JPH01308214A - Hair tonic - Google Patents

Abstract

PURPOSE:To provide a hair tonic containing a specific compound as an active component, free from said effect and exhibiting excellent trichogenic effect to alopecia. CONSTITUTION:The objective hair tonic contains the compound of formula [R<1> is (hydroxyl-substituted) 20C acyclic branched higher aliphatic hydrocarbon group] or its salt as an active component. The amount of the compound of formula in the hair tonic is usually 0.1-10wt.%, preferably 0.1-5wt.%. The hair tonic may be incorporated with amino acids, hormones, anti-inflammatory agents (e.g., extract of the root of Lithospermum officinale), vasodilators (e.g., nicotinic acid), etc., provided that these additives have no inhibitory action to the above active compound. The agent is used in the form of hair tonic, hair cream, etc., prepared by conventional method.

Description

DETAILED DESCRIPTION OF THE INVENTION "Industrial Application Field" The present invention relates to a novel hair nourishing agent.
Maximum [I] R"OH[I] 1 In the formula, R1 represents an acyclic branched higher aliphatic hydrocarbon group having 20 carbon atoms which may be substituted with a hydroxyl group." This invention relates to a hair tonic containing salt as an active ingredient.

[Conventional technology] Conventionally, various active ingredients have been used in hair nourishing agents.
Amino acids such as serine and methionine;
Vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as salicylic acid and purple root extract; hormonal agents such as estradiol; vitamins such as vitamin E; keratolytic agents; humectants; fragrances; anti-dandruff agents; Hair tonics are known that contain ingredients such as hair follicles, fatty acids, and the like.

Further, JP-A No. 60-4113 describes alcohols or derivatives thereof having an odd carbon chain length as an active ingredient of a hair tonic. Furthermore, JP-A-6L-207
321Q has 22 to 22 carbon atoms as an active ingredient of hair growth agent.
Thirty-four higher aliphatic alcohols have been described.

[Problems to be Solved by the Invention] However, the hair growth effects of all of the hair growth agents to date have been limited to only 70%.

[Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventors conducted extensive research on substances that exhibit excellent hair growth effects against alopecia without causing any side effects. - It has been discovered that a compound represented by maximum [I] or a salt thereof exhibits an excellent hair growth effect, and the present invention has been completed.

An object of the present invention is to provide a hair tonic containing as an active ingredient a compound that exhibits an excellent hair growth effect.

In the compound of general formula [E], what number of carbon atoms may be substituted with a hydroxyl group in R1? The acyclic branched higher aliphatic hydrocarbon group of O is, for example, a phydyl group (3,7,11,15-te1-lamethyl-2-hex!).
thick decen-1-yl group), isophyl group (3,7,
11,15-te]~ramythyl-1-hexadecene-3-
yl group), granyl linalyl group (3゜7.11.15-
Te1~ramethylhex]nadecane-1,6,10゜14
-yl~l error 3-yl group), 7-hydroxymethyl-3,11,15-1~keyleapcan-
Examples include groups such as 2.6,10.14-teI-laen-1-yl group and 2,3-dihydroxy-3,7,11,15-te1-lamethylhexadecan-1-yl group.

- Salts of compounds of maximum [I] include salts with alkali metals such as sodium helium and potassium; salts with alkaline earth metals such as magnesium and calcium.

Furthermore, if isomers (e.g., optical isomers, geometric isomers, tautomers, etc.) exist in the maximum [I] compound or its salt, the present invention includes all such isomers. , and the crystalline forms and solvates of .

