JPH09194385A - Antiallergic agent and preparation for external use for skin or bathing agent blended with the same agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new antiallergic agent having high safety or a preparation for external use for the skin or a bathing agent excellent in prevention and improvement of allergic skin inflammation deseases and skin irritation. SOLUTION: An extract of Salvia officinalis L. has an excellent suppressing action on the isolation of histamine, anticomplementary action and contact dermatitis-suppressing action. Consequently, the extract can be utilized as an antiallergic agent and is effective in prevention and treatment for various kinds of allergic diseases and enables application to a preparation for external use for the skin and bathing agent in every forms (e.g. medicines, quasi drugs or cosmetics) and exhibits excellent preventing and improving effect on allergic, atopic and contact dermatitis diseases, and the skin and scarp having trouble such as roughened skin and hypersensitive skin.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-allergic agent containing salvia extract as an active ingredient, specifically, a histamine release inhibitor, an anti-complement activator, a contact dermatitis inhibitor, and these. Effective in preventing and improving allergic / atopic / contact skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.) and skin and scalp troubles such as rough skin and sensitive skin. The present invention relates to a highly safe external preparation for skin and bath preparation.

The field of use thereof is various external and internal preparations in general, and specifically, liquid, emulsion, cream,
Ointments, gels, powders, granules, solids, foams, or ampoules, capsules, pills / pills, 1) external and internal medicines, 2) quasi drugs, 3) Topical or systemic skin cosmetics, 4) medicinal and / or cosmetic preparations applied to the scalp / hair (for example, shampoos, rinses, treatments, permanent liquids, hair styling products,
Hair dyes, hair nicks, hair growth and hair nourishing agents, etc.), 5) bath agents to be used by pouring into bath water, 6) oral compositions (toothpaste, gargle, gums and troches, etc.), 7) foods, etc. Can be mentioned.

[0003]

2. Description of the Related Art Today, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria caused by drugs, etc. due to deterioration of environmental conditions, changes in lifestyle, increase in stress due to complication of social life, etc. An increasing number of people are suffering from allergic diseases, rough skin, and sensitive skin. In particular, atopic dermatitis is attracting attention as one of the modern diseases, as its increase is exclaimed not only in children but also in a wide age group up to adults.

Originally, in order to eliminate foreign substances (bacteria, pollen, mites, etc .: antigens) invading the body, it is necessary to protect the body by producing biological components (antibodies, lymphocytes, etc.) that oppose them. It has an immune function that works for. However, sometimes the reaction becomes irritable and it becomes harmful to the body,
It can cause various illnesses. This impaired reaction due to the immune function is called allergy and is classified into four types.

[0005] The type I allergic reaction is the most frequently occurring type and mainly involves immunoglobulin E (IgE) antibodies. The onset process is the first step in which IgE antibodies are produced from B cells against foreign antigens and IgE antibodies are fixed to mast cells and basophils to form sensitization. Sensitized cells contacted with the antigen again. The second step in which chemical mediators such as histamine, serotonin, and SRS-A are released, and the released chemical mediators cause smooth muscle contraction, vascular permeability enhancement, edema, nerve stimulation, etc. It is roughly divided into the 3rd stage that develops allergic symptoms. Atopic dermatitis,
Typical allergic diseases such as acute urticaria, bronchial asthma, hay fever, rhinitis and gastrointestinal allergies fall into this type.

In the type II allergic reaction, when a foreign substance invading from the outside reaches cells such as red blood cells or cells in the body, IgG or I
The gM antibody participates in the reaction and causes the body itself to become an antigen cell. To remove this, the complement system (a system of serum proteins that promote antigen-antibody reaction) is activated, and cells are destroyed by phagocytic cells such as polymorphonuclear leukocytes and macrophages. As a result, hemolytic anemia, decreased platelets,
Allergic symptoms such as blood group incompatibility and drug allergies develop.

[0007] The type III allergic reaction is mainly caused by IgG antibodies, and its onset process is caused by a complicated mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. An antigen-antibody conjugate produced by binding an antibody to an antigen is deposited in various tissues such as blood vessels, kidneys, and liver to activate the complement system to cause damage. Diseases such as serum sickness, filamentous nephritis, chronic pneumonitis, rheumatoid arthritis, viral hepatitis are associated with this form.

Type I to III type allergic reactions are all caused by antibodies. Symptoms appear in 2 to 3 minutes after contact with the antigen, and they reach their maximum in a few ten minutes. Is called delayed allergy because it involves lymphocytes and the symptoms slowly appear 24 to 48 hours after the antigen enters the body. In this reaction, lymphocytes react with antigens to release various inflammatory factors called lymphokines (macrophage chemotactic factor, lymphocyte chemotactic factor, macrophage activating factor, etc.) and work to eliminate the antigen, When this reaction progresses excessively, allergies develop as a disorder reaction. Examples are contact dermatitis, tuberculosis, organ transplant rejection and metal allergies.

[0009]

Many of the conventionally used antiallergic agents have relatively clear points of action.
It is a drug for diseases caused by type I allergic reaction. Examples include antispasmodics that relax smooth muscles, sympathomimetics that suppress hyperpermeability of capillaries, and antihistamines. These are contrastive therapeutic agents that act in the third stage. Moreover, most of them are synthetic drugs, and there is a problem in terms of side effects.

On the other hand, the most active researches on antiallergic agents involved in type I allergic diseases show an antagonistic effect on the released chemical mediators, which are agents that suppress the release of chemical mediators. The development of drugs that suppress the second stage, such as drugs, has not been found to have sufficient efficacy. At present, no specific anti-allergic agent for type II-IV type allergic reaction has been found.

