KR20180096948A - A cosmetic composition for promoting hair growth and preventing hair loss - Google Patents

A cosmetic composition for promoting hair growth and preventing hair loss Download PDF

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KR20180096948A
KR20180096948A KR1020170023380A KR20170023380A KR20180096948A KR 20180096948 A KR20180096948 A KR 20180096948A KR 1020170023380 A KR1020170023380 A KR 1020170023380A KR 20170023380 A KR20170023380 A KR 20170023380A KR 20180096948 A KR20180096948 A KR 20180096948A
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hair
weight
parts
hair loss
supernatant
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KR101977456B1 (en
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한윤섭
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한윤섭
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

Abstract

The present invention relates to a cosmetic composition for promoting hair growth and preventing hair loss. More specifically, the present invention relates to a cosmetic composition which uses a combination of a pyrrolidinyl diaminopyrimidine oxide component, an azelamide MEA component, and a Polygoni multiflori Radix extract component, and through a synergistic effect of the above combination, provides desirable effects in promoting the blood circulation of scalp, preventing itchiness, promoting hair growth, and preventing hair loss. The cosmetic composition comprises, with respect to 100 parts by weight of purified water: 0.1-10.0 parts by weight of azelamide MEA; 0.1-10.0 parts by weight of a pyrimidine oxide derivative; and 0.1-10.0 parts by weight of an extract of Polygoni multiflori Radix. In particular, the extract of Polygoni multiflori Radix is prepared by mixing 50-150 parts by weight of Polygoni multiflori Radix formed by washing, drying, and pulverizing the roots of Polygoni multiflori Radix, with 800-1,000 parts by weight of purified water in 1 : 9 ratio; heating the mixture at 70-80°C for 10-14 hours and filtering the same to provide a supernatant; and storing the supernatant in a thermo-hygrostatat 100-110°C for 30-90 minutes, thereby evaporating 0.4-0.6% of the initially supplied supernatant. In addition, the pyrimidine oxide derivative is pyrrolidinyl diaminopyrimidine oxide.

Description

모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물 {A cosmetic composition for promoting hair growth and preventing hair loss}[0001] The present invention relates to a cosmetic composition for promoting hair growth of a hair and preventing hair loss,

본 발명은 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물에 관한 것으로, 보다 상세하게는 피롤리디닐디아미노피리미딘옥사이드 성분과 아젤라마이드엠이에이 성분 및 하수오 추출물 성분을 복합 사용하여, 상기 복합효과의 상승 작용으로 두피의 혈행을 촉진시키며, 가려움증을 예방하고, 모발의 육모 촉진과 탈모를 예방하는 탁월한 효과를 부여하는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for promoting hair growth of hair and preventing hair loss, and more particularly, to a cosmetic composition for preventing hair loss by combining the pyrrolidinyl diaminopyrimidine oxide component, the azelamide mental component, To promote the blood circulation of the scalp, to prevent itching, and to provide an excellent effect of promoting hair growth of hair and preventing hair loss.

현대 산업사회는 무한 경쟁사회이며, 타인보다 아름다운 외모는 또 하나의 중요한 경쟁력으로 인식되어 끊임없이 외모를 가꾸기위한 다양한 형태가 나타나고 있지만 산업사회가 발생할수록 환경 오염 등의 주위 환경이 악화되고 무한 경쟁에 따른 스트레스 증가, 서구화된 식습관, 잦은 파마와 염색, 잘못된 두피관리들로 인하여 탈모 인구가 점차 증가하고 있다.Modern industrial society is an infinite competition society, and beautiful appearance than other people is recognized as another important competitiveness. There are various forms for constant appearance, but as the industrial society develops, environmental pollution and other environmental conditions deteriorate and infinite competition Increased stress, westernized eating habits, frequent perms and dyes, and incorrect scalp care have led to an increasing number of hair loss populations.

