JPH04173720A - Hair growth agent - Google Patents
Hair growth agentInfo
- Publication number
- JPH04173720A JPH04173720A JP2299417A JP29941790A JPH04173720A JP H04173720 A JPH04173720 A JP H04173720A JP 2299417 A JP2299417 A JP 2299417A JP 29941790 A JP29941790 A JP 29941790A JP H04173720 A JPH04173720 A JP H04173720A
- Authority
- JP
- Japan
- Prior art keywords
- hair growth
- extract
- leaves
- thuja orientalis
- hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003779 hair growth Effects 0.000 title claims abstract description 20
- 239000002075 main ingredient Substances 0.000 claims description 2
- 201000004384 Alopecia Diseases 0.000 abstract description 15
- 239000003795 chemical substances by application Substances 0.000 abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 9
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 abstract description 8
- 240000002924 Platycladus orientalis Species 0.000 abstract description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 abstract description 5
- 231100000360 alopecia Toxicity 0.000 abstract description 5
- 229960003500 triclosan Drugs 0.000 abstract description 5
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 abstract description 4
- 239000008213 purified water Substances 0.000 abstract description 4
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 abstract description 4
- 229960004172 pyridoxine hydrochloride Drugs 0.000 abstract description 4
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 abstract description 4
- 239000011764 pyridoxine hydrochloride Substances 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 229930007845 β-thujaplicin Natural products 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 241000218691 Cupressaceae Species 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 2
- 238000002386 leaching Methods 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 229960001295 tocopherol Drugs 0.000 abstract description 2
- 229930003799 tocopherol Natural products 0.000 abstract description 2
- 235000010384 tocopherol Nutrition 0.000 abstract description 2
- 239000011732 tocopherol Substances 0.000 abstract description 2
- 229940124549 vasodilator Drugs 0.000 abstract description 2
- 239000003071 vasodilator agent Substances 0.000 abstract description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract description 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002070 germicidal effect Effects 0.000 abstract 1
- 230000002879 macerating effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 210000004209 hair Anatomy 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 8
- 230000003676 hair loss Effects 0.000 description 8
- 208000024963 hair loss Diseases 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 206010068168 androgenetic alopecia Diseases 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 229940075894 denatured ethanol Drugs 0.000 description 2
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- -1 That is Chemical compound 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 201000002451 Overnutrition Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020823 overnutrition Nutrition 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 208000002271 trichotillomania Diseases 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
［発明の目的］
［産業上の利用分野］
本発明は、ソクハクの抽出物を主成分することにより、
脱毛を予防し、発毛効果を高めた育毛剤に関する。[Detailed Description of the Invention] [Object of the Invention] [Industrial Field of Application] The present invention provides the following advantages:
This invention relates to a hair growth agent that prevents hair loss and enhances hair growth.
［従来の技術］
脱毛機構の解明が進むと共に、これに対応する養毛剤、
発毛剤も開発されている。即ち、頭皮の血行促進、毛母
細胞の活性化、頭皮の脂・質分泌抑制、頭髪への栄養補
給などを目的として、各種の製剤が使用されている。[Conventional technology] As the mechanism of hair loss progresses, hair growth agents,
Hair growth agents have also been developed. That is, various preparations are used for the purpose of promoting blood circulation in the scalp, activating hair matrix cells, suppressing the secretion of lipids and substances in the scalp, and providing nutrition to the hair.
［発明が解決しようとする課題］
近年、社会の高齢化が進みまた、社会機構の複雑化、多
様化に伴うストレスの増加や、食生活の欧米化による栄
養過多などにより、脱毛の悩みを訴える人が中高年のみ
ならず、若年層、女性にまで拡大してきている。[Problem that the invention aims to solve] In recent years, society has become aging, and people are complaining of hair loss due to increased stress due to the increasing complexity and diversification of social structures, as well as overnutrition due to the Westernization of dietary habits. The number of people affected is not only middle-aged and elderly, but also young people and women.
脱毛症の原因は先天的なもの、社会環境の変化に基づく
後天的なものなど、種々考えられる。There are various possible causes of alopecia, including congenital causes and acquired causes due to changes in the social environment.
また、フケ症などによる炎症性の脂漏性脱毛症も−ある
。There is also inflammatory seborrheic alopecia caused by dandruff.
