JP2008110992A - Antibacterial composition and skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antibacterial composition which can synergistically reinforce respective antibacterial actions of hinokithiol and triclosan or isopropylmethylphenol even in various states of the skin and the scalp which differ in the amount and the ratio of sweat and sebum, and a skin care preparation comprising the antibacterial composition. <P>SOLUTION: The antibacterial composition for anti-Staphylococcus epidermidis, anti-propionibacterium acnes, anti-Malassezia furfur and the like comprises hinokithiol and triclosan and/or isopropylmethylphenol and the skin care preparation comprises the composition. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an antibacterial composition and an external preparation for skin containing the antibacterial composition.

  It is said that body odor such as odor that gives a person unpleasant feeling is caused by sweat mixed with sebum, which is decomposed by Staphylococcus epidermidis.

  The occurrence of acne is said to be related to the growth of Propionibacterium acnes, an endodermal follicle bacterium, and the lipase produced by this acne decomposes sebum to produce fatty acids, thereby causing inflammation. It is supposed to be.

  Dandruff is composed of secretions of sebaceous glands and sweat glands, exfoliation of the epidermis, etc., and the scalp is stimulated by the proliferation of dandruff-causing fungi (Malassezia furfur), and the occurrence of dandruff is promoted.

  Conventionally, in order to suppress the generation of body odor, acne, and dandruff caused by the skin, compounds having antibacterial activity have been used in the skin resident bacteria that are these causative bacteria (for example, Patent Documents 1 to 6). See).

  On the other hand, sweat glands and sebaceous glands exist in human skin and scalp, and the amount of sweat and sebum varies from time to time, and the antibacterial activity of antibacterial compounds differs between the state where there is a lot of sweat (moisture) and the amount of sebum There was a possibility.

  Therefore, a deodorant agent that can maintain antibacterial activity against odor-causing bacteria has been reported by using triclosan and isopropylmethylphenol in combination with a skin state that secretes a lot of sweat and a skin state that secretes a lot of sebum (patent) Reference 7).

  However, the above-described technology has been limited to the ability to maintain antibacterial activity against odor-causing bacteria even in different skin conditions, and cannot synergistically enhance the antibacterial activity of each of the antibacterial compounds. In addition, no antibacterial activity has been reported for acne bacteria and dandruff-causing bacteria in different skin and scalp conditions.

JP-T-2004-521145 Special table 2007-529445 gazette JP-A-7-33624 JP 2006-213633 A Japanese Patent Laying-Open No. 2005-53867 JP 2005-179216 A JP 2006-96719 A

  The present invention has been made in view of the above prior art, and has antibacterial activity possessed by hinokitiol and triclosan or isopropylmethylphenol even in various skin and scalp skin conditions with different amounts and ratios of sweat and sebum. It is an object of the present invention to provide an antibacterial composition that can be synergistically enhanced, and an external preparation for skin containing the antibacterial composition.

That is, the present invention
[1] An antibacterial composition containing hinokitiol and triclosan and / or isopropylmethylphenol, and [2] an external preparation for skin comprising the antibacterial composition of [1] About.

  The antibacterial composition according to the present invention synergistically enhances the antibacterial activity inherent to each of hinokitiol and triclosan or isopropylmethylphenol, even in various skin and scalp states with different amounts and ratios of sweat and sebum. There is an effect that can be.

  Moreover, since it exhibits excellent antibacterial activity against odor-causing bacteria, acne bacteria, and dandruff-causing bacteria, it is a deodorant agent that exhibits anti-odor odor-causing bacteria effects, an acne skin external preparation that exhibits anti-acne bacteria effects, It is useful as an external preparation for skin, such as anti-dandruff hair cosmetics, that exhibits the effect of dandruff-causing bacteria.

  The antibacterial composition according to the present invention contains hinokitiol and triclosan and / or isopropylmethylphenol (hereinafter abbreviated as IPMP) as essential components.

  In the antibacterial composition according to the present invention, the contents of hinokitiol as the first component and triclosan and / or IPMP as the second component are not particularly limited, but preferably 0.1: 1 by weight. -10: 1, more preferably 0.2: 1 to 5: 1, still more preferably 0.5: 1 to 2: 1. When the content of the first component exceeds 10 parts by weight of the second component, and less than 0.1 part by weight, a synergistic enhancing effect of antibacterial activity cannot be expected, which is not preferable.

