JP2000143524A - Antiinflammatory agent containing extract of amaranthus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject safe antiinflammatory agent having an antiinflammatory action, an inhibitory action on carrageenan edema at the bottom of the foot, an inhibitory action on histamine isolation and an inhibitory action on arachidonic acid metabolic activity, useful for preventing and improving atopic dermatitis, etc., by making the agent include an extract of amaranthus. SOLUTION: This antiinflammatory agent contains an extract of amaranthus as an active ingredient. For example, the extract is obtained by immersing leaves of amaranthus (a plant of the genus Amaranthus of the family Amaranthaceae) in 50% ethanol solution, extracting a plant material from the leaves at a room temperature for 3-7 days and nights, filtering the extracted solution with suction to give an extracted solution. The agent contains >=0.001 wt.%, especially 0.5-20 wt.% of the extract mixed and further may be blended with various kinds of oils and fats such as avocado oil, etc., a wax such as beeswax, a mineral oil such as liquid paraffin, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a novel and safe anti-inflammatory agent containing an amaranth extract, an inhibitor of carrageenan footpad edema, an inhibitor of histamine release, an inhibitor of arachidonic acid metabolic activity, and a pharmaceutical / medicine department. The present invention relates to application to various cosmetic compositions or foods and drinks in the field of foreign goods or cosmetics.

[0002] The field of application is, for example, all kinds of internal and external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, Powder, granule, solid, liquid, gel or foam 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics (for example, lotions, emulsions, creams) , Ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, depilatory, depilatory, shaving treatments, aftershave lotion, pre-show lotion, shaving cream, etc.), 4) scalp and hair And / or cosmetic preparations (eg, shampoos, rinsing agents, treatment agents, permanent solutions, hair dyes, hair styling agents, hair tonics, hair growth / hair restoration, etc.), and 6) hand Bath agents to be used; 7) In addition, liquid odor and deodorant inhibitors, sanitary articles, sanitary cotton, wet tissues, and the like.

[0003] Further, as foods and drinks, oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and yuden noodles Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy, mizuame, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, Sprinkled or processed vegetables and fruits, such as canned and bottled vegetables and fruits, cheese,
It is used for dairy products such as butter and yogurt, miso soup, soup, fruit juice, vegetable juice, whey drinks, soft drinks, drinks such as liquors, and other general foods and drinks such as health foods.

[0004]

2. Description of the Related Art Today, environmental conditions are deteriorating, lifestyles are changed, and stress is increased due to the complication of social life. More and more people are suffering from inflammatory and allergic diseases, as well as rough and dry skin. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, with its increase being sought in not only children but also in a wide range of ages up to adults.

[0005] In order to eliminate foreign substances (antigens such as bacteria, pollen, mites, etc.) that have invaded the body, the body must produce biological components (antibodies, lymphocytes, etc.) to counter it and protect the body. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into two groups, immediate allergy and delayed allergy, and allergies are further classified into four types I to IV according to the mechanism of onset.

Among allergic reactions, type I is the type most frequently occurring as an allergy, and is a reaction mainly involving an immunoglobulin E (IgE) antibody. This IgE is produced against allergens that have entered the body and has a strong effector effect on mast cells and basophils. Mast cells and basophils (a type of leukocyte) Cells having granules containing pharmacologically active amines such as serotonin, the former being present around blood vessels and connective tissues, and the latter being present in blood. Ig on these cell membranes
Receptor that binds E antibody is present and has the property of strongly binding to IgE antibody, and bound to mast cells and basophils
When the same allergen binds again to IgE antibody,
Numerous active substances such as histamine and serotonin described above are released from these cells with degranulation, causing various allergic symptoms, itching and redness with blistering and eruption of the skin (urticaria), nose and eyes Symptoms of inflammation and itching and increased secretion of nasal discharge and tears, or symptoms of choking of the trachea and causing attacks of dyspnea (bronchial asthma) are classified as allergic diseases of this type. ing.

[0007] In the case of type I allergy, the process can be roughly divided into three stages, which are classified into each stage from the point of action, and prevent, alleviate or treat allergic diseases accompanied by inflammation by drug administration or the like. Attempts have been made to do so. That is, when an exogenous antigen enters the body, an immunocompetent cell line produces an IgE antibody, and the IgE antibody is distributed in airway, skin, gastrointestinal organs and other mast cells, or in the blood. Sensitization is established by sticking to basophils. This is the reaction referred to as the first step.

Next, when the sensitized cells are again contacted with an antigen, the cells undergo morphological changes such as vacuolation, swelling, and degranulation, and release chemical transmitters such as histamine, serotonin, and SRS-A. I do. This is the second stage reaction.

[0009] The released chemical messenger acts on contraction of smooth muscle such as bronchial muscle and gastrointestinal tract, enhancement of capillary permeability, migration of neutrophils, aggregation of platelets, and the like. The process of developing inflammatory allergic symptoms such as gastrointestinal allergy, nasal allergy, and hives with diarrhea is the third stage reaction.

Therefore, drugs acting in the first and second steps in a narrow sense are prophylactic drugs for allergic reactions and
Those acting at the stage can be considered as symptomatic treatments. Currently, the most active research on anti-inflammatory and anti-allergic drugs is the development of drugs that suppress this second stage.

[0011] Type II allergy is known as a damaging reaction caused by the destruction of tissue cells by IgG and IgM antibodies. The IgG and IgM antibodies that act on this system significantly activate the complement system when linked to an antigen. (Effector action). The reaction mechanism is based on the fact that IgG or IgM antibodies bind to antigen cells such as microorganisms, thereby activating the complement system and destroying target cells.

The function of the complement system is to activate a protease system in a target cell in a chain, form and destroy a membrane damage complex (MAC), and generate a group of fragments called anaphylatoxins. It takes complex steps such as promoting histamine release from mast cells and attracting polymorphonuclear leukocytes and macrophages to promote foreign body treatment. However, such reactions are caused by virus-infected autologous cells, tissue cells or erythrocytes to which haptens (substances that are not antigenic in nature but produce antibodies when bound to proteins, etc.) or bacteria are bound or adhered. In an immune disease, even if the cells are in their own normal cells, the living body recognizes and causes them as antigen cells. Typical types II allergic diseases include aplastic anemia and hemolytic anemia.

