of scalp skin cells such as assembly extract and Korean ginseng extract have been blended. 2. Description of the Related Art Nourishing cosmetics are known. More recently, a number of hair-growing cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. Also, cell activators have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

[0004] On the other hand, androgenetic alopecia is said to be one of the causes due to excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, etc. Is presumed to be caused by complicated intertwining.

[0005] Therefore, at present, simply using an androgen-suppressing component does not bring about hair growth. Furthermore, even if an antiandrogen is used as a hair restorer in order to suppress the hyperplasia of the sebaceous glands, which is said to be caused by the excessive action of androgen, the effect is not sufficient.

[0006] The forsythia extract according to the present invention is a substance that has been used as a detoxification, drainage, anti-inflammatory and diuretic. However, it was not known that the forsythia extract had hair growth and hair growth effects. Examples of the composition of the forsythia extract include an oral composition (JP-A-63-60918), a deodorant (JP-A-63-5754), and a deodorant (JP-A-63-21059). However, no application as a hair nourishing cosmetic was found.

Accordingly, an object of the present invention is to provide a hair restoration cosmetic which promotes peripheral blood flow of the scalp, activates hair matrix cells, and has excellent hair growth, hair loss prevention and dandruff prevention effects. .

[0008]

Means for Solving the Problems In order to achieve the above object, the present inventors have conducted various studies on promoting peripheral blood flow of the scalp and activating hair matrix cells. It has been found that hair cosmetics exhibit excellent hair growth and hair growth effects.

[0009] The forsythia extract according to the present invention is a component extracted from the fruits of Forsythia or Chinese Forsythia native to China of the Oleaceae family, or Korean Forsythia native to the Korean Peninsula. The components to be extracted are oleanolic acid, a triterpenoid, phillyrin, lignans, and pinore.
sinol, arctiin, matairesinol, matairesinoside,
Forsythoside A, a caffeic acid derivative, and the like.
As the extraction solvent, hot water, hydrous alcohol, alcohols, acetone, ethyl acetate, chloroform and the like can be used. In particular, a 10-90% aqueous ethanol solution is preferred as the extraction solvent.

[0010] In the following text, the compounding amount is indicated based on the pure content (converted to the dry residue) of the extract obtained by extraction with water or a 50% aqueous ethanol solution.

The compounding amount of the forsythia extract of the present invention in the hair-growing cosmetic is 0.001 to 5.0% by weight based on the total amount.
And more preferably 0.005 to 2.0 wt.
%. That is, if the amount is less than the lower limit, the desired effects of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, the effect corresponding to the increase cannot be expected.

The hair nourishing cosmetic composition of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc., according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a keratolytic agent, an antiandrogen,
An antioxidant and the like can be appropriately compounded as long as the object of the present invention is achieved.

[0014]

The present invention will be described below in detail with reference to examples and comparative examples. In addition,% shown in an Example shows weight%.

The test methods for promoting mouse hair growth, the test methods for promoting human hair growth, and the practical test methods described in the Examples are shown below.

(1) Mouse Hair Growth Promotion Effect Test Method The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight 35 g) was cut with an electric hair clipper, and completely depilated with a depilatory cream. From the next day, each sample of Example and Comparative Example was applied twice daily in the morning and evening on the skin of the test part, 0.2 g per animal.
Applied. A group of 10 animals was used for one sample. In addition, a base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed, and 20 hairs were randomly removed from the sample application site, measured for each length, and the average value of each group was calculated. Next, a value obtained by dividing the average value of the examples or the comparative examples by the average value of the control group was used as the hair growth promoting effect in the determination.

(2) Test Method for Promoting Human Hair Growth The hair of 10 test subjects, who are male pattern baldness, was shaved at a position 5 cm above the ears of the head into circular shapes of 1 cm in diameter at two places on the left and right. About 3 ml of the sample of the example or the comparative example was applied on the left side twice a day every morning and evening to the hairy test site, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test by shaving 20 hairs on each of the left and right test sites and averaging the length of the 20 hairs on the left side (to which the example or the comparative example was applied) (B ) Was divided by the average value (A) of the lengths of the 20 hairs on the right side (untreated), and the judgment results were shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical Test Method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results show that the hair growth effect, the hair loss prevention effect, and the anti-dandruff effect are “hair has become bristle or hair has increased,” “hair loss has decreased,” and “hair loss has decreased. The number of respondents. "

Examples 1 to 6, Comparative Examples 1 to 3 Oily hair tonic In the raw material composition shown in Table 1, active ingredients were blended as shown in Table 2 to prepare hair tonics, and the above-mentioned various tests were carried out. In addition, the pepper tincture used in the comparative example was the one described in the Japanese Pharmacopoeia.

[0020]

[Table 1]

[0021]

[Table 2]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the components (A) and (B) are mixed, stirred and dispersed. Fill. When used, the contents are shaken and dispersed uniformly.

(2) Characteristics The results of various tests performed on each oily hair tonic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had low mouse and human hair growth promoting effects, and the results of practical tests were not good. Particularly in Comparative Example 1 containing pepper tincture, three persons complained of mild skin irritation in a practical test.

On the other hand, the hair restoration cosmetics of the present invention of Examples 1 to 6 exhibited a high hair growth promoting effect, and clearly showed good results in all the tests. Examples 1 to 6 did not cause any skin irritation in various tests on human skin.

Examples 7 to 12 and Comparative Examples 4 to 6 Hair cream In the raw material composition shown in Table 3, active ingredients were blended as shown in Table 4 to prepare a hair cream, and various tests were carried out.
The results are shown in the right column of Table 4.

[0026]

[Table 3]

[0027]

[Table 4]

(1) Preparation method After dissolving the component (B) shown in Table 3 in the component (A) or the component (C), the components (A) and (C) are dissolved by heating to 80 ° C and mixed. did. Further, when cooled to 50 ° C. while stirring, the component (D) was added, and stirring was continued to 30 ° C. to prepare each hair cream.

(2) Characteristics As shown in Table 4, Examples 7 to 12 exhibited a high hair growth promoting effect, and exhibited excellent results over all tests.

On the other hand, Comparative Examples 4 to 6 were clearly inferior in various properties as compared with the hair creams of Examples of the present invention.

[0031]

As described above, the present invention improves peripheral blood flow of the scalp, activates hair matrix cells, and is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect,
It is clear to provide hair nourishing cosmetics without skin irritation.

Continuation of the front page (56) References JP-A-2-48517 (JP, A) JP-A-63-60918 (JP, A) JP-A-63-21059 (JP, A) JP-A-63-5754 (JP) , A) (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/06

Claims (1)

(57) [Claims] A hair nourishing cosmetic comprising a forsythia extract.