  In addition to the first component and the second component, the antibacterial composition of the present invention contains a solvent, a surfactant, an antioxidant, a sequestering agent, etc., as long as the effects of the present invention are not impaired. It can mix | blend suitably.

  The antibacterial composition of the present invention can be used by blending with an external preparation for skin. Specifically, it is used for skin external preparations applied to the skin and scalp such as face wash, lotion, milky lotion, skin cream, foundation, lipstick, deodorant agent, acne prevention / treatment agent, shampoo, hair tonic, hair restorer. Can do. In particular, since it exhibits excellent antibacterial activity against odor-causing bacteria and acne bacteria, it can be suitably used for acne skin external preparations such as deodorant agents and acne prevention / treatment agents. Also, because it exhibits excellent antibacterial activity against dandruff-causing bacteria, it is suitable for use in hair tonics, dandruff lotions, scalp cosmetics such as scalp refreshers, and anti-dandruff hair cosmetics such as shampoos and other detergents. be able to.

  When the antibacterial composition of the present invention is blended in a skin external preparation, the blending amount is not particularly limited, but is 0.001 to 3% by weight, preferably 0.01 to 2% by weight, more preferably 0 in the skin external preparation. .1 to 1% by weight. When the blending amount is less than 0.001% by weight, the antibacterial effect is inferior. When the blending amount exceeds 3% by weight, there may be a problem in safety such as skin irritation. It is not preferable.

  When the skin external preparation of the present invention is used as a deodorant agent, an antiperspirant component, a deodorant component and the like can be further blended.

  Antiperspirant component is a drug that suppresses the generation of sweat by converging the skin. For example, aluminum chloride, aluminum potassium sulfate, aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum, paraphenolsulfonic acid Zinc and the like can be exemplified.

  A deodorant component is a chemical that has the effect of eliminating odors by reacting and adsorbing substances that emit odors or masking odors. For example, metal oxides such as zinc oxide, alkyldiethanolamide, hydroxy Examples include apatite, tea extract, fragrance, and antioxidant.

  The blending amount of the antiperspirant component is not particularly limited as long as the effect of the present invention is exerted, and may be 0.1 to 20% by weight in the external preparation for skin, and more preferably 0.3 to 15% by weight. If the blending amount is less than 0.1% by weight, the deodorant effect is inferior, and if it exceeds 20% by weight, safety problems such as skin irritation may occur. This is also not preferable.

  Moreover, the compounding quantity of a deodorant component will not be specifically limited if the effect of this invention is exhibited, It is good to set it as 0.01-5 weight% in skin external preparations, and it is more preferable to set it as 0.1-2 weight%. preferable. If the blending amount is less than 0.01% by weight, the odor masking effect is inferior. If the blending amount exceeds 5% by weight, the scent may become too strong or the skin may be colored. In some cases, safety problems such as skin irritation may occur, which is not preferable.

  When the external preparation for skin of the present invention is used as an external preparation for acne, keratin softeners such as citric acid, lactic acid, glycolic acid, salicylic acid and their salts, urea, sulfur, etc .; glycyrrhizic acid, glycyrrhetinic acid, allantoin, azulene Anti-inflammatory agents such as indomethacin, ε-aminocaproic acid, camphor, menthol, zinc chloride, zinc white can be blended.

  The blending amount of the keratin softening agent is not particularly limited as long as the effect of the present invention is exhibited, and may be 0.0001 to 10% by weight in the external preparation for skin, and more preferably 0.001 to 5% by weight. In a case where the blending amount is less than 0.0001% by weight, a keratin softening effect and a peeling effect cannot be expected, and even if blending exceeds 10% by weight, no further effect can be expected. It is not preferable.

  The compounding amount of the anti-inflammatory agent is not particularly limited as long as the effect of the present invention is exhibited, and may be 0.001 to 10% by weight in the external preparation for skin, and more preferably 0.01 to 1% by weight. When the amount is less than 0.001% by weight, an anti-inflammatory effect cannot be expected, and when the amount exceeds 10% by weight, no further effect can be expected.