[0011]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have attempted to screen a substance, which is a natural product, for a substance that has an excellent antiallergic effect and has no side effects and is mild to the human body and skin. As a result, they have found that the salvia extract is highly safe and has a histamine release inhibitory action, an anti-complement activation action, and a contact dermatitis inhibitory action, and completed the present invention.

That is, the object of the present invention is to apply the salvia extract as an anti-allergic agent, specifically, as a histamine release inhibitor, an anti-complement activator, or a contact dermatitis inhibitor, and to apply these. Allergic skin inflammatory diseases (for example, redness, edema, eczema, etc.), atopic dermatitis, or rough skin or sensitive skin
It is intended to provide a skin external preparation and a bath preparation excellent in prevention and improvement of scalp troubles.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION Salvia used in the present invention is
Labiatae plant Salvia officinalis
L. (also known as sage) refers to flowers, leaves, and whole plants. The extract is the salvia as it is or after being dried and extracted with a solvent. As the extraction solvent, water, alcohols (for example, lower alcohols such as methanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, diethyl ether, dioxane, acetonitrile, Esters such as ethyl acetate and organic solvents such as xylene, benzene and chloroform can be used alone or as a mixture of two or more kinds.

The extraction conditions are not particularly limited, but usually, they may be in the range of the boiling point of the solvent at room temperature to normal pressure, and after extraction, they are filtered and concentrated and dried to be a solution or paste. It may be used in the form of gel, powder or the like. Further, in most cases, it can be used as it is, but if necessary, purification treatments such as deodorization and decolorization may be added within a range that does not affect its efficacy. As these means, an activated carbon column or the like may be used, and ordinary means generally applied depending on the type of extraction solvent may be arbitrarily selected.

The salvia extract of the present invention can be used as an antiallergic agent as it is, and can also be blended in an external skin preparation or a bath preparation. The amount to be blended is not particularly limited, and varies slightly depending on the type of external preparation for skin, the quality, and the expected degree of action, but is 0.001 to 0.5% by weight in terms of solid content in the total amount of the formulation. Is preferred.
If it is less than 0.001% by weight, no sufficient effect is observed, and 0.5
The effect cannot be expected to be enhanced even if it is blended in an amount of more than wt%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The antiallergic agent, histamine release inhibitor, anticomplement activator, contact dermatitis inhibitor, or skin external preparation and bath agent of the present invention are shown below in addition to salvia extract, if necessary. It is possible to produce it by using together with the bases and additives that are usually used for the preparation of such pharmaceuticals, quasi drugs, cosmetics and the like.

[1] Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange flower oil, cacao butter, chamomile oil, carrot oil, cucumber oil, kukui nut oil, sesame oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, Peanut oil, turtle oil, mink oil, egg yolk oil, palm (kernel) oil, hazelnut oil, owl, coconut oil, beef tallow, tallow fatty acid, lard, hardened oil, castor oil, etc.

[2] Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax and the like.

[3] Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcristan wax, squalene, pristane, etc.

[4] Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid , Synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.

[5] Alcohols ethanol, isopropanol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

[6] Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol, etc.

[7] Esters Isopropyl myristate, Isopropyl palmitate, Butyl stearate, Cholesteryl stearate,
Hexyl laurate, myristyl myristate, cetyl myristate, oleyl oleate, decyl oleate, octyldodecyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, lanolin acetate, mono Ethylene glycol stearate, propylene glycol monostearate, propylene glycol dioleate, etc.

[8] Metal Soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.

[9] Gum and water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Kyarobugomu, Quincy de, agar, casein, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C ₂ ~C ₄₎ chitin or chitosan, low-molecular chitin or chitosan, chitosan salt, sulfated chitin Or chitosan, phosphorylated chitin or chitosan, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate and its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, carboxyethyl cellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, nitro Cellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl Le methacrylate, polyacrylate, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

[10] Surfactant Anionic surfactant (carboxylate, sulfonate, sulfate ester salt, phosphate ester salt), cationic surfactant (amine salt, quaternary ammonium salt), amphoteric surfactant : Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type non Ionic surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) Agent, protein hydrolyzate derivative,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

[11] Various vitamin agents Vitamin A group: retinol, retinal (vitamin A ₁ ), dehydroretinal (vitamin A ₂ ), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (Vitamin B ₁ ), riboflavin (vitamin B ₂ ), pyridoxine (vitamin B ₆ ), cyanocobalamin (vitamin B ₁₂ ), folic acid,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D ₂ ), cholecalciferol (vitamin D ₃ ),
Dihydrotaxosterol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K ₁ ), menaquinone (vitamin K ₂ ), menadione (vitamin K ₃ ), menadiol (vitamin K ₄ ), and the like.

[12] Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc. and their sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidone carboxylic acid.

[13] Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are usually carried out according to the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are arbitrarily selected and combined), and various materials are arbitrarily selected. You can select and serve. In the case of extraction, the solvent to be used may be selected in consideration of the usage (internal use, external use, bath use) of the product to be provided and the processing treatment to be performed later. Solvent (eg,
It is preferable to use one or a mixture of two or more selected from (ethanol, propylene glycol, 1,3-butylene glycol, etc.). However, when the inclusion of the organic solvent is not preferable depending on the application, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in an arbitrary mixture with water.