The content of the compound in the hair tonic (by weight) of the present invention is not particularly limited and may be selected from a wide range, but is usually 0.1 to 10% by weight, preferably The hair growth agent of the present invention may contain amino acids (serine, methionine, etc.) and hormones (progesterone, etc.) conventionally used in hair growth agents, as long as they do not impair their effects. , estradiol, etc.), anti-inflammatory agents (purple root extract, glycyrrhizinic acid, hydrocortisone acetate, etc.), vasodilators (di'tinic acid, minoxidil, etc.), herbal extracts (Japanese cabbage extract, ginseng extract, etc.), anti-dandruff agents (hinokitiol, etc.) , sulfur, etc.), cooling agents (1-menthol, camphor, etc.), humectants (glycerin, mucopolysaccharides, pyrrolidone carboxylic acid, etc.), keratolytic agents (urea, resorcinol, etc.), fragrances (lavender oil, nectar), , bergamot, etc.), vitamin A1, vitamin F derivatives, vitamin B6, vitamin H, lecithin, fatty acids, etc., may be used by adding one or more of them.

Examples of base materials include purified water, -hydric alcohols (ethanol, isopropyl alcohol, etc.), polyhydric alcohols (glycerin, propylene glycol, etc.), higher fatty acids (palmitic acid, linoleic acid, etc.)
, fats and oils (fatty acid glycerides, olive oil, squalene, honey, etc.), liquid paraffin, surfactants (
Polyoxyethylene hydrogenated castor oil, suderyltrimethylammonium chloride, distearyldimethylammonium chloride, sodium lauryl sulfate, etc.), emulsifiers (cetyl alcohol), solubilizers, etc. can be used.

The hair tonic of the present invention can be prepared and used in various dosage forms such as hair cream, hair lotion, or hair spray according to conventional methods.

Next, the effects of the hair growth agent of the present invention will be explained.

Hair growth promotion effect test method 6-week-old BD [1. A group of 5 male mice were pricked with a safety razor from the back to the buttocks. From the next day, 1% (weighted) ) 0.2 d/mouse of ethanol solution containing testosterone was applied once a day for one week. From the 8th molar onwards, the same amount was applied twice a week for 3 weeks.

On the other hand, the test solution was 0.2 g/mouse from the 8th molar of the stinging hair.
F was applied 11 times over 3 weeks (excluding Sundays).

In addition, for the control group, 0.2 d/mouse of a solution (hereinafter abbreviated as mixed solution A) consisting of 85.5 parts by weight of ethanol, 10.0 parts by weight of fukaserin, and 4.5 parts by weight of lees-made ice was used. It was applied once a day from the 8th mound for 3 weeks (excluding Sundays).

New 7ci of the present invention: Hair growth promoting effect by hair nourishing agent (Jl
The degree of hair growth was visually observed every day and determined by the number of mice that grew hair on the entire surface of the stinging site.

In addition, in Table 1, the hair growth promoting effect observed 2 weeks and 3 weeks after administration of the test solution is shown below. −−□ The number of strokes of the test mouse is shown.

Table 1 Test liquid: Example 1 3.0 parts by weight of phytol was added to and dissolved in 97.0 parts by weight of mixed solution A to obtain a liquid.

Example 2 3.0 parts by weight of Isosoy 1 Hele was added to 97.0 parts by weight of mixed solution A and dissolved to obtain a liquid preparation.

Example 3 Add 3.0 parts by weight of phytantriol to the mixed solution (97.0 parts by weight)
Parts by weight were added and dissolved to obtain a liquid preparation.

Example 4 1-pentadecanoylglycerol was added to mixture A 97. 0 parts by weight was added and dissolved to obtain a liquid preparation.

As is clear from these results, the hair growth agent of the present invention exhibits an excellent hair growth promoting effect.

[Effects of the Invention] The compound of the present invention represented by the general formula % "In the formula, R1 has the same meaning as described above" or a salt thereof can be used as a hair tonic.

[Example] Next, as an example of the present invention, the dosage form of the hair tonic of the present invention is shown together with its composition (% by weight), but the present invention is not limited thereto.

Example 1 (hair lotion) (Ingredients) Contains M (wt%) "95% ethanol 80

Claims (1)

[Claims] (1) A compound represented by the general formula R^1-OH "In the formula, R^1 represents an acyclic branched higher aliphatic hydrocarbon group having 20 carbon atoms which may be substituted with a hydroxyl group." Or a hair tonic containing its salt as an active ingredient.