KR20090022224A - Cosmetic composition for scalp protection and trichogenousness - Google Patents

Abstract

An anti-irritant cosmetic composition with Cynanchum silfordii Hemsley, black sesame, and fermented black garlic is provided to prevent hair loss caused by inflammation and stress and promote hair growth. An anti-irritant cosmetic composition comprises Cynanchum silfordii Hemsley, black sesame, and fermented black garlic as active ingredients. The anti-irritant cosmetic composition includes a 0.001-30.0 wt% of extract from Cynanchum silfordii Hemsley, black sesame, and fermented black garlic on a dry weight basis. An extraction solvent is selected from purified water, methanol, ethanol, glycerine, ethylacetate, butylene glycol, propylene glycol, dichloromethane, hexane and their mixture.

Description

Cosmetic composition for promoting scalp protection and hair growth field {Cosmetic composition for scalp protection and trichogenousness}

Figure 1a is a diagram showing the hair growth effect of the negative control,

Figure 1b is a diagram showing the hair growth effect of the mixed extract (Example 4),

Figure 2a is a diagram showing the hair growth effect of the anti-inflammatory action of the negative control group,

Figure 2b is a diagram showing the hair growth effect of the anti-inflammatory action of the mixed extract (Example 4).

The present invention relates to a cosmetic composition for promoting scalp protection and hair growth, and more particularly, a composition comprising an extract comprising black garlic, black sesame seeds, sewage and fermented garlic, as an active ingredient and the composition as an active ingredient. It relates to a composition for promoting scalp protection and hair growth promoting.

Human hair goes through periods of growth, degeneration and rest. The exact mechanism of the hair loss phenomenon is not yet known and there are various hypotheses about this. In other words, hormonal theory caused by hormonal imbalance, stress theory caused by sudden mental pain, air pollution caused when hair is contaminated by toxic gas, etc., and sebaceous oil mixed with dandruff and other secretions cover the hair roots It is caused by overnutrition such as animal fat and blood circulation disorder due to impaired blood flow due to obstruction of blood flow due to excessive ingestion of sebum, sebum and animal fat.

Hair is one of the skin appendages, ecologically derived from the epithelium, and forms from the second month of birth. The types of hair are classified into fine hairs (Vellus hair) and thick and hard hair (terminal hair) according to their thickness. Hair growth is periodic and does not hair temporarily. Each hair follicle goes through an intermittent phase of activity and cessation. During the growing phase, ie anagen, cells of the hair follicles actively differentiate to form growing hair. After this period, the hair follicles enter the catagen, or transitional phase, where the stromal cell division stops and goes to the telogen, usually three years for growth, three weeks for degeneration, and three months for rest. This takes Normally, 85-95% of hair grows, but the number decreases with age, and faster in male baldness. In general, the causes of human hair loss include genetic factors, progression of aging, drug use, radiation therapy and post-stress stress. From a biochemical and physiological point of view, hair loss is known to be caused by three main causes: hyperactivity, problems with scalp blood circulation, and a lack of nutrients essential for hair metabolism. Although these three factors alone can cause hair loss, when hair loss factors are combined to cause synergy, hair loss is accelerated and the symptoms become worse. In particular, if genetic factors or acquired special conditions cause the production and alteration of male hormones, recognition, and signaling overworking, hair follicle tissues tend to age prematurely, which is likely to cause premature baldness. . In addition, due to genetic factors, aging, Western high-fat lifestyle and other external factors, the tension of the scalp is easily increased, or when there are symptoms such as arteriosclerosis, blood circulation disorders occur easily, and thus, there is a problem in smooth hair metabolism.