In addition, additives derived from plant or animal raw materials are
In particular, when it is applied to external preparations such as skin care and hair care and bath agents, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, reduces irritation,
Relief of stress caused by aroma, cell activation (cell aging prevention), inflammation suppression, skin and hair quality improvement, skin roughness prevention and its improvement, hair growth, hair growth, hair loss prevention, gloss addition, cleaning effect, fatigue reduction , In addition to cosmetic effects such as blood flow enhancement and warm bath effect, actions such as scenting, thickening, antiseptic and buffering can be expected. In addition to this, expect various various cosmetic and pharmacological effects of each known raw material, and enhance the desired effect by combining these.
Alternatively, it can be a product having a multi-functional effect.

In particular, by using the salvia extract of the present invention in combination with an extract of a plant which has already been known to have anti-inflammatory / anti-inflammatory / anti-allergic action, an additive or synergistic anti-inflammatory / anti-allergic action is obtained. Can be expected. Examples of such plants (herbal medicines) are Arnica, aloe (芆 舆 舆), aloe vera, Prickly pear, turmeric (healthy), hemlock plant (summer hay), citrus unshiu (Chen-skin), Coptis chinensis, psyllium (in front of car) (Children, carcass grass), Hypericum (brother's cut grass), Odorikosou (interrupted), Onami (blue ears), seaweed [green algae, brown algae, red algae], Kanosou (Yoshikusa), birch, chamomile, kawamuramogi (chinen chopsticks), Licorice (licorice), Cichlid cucumber (melon root), chrysanthemum (chrysanthemum), yellow clover (yellow oak), cucumber, wolfberry (lilies, limbs, limbs, skeletons), kudzu (kakkon), gardenia (sanushu) , Kumazasa, Clara (bitter ginseng), Mulberry (mulberry leaf, mulberry bark), Keigai (Maggot, Mushroom), Gennoshoko (Old grass), Kouhone (river bone), Scutellaria (yellow gon), Goshoi Gore (bokbunja), copaiba, burdock (burdock, Goboko), the US, rice bran,
Rice oil, comfrey, cherry leaf, pomegranate,
Sala cinnabar (marsh), salvia, salamander (sansho), shea, perilla, aojiso, chirimendiso, catamendiso (shiso leaf, shiso), linden, peony (peony medicine), janohigashi (barley winter), jiuyu, juzdama, Ginger, birch, oval ivy, horse chestnut, elderflower, yarrow,
Peppermint, senkyu, sendan, senburi (this medicine), rhubarb (daisy yellow), thyme, dandelion, touga (winter melon), touki (toki), sweetpotato, dokudami (ten drugs), tomato, trolloe, jujube (large) jujube),
Elderberry (bone grafting), carrot, hibiscus, Hakamaurabosi (bone crushing), peppermint (light load, light load leaf), adlay (Yokuinin), Hamamelis, rose (rose), Hikiokoshi (extended grass), Hishi (Hishimi), Juniper, loquat (loquat, loquat leaf), loofah, safflower (safflower), bodaiju (Bodhi tree), button (peony skin), hops, maronier, swordfish, purple (root), melissa, peach, cornflower, eucalyptus, yukinoshita Tiger ear grass), mugwort (moth leaf), lavender, gentian, forsythia (ream), rosemary (mannenrow), roman chamomile, waremokou (earthenworm) and the like.