[0013] Type III allergy is a reaction in which a large amount of an antigen-antibody conjugate formed by the binding of an antibody to an antigen is deposited and damaged in a tissue. Antibodies involved in this reaction are mainly IgG antibodies, which are reactions involving many factors such as the complement system and polymorphonuclear leukocytes, similar to type II, but the difference from type II is that the antigen is not a cell but a substance Is a major feature. still,
The reaction mechanism is that the produced antigen-antibody conjugate is deposited on tissues such as blood vessels, kidneys, joints, and skin to activate the complement system (effector effect). As a result, a large amount of anaphylatoxin is produced, which increases vascular permeability, contracts smooth muscle, and promotes the release of histamine from mast cells, resulting in inflammation.

In addition, the action of phagocytic cells such as polymorphonuclear leukocytes accumulated by the action of anaphylatoxin causes a lysosomal degranulation reaction of the cells, and various types of degradative enzymes such as proteases in the lysosome are released to the outside. This leads to further tissue and cell damage and an allergic inflammatory response. The factors that cause damage to tissues and cells by the action of phagocytic cells are not only the effects of the released enzymes, but also the excess active oxygen produced by promoting respiration with phagocytosis. The effect of is also considered important, excess active oxygen,
It has been pointed out that it has undesirable effects on living organisms, such as damage to normal tissue cells, pigmentation, and aging of cells.

Next, in the case of type I-III allergies, the reaction takes a relatively short time after contact with the antigen (a reaction appears in about 2 to 3 minutes, and the intensity of the reaction becomes maximum in about 10 minutes). In contrast to immediate allergy, the type of reaction that is classified as type IV occurs only a few hours after the reaction with the antigen, and the reaction progresses slowly thereafter. It is called delayed allergy because it takes about 24 to 48 hours to reach the maximum strength.

A feature of type IV allergy is that no antibodies such as those found in the immediate form are involved, but instead lymphocytes called T cells are involved. That is, when T cells sensitized by the antigen are activated again by the antigen, various inflammatory factors called lymphokines (macrophage chemotactic factor, lymphocyte chemotactic factor, macrophage activating factor, vascular permeability factor) , Etc.), which are thought to cause a reaction to be amplified. Among the skin reactions in delayed allergy, contact dermatitis, which is characterized by redness, swelling, induration, and local infiltration of mononuclear cells, is well known.

Various test methods have been proposed based on the allergic reaction types classified in this way, and approaches to factors effective in preventing or ameliorating allergic diseases accompanied by inflammation have been actively conducted. .

[0018]

Many of the conventionally used anti-inflammatory drugs are drugs related to diseases caused by type I allergic reactions whose action points are relatively clear. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines.
It is a contrasting therapeutic agent that works in stages, and most of it is a synthetic drug, which has a problem in terms of side effects.
Furthermore, research on the development of drugs effective against type II-III allergies has been actively conducted, but at present, no specific anti-inflammatory agent has been found yet.

[0019]

In view of these circumstances, the present inventors have made various plants useful as anti-inflammatory agents the subject of development, and as a result, the amaranth extract has a carrageenan footpad edema inhibitory action. Histamine release inhibitory action, arachidonic acid metabolic activity inhibitory action has been found,
Therefore, there is provided a highly safe cosmetic composition or food and drink which is effective for prevention and improvement of skin inflammation such as allergic and atopic properties, or skin diseases such as eczema, itching, rough skin, and skin swelling. Thus, the present invention has been completed.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION "Amaranthus" used in the present invention means "Amaranthaceae", "Amaranthaceae" and "Amara".
nthus) Plant: Amaranthus (aka Amaranthus)
tricolor L.subsp maugostanus), (A.maugostanus
L.) leaves or whole plants, but other species of the same species, A. tricolor ssp. Tricolo
r), Hydrangea senninkoku (A.caudatus L.),
Cryptomeria japonicus (A. cruentus L.), Hosoaoigaito (A. patulus Bertol), Aogaito (A. retroflexus)
L.), Haribiyu (A. spinosus L.), Amaranthus hypochondriacus (A. hypocondriacus L.), (A. ganget
icus L., etc., leaves of the genus Amaranthus (whole plant), other subgenus: A. lividus L., A. gracilis Des
t.) can also be used.

The amaranth extract to be used in the present invention is obtained by extracting leaves or whole plants of plants as they are or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Ethers such as ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more kinds of liquid mixtures. Can also be used in a state where.

The amaranth extract is dried and concentrated depending on the anti-inflammatory agent, carrageenan foot pad edema inhibitor, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, cosmetic composition or food and drink dosage form and form. Alternatively, it may be adjusted by arbitrarily performing dilution or the like.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature to normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, purification treatment such as deodorization and decolorization may be added as far as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The amaranth extract of the present invention can be incorporated into an anti-inflammatory agent, a carrageenan foot pad edema inhibitor, a histamine release inhibitor, an arachidonic acid metabolic activity inhibitor, a cosmetic composition or a food or drink. Although not particularly specified, anti-inflammatory agents, carrageenan footpad edema inhibitors, histamine release inhibitors, arachidonic acid metabolic activity inhibitors, cosmetic compositions, types of foods and drinks, quality, expected degree of action It is slightly different, and is usually 0.001% by weight or more (hereinafter, expressed as% by weight), and preferably 0.5 to 20%. If the amount is less than 0.001%, the effect cannot be expected sufficiently.