  In the external preparation for skin of the present invention, as long as the effects of the present invention are not impaired, components usually used in cosmetics and quasi-drugs as well as the above-described components can be arbitrarily blended as appropriate. For example, oily components such as fats and oils, waxes, hydrocarbons, silicones, fatty acid esters, higher alcohols, higher fatty acids, etc .; various types of nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants Surfactants; alcohols such as lower alcohols, polyhydric alcohols, saccharides and sterols; thickening polymers such as viscosity minerals and water-soluble polysaccharides; antioxidants; sequestering agents; film-forming polymer compounds; Examples include inorganic pigments, powders, pigments, pigments, dyes, vitamins, amino acids, astringents, whitening agents, animal and plant extracts, acids, alkalis and other additive components; water and the like.

  Specifically, examples of the oil component include oils and fats such as olive oil, camellia oil, macadamia nut oil and avocado oil; waxes such as carnauba wax, candelilla wax, jojoba oil, beeswax and lanolin; liquid paraffin, paraffin, petrolatum, Hydrocarbons such as ceresin, microcrystalline wax, squalene, squalane; methylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclopentasiloxane, methylhydrogenpoly Silicones such as siloxane; isopropyl myristate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, di-2-ethylhexane Neopentyl glycol, glycerol tri-2-ethylhexanoate, 2-octyldodecyl oleate, glycerol triisostearate, glycerol tri-2-ethylhexanoate, 2-octyldodecyl oleate, diisostearyl malate, triisostearic acid Fatty acid esters such as glycerol and 2-ethylhexanoic acid diglyceride; higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, and oleyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid And higher fatty acids such as acid and oleic acid.

  Surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, castor oil, hydrogenated castor oil, and alkylene oxide adducts thereof, polyglycerin fatty acid ester, polyoxyalkylene alkyl ether, polyoxyalkylene fatty acid ester, polyoxyalkylene alkylphenol. Nonionic surfactants such as polyoxyethylene sorbite fatty acid ester, polyoxyethylene alkylphenyl formaldehyde condensate, polyoxyethylene sterol and derivatives thereof, polyoxyethylene lanolin and derivatives thereof, polyoxyethylene beeswax derivatives and sugar esters; Higher fatty acid soap, alkyl sulfate ester salt, alkyl phosphate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl Phenyl ether sulfate, alkyl ether phosphate, alkyl ether carboxylate, acylmethyl taurate, N-acyl-N-methyl-β-alanine, N-acyl glycine, N-acyl glutamate, polyoxyethylene Anionic surfactants such as alkyl carboxylates, alkyl phenyl ether sulfonates, alkyl sulfosuccinic acids and salts thereof, N-acyl sarcosine and salts thereof, polyoxyethylene coconut oil fatty acid monoethanolamide sulfate; alkylamine salts; Alkyl 4 such as fatty acid amide amine salt, amine salt such as ester-containing tertiary amine salt, monoalkyl type quaternary ammonium salt, dialkyl type quaternary ammonium salt, trialkyl type quaternary ammonium salt, benzalkonium type quaternary ammonium salt Grade ammonium salt Cyclic quaternary ammonium salts such as alkylpyridinium salts, cationic surfactants such as benzethonium chloride; glycine types such as alkylglycine salts, carboxymethylglycine salts, N-acylaminoethyl-N-2-hydroxyethylglycine salts Amphoteric surfactants, aminopropionic acid type amphoteric surfactants such as alkylaminopropionate and alkyliminodipropionate, aminoacetic acid betaine type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine And amphoteric surfactants such as sulfobetaine-type amphoteric surfactants such as agents and alkylhydroxysulfobetaines.

  Examples of alcohols include lower alcohols such as ethanol, isopropanol, and butanol; 1,3-butanediol, isoprene glycol, glycerin, polyglycerin, ethylene glycol, polyethylene glycol, polypropylene glycol, 1,2-pentanediol, 1, Examples include polyhydric alcohols such as 2-hexanediol and 1,2-octanediol; saccharides such as sorbitol, mannitol, glucose, sucrose, xylitol, lactose, and trehalose; and sterols such as cholesterol and phytosterol.