On the other hand, a number of enzymes necessary to perform the metabolic activity of the human body, including hair metabolism, properly produced and nutrients such as hormones, vitamins, minerals, essential amino acids and lipids must be supplied in order to perform normal activities, a very narrow range of temperature And maintenance of pH conditions. However, when the human body is exposed to long-term stresses such as excessive physical dissipation, serious illness, chemotherapy and nutritional imbalance, the human body tends to maintain homeostasis by concentrating the metabolic elements in more essential tissues for survival. As hair-lowering action of lowering priority in hair slows down, the balance of hair loss and hair growth progresses toward hair loss. These nutrient factors cause alopecia areata, hair loss after radiation and chemotherapy, and accelerate hair loss due to genetic factors and aging.

Recently, due to environmental factors such as air pollution, mental stress, and excessive use of hair beauty products, alopecia, commonly known as baldness, in a round or irregular shape, is becoming more common, and the age is gradually decreasing. Although baldness and other alopecia can cause serious stress on the parties and can lead to loss of self-confidence, it may be desirable to treat them early, but commercially available baldness treatments may not be as effective. There is no problem at all, and medically unproven, there is a problem that causes serious side effects.

Various attempts have been made to treat baldness caused by the above factors. Surgical methods include scalp scalp, alopecia reduction, and histopathoplasty, and recently developed autologous hair transplantation. Although the surgical method is excellent in terms of its effectiveness, it is difficult to be widely used because the patient's economic and mental burden on the surgery is very large.

Various external preparations are used. Minoxidil, which is approved by the US FDA, has capillary expansion function to prevent hair loss by applying it to the scalp, but it must be applied twice a day continuously and the drug is applied to the scalp for 3 to 4 hours. Not only is it inconvenient to have some effect, but also insignificant in terms of the corresponding effect, and it is a situation that side effects such as itching and irritation appear. In addition, the FDA-approved oral drug finasteride has the effect of inhibiting the production of the male hormone DHT (5α-dihydrotestosterone), which causes hair loss, and is known to exhibit hair growth or hair loss inhibitory effects when taken for 6 months to 1 year. However, if you stop taking the problem to return to its original state within two months, side effects include decreased sexual desire, such as erectile dysfunction, erectile dysfunction, etc. Women are known to not take because of the risk of birth defects.

On the other hand, attempts to promote hair growth by applying or taking on the scalp using the extract of the herbal ingredient. In case of using the extract of orchid family (Korean Patent No. 157667), In case of using the wormwood and mandrel (Korean Patent No. 161338); When using the Manzacho extract as an active ingredient (Korean Patent Publication No. 91-106); Hair growth promoting agent using pine leaf extract (Korean Patent Publication No. 96-40346); Hair growth promoting agents using silkworms (Korean Patent Publication No. 90-2757); The use of organgal root, danner ginseng root, red bean root, red ginseng and white porcelain (Korean Patent No. 259037); In the case of using the oil obtained by heating atomic hemp, latent species, latent fetus, silk yarn and pupa at about 200 ° C. for about 15 minutes (Korean Patent Publication No. 90-2757), and the like have been disclosed.

The present inventors found that extracts of sewage, black sesame, and fermented black garlic are effective in preventing hair loss, hair growth and wool, and are effective in preventing hair loss and promoting hair growth due to less skin irritation, and inflammation caused by various factors. The present invention was completed by revealing that the extract of the present invention is effective for promoting hair growth through the alleviation of inflammation from the results of the research on the requirement of difficulty in hair growth.

The present invention has been researched and developed in order to solve such a conventional problem, and effectively prevent hair loss and promote hair growth, and also to protect the scalp through skin irritation and to prevent hair loss through anti-inflammatory action and to promote hair growth. It is an object of the present invention to provide a composition for sustaining and preventing hair loss and promoting hair growth comprising the same as an active ingredient.

In order to achieve the above object, the present inventors use cosmetics containing senaum (Cynanchum silfordii Hemsley) extract, Sesameum indicum L. and / or garlic (Allium scorodorpasum var. Viviparum Regel, GARLIC) extract among various natural products. By selecting a composition, confirming its efficacy as a cosmetic raw material, and developing a method of using the same, it provides a method of increasing the selection range of various cosmetic raw materials and producing a cosmetic having a multifunctional effect without skin irritation.