The anti-inflammatory agent, the carrageenan foot pad edema inhibitor, the histamine release inhibitor, the arachidonic acid metabolic activity inhibitor, the cosmetic composition or the food or drink of the present invention may further comprise, if necessary, The components and additives used in pharmaceuticals, quasi-drugs, cosmetics, foods and beverages and the like can be arbitrarily selected and used in combination within a range that does not impair the effects of the present invention.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are usually processed according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, and the processing to be performed later. Usually, water and a water-soluble organic solvent (eg, ethanol) are used. , Propylene glycol, 1,3-butylene glycol, etc.).
However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

In the case of edible products, health and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and the like, improvement of taste, imparting of color tone, aroma and gloss, stabilization, It can be used for the purpose of thickening and preserving. Furthermore, in addition to these, various cosmetic and pharmacological effects of each known raw material are expected, and by combining these, the intended effect is enhanced or multi-functional. It is also possible to make a product that expects an effect.

Specific plants (crude drugs) as raw materials include:
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Fuji), Aotsu Lafuji (Kibo Komi), Acacia, Akashoma (Akasho-ma), Akasugi Fruit, Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Kanekane Akane), Ayajiou Jiou (Jihuang), Agi (Awei),
Akinire (Royu skin), Akebi (Kidori), Asa (Asako-jin), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Amacha (Amacha), Ashitaba (Asahi), Amana (Kojingi), Azuki (red azuki beans), acerola, asenyak
(Asenyaku), Anise, Abemaki fruit, Avocado, Ama, Amacha (sweet tea), Amachaworu, Amadokoro (Tamatake), Amigasa lily (Shellfish), Altea, Arnica, Aloe (luxe),
Aloe vera, angelica, apricot honganzu (almond jelly), ansokkou (benzuka), igakozorina (biliary head), rush (light heart grass), knotweed (tiger cane root), strawberry,
Fig (fructose) or its leaves, Ichihatsu (primary), Ichibi (Aoi-ko), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo leaves, Ginkgo), Itohimemegi (Enshi), Carob bean, Inuazuna (Teilexi), rice seed or The seed coat is seed coat, Inondo seed, Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco (Iwatakechi), oolong tea, fennel
(Fengxiang), Ukiyagara (Mitsuryo), Uguisukagura fruit, Himeuikyo, Turmeric (Utsukin), Duckweed (Buoying), Usubasaishin Keirinsaishin (spicy), Usveniaoi,
Pterodactyla mushroom, Nepenthes (summer hay), Udo or Shishido (Kang, Independent, Tang Independent), Plum (Ume) or its pulp, Vladigashi, Uwaurushi (Kusacokomomo), Unshurikan (Chen skin), Estragon, Ezogoke (Ezo fivega) ), Echinashi (Echinacea vulgaris), Echinida, Enokitake (Enoki mushroom), Ebisugusa / Cassia tora (Keyoshiko), Elderberry fruit, Elemi, Eringy (pre-rotus Erinji), Endu (rice flower, soybean rice), ogi・ Kibanaoogi (Astragalus), Ouren (Organic),
Giant crows (caronine), giant clam (self-defense), giant psyllium (vegetative child, vegetative grass), great hazel (haruko), great okana okera (white aphid), great oyster shabushi fruit, great hawthorn hawthorn (Yamasato), great oyster (narukoyuri, Kagikurumabanarukoyuri), Sasanoyuki, Sasanoyuki, barley (barley), Ooishigusa (cereal grass),
Oguruma (turning over), Okra fruit, Panax ginseng and Caribbean ginseng (Ginseng), Hypericum perforatum, Hypericum perforatum, St. John's wort (Brother's cut grass), Odorikosou (intermittent), Onamimi (blue ears), Onigurumi, Oninoyagara・ Hatakata lily (Yuri), Ononis, Halibut (Rihayu), Ominaeshi (Loose), Dutch mustard (Crasson), Dutch jelly, Dutch honeybee, Olive (fruit, seed, leaf), Oregano, orange fruit or pericarp, Caykei Jio (ripe ground yellow), cacao seeds, oysters or leaves thereof (persimmon), kagi kazura (choto), cassia, casino fruit (kozumi), gajutsu (shazajutsu), kashiwa (basin tree, basin leaves), cascarilla, Cascara sagrada, kanikusa (kinsato), valerian (valer), birch or weeping birch (white birch), pumpkin, kapok seed, kahok Nshou (蜀椒),
Gama (bamboo), chamomile, roman chamomile, chamilia
(Weeds), camucam / camouflage, crow squirrel (gold melon), crow squirrel (midsummer), mussel, guarana seeds, karahoo (thick), karaya, karin (gourd), garcinia, kawataketake, kawaranadeshiko (stone bamboo), ezokawaranadeshiko ( Qumugi, Quumiko), Japanese mugwort (Inchinko), Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kantou, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiro strawberry, Maple strawberry, European strawberry), Kiwi fruit, Kikarasuuri
(Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Drosophila), Catalpa (Azumi), Rigid ridge (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe,
Peppermint, Kinna, Chinese linden (Shincona, Red linden), Yellowfin (Huangbashi), Gymnema sylvestre, Cabbage, Cabbage immature fruit, Cucumber, Gyoryu (Nishikawayanagi ・
Teriyaki), Kiraja saponaria, Kiraya, Kiran-sou (gold acne grass), kumquat fruit, betel, kinmizuki
(Sengaku grass), guava fruit, guayule, Quercus infectria (gallicia), cucumber nuts, wolfberry (mugi, gugi, gugi leaves, skeletal bark), cedar grass (Tenmen Fuyu), vine (kuzukon), camphor tree, gooseberry Fruits, gardenia, gardenia, black clover, kumazasa, black pine, horseradish, clara, bittersweet, cranberry fruit, chestnut or its skin, curculigo latifolia fruit, grapefruit, buckthorn, black crocodile (rescue) , Kurobana Hikiokoshi, Clove (cloves, cloves), Gumbinazuna (Sekimei, Sekimeishi), Kaigai (Ikutake, Ikutakeho),
Celosia (cow flower, rooster), bay laurel, kenashisarutoribara (Tsubukuryo, Yamakiko), gentian,
Gennoshoco (Old treasured grass), Koji / Tachibana / Obenimikan / Ponkan / Santara (Tachibana skin), Koushinbara (Monthly flower), Kouzuikka, Kozo fruit, Kocha (tea), Kouhone (river bone), Kohon (waramoto, Kara straw book), Koulyang, Cilantro fruit, Kou Ren (Kohren), Koganebana (Yellow Gon), Cowberry (Koshibachi), Coconut fruit, Goshyu (Gusyuyu), Goshoi strawberry (Ubonashi), Pepper (Hot pepper), Copaiba balsam, Coffee beans , Kobushi magnolia, burdock, burdock, burdock, sesame
(Sesame seeds), Sesame grass (Ginseng), Gomishi (Gomiko), Sanekazura Binankazura Matsubusa, Wheat (wheat), Rice
Rice bran (red bran, white bran), rice oil, cola, acuminata seeds,
Cola vera seeds, fenugreek fruit, colombo, conzlango, kelp, konjac, comfrey (finnari grass), sisal (sisalasa), saxima buttonpul (weird sen), cherry (oshima cherry, yamazakura, oyamazakura),
Leaf, flower, fruit, bark (cherry bark), cherry, pomegranate, sasa, sasanqua, sajiomodachi, sweet potato, sweet potato , Sugar beet, jujube jujube (acid jujube), saffron (banana safflower, western safflower), pomelo fruit, sabonso, salmonberry fruit, sarashinasho (masuma), salvia (sage), sawagikyo (yamachona), sawagurumi (yamakotomo) ), Sanshin ginseng (San carrot), Sanshuyu (sanshuyu), Sansho