실 예로서, 미용 가꾸기 중 에는 샴푸, 파마, 염색 등의 행위가 있는데, 소득 수준이 높아질수록 상기 행위가 빈번 해 지지만 반대로 모발관리에서는 화학제품 사용 및 스트레스 등으로 인해 탈모라는 원치 않는 현상이 나타나고 있는 실정이다.As a practical example, there are behaviors such as shampooing, perming, dyeing, etc. during beauty care. The higher the income level, the more frequent the above actions. On the contrary, in hair care, unwanted phenomenon of hair loss due to use of chemical products and stress is appearing It is true.

모발의 성장 주기는 통상 성장기(Anagen)와 휴지기(Telogen)로 나타나며 통상 휴지기 탈모는 모발의 정상적인 성장주기가 휴지기로 접어 들면서 나타나는 탈모이다.The growth period of hair is usually represented by anagen and telogen, and resting hair hair loss is a hair loss that occurs when the normal growth cycle of the hair enters the resting period.

사람의 모발은 3 내지 6년 주기로 생장과 소멸을 반복하는데 3 내지 6년 가량 성장한 모발은 약 3 내지 4주에 걸쳐 퇴화한 후 3 내지 5개월 가량 모발이 빠진 상태가 지속되는 휴지기로 접어든다.Human hair grows and disappears repeatedly every three to six years. Hair that has grown for about three to six years is degraded over about three to four weeks, and then falls into a resting state in which hair remains missing for about three to five months.

보통 휴지기로 접어드는 모발은 전체 모발의 10% 정도 인데, 이런 형태로 모발이 휴지기에 접어들면서 머리카락이 빠지는 형태의 탈모는 휴지기 탈모라고 하며, 휴지기 탈모는 시간이 지나면 대체로 정상적으로 회복되는 것을 알려져 있다.It is known that the hair that falls into the rest period is about 10% of the total hair, and the hair loss in the form in which the hair falls out as the hair breaks into the resting period is called the resting hair loss, and the resting hair loss is generally known to recover normally over time.

통상적으로 알려진 탈모의 원인으로는 유전적 요인과 스트레스가 대표적이며, 유전적 요인으로 인한 탈모와 스트레스로 인한 탈모는 큰 차이를 보이는데, 스트레스로 인한 탈모는 일반적으로 원형 탈모이고 치료가 가능하다고 알려져 있지만, 유전적인 요인으로 인한 탈모는 그 치료가 어렵다고 알려져 있다.Common causes of hair loss include genetic factors and stress. Hair loss due to genetic factors and hair loss due to stress are very different. Stress-induced hair loss is generally known as round hair loss and treatment is possible , Hair loss caused by genetic factors is known to be difficult to treat.

탈모의 유전적 요인으로 탈모 유전자는 부계와 모계 모두에서 유전될 수 있으며, 현재까지 탈모의 원인으로 남성 호르몬인 테스토스테론(Testosterone)이 관여 한다고 알려져 있으며, 5 알파-리덕타제(α-reductase)가 관여하여 테스토스테론이 디하이드로테스토스테론(Dihydrotestosterone, DHT)으로 산화되면서 탈모가 빠르게 진행되는 것으로 알려져 있다.As a genetic cause of hair loss, hair loss genes can be inherited from both the paternal and maternal lines. It is known that testosterone, which is a male hormone, is involved in hair loss, and 5 alpha-reductase is involved It is known that testosterone is rapidly oxidized to dihydrotestosterone (DHT), leading to rapid hair loss.

이처럼, 다양하고 복잡한 탈모 원인에 대하여, 열액 순환 촉진, 남성 호르몬 작용 억제, 모근 기능 강화 등을 목적으로 하는 성분 등이 시중에 제품으로 판매되고 있으나, 뚜렷한 효과를 지닌 것은 아직까지 없는 상태이고 부작용의 문제가 제기되기도 하였다.As described above, ingredients for the purpose of promoting heat circulation, inhibiting male hormone function, and enhancing hair follicle function are sold as products for various complicated hair loss causes, but there is no specific effect yet, Problems were also raised.