  As the thickening polymer, for example, bentonite, smectite, beidellite-based, nontronite-based, saponite-based, hectorite-based, soconite-based, stevensite-based viscous minerals; carrageenan, guar gum, xanthan gum, gum arabic, Examples include karaya gum, tragacanth gum, dextran, amylose, amylopectin, agarose, pullulan, chondroitin sulfate, sodium pectate, alginic acid, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and the like.

  Examples of the antioxidant include α-tocopherol and its derivatives, ascorbic acid and its derivatives, erythorbic acid, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, sulfurous acid, bisulfite, thiosulfuric acid, thiolactic acid, thioglycol An acid, L-cysteine, N-acetyl-L-cysteine, etc. can be mentioned.

  Examples of the sequestering agent include edetate, phosphoric acid, sodium polyphosphate, sodium metaphosphate, alanine, sodium oxalate, nitrilotriacetic acid, 1,2-diaminocyclohexane-tetraacetic acid, N-oxyethylethylenediamine- Triacetic acid, ethylene glycol bis-tetraacetic acid, ethylenediamine-tetrapropionic acid, 1-hydroxyhexane-1,1-diphosphonic acid, phosphonoacetic acid, diethylenetriaminepentaacetic acid, 1,2-cyclohexanediaminetetraacetic acid, ethylenediaminediacetic acid, triethylene Examples thereof include tetramine hexaacetic acid.

  The external preparation for skin of the present invention can be used as pharmaceuticals, quasi drugs, cosmetics and the like. Specifically, it can be used in various forms such as lotions, aerosols, sticks, powders, roll-ons, creams, gels, emulsions, sheet preparations, etc., and preparations may be produced by generally known methods. .

<Test Example 1>
Staphylococcus epidermidis IAM1296 was used as the odor-causing bacterium. Propionibacterium acnes ATCC 6916 was used as the acne-causing bacterium. As a dandruff-causing bacterium, Malassezia furfur (Malassezia furfur NBRC0656) was used.

(Preparation of inoculum solution)
Staphylococcus epidermidis and Propionibacterium acnes as inoculum liquids were cultured at 35 ° C. on an agar medium, then transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution with a bouillon medium to about 10 ⁷ cells / mL was used as a bacterial solution for inoculation. Propionibacterium acnes was anaerobically cultured.

In addition, malassezia furful was cultured at 30 ° C. on an agar medium, then transplanted to a bouillon medium and cultured at 30 ° C. A solution obtained by diluting the obtained culture solution with a bouillon medium to about 10 ⁷ cells / mL was used as a bacterial solution for inoculation.

(Preparation of dilution series)
Hinokitiol (Comparative Example 1), Triclosan (Comparative Example 2), and IPMP (Comparative Example 3) were prepared to 3000 μg / mL using 70% ethanol as a diluent solvent, and diluted serially to 11 stages to prepare a dilution series. .

  Moreover, the dilution series was similarly prepared about the equivalent mixture (Example 1) of hinokitiol and triclosan, and the equivalent mixture of hinokitiol and IPMP (Example 2).

(Measurement of minimum bactericidal concentration (MBC))
For each 1 mL of the dilution series containing each test substance, 9 mL of each agar medium was placed in a petri dish, and each of the inoculums was streaked to a length of about 1 cm. Culturing was carried out at 35 ° C. for Staphylococcus epidermidis and Propionibacterium acnes, and the presence or absence of growth of the bacteria after 5 days was determined. Moreover, about malassezia furfur, it culture | cultivated at 30 degreeC and the presence or absence of the growth of a microbe after 5 days was determined. Propionibacterium acnes was anaerobically cultured.

  At a concentration at which no growth was observed, the bacteria were collected from the inoculated streaks, transplanted to a fresh agar medium, and further cultured for 3 days. At this time, the minimum concentration at which no growth was observed was determined as MBC, and the concentration of each component at that time was shown in Tables 1 to 6 (without addition of treolein). Tables 1 and 2 relate to Staphylococcus epidermidis, Tables 3 to 4 relate to Propionibacterium acnes, and Tables 5 to 6 relate to Malassezia flufur.

