JPH01135711A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic promoting hair growth and hair production, preventing removal of hair, suppressing secretion of sebum, having no side effects, comprising a substance having a specific alpha,beta-unsaturated ketone structure or a purified oil consisting essentially of the substance as an active ingredient. CONSTITUTION:A hair tonic containing one or more (e.g., preferably pennyroyal oil, mountain mint oil or American wild mint oil containing 65-95% pulegone) selected from pulegone, piperitenone, isopiperitenone, carvenone, cyclocivenone, diosphenol, calahanaenone, compounds having an alpha,beta-unsaturated ketone structure and purified coils consisting essentially of these substances as an active ingredient. The amount of the substance blended is substantially 0.001-5.0wt.%, preferably 0.1-3.0wt.% in a base of hair tonic.

Description

Detailed Description of the Invention [Field of Industrial Application] The present invention provides a novel nutritional supplement containing as an active ingredient a substance having a specific α,β-unsaturated ketone structure or an essential oil containing such substance as the main ingredient. More specifically, the purpose of the present invention is to provide a hair nourishment that improves or normalizes the functions of the hair and scalp and has excellent nourishing and hair growth effects.

[Prior Art] Various hair nourishing agents have been used for the prevention and treatment of various physiological symptoms such as baldness, thinning hair, dandruff, and seborrhea.

In general, as a combination drug of Gomoryo, so-called hair growth agent,
It is mainly used for the purpose of promoting blood circulation in the scalp, activating hair matrix cells, suppressing scalp lipid secretion, and providing nutrition to the hair.For example, vitamin E and its derivatives, carpronium chloride, swertianogen extract),
Vasodilators such as Reingen, female hormones such as estradiol and ethinyl estradiol, skin function promoters such as pantothenic acid and its derivatives, cephalanthine and mononitroguaiacol, keratolytic agents such as salicylic acid, resorcin, and benzalkonium chloride. Various ingredients have been used, including disinfectants, anti-inflammatory agents such as glycyrrhetinic acid and allantoin, vitamins such as vitamin 86, and amino acids such as methionine and serine. By externally applying a hair tonic containing these ingredients, it is expected to suppress dandruff and itching, prevent or suppress hair loss, and furthermore exhibit the effect of promoting hair growth and growth.

In addition, in recent years, it has been said that excess or imbalance of male hormones is the cause of hair loss, and the addition of anti-androkening agents to hair growth preparations has been considered.In particular, for androgenetic alopecia, 5α-dihydrotestosterone, an active hormone, is being considered. It has been suggested that this may be involved, and research and development efforts are underway to suppress this generation.

In other words, 5α-dihydrotestosterone is known to be produced when testosterone is reduced by testosterone-5α-reductase in hair color, and from this, inhibiting testosterone-5α-reductase can prevent the occurrence of androgenetic alopecia. It is thought that it can be prevented and suppressed.

Antagonists that specifically inhibit testosterone-5α-reductase are being sought. Substances such as spironolactone and progesterone have been discovered as such anti-androgen agents, and their effectiveness as hair restorers has been reported.

[Problems to be solved by the invention] Hair tonics are effective in promoting hair growth, preventing hair loss, suppressing sebum secretion, and treating dandruff and itching. A highly safe product that does not cause skin irritation or skin irritation is desired.

However, although conventional hair nourishing agents are useful in terms of preventing hair loss and improving the scalp, there are few that actively promote hair growth and hair growth. There were some things that I wasn't completely satisfied with.

In addition, the progesterone mentioned in Men is reported to be very effective as a hair tonic, but on the other hand, it is also known to have hormonal effects, and other testosterone-5
Even in the case of steroidal compounds that are α-reductase inhibitors, there is a concern that they may exhibit some or all undesirable hormonal effects, and in this respect as well, they have not been fully satisfactory.

[Means for Solving the Problem] In view of the above circumstances, the present inventors have developed a method that has even more excellent nourishing and hair-growth effects, and at the same time has no adverse effects such as hormonal effects.
As a result of various studies to obtain a highly safe hair growth agent,
Substances with specific α,β-unsaturated ketone structures or essential oils containing these substances have excellent nourishing and hair growth promoting effects, are extremely effective as hair nourishing agents, and are also safe. With this knowledge, we have completed the present invention.

That is, the present invention relates to a hair tonic containing one or more selected from pulegone, piperitenone, isopiperitenone, carbenone, cyclocypenone, diosphenol, carahanaenone, and essential oils containing these substances as main components.

The configuration of the present invention will be explained below.

In the present invention, brevon, piperitenone, isopiperitenone, carbenone, cyclocypenone, diosphenol, and carahanaenone are compounds having an α,β-unsaturated ketone structure, and these substances can be synthesized or derived from natural plants. It is possible to use rrim from the essential oil obtained by extraction and purification. Similarly, essential oil itself containing the listed substance as a main component can also be suitably used. For example, 65-95% pulegone
3 infused benny royal oil, mountain mint oil, American wild pepper oil and piperitenone.
Particularly preferred essential oils include Megsabatuka oil containing 0% and 65% pulegone.

In the present invention, these specific α.

One or more of the substances or essential oils having a β-unsaturated ketone structure are selected and used in combination as necessary.