먼저, 처음에는 남성의 전립선 치료제로 사용하던 머크(Merck)사(社)의 프로스카(Proscar)는 전립선 비대증 환자에게 사용되다가 이를 사용하는 환자들 사이에서 일부가 탈모 개선효과를 나타내는 것으로 알려져, 이후 발모용 원료로 미국식품의약품안전청(FDA)에서 1997년에 5 알파-리덕타제 저해 성분으로 1일 1mg 피나스테라이드 성분 용량을 남성형 탈모용으로 승인했다.First, Merck's Proscar, which was initially used as a treatment for male prostate cancer, is used in patients with hyperplasia of the prostate gland, and it is known that some of them use it to improve hair loss, In 1997, the US Food and Drug Administration (FDA) approved a dose of 1 mg of pinasteride daily for men's hair loss as a 5-alpha-reductase inhibitor.

이는, 피나스테라이드 성분이 5 알파-리덕타제 효소의 억제로 테스토스테론이 디하이드로테스토스테론으로 산화되는 것을 막아 탈모를 예방하는 효과를 확인한 것이다.This confirms that the finasteride component prevents the oxidation of testosterone to dihydrotestosterone by inhibition of the 5 alpha-reductase enzyme to prevent hair loss.

그리고, 스트레스로 인한 탈모는, 스트레스가 지속적으로 쌓이게 되면 혈액순환장애와 불면증 등을 유발하게 되고, 이로 인한 두피의 긴장상태는 두피를 지성으로 변화시켜 모발의 발육은 물론 모발의 성장 및 발생에까지 악영향을 주게 된다.In addition, the hair loss due to stress causes the blood circulation disorder and insomnia when the stress is continuously accumulated, and the tension of the scalp caused by this changes the scalp to the intelligence, so that the hair growth as well as the hair growth, .

또, 식생활에 의한 탈모는, 현대인의 식생활이 서구화되면서 지방이 많이 함유된 기름진 음식, 고소한 음식 등을 자주 섭취하게 되는데, 이러한 음식들은 남성호르몬과 같은 효과를 내어 두피를 지성으로 변화시키며 탈모를 유발하게 된다.In addition, the eating habits due to the diet of the modern people is westernized, fatty foods containing a lot of fatty foods, such as food often eat, such as sex hormones, such as the effects of the male hormone to change the scalp to intelligence, causing hair loss .

또한, 술은 알코올 성분이 염증 및 피지분비를 촉진시키고, 흡연은 체온을 떨어뜨려 혈관을 수축시켜 혈액순환을 방해해 비타민의 부족현상을 불러오며, 이러한 현상들은 탈모의 유발과 모발의 성장 및 발생에 악영향을 미치므로 적당한 음주와 금연 및 비타민 섭취 등을 통해 탈모 예방 관리를 해야 한다.Alcohol also promotes inflammation and sebum secretion, and smoking lowers body temperature to constrict blood vessels, interfering with blood circulation, leading to vitamin deficiency. These phenomena lead to hair loss, hair growth and development , It is necessary to prevent and control hair loss through appropriate drinking, smoking and vitamin intake.

그리고, 자외선에 의한 탈모에는 강한 자외선이 두피에 직접적인 자극을 주어 모근을 건조하게 만들고 염증을 증가시켜 탈모를 촉진시키며, 상기 자외선으로 인해 모발의 단백질 층인 케라틴이 파괴되는 손상을 입혀 머리카락이 가늘어지며 결국 탈모를 유발시키게 된다.In addition, strong ultraviolet rays give direct stimulation to the scalp to make the hair follicle dry, increase inflammation, promote hair loss, and damage the keratin, which is a protein layer of hair due to the ultraviolet rays, Causing hair loss.