The black garlic used in the present invention is garlic made by ripening for about one month at a constant temperature and humidity. The black garlic first turns brown and finally turns black. In the present invention, black garlic made by ripening garlic for about one month at a constant temperature and humidity was used. The sewage, black sesame and fermented black garlic extracts or mixtures are the leaching or mixed liquor obtained by leaching or transferring, or the concentrate obtained by partially or fully concentrating the leaching or mixed liquor, or the extract extract or mixed prepared by drying the concentrate. Extracts and extracts or mixed liquors.

In addition, the present invention is characterized in that the natural sewage, black sesame and fermented black garlic extract is contained in 0.01 ~ 70.0% by weight based on the total weight of the composition. In addition, the cosmetic composition according to the present invention may contain, in addition to the above-mentioned extract, other components that can give a synergistic effect to the main effect, preferably within the range of not impairing the main effect of the present invention.

In addition, the natural sewage, black sesame and fermented black garlic extract according to the present invention extract one or more selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane Alternatively, the mixture is extracted and chilled at room temperature of 70 to 85 ° C. using a mixed solvent, and the resulting suspension is filtrated under reduced pressure or freeze-dried at 50 ° C. or less.

The mixed extracts defined herein are polar solvent soluble extracts and nonpolar solvent soluble extracts soluble in lower alcohol solvents such as water, methanol, ethanol and butanol, preferably ethanol soluble extracts, more preferably 70% ethanol soluble extracts. It features.

Sewage, black sesame and black garlic extract of the present invention is characterized in that the composition ratio of the dry weight ratio (g / g) of sewage: black sesame: black garlic (0.001 ~ 30: 0.001 ~ 30: 0.001 ~ 30).

Hereinafter, the present invention will be described in detail.

The sewage and black sesame extract of the present invention is sewage and black sesame first, after washing and drying the sewage in the shade after shading, 1 to 10, preferably 1 to 5 times the volume of water, methanol, ethanol, butanol Polar solvents of C1 to C4 lower alcohols such as or a mixed solvent having a mixing ratio of about 1: 0.1 to 1:10, preferably 70% ethanol, for 0.5 to 10 hours, preferably 2 to 5 hours. Extraction is performed by cold extraction at room temperature of 70 to 85 ° C., and the resulting suspension is filtered. The resulting liquid is further concentrated under reduced pressure or freeze drying at 50 ° C. or less.

The present invention provides a composition for preventing hair loss and promoting hair growth, which contains a mixed extract of sewage, black sesame and fermented black garlic obtained as the active ingredient.

Hair loss prevention and hair growth promoting composition of the present invention, the total weight of the composition comprises 0.001 to 30.0% by weight.

Hereinafter, the present invention will be described in detail by the following Examples and Experimental Examples.

However, the following Examples and Experimental Examples are only illustrative of the present invention, the contents of the present invention is not limited by the following Examples, Reference Examples and Experimental Examples.

Example  One. Shouao  Preparation of single extract

The sewage was subdivided and dried, refluxed three times for 5 hours with a 70% (V / V) ethanol aqueous solution, and the mixture was cooled and then filtered through a Whatman # 10 filter paper. The filtered extract was concentrated under reduced pressure and lyophilized at 50 ° C or lower. Sewage extracts were prepared using one or more solvents selected from purified water, ethanol, butylene glycol, and propylene glycol, such that the vacuum concentrate and the lyophilisate contained 0.001-70.0 wt%.

Example  2. Preparation of Black Sesame Single Extract

The black sesame seeds were washed well to remove impurities, dried and refluxed three times for 5 hours with an aqueous 70% (V / V) ethanol solution, and then cooled and filtered through a Whatman # 10 filter paper. The filtered extract was concentrated under reduced pressure and lyophilized at 50 ° C or lower. Black sesame extract was prepared using one or more solvents selected from purified water, ethanol, butylene glycol, and propylene glycol so that the vacuum concentrate and the lyophilisate contained 0.001 to 70.0% by weight.