(Sansho), Sandscon (Soybean root), Shea (Carite), Cyanoki fruit, Shiitake (Shitake mushroom), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla, Aodiso, Chirimendiso, Catamendiso (Perilla leaves, Perilla) ), Rosewood, linden, Chinese pine, Chinese forsythia (forsythia), shimeji (hinshimeji,
Shakashimeji, Hatakeshimeji, Oshiiroshimeji, Bunashimeji, Shirotamogitake),
Peony (Shakuyaku), Shajin (Shasan), Janohige (Bakumon winter), Juzudama, Palm fruit, Ginger (Ginger), Shobu (Iris, Iris root), Shozuku fruit, Shirakashi seed, Shirogoshi butterfly seed, White adzuki bean (chicken bone) Grass), Shirobanairis (Small iris), Shirobanatsuta flower, Shirominanten (Namitenmi), Cinchonasakusylbra, Jinkoge (Mizuka, Mizuka flower, Shencho flower), Cinnamon, Watermelon (watermelon), Honeysuckle (Golden flower, Shinobi) Sorrel (acid model), Swimberry fruit, Stevia, Strawberry fruit, Suzu Psycho (Long Xu), Japanese horsetail (Thorn thorn), Suberhiyu (Horse ken,
Kento), plum fruits, cones of Scots pine,
Larch, vegetation, walnuts,
Hawthorn, dandelion, horse chestnut (malonie), pear fruit, prunus officinalis, elderberry, yellowtail (juniper, morimatsu), northern yaw (milfoil), yellow pears, yellow pears Mint, mint, horseradish, horseradish, sekisho, zeniyaoi, hirohasenega, senega, seri, celery, senkyu, senkyu (river cucumber), sendan, senburi (drug), senna fruit or leaves,
Senninsou (great tate), souka (grass), buckwheat seeds, soybean potato, rhubarb (daisuki), radish, soybean, daidai (orange peel, kikomi), takatodai (daigei), takawarabi (gull),
Dark sweet cherry fruit, hollyhock, hollyhock (thyme, Hyakurika), hollyhock, tamarind seeds, onion, tamshiba (spicy), taro bark or its root bark, tanjin (dansin), dandelion (gakko British) or shirobana dandelion, moko dandelion, dammar , Cherry fruit, chigaya or its roots (chinese radish), ginseng carrots (bamboo ginseng),
Chicory, Korean ginseng (Gomiko), Chinese radish (Ohta), Korean lance (Wuyi), Korean ginseng
(Ginseng), Artemisia (Aiba), Choreimaitake
(Irei), Japanese Ginseng, Japanese chestnut (mushroom),
Camellia, camellia, clover (lacquer lacustrine), communis (duckweed), vines (red azuki), vines (red bean), vines (vegetables), vines (four-leaf ginseng), vines, deiko, teuchigurumi, duberry fruit, tengusa , Tencha (tencha), tendai yak (crowd medicine), toga (winter gourd),
Pepper (pepper), corn (toki), calendula (marigold), corn or corn hair (southern hair), horned rice mochi (female child), torindo (ryubiru),
Tokusa (pirate), Dokudami (jujutsu), Tokon (root), Toshishi, Mamedaoshi and Neashikazura, Eucommia (Tonaka, Tonakaha), Ash (Cowhide), Tomato, Tragant, Triacanthus seed, Tormentilla, Doronoki, Troroaoi, Nai Zeria berry fruit, yam yam (Yamayaku), nagi ramen (butcher bloom), naginata koju, nazuna, rapeseed, jujube, jujube (daijutsu), nanawaibara (gold sakurako), nameko, narko lily (yellow), peanut (peanut) , Nanten (Minami Tenmi), Nigaki (Maki),
Sagebrush (bitter mosaic), nutmegium, kei nikkei (cinnamon bark)
Fruits / flowers or foliage of Keishi (Chrysanthemum), Chinese chive (Niriko), Elderberry (bone-attached tree), Garlic (Gourd), Nurde (Golden), Leek, Nozami (Ohiji), Neubara (Yomi), Yarrow,
Japanese radish (maehu), wild rose, peach, palm, pineapple fruit, hibiscus (Bussouge, Furinbussuge, Roselle), Hakamauraboshi (bone crushing supplement), Hakusen (ringworm skin), Hakuruberry fruit, Hakobe (Horiko), Hashibami (Haruko) , Hasiridokoro (Roth root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland jelly), Naked mulberry, Batata, Hachiku Madake (Bamboo boiled), Patchouli, Mint (Lightly loaded, Lightly loaded leaves), Adlay (Yokinin) ), Hanasuge (chimbo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice koji), Habu grass, Paprika, Hamago and Mitsuba Hamago (Thornbrush) , Hamabishi (Satsuriko), Hamanas (Maikai flower), Hamabo fu (Hama windbreak), Hamamelis, Rose (rose), Haratake (Haratake, White-faced Oharata) Mosquitoes, Uskimorinokasa), Parietaria, Harunire (yellow, yu white skin, yuba), breadfruit, giant forsythia (sun dried), lizard carrot (party party), pecan nut, ganganana
(Shirubi, Suzuka Hana), Hikikoshi (Extended Life Grass), Hishi (Ryomi),
Pistachio, beet, hitsuba (stone reed), hitspotter fern, hinotainokozuchi (cow knee), hinoki, hiba, castor,
Sunflower, bell pepper, Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta fruit, Juniper, Billacucu, Hyouyu fruit, Belowudo oil, Hiroohinagusa (Hakutooka), Loquat (loquat, loquat leaf), Betel wax (large clothing skin, Betel palm), spruce buds (southern wicker), butterflies, coltsfoot (winter flowers, wisteria leaves), fujibakama (orchid grass), wisteria beans (flat beans), grape berries or pericarp, seeds and leaves, beech, beetle Brazilian liquorice, Brazilian carrot, black currant fruit, blackberry, plum fruit, flucellaria, blueberry (Prunus avium), prunes, blonde psyllium, bundou (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruits, Peruvian Berg, Boysenberry Fruit, Bow Few (Windbreak), Ho Lenovo, nightshade
(Torone), Onoki (Japanese magnolia, park), Bokeh (Gourd), Hosobananaokera (Aojutsu), Hosobabarengiku, Bodaiju (Bodai tree), Button (peony, Peony bark), Hops, Jojoba, White berry fruits, Hongshimeji , Hong Onik
Daigei), Maizulten Nanshaw (Tennan star), Maitake (Maitake), Ephedra (mao), Macadamia nut, Macri
(Seaman grass), magwa (mulberry white skin, mulberry leaf), magnolia splengeri, matabi (mokuten tate), matsukasa, matsuba, matsuhod
(Bukuryo), mayola (Hanaminka), malvanozadin (bitter), mulberry fruit, quince, mango, mangosteen, manshu walnut, mandarin fruit, mannentake (reishi), fruit of Rutaceae plant (komi), mishimasaiko (saiko), Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Myoga, Miracle Fruit Fruit, Myrrh, Mirobaran, Mukuge (Mokugei), Mukunoki, Mukuroji, Murasaki (Murasaki), Murasakikisukibu, Omurasakisikib (Purple pearls), purple corn, red swordfish (mother grass), mebaugi, melaleuca, melissa, melilot, melon fruit, sagebrush, mosouchikku, mokkou (wood incense), maple leaf daisies, peach leaves (peach leaves), fruits and seeds (peach peaches) ), Bean sprouts, morello cherry fruit, moroheiya (burlap), yakawa murasa Potatoes, Yakuchi
(Masutoshi), cornflower (cornflower), cornflower mint, yashabushi (arrow wheel) / Himeyashabushi / Obayashishabushi fruit, peel, fruit panicle, yachiyanagi, yatsude (octagonal gold plate), mistletoe (willow parasite), willow (kawayanagi, tayanagi, Weeping willow, red willow willow, pussy willow, inukoriyanagi, kinuyanagi, kolyanagi, unryuyanagi, miyayamanagi, yamayanagi, shirabanyanagi, tyrikkinuyanagi, foxgrew willow, dragonflies, purple wolfberry, beetle
(Land), alder (Yamaharu), bayberry (Yumebai), mugwort, eucalyptus, snowy citrus (tiger ear grass), yucca flebifolia, yuzu fruit, lily, yorigusa, mugwort
(Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaves / fruit, lavender, longan (longan meat), agave (Aono agave, fukurin agave), ryocha (green tea), apple fruit, gentian,
Lubas suavisimus (sweeten), litchi (litchi, lichi nucleus), lettuce (chisha), red currant fruit, lemon fruit, lemongrass, forsythia (forsythia: forsythia, forsythia), astragalus, wax palm, rokon (reed: Rone), Loganberry fruit, Rosemary
(Mannenrou), Rosehip (Nobara), Wasabi and Waremokou (Jiyu).