Other specific examples of plants (herbal medicines) that can be used in the field of cosmetics are eye (indigo leaf), blue vine (seifuto), Aotsutsurafuji (Kibo), acacia, red currant fruit, red grape, red megalois ( Akabashi),
Akane (Akane grass root), Akayajiou-jiou (ground yellow), Agi (Awe), Akinire (楔 楡 涡), Akebi (Kizu), Asa (Asakohito), Morning glory (Dagushi), Ashitaba (tomorrow), Azuki (red azuki bean), Asenyak (Asenyaku), Acerola, Anise fruit, Abemaki fruit, Avocado, Ama, Amacha (sweet tea), Amacha vine, Amadokoro (Tamatake),
Aigasyuri (shellfish), almonds, altea, apricot hon apricots, ansokkou (benzoic incense), igakozorina (territorial gall head), knotweed (tiger root), strawberries,
Fig or its leaf, citrus (Fuyu Aoi), ginkgo (Ginkgo biloba, Ginkgo biloba), Itohimehagi (Distant), locust bean, rice seed or seed coat, inonodo seed, ibukimikosou, nettle, ylang-ylang, fennel (incense) , Ukiagara (Sanryo), Uguisukagura fruit, Usvenia mallow, Usbenitachiaoi, Usubasaishin Keirinsaishin (spicy), Udo or Shishiudo (猌 Activated, Independently active, Tang Independent), Ume (Umeume) or its flesh, Vladimir Urushi, Uruushi , Estragon, Eleuthero (Ezo Goka), Enoki, Ebisugusa (Keimeiko), Elderberry fruit, Elemi, Enju (Sophorae, Sophoraceae rice), Ougi-Kibanaougi (Yellow 萆), Okarasuri (Karonin), Otsutsurafuji (Otsutsurafuji) Self-defense), hazel (Haruko), Obana okera okera (white) ), Obayashi turbocharger busi fruit, Oomi hawthorn, hawthorn (hawthorn), barley (barley), Oguruma (旋覆), okra fruit, Asian ginseng (red ginseng, carrot), Juglans, Gastrodia elata (Tian Ma),
Oniyuri, Sasayuri and Hakatayuri (Yuri), Ononis,
Halibut, oat, strawberry, duck, mustard, orange jelly, duckweed, olive, oregano, orange fruit or peel, kaisekiou (ripe yellow), cacao seed, persimmon or its leaf (persimmon)蒂), Kagizura (fishing hook), Cassia, Cassino ki fruit (楮 fruit), Gajutsu (蜪 朮), Kashiwa (camellia tree, camphor leaf),
Cascarilla, cypress (Kinshato), pumpkin, Kapok cypress seeds, Kahok Sansho (Pepper pepper), Gama (Camellia),
Kamiyatsude (grass), crow cucumber (sea melon), crow bishaku (half-summer), oats, guarana seeds, karaya, karin (wood melon), kawayanagi, kawaratake, kansui (sweetening), candelilla, kanto, canna, raspberry, kiwi fruit, Kikyo (Kikyo, Kikyo root), Catalpa (Ajimi), Rumex (Yotei), Kizuta, Kidachialoe, Kidachiha, Kinaki, Gymnema sylvesta, cabbage, cabbage unripe fruit, Kiraja saponaria, Kiraya,
Kumquat fruit, betel, Quercus japonicus (Sengakuru), Guayule, Quercus infectoria (Gallicus), Kukui nut, Kusagikazura (Tenmon winter), camphor tree, gooseberry fruit, Kunugi (Galleria japonica), Bear vine (horse whisker), cranberry fruit, Chestnut or its astringent skin, Curculigo latifolia fruit, Grapefruit fruit, Black buckthorn, Black vulgare (rescue required), Chlorella, Guava fruit, Kaito (corolla, corolla), Laurel, Gentiana, Cilantro fruit, Koushinbara (monthly flower), Kousui mint, Kozo fruit, black tea, Kouhon (straw and Karamoto), Kouryan, cowberry (Koshitachi), coco fruit,
Goshuyu, pepper, coffee beans,
Kobushi, Tamushiba, Magnolia (Spicy), Kobotsuduru,
Sesame seeds, sesame seeds (genus), wheat (wheat), cola acminata seeds, cola vera seeds, fenugreek fruits, colombo, conzulango, kelp, konjak, saxima button vines, cherry blossoms and fruits. Bark (cherry bark), Sasa, Sasanka, Sagemodaka (Sawataki), Sweet potato, Sugarcane, Sugar beet, Sanebutojutsume (Satsuma Ren), Saffron (Banbokuhana, Nishibana),
Pomegranate fruit, sapon, fruit of salmon berry, syringa (mountain root vegetable), carrot ginseng (37 ginseng), sanshyu (yamatake mushroom), sandscon (mountain bean root), cyanoki fruit, shiitake mushroom, zion (purple garden), digitalis, shikunshi ( Ambassador), Rosewood, Chinese Forsythia (Forsythia), Striped daisies (Chrysanthemums), Spiraea, Potato, Shajin (Shasan), White Oak Seeds, Seeds of White-billed Blossoms, White Syringe, White Flower, White Minami Tenten (South Tenmi), Palm Fruit , Shobu (iris, iris root), shozuku fruit, cinchonasucir bra, cinnamon, watermelon (watermelon), honeysuckle (gold and silver flower, endurance winter), sorrel (acidic acid), swimberry fruit, strawberry fruit, horsetail (question), Stevia, plum fruit, Pinus sylvestris, Larch Seiyougurumi, hawthorn, pear fruit, meadowsweet, juniper, western rose, western Liquidambar formosana butterfly me,
Mistletoe, edifice, horseradish, horseradish, sesame root, mallow, senega, celery, celery, senna fruit or leaf, sengweed (grass), buckwheat (fruit), buckwheat seed, somei yam, radish, soybean, red sea bream (Orange peel, Minami), Takatodai (Oops), Takarabi (Gourd), Dark sweet cherry fruit, Tachijakoso (Hyurika), Tachibana (Tachibana peel),
Willow, tamarind seeds, onions, aralia or its root bark, tanjin (danshen), danmar, cherry fruits, chigaya or its roots (chion root), chicory, cloves (cloves, cloves), ginseng (chondria spp.), Ginseng (daihuang). ), Ginseng (garden), ginseng (carrot), ginseng (bamboo leaf), choreimaitake (bottle), psyllium, camellia, Centella asiatica, clover (lacquer grass), commune (duckweed), tsuzukizuki. (Red adzuki bean), Tsurudokudami (Japanese head crow), Tsuruna (Japanese apricot), Ginseng (Soybean ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry fruit, Agarwood, Tendaiyaku (crow), Capsicum (corn pepper), Corn or corn hair (nanban) Hair), Tounezumimochi (Sadako),
Ginseng (dragon gall), ginseng (root root), carrot ginseng (Ginseng ginseng), eucommia (Dunzhong, Duzhong leaf), tomato,
Tragant, Triacanthus seeds, Tormentilla, Doronoki, Nigeria berry fruit, Chinese yam yam (mountain drug), Nagikadada, Naginatakouju, Nazna, rapeseed, Natsumikan, Naniwaibara (gold cherry child), Narukoyuri (yellow sprout), Nankin bean (peanut), groundnut (Namitenmi), nigaki (bitterwood), sagebrush (bitterness), nutmeg, nikkei (cinnamon skin), leek (drug), garlic (garlic), nulde (quintuplet), leek, thistle (daikon), noira (nobara) (Actual), Yarrow, Pleurotus cornucopiae (pre-hu), Novara, Peach, Palm, Pineapple fruit, Hakusen (tinea bark), Huckleberry fruit, Hakobe (harsh), Hazel (Haruko), Hasiridokoro (roth root), Basil, Lotus (lotus). (Meat, lotus), parsley, hadakamugi, batata, hachiku madake (boiled bamboo), pachoー, Hanasuge (familiar mother), banana, hanahakka, vanillabins, hahacogusa (mouse koji), hub grass, paprika, hamagou mitsubahamagou (vine vine), hamasuge (kazushi), habushi (shitsuriko), hamanus (hamanasu) Maikai flower), Hamabofu (Hamafufu), Paeritalia, Harunire (Insect skin, Elm white hide, Elm leaf), Breadfruit, Hyougi (Shooting), Peanut ginseng (Party ginseng), Pecan nuts, Hembanbana (stone garlic, Suzuka Suzuka) , Pistachio, beet, Hitotsuba (Ishidashi), Hinako no Kochi (Bovine knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himegama (scented), Himematsutake, Pimenta fruit, Hiyu fruit, Birodoaoi, Hirahainagusa (Bald head), Hirohase Nega (Senega), Betel Nut (Large skin, Rinko Ren), Futokazura (Nantan), Fuki Fukita Popo (款冬 flower, 款冬 leaves), Eupatorium fortunei (Rankusa), hyacinth bean (扁豆), Butcher Bloom, grapes, beech,
Fuyushinsakutake (caterpillar), Brazilian licorice, black currant fruit, blackberry fruit, plum fruit, fulceraria, blueberry fruit, prunes, blond psyllium, bundou (mung bean), belladonna, berry fruit, boysenberry fruit, bow-wow (windbreak) ), Spinach, physalis (Torone), honoki (Japanese magnolia), bokeh (wood melon), Hosobana okera (Sosaku), Hosobabarengiku, jojoba, white berry fruit, honshimeji, maizerutennansho (tennan star),
Mahou (mahuang), macadamia nuts, maculi (seagrass), matatabi (wooden Tate), matsukasa, matsuhod (boiled scales), marigold, malvanojazin (bitter ginseng), mulberry fruit, quince, mango, mangosteen, manshu gurumi, mandarin Fruits, Ganoderma lucidum (Ganoderma lucidum), Citrus fruit (Curveraceae), Mishima Psycho (Saiko), Mizokakushi (Harenbei lotus), Misohagi (Cendula vegetable), Mitsugashiwa, Mitsuba, Midorihaka, Mimosa, Myoga,
Miracle Fruit Fruit, Myrrh, Myrobalan, Mukuge (Kaki), Mukunoki, Purple Corn, Swordfish (Issue Herb), Meburokigi, Melaleuca, Merrilot, Melon Fruit, Mokoyomogi, Musouchiku, Mokkou (woody incense), Momijiba Daiou, Momo fruit Seeds (peach seeds), bean sprouts, morelo cherry fruits, moroheiya, yakawamurasakiimo, yakchi (maschi), yagurumasou, yagurumahaka, yashabushi (arrow wheel), yachiyanagi, yadede (octagonal metal plate), mistletoe (willow parasitism), willow deer Leaf, tadpole, yam koji (purple gold beef), pokeweed (commercial land), yamahanoki (yamaharu), bayberry (pickle plum), yucca flavifolia, yuzu fruit, lily, yogurt, lime fruit, rye, lakanka fruit, raspberry fruit , Longan, green tea, Apple fruit, Rubasu-Suabishimusu (甜涼), some lettuce, red currant fruit, lemon fruit, lemon grass, Rengesou, Rouyashi, loganberry fruit, rose hips, seaweed, wasabi, and the like.