Example  3. Black garlic  Preparation of single extract

Black garlic extract is garlic made by ripening for about 1 month at a constant temperature and humidity. The black garlic first turns brown and finally turns black. In the present invention, black garlic made by ripening garlic for about one month at a constant temperature and humidity was used. After removing impurities of black garlic, it was washed well in the shade and dried. The mixture was refluxed three times for 5 hours with 70% (V / V) ethanol aqueous solution, and then cooled and filtered with Whatman # 10 filter paper. The filtered extract was concentrated under reduced pressure and lyophilized at 50 ° C or lower. Black garlic extract was prepared using one or more solvents selected from purified water, ethanol, butylene glycol, and propylene glycol so that the vacuum concentrate and the lyophilisate contained 0.001 to 70.0% by weight.

Example  4. Shouao , Black sesame seeds and Black garlic  Preparation of Mixed Extract

Sewage, black sesame seeds and black garlic were washed, rinsed, dried, and refluxed three times for 5 hours with 70% (V / V) ethanol aqueous solution, and then cooled and filtered with Whatman # 10 filter paper. The filtered extract was concentrated under reduced pressure and lyophilized at 50 ° C or lower. Sewage, black sesame and black garlic mixed extracts were prepared using one or more solvents selected from purified water, ethanol, butylene glycol, and propylene glycol to contain 0.001-70.0 wt% of the reduced pressure concentrate and the lyophilisate.

Experimental Example  1. Hair growth promoting effect experiment

Hair growth promoting effect test using black mice (C57BL / 6, male), 5 weeks of age to remove the hair on the back and prepared in Examples 1 to 4 in the central region, such as the next day for 5 dogs per group One single and mixed extracts were applied 100 microliters each. For comparison of hair length and hair growth over time, the natural growth state was observed without applying the test substance to the control group, and 1% minoxidil was used as the positive control group.

The results are shown in Table 1 below, and FIG. 1 is a photograph of external morphological changes showing the hair growth process according to the application of the test material according to Example 4. FIG.

TABLE 1

Sample Name Indicators Elapsed days 7 days 10 days 14 days Control Hair Length (mm) Growth Rate (%) 0.52 ± 0.14 15.3 0.79 ± 0.22 23.2 1.72 ± 0.28 50.6 Positive control (1% minoxidil) Hair Length (mm) Growth Rate (%) 1.30 ± 0.16 38.2 2.35 ± 0.21 69.1 3.13 ± 0.28 92.1 Sewage Extract (Example 1) Hair Length (mm) Growth Rate (%) 0.90 ± 0.10 22.9 1.72 ± 0.17 49.1 2.91 ± 0.21 83.1 Black sesame extract (Example 2) Hair Length (mm) Growth Rate (%) 1.23 ± 0.11 35.1 1.83 ± 0.15 53.3 3.15 ± 0.20 90.0 Black Garlic Extract (Example 3) Hair Length (mm) Growth Rate (%) 0.85 ± 0.09 24.3 1.66 ± 0.20 47.4 3.05 ± 0.27 87.1 Mixed Extract (Example 4) Hair Length (mm) Growth Rate (%) 1.41 ± 0.15 39.2 2.31 ± 0.25 64.2 3.34 ± 0.30 92.7

As shown in Table 1 and Figure 1, the mixed extract (Example 4) showed a similar or superior hair growth effect to the minoxidil positive control.

Experimental Example  2. Skin irritation experiment

The degree of irritation to the skin of the rabbit was measured for the composition prepared in Examples 1 to 4, and for this purpose, rabbit hair was removed 24 hours prior to the application of the composition to treat treatment and normal skin and wound skin. The control compartment was divided. The coating method was applied once to the application site by 1 gram per rabbit. Untreated control compartments were applied in equal amounts of sterile physiological saline and covered with gauze. In order to prevent evaporation of the sample, it was covered with a solid material foil having no permeability and reactivity, and fixed with a tape and then applied for 24 hours, 72 hours, and 120 hours. After the end of the application time using a saline solution was lightly cleaned with the application site. The appearance, feed and beverage consumption and clinical symptoms were observed daily for one week after the administration of the sample material.