For Formulation +1, it is important to use an effective amount of the listed substance that can achieve the desired purpose, and considering the appearance, odor, etc. of the final product, although not limited, substantially 0. 0
01-5.0% by weight, preferably 0.1-3.0% by weight
It may be used within the range of .

Thus, the specific substance or rust oil according to the present invention is
By applying it to the hair and scalp, it promotes the normalization or normalization of its functions and exhibits excellent nourishing and hair-growth effects. In addition, for the above specific substances and sesame oil, a patch test on humans,
An animal test using continuous application using domestic rabbits has confirmed that it is highly safe and does not cause skin irritation.

The hair tonic according to the present invention can be applied by blending it into various forms of base materials commonly known as hair products in accordance with conventional methods. Specific examples of these include hair tonics, hair liquids, hair lotions, hair creams, hair rinses, hair shampoos, hair setting lotions, hair sprays, hair bags, and the like.

The components that make up these base materials include purified water,
Alcohols, polyhydric alcohols, mineral oils, fats and oils, higher fats, oils such as higher alcohols, surfactants, skin beautifying ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances, etc., and regular cosmetics. The components may be appropriately selected and used from among the components that can be used.

In addition to the essential ingredients of Moeki, the present invention also contains vasodilators, female hormones, skin function brighteners, local stimulants, keratolytic agents, anti-inflammatory agents, bactericidal agents, and vitamins, which are commonly known as hair tonic ingredients. , amino acids, herbal medicine extracts, moisturizing agents, etc., may be used in combination as necessary in the hope of further enhancing the nourishing and hair-growing effects.

[Example] Next, the present invention will be further explained with reference to Examples. These do not limit the present invention in any way.

Example [11] In order to confirm the effects of the present invention, samples were prepared as shown below, and then a test for promoting effect on nourishing and hair growth was carried out for evaluation and investigation).

Preparation of Samples Using a 60% by weight aqueous ethanol solution, each specimen was added at various concentrations as shown in Table 1 to prepare samples. In addition, the addition concentration is weight %.

Table 1 Nutrient/Hair Growth Promotion Effect Test A group of 7 Hartley guinea pigs (female) weighing approximately 400 g were used. Hair was removed from the back of each guinea pig, and the right side was used as a control side without application, and the left side was used as a test side. 1)～(1
After applying 0.1 ml of each of 0) twice a day for 22 days, hair was randomly removed from the applied and non-applied areas.
By examining the difference in the average length of 10 hairs between the control side and the test side, the elongation speed was determined and the effect on the growth of the guinea pig's body hair was investigated.

The results are shown in Table 2.

(Leaving space below) Table 2 Number of total animals As seen in Table 2, samples (1) to (9), that is, when the substance or essential oil according to the present invention was applied, the non-applied area on the control side, and Compared to those to which only ethanol solution was applied, hair growth was faster, especially in sample (1).
) to (4) and (8) to (9), this was remarkable.

As described above, it can be seen that the substances and essential oils according to the present invention promote hair growth and are extremely excellent hair nourishing agents.

Actual Mi example [2] Hair lotion (prescription) (city 1ii%) (1)
Camphor 0.05 (2)
Capsicum tincture 0.1 (3) f
f1-Menthol 0.1 (4) Vitamin E acetate 0.05 (Pulegone 1.5 (6) Denatured ethanol 60.0 (71 Fragrance
Appropriate amount (8) Purified water
Remaining amount example [3] Hair cream (formulation) (weight%) (1)
Stearic acid 0.5(2)
Squalane 1.0 (3) Liquid paraffin 40.0 (4) Polyoxyethylene cetyl 1.5 Ether (20E, 0
．． ) (4 Polyoxyethylene cetyl 2.5 ether ('5 E, O,) ((to) Sorbitan monostearate 1.5 (
7) Methylparaben 0.1 (8)
Triethanolamine 1.0 (9)
1.3-butylene gellicol 5.0 (10)
Piperitenone 1.0 (11)
Fragrance Amount 02) Purified water Remaining amount Example [4] Hair shampoo (prescription) (wt%) (11 Sodium alkyl ether sulfate 16. ROM (2) Lauric acid jetanolamide 4.0 (
3) Propylene glycol 2.0 (4
) Preservative appropriate amount (5) Pigment
Appropriate amount (6) Fragrance
Appropriate amount (7) Benny royal oil 1.0 (8) Purified water
Examples [2] to [4] were manufactured according to a conventional method and made into products.

[Effects of the Invention] As explained above, according to the present invention, substances having a specific α,β-unsaturated ketone structure or essential oils containing these substances as main components effectively exhibit a hair growth promoting effect. By incorporating Ni, the function of the hair and scalp is improved and normalized, and the effect of promoting nourishment and hair growth can be measured.In addition, we have obtained a hair nourishment that is highly safe and excellent in comparison to Ni. It is now possible to provide this.

2. Applicant: Kobayashi Kose Co., Ltd.

Claims (1)

[Claims] (1) A hair nourishment containing as an active ingredient one or more selected from pulegone, piperitenone, isopiperitenone, carbenone, cyclocypenone, diosphenol, carahanaenone, and essential oils containing these substances as main ingredients.