In addition, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud / mud (fango) Species, for example, sea mud or mud (silicon dioxide, silicon dioxide,
Titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium,
Iron, copper, nickel, zinc, lead, manganese, arsenic, water, vitamin B, vitamin A, phytohormone "diberlin,
Cytokinin, absciscin ")

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra sp.
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Cyanobacteria (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include cockscomb extract, bovine / human placenta extract, swine / cattle stomach, duodenum or intestinal extract or decomposed product thereof, and swine / cattle spleen extract. Products or their decomposed products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolites Yeast metabolites, yeast extract, rice ferment extract, rice bran ferment extract, Euglena extract, lactic acid fermentation of raw milk and skim milk powder, trehalose or derivatives thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, tocopherol and its derivatives, N-acetyltyrosine and its derivatives,
Glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placental extract, silk extract,
Plant extracts (mulberry, corn, smelt, Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, edulis, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamerisu, yamaguwa, enmeshi, kyoto , Continued spouse,
Sun-dried, mao, sengoku, dokkatsu, psycho, boufu, hamabofu, ougon, peony skin, peonies, gennoshoko, kakkon, licorice, quintoko, aloe, ginger, safflower, green tea, black tea, asenyaku, etc.).

(20) Melanin dye reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.).

(26) Anti-inflammatory agents Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-camphor, hydrocortisone,
Guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizinic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, Eight's extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, lactic acid Sodium, Mini Sasanishiki extract, etc.

(29) Hair Agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, show tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Topical stimulants Pepper tincture, nonylate vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid and derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(34) Antiseborrheic agents pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(35) Keratolytic agents Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate, etc.).

(38) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(39) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(40) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, Great Fenxia essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(41) Dyes and Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(42) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(43) Nutrition Enhancer Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(44) Dairy products Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Plant polysaccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, cell activators, keratolytic agents, wound healing agents, hair removal Ingredients, foaming agents, thickeners, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, etc. are expected to be added and synergistic effects are expected when used in combination with these agents. it can.