상기의 문제점을 해결하기 위해서 탈모 예방과 발모 촉진 등의 연구가 많은 연구자들에게 주어진 과제였으며, 지금도 수많은 해결 방법과 연구 성과가 발표되고 있고 이를 통한 수많은 선행 기술들이 제시되고 있으며, 대표적으로 특허문헌 1 내지 특허문헌 6 등의 기술내용이 있었다.In order to solve the above problems, researches such as prevention of hair loss and promotion of hair growth have been given to many researchers. Numerous solutions and research achievements have been announced, and many prior arts have been proposed through them. Patent Document 6, and the like.

이외에 공지된 기술로는 현존하는 탈모방지 치료제 중에서 미국 FDA에서 허가한 외용 미녹시딜(minoxidil)은 그 고유한 칼륨통로개방제(Potassium channel opener)로서의 혈관확장 기능 외에 휴지기의 모발주기에서 성장기로 유도하고, 유도된 성장기 모발주기를 계속 유지시키는 활성이 보고되었다(British Journal of Dermatology. 2004;150: 186-194).In addition, the known minoxidil, which is approved by the US FDA among the existing anti-hair restorative drugs, induces vasodilating function as a potassium channel opener, which is inherent in the hair cycle of the resting period, Activity to keep the induced growth period of the hair cycle was reported (British Journal of Dermatology. 2004; 150: 186-194).

피리미딘 유도체인 미녹시딜(2,4-디아미노-6 피페리디노-피리미딘-3-옥사이드)의 모발 성장 효과에 관한 메커니즘은 아직도 확실히 밝혀져 있지 않으며, 다만 처음 약물이 개발될 당시에 가진 칼륨통로 개방 효과에 따른 혈관 확장에 의한 효과로 많이 인식되고 있다.The mechanism of the hair growth effect of the pyrimidine derivative minoxidil (2,4-diamino-6piperidino-pyrimidine-3-oxide) is still unclear. However, the mechanism of the hair growth of the potassium channel It is widely recognized that the effect of vasodilatation depends on the effect.

그 후에도 다양한 피리미딘 유도체 및 신규 화합물을 대상으로 일반적인 칼륨통로 개방 효과와 이에 따른 모발 성장 효과에 대한 보고가 있고(J Invest Dermatol 2005 124 (4) :686-94), 피리미딘옥사이드의 여러 유도체의 모발 성장에 관한 특허가 출원되고 있다(미국특허 제5,034,387호 및 제4,945,093호). 이전의 피리미딘옥사이드 유도체의 모발 성장에 관한 특허는 이전에 나온 미녹시딜 약물의 구조를 포함하는 광범위한 유도 구조체를 포괄한 것이며, 각 개별 유도체의 모발 성장작용은 일반적으로 인정되는 기술이다.Thereafter, a variety of pyrimidine derivatives and novel compounds have been reported to have a general effect on the opening of potassium channels and thus the hair growth effect (J Invest Dermatol 2005 124 (4): 686-94), that of several derivatives of pyrimidine oxides A patent for hair growth has been filed (U.S. Patent Nos. 5,034,387 and 4,945,093). The patent for the hair growth of the previous pyrimidine oxide derivatives encompasses a wide range of derivational structures including the structure of the previously described minoxidil drugs, and the hair growth action of each individual derivative is a generally accepted technique.

하지만 이러한 기술들에는 모발 성장에 필요한 혈행촉진, 5 알파-리덕타제의 저해, 칼륨통로 개방 효과, 등에서 언급되고 있으나 아직까지 정확한 메카니즘에 대한 기술적 진보 결과를 제시하고 있지 않으며 5 알파-리덕타제의 저해의 아젤라마이드엠이에이 성분, 칼륨통로 개방 효과의 피롤리디닐디아미노 피리미딘옥사이드 성분, 혈행촉진의 하수오 추출물 성분을 혼합 사용하여 복합 시너지 효과에 대해서는 어느 곳에도 언급되어 있지 않다.These techniques, however, are mentioned in terms of promoting blood flow for hair growth, inhibition of 5 alpha-reductase, opening of potassium channel, etc. However, no technical progress has been made yet to the exact mechanism and the inhibition of 5 alpha-reductase , The azelamide-mye component of the azelaic acid, the pyrrolidinyldiaminopyrimidine oxide component of the potassium channel opening effect, and the sulfated-water extract component of the blood circulation promoting effect.