As the material of the animal-derived raw material, a chicken cob extract, a bovine / human placenta extract, a pig / cow stomach or duodenum or an intestinal extract or its degradation product, water-soluble collagen, acylated collagen, etc. Collagen derivative, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, silk protein, silk protein hydrolyzate, pig / cattle blood cell protein hydrolyzate (globin peptide),
Pig and bovine hemoglobin degradation products (hemin, hematin, heme iron, etc.) and milk can be used.

[14] Microbial culture metabolites Yeast metabolites, yeast extract, rice fermentation extract, rice bran fermentation extract, Euglena extract, lactic acid fermented product of skim milk powder, etc.

[15] α-Hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

[16] Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

[17] Ultraviolet absorber p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative,
Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B ₆ derivative, oxybenzone, benzophenone, guaiazulene, shikonin, baicalin, baicalein,
Berberine etc.

[18] Antioxidant Ascorbic acid and salts thereof, stearic acid ester, tocopherol and ester derivatives thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

[19] Anti-inflammatory agents Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizinic acid and Its salts, glycyrrhetinic acid and its salts, etc. It should be noted that an additive or synergistic anti-inflammatory / anti-allergic action can naturally be expected by using the salvia extract of the present invention in combination with the above-mentioned anti-inflammatory agent.

[20] Astringents Lactic acid, tartaric acid, succinic acid, citric acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannin Acid etc.

[21] Thickener Hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, gum arabic, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylate, carboxyvinyl polymer,
Carrageenan, pectin, alginic acid and its salts, casein, gelatin, etc.

[22] Moisturizers Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, sodium lactate and the like.

[23] Sterilizer / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate.