Further, the anti-inflammatory agent, carrageenan foot pad edema inhibitor, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, cosmetic composition, and food and drink of the present invention can be in any dosage form.
Capsule, powder, granule, solid, liquid, gel,
It can be used by blending it in foams, emulsions, creams, ointments, sheets and other pharmaceuticals, quasi-drugs, skin and hair cosmetics, and foods and beverages.

Specifically, for example, preparations for internal and external use, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, etc .; , Aftershave lotion, pre-show lotion, shaving cream, shampoo,
Hair cosmetics such as rinses, hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair restoration, foundation makeup, lipstick, blusher, eyeshadow, eyeliner, makeup cosmetics such as mascara, perfumes, Bath agent, other, toothpaste, mouth freshener / gargle,
It can be applied to various products such as deodorant and deodorant, sanitary cotton, wet tissue, and can be used for general foods and drinks.

The methods of adding the anti-inflammatory agent, carrageenin foot pad edema inhibitor, histamine release inhibitor, arachidonic acid metabolic activity inhibitor, cosmetic composition, and food and drink of the present invention are added in advance. However, it may be added during the production, and may be appropriately selected in consideration of workability.

[0087]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) 100 g of amaranth leaf is 50%
After immersion in 400 mL of an ethanol solution and extraction at room temperature for 3 to 7 days and nights, suction filtration is performed to obtain about 1.0 kg of an extract (dry solid content: 0.1 to 1.0% by weight).

(Production Example 2) 100 g of amaranth leaves are immersed in 400 mL of purified water (about 80 ° C.), heated and extracted for about 5 to 7 hours, filtered, and the extract (dry solid content: about 0.1 to 1.0 weight) %)
About 1.0 kg.

(Production Example 3) 100 g of amaranth leaves are 70%
Ethanol solution or 30% 1,3-butylene glycol solution,
Or a 60% propylene glycol solution or purified water (about 30
C) immersed in 400 mL and extracted at room temperature for 3-7 days and nights.
Filter the extract (dry solids: about 0.1-1.0% by weight) to about
Get 1.0kg.

(Test 1) Carrageenin footpad edema suppression test It is known that carrageenan-induced edema changes in chemical mediators involved in inflammation that occurs after administration. For example, within 1 hour of administration, serotonin and histamine are 1-2
It is said that the kinins are involved in the time and the plastaglandin system is involved in the second and subsequent hours, and the time from the start of the test to the time when the inhibitory effect appears is used to estimate which chemical mediator is being suppressed. be able to. Therefore, a substance that suppresses edema of the carrageenan footpad can be expected to have an anti-inflammatory reaction. This test was performed using mouse footpad edema test (Cosmetic Journal, 2
3,267 (1990)), the extract obtained in Production Example 1 was examined.

(Test Method) a. After evaporating the solvent under reduced pressure, the sample extract was redissolved in purified water so that the solid content concentration became 10% by weight, and used for the test. or,
When used in combination, the respective solid content concentrations were adjusted to 10% by weight. The same concentration of dipotassium glycyrrhizinate was used as a positive control. b. Measurement of edema swelling rate The thickness of the right hind footpad of a 6-week-old ICR female mouse was measured in advance with a dial thickness gauge, and the carrageenin was administered twice, one hour before administration, and the test drug 25 mg was added to the right. It was applied to the hind limbs so that it could be carefully rubbed with fingers 30 times. An hour later,
Physiological saline containing 2% λ-carrageenin 25μ under the right hind footpad
L was administered, and thereafter, the thickness of the footpad was measured every 1 hour for 4 hours, and the difference from the footpad thickness before the λ-carrageenin administration was determined. The suppression rate was determined by comparison. In the test, 7 to 8 mice were used.

[0093]

[Table 1]

(Test Results) As shown in Table 1, it was confirmed that the amaranth extract of the present invention has an effect of suppressing the foot pad edema of mice caused by carrageenin, a carcinogen, as compared with dipotassium glycyrrhizinate. , Can be used as anti-inflammatory agent.

(Test 2) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an anti-inflammatory effect. In this study, compound 48, a histamine release reagent from rat mast cells, was used.
/ 80 to release histamine (J. Soc. Cosmet. Ja
pan, Vol. 25, No. 4, P. 246 (1992)) and Production Example 1
The extract obtained in was examined.

(Test Method) a. After distilling off the solvent from the sample extract under reduced pressure, the sample extract was redissolved in purified water so as to have a solid content concentration of 0.5% by weight, and used for the test.
The same concentration of dipotassium glycyrrhizinate was used as a positive control. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
Add compound48 / 80 to a final concentration of 1 μg / mL and add 3
Incubated at 7 ° C for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, histamine released from the supernatant was extracted and purified, and color was developed with o-phthaldialdehyde.
The fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured, and the histamine release inhibition rate was calculated by the following equation (Equation 1).

[0097]

## EQU1 ## Histamine release inhibition rate (%) = ｛1- (A−
C) / (BC)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added in the presence of a sample in mast cells B: Released when a histamine releasing agent was added to mast cells Fluorescence intensity of histamine C: Fluorescence intensity of histamine naturally released from mast cells (A, B, and C are measured values minus blind values)

[0098]

[Table 2]

(Test Results) As shown in Table 2, it was confirmed that the amaranth extract of the present invention has a histamine release inhibitory action. In addition, it has the same histamine release inhibitory action as dipotassium glycyrrhizinate and can be used as an anti-inflammatory agent.

(Test 3) Inhibition test of arachidonic acid ear edema In the type I allergic reaction, the reaction of the IgE antibody and the antigen destroys the phospholipids of the cell membrane and releases arachidonic acid, which is affected by the action of various enzymes. Prostaglandin, one of the transmitters, is metabolized to SRS-A,
Develops various allergic symptoms. Therefore, a substance having an action of suppressing the metabolic activity of arachidonic acid can be expected to be used as an anti-inflammatory agent. In this test, a hydrophilic ointment containing the extract obtained in Production Example 1 was formulated, and the method of Shinno et al. (“The effect of 3.4-dihydroxychalcones on mouse arachidonic acid ear edema”: 113th Annual Meeting of the Pharmaceutical Society of Japan) See and examined.