(Examination of the effects of sebum components)
In order to examine the bactericidal effect due to the influence of sebum components, treolein was added as a sebum component and the following test was performed. That is, for each 1 mL of the dilution series containing each test substance, 0.1 wt% triolein and 8.9 mL of agar medium were placed in a petri dish, and for each, the inoculum was about 1 cm long as described above. Streaked and cultured.

  After determining the presence or absence of growth of the bacteria after 5 days, MBC was determined in the same manner as described above, and the concentration of each component at that time was shown in Tables 1 to 6 (added with treolein). Tables 1 and 2 relate to Staphylococcus epidermidis, Tables 3 to 4 relate to Propionibacterium acnes, and Tables 5 to 6 relate to Malassezia flufur.

  The antibacterial activity can be evaluated by MBC. When the test substance concentration is low, there is no effect on microorganisms, but as the concentration is increased, growth inhibition occurs, and then growth stops. As the concentration increases further, the microorganisms will die. The density at this time is expressed as MBC.

  From the results of Tables 1, 3 and 5, hinokitiol alone (Comparative Examples 1-1 to 1-3) or triclosan alone (Comparative Examples 2-1 to 2-3) has MBC due to the presence of triolein which is a sebum component. It becomes high and it turns out that antibacterial activity falls. On the other hand, when hinokitiol and triclosan were used in combination (Examples 1-1 to 1-3), MBC was remarkably low in the presence and absence of treolein, and the antibacterial activity of both was synergistically remarkable. It can be seen that it is enhanced.

  In addition, from the results of Tables 2, 4, and 6, from hinokitiol alone (Comparative Examples 1-1 to 1-3) or IPMP alone (Comparative Examples 3-1 to 3-3), due to the presence of triolein as a sebum component, It can be seen that MBC increases and antibacterial activity decreases. On the other hand, when hinokitiol and IPMP were used in combination (Examples 2-1 to 2-3), MBC was extremely low in the presence and absence of treolein, and the antibacterial activity of both was synergistically remarkable. It can be seen that it is enhanced.

  As described above, from the results of Tables 1 to 6, the antibacterial composition of the present invention synergistically has the antibacterial effect inherent in each of hinokitiol and triclosan or isopropylmethylphenol, even in a skin state with a lot of sweat or a skin with a lot of sebum. It can be seen that the antibacterial activity superior to the normal skin bacteria such as the odor-causing bacteria, acne bacteria, and dandruff-causing bacteria can be demonstrated in various skin conditions.

<Test Example 2: Deodorant agent>
(Sample preparation)
According to the composition described in Table 7, each deodorant agent of Examples 3 to 4 and Comparative Examples 4 to 6 was prepared by a conventional method and subjected to the following evaluation. In addition, the compounding quantity in a table | surface represents weight%.

(Evaluation of deodorant)
For 10 male subjects determined to have a strong odor, each sample was applied to one armpit of the subject, and the other armpit was not applied as a control. The odor was determined according to the following evaluation criteria before and immediately after application and after 3 hours, and the average value was adopted. The results are shown in Table 7.

<Evaluation criteria>
No odor ... 0 point Slightly odor ... 1 point Slightly odor is weak ... 2 points Clear odor ... 3 points Very strong odor ... ... 4 points

  From the results in Table 7, it can be seen that the deodorant agent of the present invention has an excellent deodorizing effect and also maintains the effect.

<Test Example 3: Acne skin preparation for acne>
(Sample preparation)
According to the composition described in Table 8, each of the acne skin external preparations of Examples 5 to 6 and Comparative Examples 7 to 9 was prepared by a conventional method and subjected to the following evaluation. In addition, the compounding quantity in a table | surface represents weight%.

(Evaluation of acne skin external preparation)
Each sample was applied to one subject's cheek to 10 patients with acne for 2 weeks a day for 4 weeks, and the number of people with improvement was determined according to the following evaluation criteria. The results are shown in Table 8.

<Evaluation criteria>
Effective: Improvement of acne is observed.
Slightly effective: Slight improvement in acne is observed.
Invalid: Acne is not improved.