[24] Fragrances Natural animal fragrances such as musk, civet, castorium and ambergris, anise essential oils, angelica essential oils, ylang-ylang essential oils, iris essential oils, fennel essential oils, orange essential oils, cananga essential oils, caraway essential oils, cardamom essential oils, Guayak Wood Essential Oil, Cumin Essential Oil, Chromody Essential Oil,
Cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, large spice essential oil, tuberose essential oil , Clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Hydrangea Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boadrose Essential Oil, Homoku Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemon Essential Oil, Lemongrass Essential Oil, Rose Vegetable flavors such as Marie essential oil and Japanese peppermint essential oil, and other synthetic flavors.

[25] Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, endu dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, seaweed pigment, hibiscus pigment, grape fruit pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

[26] Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-allergic agents, cell activating agents, keratolytic agents, A wound healing agent, a foam increasing agent, an oral agent, a deodorant / deodorant, an enzyme, etc. may be used in combination as necessary to prepare the above-mentioned various preparations.

The dosage form of the anti-allergic agent, histamine release inhibitor, anti-complement activator and contact dermatitis inhibitor of the present invention is arbitrary, and liquid, emulsion, cream, ointment, gel,
Powder, granules, solid, foam, or ampoule, capsule, pill / tablet for external / internal drug, quasi drug, skin / hair cosmetics and bath agent Can be used.

Specifically, external / internal medicinal preparations, basic cosmetics such as lotions, emulsions, creams, ointments, oils, packs, facial cleansers and skin cleansers, shampoos, rinses, hair treatments, hair styling products, Perms, hair dyes, hair tonics, hair cosmetics such as hair growth and hair nourishment, foundations, lipsticks, blushers, eye shadows, eye liners,
Make-up cosmetics such as mascara, liquid / powder / solid bath agents, toothpaste, mouthwash, mouthwash, hygiene products,
Examples include wet tissues and the like, and can be applied to other general food and drink.

Regarding the method for adding the salvia extract of the present invention to various preparations or external preparations for skin and bath agents,
It may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0050]

Example 1 Next, the present invention will be described in more detail with reference to production examples, test examples, and formulation examples, but it goes without saying that the present invention is not limited thereto.

(Production Example 1) 100 g of dried salvia flower
It is dipped in 1 L of a 50% ethanol solution, extracted at room temperature for 3 days and night, and suction-filtered to obtain an extract (dry solid content 1.3 to 2.3% by weight).

(Production Example 2) 100 g of dried salvia whole plant
Was gently warmed and extracted with 1 L of an equal volume mixture of 30% propylene glycol solution and 30% 1,3-butylene glycol solution at 50 ° C for 6 hours, and suction filtration was performed to extract (dry solid content 1.3 ~
2.3% by weight).

(Production Example 3) 100 g of dried salvia flower was soaked in 500 ml of hexane for 1 day and then the solvent was distilled off, and the obtained paste-like substance was treated with 45% 1,3-butylene glycol solution 1
Redissolved in L, suction filtered and extracted (dry solids 1.3 ~
2.3% by weight).

(Test 1) Histamine release inhibition test In the type I allergic reaction, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second step. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, comp, a histamine release reagent from rat mast cells, was used.
Test method to release histamine at ound48 / 80 (J. Soc. Cos
The extract obtained in Production Example 1 was investigated using met.Japan, Vol.25, No.4, P.246 (1992)).

(Test method) a. After the solvent was distilled off from the sample extract under reduced pressure, it was redissolved in purified water to a solid content concentration of 0.01, 0.02, and 0.10% by weight, and used for the test. As positive controls, dipotassium glycyrrhizinate and sodium cromoglycate were used at the same concentration. b. Measurement of the amount of free histamine A 0.2 ml sample was added to 1.2 ml of mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / ml and incubated at 37 ° C. for 15 minutes. After cooling with ice and stopping the reaction, the reaction solution was centrifuged, and histamine released from the supernatant was extracted and purified, and color was developed with o-phthaldialdehyde, and the fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. The histamine release inhibition rate was calculated by the following formula.

[Equation 1]

(Test Results) As shown in Table 1, it was confirmed that the salvia extract of the present invention has a very excellent histamine release inhibiting effect as compared with dipotassium glycyrrhizinate and sodium cromoglycate.

[Table 1]

(Test 2) Measurement of anti-complement activity The complement system is greatly involved in type II and type III allergic reactions. Anaphylatoxins produced by complement activation are
It has a function of significantly promoting the degradation of antigens by phagocytic cells, and at the same time, has a function of increasing the permeability of capillaries, a function of contracting smooth muscle, and a function of releasing histamine from mast cells. Cause symptoms like. When phagocytic cells try to remove antigens by the action of anaphylatoxin, degranulation reaction of lysosomes occurs, and various types of hydrolytic enzymes such as proteases in lysosomes are released to the outside of tissues and cells. Impede. Furthermore, complement is also activated in the cell wall of microorganisms (such as Staphylococcus aureus, which is an aggravator of atopic dermatitis). Therefore, an anti-allergic effect can be expected by suppressing this complement activity. In this test, the extract obtained in Production Example 1 was examined using an anti-complement activity measuring method using the hemolytic reaction of sensitized red blood cells as an index.