Evaluation of skin reaction was judged using 'toxicity test criteria' of medicines. In addition, the degree of irritation to the skin was evaluated by the method of calculating P.I.I. (Primary Irritation Index) of Draize, which is commonly used, and the results are shown in Table 2 below.

TABLE 2

Sample Name P.I.I. Result 24 hours 72 hours 120 hours Control 0.1 (no irritation) 0.1 (no irritation) 0.1 (no irritation) Sewage Extract (Example 1) 0.5 (low stimulation) 0.1 (no irritation) 0.1 (no irritation) Black sesame extract (Example 2) 0.3 (low stimulation) 0.1 (no irritation) 0.1 (no irritation) Black Garlic Extract (Example 3) 0.8 (low stimulation) 0.5 (low stimulation) 0.3 (low stimulation) Mixed Extract (Example 4) 0.5 (low stimulation) 0.3 (low stimulation) 0.1 (no irritation) P.I.I. (No stimulation) 0 ←← →→ 5 (strong stimulation)

As shown in Table 2, PII is 0.8 ~ 0.3 at 24 hours, hypoallergenic at 72 hours, 0.5 to 0.1 at 72 hours, and 0.1 stimulus at 120 hours, resulting in less skin irritation. It can be seen.

Experimental Example  3. Experiment for promoting hair growth in case of skin inflammation

In order to determine the effect of the mixed extract obtained in Example 4 on the hair growth of the skin inflammation-induced mouse experiments in the same way as Experimental Example 1 in the mouse with skin inflammation is shown in Figure 2 the results. As a result, as shown in FIG. 2, in the control group of FIG. 2a), hair growth did not occur after 2 weeks, but as shown in FIG. 2b), the mixed extract application site showed anti-inflammatory activity in the mouse with dermatitis. It was confirmed that the effect on.

As described above, the present invention relates to a composition for promoting scalp protection and hair growth containing a mixture of sewage, black sesame, and fermented black garlic, and does not irritate the scalp and has an excellent effect of promoting hair growth. . In addition, in the case of hair loss due to the expression of inflammation, anti-inflammatory action has been shown to promote hair growth.

In addition, the present invention is a natural herbal extract as a main raw material does not have side effects caused by hormones and the like is harmless to the human body.

The present invention finds that it has little skin irritation and has excellent hair loss prevention and hair growth promoting effect in vivo, and thus can be usefully used as a hair loss preventing agent, scalp protector and hair growth promoting agent for the treatment and prevention of baldness and baldness. Can be.

Claims (9)

Cosmetic composition containing sewage, black sesame, fermented black garlic mixed extract as an active ingredient The method of claim 1, The sewage, black sesame, fermented black garlic extract is a cosmetic composition, characterized in that it contains 0.001 to 30.0% by weight based on the total lyophilized weight. The method according to claim 1 or 2, The extraction solvent is a cosmetic composition, characterized in that selected from purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, hexane and mixtures thereof. The method of claim 1, Cosmetic composition, characterized in that used for anti-inflammatory. The method of claim 1, Cosmetic composition, characterized in that used for the purpose of stress relief. The method of claim 1, Cosmetic composition, characterized in that used for protecting the scalp. The method of claim 1, Cosmetic composition, characterized in that used for promoting hair growth. The method of claim 1, Cosmetic composition, characterized in that used for preventing hair loss. The method according to claim 1, wherein the corresponding accelerator is prepared in the form of any one of the hair rinse used after scalp / hair wash, a hair shampoo including a gel / spray form scalp / hair care agent and a soap component. Hair loss prevention and hair growth / hair growth promoting cosmetic composition.

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