この様に、複雑な要因からなる脱毛症に対する薬剤が種
々様々に開発されている。As described above, a wide variety of drugs have been developed to treat alopecia caused by complex factors.
しかしながら、これらの薬剤は発毛の促進、膜上予防、
頭皮の脂質分泌の抑制、フケの発生、かゆみに対して、
ある程度の改善効果は見られるものの、発毛効果を期待
するうえで、十分満足の行くものではなかった。However, these drugs promote hair growth, prevent membrane formation,
Suppresses scalp lipid secretion, dandruff, and itching.
Although a certain degree of improvement effect was observed, the results were not fully satisfactory in terms of expected hair growth effects.
［課題を解決するための手段］
本発明は、ソクハクの抽出物を主動成分として含む育毛
剤に関する。[Means for Solving the Problems] The present invention relates to a hair growth agent containing an extract of Sokuhaku as an active ingredient.
本発明者等は、上記の問題点に鑑み、禿、脱毛を防止な
いし治療しつる薬剤の開発を目的とじて検討を重ねた結
果、ソクハクの抽出物が皮膚、毛髪に対して保温効果を
有し発毛促進効果を有することを見出し、この発明を完
成した。In view of the above-mentioned problems, the present inventors conducted repeated studies with the aim of developing a drug that can prevent or treat baldness and hair loss. As a result, the present inventors found that an extract of Sokuhaku has a heat-retaining effect on the skin and hair. They discovered that this product has a hair growth promoting effect and completed this invention.
ソクハクは、コノテガシワ（Ｂｉｏｔａ ｏｒｉｅｎｔ
ａｌｉＳ）の葉の抽出物で己未がら止血、抗炎症作用な
ど各種の薬効を示す生薬として、中国１日本において使
用されていた。また、ソクハクがテストステロン５−α
リダターゼ阻害作用を有することは知られていた。（特
開昭６４−３１２５号公報）しかしながら、ソクハクが
保湿効果を有しており、脱毛を予防し、発毛を促進する
ことは本発明者らの検討の結果得られたものである。Biota orient
AliS) leaf extract was used in China and Japan as a herbal medicine that exhibits various medicinal effects such as hemostasis and anti-inflammatory effects. Also, Seokhaku is testosterone 5-α
It was known to have a lidatase inhibitory effect. (Japanese Unexamined Patent Publication No. 64-3125) However, as a result of studies conducted by the present inventors, it has been found that sokuhaku has a moisturizing effect, prevents hair loss, and promotes hair growth.
［発明の構成］
ソクハクの抽出物は、ヒノキ科の植物コノテガシワの新
鮮な枝葉を採取し砕いた後、７５％エタノールに２４時
間冷浸し、パーコレーション法により浸出し、浸出液を
７５〜８０℃で減圧ａ縮、５〜１０℃で一夜放置し不要
物を除去したものである。[Structure of the Invention] The extract of Sokuhaku is obtained by collecting and crushing the fresh branches and leaves of Konotegashiwa, a plant belonging to the Cupressaceae family, and then cold soaking them in 75% ethanol for 24 hours, leaching them by percolation method, and vacuuming the leachate at 75 to 80°C. It was left to stand at 5 to 10°C overnight to remove unnecessary substances.
本島は、エキス分として３０〜５５％、還元糖類（グル
コースとして）を１５〜２５％含み、１ｍｌは原生薬Ｌ
ｏｇに相当する。Honjima contains 30-55% as an extract and 15-25% reducing sugars (as glucose), and 1ml is an original medicine L.
Corresponds to og.
配合量としては、本島の５倍希釈液を、育毛剤として２
〜１５重量％範囲、好ましくは５〜１０重量％含まれて
いればよい。The blending amount is 5 times diluted solution of Honjima and 2 times as hair growth agent.
-15% by weight, preferably 5-10% by weight.
本発明の育毛剤には、ソクハクのほかに天然抽へ出物と
してヒノキチオール、血管拡張剤としてトコフェロール
、栄養補給剤として塩酸ピリドキシン、殺菌剤としてト
リクロサンを含んでおり、これらの有効成分の他、香料
、アルコールおよび精製水などの通常の育毛剤を構成す
る成分も適宜配合される。In addition to Sokuhaku, the hair growth agent of the present invention contains hinokitiol as a natural extract, tocopherol as a vasodilator, pyridoxine hydrochloride as a nutritional supplement, and triclosan as a bactericide.In addition to these active ingredients, it also contains fragrance. Ingredients constituting ordinary hair growth agents, such as alcohol, purified water, etc., are also appropriately blended.