(Test method) a. Gelatin / Veronal buffer (GVB ²⁺ ) Sodium chloride 1.7g, barbital 0.115g, barbital sodium 0.075g, calcium chloride 0.015g, magnesium chloride 0.010g, gelatin 0.2g, purified water 100ml are mixed to adjust pH 7.5. After that, the total volume was adjusted to 200 ml with purified water. b. Sheep erythrocyte (SRBC) suspension The sheep blood cells were centrifuged at 2,000 rpm for 5 minutes, washed three times with physiological saline, and GVB ²⁺ was added to the residue to prepare a 10% SRBC suspension, and finally SRBC. 3.05 in 0.25 ml suspension
When 0.1 ml of a 0.1% sodium carbonate solution was added for complete hemolysis, the absorbance at 540 nm was adjusted to 0.455. c. 0.2 ml of anti-SRBC mouse serum 10% SRBC suspension was intravenously injected into the tail of an IVCS male mouse, and 4 days after that, blood was collected and serum was separated.
It was used after being diluted 40-fold with B ²⁺ . d. Complement Guinea pig fresh serum was diluted 20-fold with GVB ²⁺ and used. e. After the solvent was distilled off from the sample extract under reduced pressure, it was redissolved in purified water to a solid content concentration of 0.5% by weight and subjected to the test. Moreover, the same concentration of dipotassium glycyrrhizinate was used as a positive control. f. Measurement of anti-complement activity 0.2 ml sample to 0.5 ml GVB ²⁺ and 0.5 ml anti-SRBC serum, S
After 0.25 ml of RBC suspension and 0.25 ml of complement solution were added successively, the reaction was carried out for 60 minutes in a constant temperature bath at 37 ° C. In ice water 10
After stopping the reaction by leaving it for a minute, the reaction solution was centrifuged at 2,000 rpm for 10 minutes to separate unlysed red blood cells, and the supernatant was removed.
The OD value at 540 nm was measured. In addition, a sample containing purified water instead of the sample was used as a control, and a blank containing no serum was set for each sample and the control, and the complement inhibition rate (= anti-complement activity) was determined by the following formula.

[Equation 2]

(Test Results) As shown in Table 2, it was confirmed that the salvia extract of the present invention has a strong anti-complementary activity far exceeding that of dipotassium glycyrrhizinate.
Expected to have the effect of suppressing the development of type-allergic symptoms.

[Table 2]

(Test 3) Contact dermatitis inhibition test In the contact dermatitis reaction, T sensitized with the antigen was used.
Upon contact with the same antigen again, lymphocytes release various lymphokines that activate macrophages and lymphocytes, causing an inflammatory reaction. Therefore, a substance that suppresses a series of inflammatory reactions against the same antigen can be expected to be used as a delayed type (IV type) allergic agent. In this test, a hydrophilic petrolatum ointment containing the extract obtained in Production Example 1 was prescribed, and the method of Nakamura (Nippon Pharmacologic, 76, 595 (1
980)), and its effect on the para-phenylenediamine-induced contact dermatitis reaction was examined.

(Test method) a. Sample The extract was concentrated by distilling off the solvent under reduced pressure, and hydrophilic Vaseline ointment containing 10.0% by weight in terms of solid content was produced and used by a conventional method. b. Measurement of edema swelling rate First, 0.1 ml of 2.5% paraphenylenediamine / acetone: olive oil = 4: 1 (hereinafter, PPD) was continuously applied to the shaved abdominal skin of mice (BALB / c female mice: about 8 weeks) for 3 days. After application, sensitization was carried out, and after 5 days, 20 mg of the test drug was applied to the auricle three times at intervals of 1 hour. One hour after the final application, the test drug was thoroughly wiped off, and 20 μl of PPD was applied to the auricle to induce it. 17 hours after induction, the test drug was again applied to the auricles that had been evoked twice at 1-hour intervals, and 19 hours after the induction, the test drug was thoroughly wiped off, and 24 hours after the induction, both auricles were punched to a certain area (diameter 5.0 mm) and weighed it. For the determination, the swelling rate was measured from the difference in the weight of the untreated one-sided auricle and compared with the control group to calculate the dermatitis suppression rate. In addition, 8-9 mice were used for the test.

(Test Results) The inhibition rate of the salvia extract of the present invention was 76.2% (p <0.01), confirming that it has a contact dermatitis inhibitory action.

(Test 4) Safety test (1) Primary skin irritation test The extracts obtained in Production Examples 1 to 3 were prepared so that the solid content concentration was about 20% by weight, and the back was shaved. 2 × on the skin of Japanese white rabbits (female, 3 animals per group, weighing around 3,800 g)
0.03 ml was applied per 2 cm ² square. Judgment was performed 24, 48, and 72 hours after the application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative. (2) Skin cumulative irritation test The extracts obtained in Production Examples 1 to 3 were prepared so that the solid content concentration was about 20% by weight, and the flank was shaved (2 × 4c).
m ² ) Hartley guinea pigs (female, 3 animals per group, weighing about 320 g) were applied to the skin once a day, 5 times a week, at 0.5 ml / animal. The application was carried out for 2 weeks and the shearing was done on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, all the animals were judged to be negative because no erythema or edema was observed for 2 weeks after application. (3) Acute toxicity test The extracts obtained in Production Examples 1 to 3 were concentrated under reduced pressure, dried, and fasted for 4 hours before the test ddy mice (female, 5 mice per group, body weight about 28 g). Oral administration of 2,000 mg / kg was carried out and the onset and extent of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and there was no abnormality in the autopsy results. LD ₅₀ is 2,000m
It was judged to be g / kg or more.