  From the results in Table 8, it can be seen that the acne skin external preparation of the present invention exhibits an excellent acne improving effect.

<Test Example 4: Anti-dandruff hair cosmetic>
(Sample preparation)
According to the composition described in Table 9, each hair tonic of Examples 7-8 and Comparative Examples 10-12 was prepared by a conventional method and subjected to the following evaluation. In addition, the compounding quantity in a table | surface represents weight%.

(Evaluation of anti-dandruff hair cosmetics)
Ten subjects who were aware of dandruff were allowed to use each sample twice a day for 4 weeks, and the number of people who improved was determined according to the following evaluation criteria. The results are shown in Table 9.

<Evaluation criteria>
Effective: Improvement of dandruff is recognized.
Slightly effective: Slight improvement in dandruff is observed.
Invalid: Dandruff is not improved.

  From the results of Table 9, it can be seen that the anti-dandruff hair cosmetic of the present invention exhibits an excellent anti-dandruff effect.

  Hereinafter, the formulation example of the external preparation for skin concerning this invention is shown. In addition, a compounding quantity is weight%.

(Formulation Example 1: Liquid deodorant)
Zinc paraphenol sulfonate 2.0
Ethanol 30.0
1,3-butylene glycol 3.0
Hinokitiol 0.1
Isopropylmethylphenol 0.1
Polyoxyethylene (50) hydrogenated castor oil 0.5
Perfume
Purified water residue Total 100.0

(Formulation example 2: Deodorant spray)
Purified water 30.0
Ethanol 20.0
Hinokitiol 0.2
Isopropylmethylphenol 0.1
Dimethyl ether 49.7
Total 100.0

(Formulation example 3: powder spray)
Chlorohydroxyaluminum 3.0
Silica anhydride 1.5
Silicone-treated talc 1.5
Zinc oxide 0.5
Triclosan 0.01
Hinokitiol 0.01
Isopropyl myristate 2.18
Dimethylpolysiloxane 1.0
Sorbitan fatty acid ester 0.3
Liquefied petroleum gas 90.0
Total 100.0

(Formulation example 4: Deodorant stick)
Stearyl alcohol 25.0
Polyethylene glycol 10.0
Chlorohydroxyaluminum 20.0
Cyclic dimethylpolysiloxane 44.6
Triclosan 0.15
Hinokitiol 0.15
Fragrance 0.1
Total 100.0

(Formulation Example 5: Deodorant Stick)
Isopropyl myristic acid ester 10.0
Sodium stearate 10.0
Cetanol 3.0
Propylene glycol 25.0
Hinokitiol 0.2
Isopropylmethylphenol 0.1
Purified water 1.0
Ethanol residue
Perfume proper amount total 100.0

(Formulation Example 6: Roll-on deodorant)
Ethanol 30.0
Polyoxyethylene (40) hydrogenated castor oil 1.0
Chlorohydroxyaluminum 10.0
Hydroxypropyl methylcellulose 0.5
Triclosan 0.1
Hinokitiol 0.1
Perfume
Purified water residue Total 100.0

(Prescription Example 7: Deodorant Mist)
Ethanol 45.0
Polyoxyethylene (50) hydrogenated castor oil 0.5
Zinc paraphenol sulfonate 0.3
Cross-linked polystyrene 5.0
Hinokitiol 0.2
Isopropylmethylphenol 0.1
Perfume
Purified water Total remaining 100.0

(Prescription Example 8: Deodorant Gel)
Ethanol 60.0
Carboxyvinyl polymer 0.4
Cyclic silicone 1.0
Polyether-modified silicone 0.5
Hinokitiol 0.1
Triclosan 0.2
Triethanolamine 0.4
Silicone powder 1.0
Perfume
Purified water Total remaining 100.0

(Formulation example 9: Acne cream)
Stearyl alcohol 8.0
Stearic acid 3.0
Purified lanolin 6.0
Hinokitiol 0.2
Triclosan 0.2
Glycerin 3.0
Glyceryl monostearate 2.0
Polyoxyethylene cetyl ether 3.0
Perfume
Purified water Total remaining 100.0