以下に実施例、比較例をあげて、更に詳細に説明するが
、本発明はこれによって限定されるものではない。The present invention will be described in more detail below with reference to Examples and Comparative Examples, but the present invention is not limited thereto.
［実施例］
゛ソクハク抽出物 １０ｍ１ヒノキチオール
Ｏ，１ｇ酢酸トコフェロール
０．１ｇトリクロサン ０１０
５ｇ塩酸ピリドキシン ＯｌｌｇＤ−パン
トテニルアルコール ○、１ｇイソプロピルメチルフ
ェノール ０１１ｇ上記の成分を９５ ｖ ／ ｖ％変
性エタノール５３ｍ１に瀉解した後、精製水をもって全
量を１００ｍ１とした。[Example] Sokuhaku extract 10ml hinokitiol O, 1g tocopherol acetate
0.1g triclosan 010
5 g Pyridoxine hydrochloride Ollg D-pantothenyl alcohol ○, 1 g Isopropylmethylphenol 011 g After the above components were dissolved in 53 ml of 95 v/v% denatured ethanol, the total volume was made up to 100 ml with purified water.
し比較例］ 実施例よりソクハク抽出物、ヒノキチオール。Comparative example] Sokuhaku extract and hinokitiol from the examples.
酢酸トコフェロ−ルおよびトリクロサンを除いた成分、
即ち
塩酸ピリドキシン ＯｌｌｇＤ−バントテ
ニルアルコール ０１１ｇイソプロピルメチルフェノ
ール ０１１ｇ上記の成分を９５ ｖ ／ ｖ％変性エ
タノール５３ｍ１に渚解した後、精製水をもって全量を
１００ｍ１とした。Ingredients excluding tocopherol acetate and triclosan,
That is, pyridoxine hydrochloride Ollg D-bantothenyl alcohol 011 g Isopropylmethylphenol 011 g After the above components were dissolved in 53 ml of 95 v/v% denatured ethanol, the total volume was made up to 100 ml with purified water.
試験成績
（１）対象
２０〜６０才の男性型脱毛症の男子３２人を無作為に実
施例群１６人と比較例群１６人に二分した。Test Results (1) Subjects Thirty-two men with androgenetic alopecia aged 20 to 60 were randomly divided into two groups: 16 in the example group and 16 in the comparative group.
男性型脱毛症の病型は■型ないしＩＶ型、ステージ−は
初期ないし中期に分類される。The disease type of androgenetic alopecia is classified as type ■ to type IV, and the stage is classified as early to middle stage.
（緒方知三部：禿頭の成り立ちについて総合臨床 ２．
１０１−１０６ （１９５３１＋（２）投与方法、期間
毎日、朝夕の２回、適量を前頭部から頭頂部にかけて滴
下し、軽く塗擦した。(Tomozo Ogata: Comprehensive clinical study on the origins of baldness 2.
101-106 (19531+(2) Administration method and period) An appropriate amount was dropped from the forehead to the top of the head twice daily, morning and evening, and rubbed lightly.
（３）投与期間
２７週間とし薬剤の使用量は実施例、比較例とも１週間
につき３０ｍ１とした。(3) The administration period was 27 weeks, and the amount of drug used was 30 ml per week in both Examples and Comparative Examples.
（４）結果
■洗髪時の抜は毛数
洗髪時の抜は毛数を回収し毛の太さおよび本数を一１１
定した。(4) Results ■ Number of hairs removed during hair washing Collect the number of hairs removed during hair washing and calculate the thickness and number of hairs by 111
Established.
表 １ 洗髪時の抜は手数（硬毛） 抜は手数は１６人の平均値である。Table 1 Number of steps required to remove hair when washing (terminal hair) The number of moves is the average value of 16 people.
実施例では試験開始後６週後から抜は毛が有意に減少し
、比較例では、１２週後がら若干減少した。In the Examples, the number of hairs pulled out significantly decreased after 6 weeks from the start of the test, and in the Comparative Examples, it decreased slightly after 12 weeks.