(Formulation Example 1) Face wash cream 1. Myristic acid 25.0% by weight 2. Stearic acid 5.0 3. Beef tallow fatty acid 5.0 4. Propylene glycol 8.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Production example Salvia extract according to 1 1.0 8. Preservative, fragrance proper amount 9. Purified water 100 remainder

(Formulation Example 2) Soft lotion 1. Glycerin 5.0% by weight 2. Propylene glycol 4.0 3. Oleyl alcohol 0.1 4. Polyoxyethylenesorbitan monolaurate (20E.O.) 1.5 5. Polyoxyethylene lauryl ether ( 20E.O.) 0.5 6. Ethanol 10.0 7. Salvia extract according to Production Example 1.5 8. Preservatives, flavors 9. Proper amount of purified water 100

(Formulation Example 3) Emollient cream 1. Stearic acid 2.0% by weight 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Salvia extract according to Production Example 2.0 10. Preservatives, flavors appropriate amount 11. Purified water 100 remainder

(Formulation Example 4) Pack 1. Glycerin 5.0% by weight 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene oleyl ether (15E.O.) 1.0 6. Methyl paraoxybenzoate 0.2 7. Salvia water extract 1.0 8. Preservative, fragrance proper amount 9. Purified water 100 residue

(Formulation Example 5) Powder foundation 1. Sericite 40.0% by weight 2. Mica 15.0 3. Titanium oxide 10.0 4. Nylon powder 5.0 5. Talc 17.0 6. Methylpolysiloxane 1.5 7. Liquid paraffin 10.0 8. Vaseline 1.4 9. Dry powder of salvia extract according to Production Example 0.1 10. Suitable amount of color pigment 11. Suitable amount of antioxidant 12. Suitable amount of bactericidal preservative, perfume

(Formulation Example 6) Shampoo 1. Alkyl sulfate triethanolamine salt 15.0% by weight 2. Palm oil fatty acid monoethanolamide 5.0 3. Ethylene glycol monostearate 2.0 4. Salvia extract according to Production Example 3 1.5 5. Preservative Agents, pigments, and fragrances 6. Traces of purified water 100

(Formulation Example 7) Hair tonic 1. Ethanol 15.0% by weight 2. L-menthol 0.1 3. Glycerin 15.0 4. Sodium hyaluronate 0.15 5. Isopropylmethylphenol 0.1 6. Hinokitiol proper amount 7. Acetic acid dl-α-tocopherol Appropriate amount 8. Salvia extract according to Production Example 1.5 9. Residue to be purified water 100

(Formulation Example 8) Granular bath agent 1. Sodium hydrogen carbonate 50.0 2. Anhydrous sodium sulfate 30.0 3. Sodium chloride 10.0 4. Dry powder of salvia extract according to Production Example 10.0 5. Appropriate amount of pigment 6. Appropriate amount of perfume

(Test 5) Use effect test The effects of actually using the external preparation for skin and the bath preparation of the present invention were examined. The test was to use 10 people aged 2 to 30 who suffer from skin diseases such as eczema and urticaria and atopic dermatitis as panelists, and twice daily in the morning and at night twice after washing the face with an appropriate amount of the cream of Prescription Example 1 on the face. It was done by applying over a period of months. Also, for 10 people (5 to 20 years old) who have similar skin irritation on the scalp and hairline,
After daily hair washing, a hair tonic of Formulation Example 7 was applied to the scalp for 1 month to perform a use test. Furthermore, for the bath agent of Prescription Example 8, a bath agent for 1 month was used as a control for 20 people aged 2 to 60 who have dry skin with dryness, skin diseases such as eczema and urticaria, and atopic dermatitis. I had them take a bath in the melted bath water and tried a monitor test. As a control, cream and hair tonic were purified water except for salvia extract, and bath agents were prepared by the same method, which was corrected with anhydrous sodium sulfate instead of dry powder of salvia extract.

The condition of the skin or scalp one month after the start of use was evaluated according to the following criteria.・ Effect of improving skin (scalp) inflammation Effective: Redness and itch associated with inflammation such as eczema and rough skin improved somewhat Effective: Redness and itch associated with inflammation such as eczema, rough skin slightly improved Ineffective: Before use And no change

The results of use are shown in Table 3 (the numbers are the number of people).
No one complained of abnormalities on the skin or scalp during the period of use. As is clear from this, it was confirmed that the use of the external skin preparation and the bath preparation containing the salvia extract of the present invention has an excellent effect of improving the inflammation of the skin / scalp.

[Table 3]

[0075]

INDUSTRIAL APPLICABILITY The salvia extract of the present invention has excellent histamine release inhibitory activity, anti-complement activity activity and contact dermatitis inhibitory activity, and is extremely safe. Therefore, it can be used as an anti-allergic agent, specifically, a histamine release inhibitor, an anti-complement activator, a contact dermatitis inhibitor, and various allergies such as eczema, urticaria, atopic dermatitis, allergic rhinitis, and hay fever. It is effective in the prevention and treatment of sexual disorders. Further, it can be applied to all forms of pharmaceuticals (medicines, quasi drugs, cosmetics). In particular, the skin external preparation and bath preparation according to the present invention are allergic / contact skin inflammatory diseases (eg, redness, eczema, edema, swelling, etc.)
Also, it can be used for the purpose of prevention and improvement of skin / scalp having troubles such as atopic dermatitis, rough skin, and sensitive skin. In addition, it can be applied to oral compositions and foods.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 7/02 A61K 7/02 Z 7/06 7/06 7/075 7/075 7/50 7 / 50

Claims (5)

[Claims] 1. An antiallergic agent comprising a salvia extract. 2. A histamine release inhibitor comprising a salvia extract. 3. An anti-complement activator containing salvia extract. 4. A contact dermatitis inhibitor comprising a salvia extract. 5. An agent according to any one of claims 1 to 5
An external preparation for skin and a bath preparation, which comprises at least one species.