(Test Method) a. The sample extract was concentrated under reduced pressure by distilling off the solvent, and a hydrophilic ointment containing 10.0 wt% in terms of solid content was produced and used by a conventional method. An ointment containing dipotassium glycyrrhizinate was used as a positive control. b. Measurement of edema swelling rate Apply the above-mentioned ointment in advance of about 3,2,1
Three hours before, a mouse (Slc: ICR female mouse, about 6 weeks old) was applied to the right pinna carefully so as to be carefully rubbed. Immediately before arachidonic acid application, wipe off the ointment adhering to the pinna,
5% by weight arachidonic acid (SIGMA) 2 dissolved in acetone
0 μL was applied, and after 1 hour, the auricle was punch-excised (5.0 mm). Similarly, the left pinna was resected, and the arachidonic acid ear edema swelling rate was measured from the weight difference between the left and right pinna. For the determination, the ear edema suppression rate was calculated by comparing with the ear edema swelling rate of the control group to which only the base was applied as a blank. In each test system, 7 to 8 mice were used.

[0102]

[Table 3]

(Test results) As shown in Table 3, the amaranth extract of the present invention showed almost the same ear edema suppression rate as dipotassium glycyrrhizinate, and was confirmed to have an arachidonic acid metabolic activity inhibitory activity.

(Test 4) Safety test (1) Primary skin irritation test The amaranth extract obtained in Production Examples 1 to 3 was prepared with purified water so that the solid content concentration was about 10.0% by weight.
Japanese white rabbit with shaved back (female, 3 per group, weight 2.
3 kg). Judgment is 24,48,72 after application
Erythema and edema were used as indicators by the primary irritation scoring method at time. The result was negative in all animals without any erythema and edema.

(Test 5) Safety Test (2) Skin Cumulative Irritation Test Similarly, the amaranth extract obtained in Production Examples 1 to 3 was prepared in purified water so that the solid content concentration was about 10.0% by weight. Once a day, 5 times a week on the skin of Hartley-type guinea pigs (female, 3 animals per group, body weight around 320 g) with shaved flank
Each time, 0.5 ml / animal was applied. The application takes place over two weeks,
Shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indices. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 6) Safety test (3) Acute toxicity test Similarly, powder obtained by concentrating and drying the amaranth extract obtained in Production Examples 1 to 3 under reduced pressure (dry solid content: about 10.0)
Weight percent) was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old) in a 2,000 mg / kg dose fasted for 4 hours before the test. Observed. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore,
LD50 was determined to be 2,000 mg / kg or more.

(Prescription Examples) Production of various anti-inflammatory agents, histamine release inhibitors, arachidonic acid metabolic activity inhibitors, external preparations for the skin or baths, and foods and drinks. However, the formulation examples may be those manufactured by a conventional method in the manufacture of each product, and only the compounding amounts are shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. Amaranthus hot water extract 7.0 11. Appropriate perfume and preservatives 12. Purified water 100

(Formulation Example 2) Peel-off pack wt% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Amaranthus 50% ethanol extract 5.0 7. Fragrance, Preservative qs 8.Purified water 100 residue

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Amaranthus 30% phenolic alcohol extract 5.0 7. Perfume, Preservative qs 8.Purified water 100 residue

(Formulation Example 4) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Amaranthus hot water extract 8.0 7. Appropriate amount of fragrance and preservative

(Formulation Example 5) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Amaranthus 30% ethanol extract 5.0 5. pH adjuster qs 6. Preservative qs 7 .Remaining amount of purified water 100

(Formulation Example 6) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Amaranthus 50% 1,3-butylene glycol extract 10.0 6.Appropriate amount of pH adjuster 7.Appropriate amount of preservative 8.Purified water 100 residue

(Formulation Example 7) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Amaranthus 50% ethanol extract 3.0 6. Preservative qs 7.Purified water 100 residue

(Formulation Example 8) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Amaranthus 50% ethanol extract 7.0 5. Purified water 100 Residue

(Formulation Example 9) Granule bath agent weight% 1. Sodium bicarbonate 60.0 2. Anhydrous sodium sulfate 30.0 3. Borax 5.0 4. Amaranthus 50% 1,3-butylene glycol extract powder 5.0

(Formulation Example 10) Coating protective agent A gauze or liniment cloth is impregnated with a formulation liquid obtained by mixing an appropriate amount of an amaranth hot water extract, an antibiotic, an anti-inflammatory, etc.
Attach to trauma. Alternatively, the amaranth hot water extract may be directly applied locally and covered with gauze or the like.

(Formulation Example 11) Mentsuyu liquid wt% 1. Soy sauce 80.0 2. Black vinegar 2.0 3. Glucose 13.0 4. Sodium glutamate 2.0 5. Amaranthus hot water extraction powder 3.0

(Formulation Example 11) Udon or buckwheat wt% 1. Flour or buckwheat flour 96.0 2. Salt 1.0 3. Amaranthus hot water extracted powder 3.0

(Formulation Example 12) Bread wt% 1. Wheat flour 90.0 2. Salt 1.0 3. Glucose 7.0 4. Amaranthus hot water extracted powder 2.0

(Formulation Example 13) Cookie weight% 1. Milk 63.0 2. Whole egg 13.0 3. Sugar 13.0 4. Constarch 5.0 5. Salt 1.0 6. Amaranthus hot water extraction powder 5.0 7. Appropriate perfume

(Formulation Example 14) Sausage wt% 1. Ground meat 91.0 2. Chicken eggs 5.0 3. Spices 1.3 4. Seasonings 0.5 5. Amaranthus hot water extracted powder 2.2

(Formulation Example 15) Beverage weight% 1. Glucose liquid sugar 33.0 2. Grapefruit juice 63.5 3. Amaranthus hot water extraction powder 3.0 4. Flavor 0.5 0.5 5. Acidulant

(Formulation Example 16) Gum weight% 1. Menthol micron 31.0 2. Grapefruit flavor 66.0 3. Amaranthus hot water extracted powder 3.0

(Formulation Example 17) Miso soup weight% 1. Tofu 40.0 2. Deep fried 2.5 3. Carrot 5.0 4. Burdock 5.0 5. Red miso 20.0 6. Amaranthus hot water extracted powder 3.0 7.