(Formulation Example 10: Acne Lotion)
1,3-butylene glycol 4.0
Glycerin 3.0
Ethanol 10.0
Polyoxyethylene (20) oleyl ether 1.0
Hinokitiol 0.05
Triclosan 0.05
Citric acid 0.01
Sodium citrate 0.1
Perfume
Purified water Total remaining 100.0

(Formulation Example 11: Acne emulsion)
Cetyl alcohol 1.0
Beeslow 0.5
Vaseline 2.0
Squalane 6.0
Dimethylpolysiloxane 2.0
Ethanol 3.0
1,3-butylene glycol 4.0
Glycerin 4.0
Polyoxyethylene (60) hydrogenated castor oil 0.3
Glycerol monostearate ester 1.0
Hinokitiol 0.15
Isopropylmethylphenol 0.2
Perfume
Purified water Total remaining 100.0

(Prescription Example 12: Acne Gel)
Dipropylene glycol 7.0
Carboxyvinyl polymer 0.4
Methylcellulose 0.2
Ethanol 5.0
Hinokitiol 0.1
Isopropylmethylphenol 0.1
Polyoxyethylene (15) oleyl ether 1.0
Potassium hydroxide 0.1
Perfume
Purified water Total remaining 100.0

(Prescription Example 13: Acne Pack)
Polyvinyl alcohol 12.0
Carboxymethylcellulose 5.0
Ethanol 7.0
1,3-butylene glycol 5.0
Polyoxyethylene (20) hydrogenated castor oil 0.5
Hinokitiol 0.1
Triclosan 0.15
Perfume
Purified water Total remaining 100.0

(Formulation example 14: solid white powder)
Sericite 15.0
Kaolin 10.0
Titanium dioxide 5.0
Zinc myristate 5.0
Magnesium carbonate 5.0
Squalane 3.0
Glycerin triisooctanoate 2.0
Hinokitiol 0.15
Triclosan 0.1
Coloring pigment appropriate amount Fragrance appropriate amount
Talc Total remaining 100.0

(Prescription Example 15: Hair Tonic)
Pantothenyl ethyl ether 0.2
Polyoxyethylene (20) Polyoxypropylene (6)
Tetradecyl ether 0.5
Hinokitiol 0.05
Triclosan 0.1
Ethanol 40.0
Perfume
Purified water Total remaining 100.0

(Formulation Example 16: Dandruff Lotion)
Hinokitiol 0.2
Isopropylmethylphenol 0.2
L-Menthol 0.25
Polyoxyethylene (50) hydrogenated castor oil 0.3
Allantoin 0.01
Ethanol 50.0
Perfume
Purified water Total remaining 100.0

(Prescription Example 17: Hair conditioner)
Olive oil 5.0
Cetanol 7.0
Cetyltrimethylammonium chloride 1.0
Stearyltrimethylammonium chloride 0.5
1,3-butylene glycol 3.0
Hinokitiol 0.2
Triclosan 0.1
Ethanol 5.0
Perfume
Purified water Total remaining 100.0

(Prescription Example 18: Aerosol hair tonic)
[Content liquid 1]
Ethanol 60.0
Tocopherol acetate 0.1
Hinokitiol 0.2
Triclosan 0.15
d-Camphor 0.2
Polyoxyethylene hydrogenated oil 0.5
Cetanol 0.3
Polyoxyethylene sorbitan monostearate 0.1
1,3-butylene glycol 2.0
Propylene glycol 2.0
Perfume
Purified water Total remaining 100.0

Contents liquid 1 89.6
LPG 10.0
Nitrogen gas 0.4
Total 100.0

Claims (8)

  An antibacterial composition comprising hinokitiol and triclosan and / or isopropylmethylphenol.   The antibacterial composition according to claim 1, which is used for anti-odor odor-causing bacteria.   The antibacterial composition according to claim 1, which is used for anti-acne bacteria.   The antibacterial composition according to claim 1, which is for anti-dandruff.   A skin external preparation comprising the antibacterial composition according to any one of claims 1 to 4.   A deodorant agent comprising the antibacterial composition according to claim 2.   A skin external preparation for acne comprising the antibacterial composition according to claim 3.   An anti-dandruff hair cosmetic comprising the antibacterial composition according to claim 4.