脱毛症に効果がある場合、硬毛の抜は毛が減少するとさ
れている。実施例においてＧよ抜は毛の防止効果は顕著
であった。When effective against alopecia, terminal hair plucking is said to reduce hair loss. In the examples, G-Yo plucking had a remarkable hair-preventing effect.
０発毛試験
生毛、軟毛の発生、硬毛の発生および皮膚所見を写真判
定も含めて、総合的に判断した。0 Hair Growth Test The appearance of downy hair, vellus hair, terminal hair, and skin findings were comprehensively evaluated, including photo evaluation.
その結果を第２表に示す。The results are shown in Table 2.
表 ２ 総 合 評 価数率は匡較例
／実施例そわぞわの改善状態にある人数を示す。Table 2 Overall evaluation rate shows the number of people who are in a state of improvement in fidgetiness in the practical example/example.
実施例においては１２週より改善の方向にあるのに反し
、比較例においては１８週になってようやく改善のきざ
しが見えてきた。In contrast to the example where the symptoms started to improve from the 12th week, signs of improvement were finally seen in the comparative example at the 18th week.
２７週では、実施例は著明および少し改善が、３３．３
％、僅かに改善も含めると６６６％に及んでいた。−万
比較例では、少し改善が１２．５％、僅かに改善を含め
てようやく５０％であり、実施例のほうが有意差をもっ
て発毛効果が優れていることは明白であった。At 27 weeks, the example showed marked and slight improvement, but 33.3
%, and including the slight improvement, it reached 666%. In the comparative example, the improvement was only 12.5%, and even the slight improvement was only 50%, and it was clear that the hair growth effect of the example was significantly superior.
皮膚所見でも落屑、掻痒感および皮脂に対して、実施例
の方が比較例と比べて優れていたが、これはソクハクの
有する保湿作用によるものである。In terms of skin findings, the Examples were superior to the Comparative Examples in terms of desquamation, itching, and sebum, and this was due to the moisturizing effect of Sokuhaku.
［発明の効果］
ソクハクの抽出物を主成分とする本発明は、抜は手数（
表１）および発毛状態の総合判定（表２）から、育毛剤
としての有効性は明らかである。[Effects of the Invention] The present invention, which contains extract of Sokuhaku as the main ingredient, can reduce the number of steps (
From Table 1) and the overall evaluation of hair growth status (Table 2), its effectiveness as a hair growth agent is clear.
これは、ソクハクの保温効果に、ヒニキチオール、酢酸
トコフェロールおよびトリクロサン添加の効果が加わっ
たためである。This is because the effects of hinikithiol, tocopherol acetate, and triclosan have been added to the heat-retaining effect of sokuhaku.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2299417A JPH04173720A (en) | 1990-11-05 | 1990-11-05 | Hair growth agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2299417A JPH04173720A (en) | 1990-11-05 | 1990-11-05 | Hair growth agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04173720A true JPH04173720A (en) | 1992-06-22 |
Family
ID=17872294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2299417A Pending JPH04173720A (en) | 1990-11-05 | 1990-11-05 | Hair growth agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04173720A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100739225B1 (en) * | 2006-09-20 | 2007-07-13 | 광덕신약 주식회사 | Composition for coloring hair containing extracts of oriental arborvitae and method of manufacturing the same |
| JP2008110992A (en) * | 2008-01-29 | 2008-05-15 | Mandom Corp | Antibacterial composition and skin care preparation |
| CN108245455A (en) * | 2018-03-02 | 2018-07-06 | 东莞市炫墨生物科技有限公司 | Loss preventing plant sends out agent and its purposes in daily chemical product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS643125A (en) * | 1987-06-23 | 1989-01-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
-
1990
- 1990-11-05 JP JP2299417A patent/JPH04173720A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS643125A (en) * | 1987-06-23 | 1989-01-06 | Ichimaru Pharcos Co Ltd | Testosterone 5alpha-reductase inhibitor |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100739225B1 (en) * | 2006-09-20 | 2007-07-13 | 광덕신약 주식회사 | Composition for coloring hair containing extracts of oriental arborvitae and method of manufacturing the same |
| JP2008110992A (en) * | 2008-01-29 | 2008-05-15 | Mandom Corp | Antibacterial composition and skin care preparation |
| CN108245455A (en) * | 2018-03-02 | 2018-07-06 | 东莞市炫墨生物科技有限公司 | Loss preventing plant sends out agent and its purposes in daily chemical product |
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