(Test 7) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. The test used is to worry about dry skin, rough skin, eczema, atopic dermatitis and other skin diseases.
A panel of 10 50-year-olds, twice daily, morning and night,
After washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. Also, for 10 people (5 to 50 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of Hair Tonic of Formulation Example 8 to the scalp for 3 months after daily hair washing. The use test was carried out by.

The bath preparation of Formulation Example 9 was also applied to 10 patients aged 3 to 65 years old who suffer from skin diseases such as dry skin, rough skin, eczema, and atopic dermatitis for 4 months. The test was performed once a day by always bathing in a bath with an appropriate amount of a bathing agent dissolved therein. Controls include latex,
A mixture obtained by removing the amaranth extract of the present invention from the hair tonic by the same method was used. The bath preparation was prepared in the same manner as above except that anhydrous sodium sulfate was used instead of the dry powder of the amaranth extract of the present invention. The evaluation was performed according to the following criteria. The results are shown in Table 4 and the numbers in the table represent the number of persons. No one complained of abnormalities on the skin or scalp during the use period.

"Effect of improving skin (scalp) disease" Efficacy: Redness, itching, dry skin and rough skin due to inflammation such as eczema were improved. Somewhat effective: Redness and itching, dry skin, and rough skin due to inflammation such as eczema were slightly improved. Ineffective: No change from before use.

[0129]

[Table 4]

(Test Results) As shown in Table 4, the use of the cosmetic composition (emulsion, hair tonic, bath preparation) containing the amaranth extract of the present invention resulted in inflammation due to eczema, itching,
A good effect was confirmed on the improvement of skin and scalp inflammation such as dry skin and rough skin.

(Test 8) Use Effect Test The effect of the food of the present invention actually used was examined. Use tests include dry skin, rough skin, eczema,
5-50 years old suffering from skin diseases such as atopic dermatitis
0 people were panelists, and they were divided into twice daily (approximately 10:00 a.m. and 3:00 p.m.) and asked to drink 5 cookies of Formulation Example 13 (amount per day, about 50 g) for 3 months. Was.

As a control, a cookie prepared by removing the amaranth extract of the present invention from a cookie was used in the same manner. The evaluation was performed according to the following criteria. The results are as shown in Table 5, and the numerical values in the table represent the number of persons. No one complained during the period of use.

"Effect of improving skin (scalp) disease" Efficacy: Redness, itching, dry skin and rough skin due to inflammation such as eczema were improved. Somewhat effective: Redness and itching, dry skin, and rough skin due to inflammation such as eczema were slightly improved. Ineffective: No change from before use.

(Test Results) As shown in Table 5, the use of the amaranth extract of the present invention in foods was effective in improving skin diseases such as inflammation, itching, dry skin and rough skin due to eczema. Was confirmed.

[0135]

[Table 5]

[0136]

Industrial Applicability The amaranth extract of the present invention has a carrageenan foot pad edema inhibitory action, a histamine release inhibitory action, and an arachidonic acid metabolic activity inhibitory action, and is safe for internal or external use in humans or animals. Things. Therefore, it can be used as an anti-inflammatory agent, specifically, a carrageenan foot pad edema inhibitor, a histamine release inhibitor, an arachidonic acid metabolic activity inhibitor, rough skin, dry skin, eczema, hives, atopic dermatitis, allergic It is effective for prevention and improvement treatment of various inflammatory diseases such as rhinitis and hay fever. Further, it can be applied to all forms of preparations (medicines, quasi-drugs, cosmetics, foods).

Continuation of the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (Reference) A61K 7/48 A61K 31/00 607E 4B047 A61P 7/10 629 4C083 29/00 643F 4C088 43/00 643D // A21D 13 / 08 A21D 13/08 A23G 3/30 A23G 3/30 A23J 3/00 506 A23J 3/00 506 A23L 1/16 A23L 1/16 A 1/22 1/22 D A61K 7/00 A61K 7/00 U KW 7/06 7/06 7/075 7/075 7/50 7/50 A23L 2/00 FF term (reference) 4B014 GB13 GG18 GK12 4B017 LC03 LG20 LL09 4B018 LB01 LB02 LB08 LE05 MD48 ME07 MF01 4B032 DB01 DK29 DL20 4B046 LC06 LG25 4B047 LB03 LB09 LE01 LF04 LF07 LF08 LF09 LG37 LP01 4C083 AA082 AA111 AA112 AA122 AB272 AB312 AB352 AC022 AC072 AC102 AC122 AC182 AC242 AC352 AC402 AC422 AC432 AC532 AC542 AC692 AC782 AC902 AD112 CC31 CC31 CC37 CC31 CC23 CC31 CC31 CC23 EE22 EE41 4C088 AB12 AB99 AC01 AC05 B A08 BA09 BA10 MA52 MA63 NA14 ZA34 ZA89 ZB11 ZB13 ZC13 ZC21

Claims (6)

[Claims] 1. An anti-inflammatory agent comprising an amaranth extract. 2. A carrageenan footpad edema inhibitor comprising an amaranth extract. 3. A histamine release inhibitor comprising an amaranth extract. 4. An arachidonic acid metabolic activity inhibitor comprising an amaranth extract. 5. A method according to claim 1, wherein at least one of the anti-inflammatory agent, the carrageenan footpad edema inhibitor, the histamine release inhibitor and the arachidonic acid metabolic activity inhibitor is combined. And a cosmetic composition. 6. A combination of any one or more of the anti-inflammatory agent, the carrageenan foot pad edema inhibitor, the histamine release inhibitor, and the arachidonic acid metabolic activity inhibitor according to claims 1 to 4. Food and drink.