[특허문헌 1]. 대한민국 공개특허공보 10-2011-0045341호. 효모, 금, 프로폴리스, 인삼, 마치현, 정향, 하수오를 혼합한 복합추출물이 함유된 두피 및 모발 개선제용 조성물(공개일자 2011년 05월 04일)[Patent Document 1]. Korean Patent Publication No. 10-2011-0045341. A composition for scalp and hair improving agent comprising a complex extract of yeast, gold, propolis, ginseng, marjoram, clove, and garlic mixed (disclosed on May 04, 2011) [특허문헌 2]. 대한민국 공개특허공보 10-2011-0108481호. 인삼 사포닌 대사체를 포함하는 탈모방지 또는 발모촉진용 조성물(공개일자 2011년 11월 06일)[Patent Document 2]. Korean Patent Publication No. 10-2011-0108481. A composition for preventing hair loss or promoting hair growth comprising ginseng saponin metabolite (published on November 06, 2011) [특허문헌 3]. 대한민국 공개특허공보 10-2004-0017393호. 탈모방지샴푸(공개일자 2004년 02월 27일)[Patent Document 3]. Korean Patent Publication No. 10-2004-0017393. Hair loss prevention shampoo (public date February 27, 2004) [특허문헌 4]. 대한민국 공개특허공보 10-2011-0127447호. 탈모방지 또는 육모 촉진용 조성물(공개일자 2011년 11월 25일)[Patent Document 4]. Korean Patent Publication No. 10-2011-0127447. Composition for preventing hair loss or promoting hair growth (published on November 25, 2011) [특허문헌 5]. 대한민국 공개특허공보 10-2010-0120332호. 식물혼합추출물을 함유하는 발모제 조성물 및 이의 제조방법(공개일자 2010년 11월 16일)[Patent Document 5]. Korean Patent Publication No. 10-2010-0120332. The present invention relates to a hair growth inhibitor composition containing plant extracts and a process for producing the hair growth inhibitor composition (published on November 16, 2010) [특허문헌 6]. 대한민국 공개특허공보 10-2007-0041890호. 모발 성장 촉진용 외용제 조성물(공개일자 2007년 04월 20일)[Patent Document 6]. Korean Patent Publication No. 10-2007-0041890. Composition for external application for promoting hair growth (Published date Apr. 20, 2007)

상기와 같은 종래기술의 문제점을 해결하기 위한 것으로서, 본 발명은 5 알판-리덕타제 저해 효과로 알려진 아젤라마이드엠이에이 성분과, 칼륨통로로서의 피리미딘옥사이드 성분과, 혈행촉진에 효과적인 하수오 추출물 성분을 혼합하여, 육모 촉진 효과 및 탈모 방지를 동시에 함축하는 칵테일 요법으로서의 시너지 효과를 통해 두피의 탈모 예방과 발모 촉진에 보다 효과적인 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물을 제공하는데 그 목적이 있다.In order to solve the problems of the prior art as described above, the present invention relates to a pharmaceutical composition comprising an azelamide mental component, which is known as a 5-alpano-reducticase inhibitory effect, a pyrimidine oxide component as a potassium channel, It is an object of the present invention to provide a cosmetic composition which promotes hair hair growth more effectively in preventing scalp hair loss and promoting hair growth through synergistic effect as a cocktail therapy which concurrently promotes hair growth promoting effect and hair loss prevention.

본 발명의 다른 목적은, 아젤라마이드엠이에이, 피리미딘옥사이드 유도체, 하수오 추출물 성분을 1 : 1: 1 의 비율로 혼합 사용하여 두피 탈모 예방 및 육모 효과에 시너지 칵테일 효과를 제공하고, 상기 조성비 성분을 함유하는 샴푸, 두피 에센스, 헤어트리트먼트 등의 다양한 화장료 조성물에 제공하는데 그 목적이 있다.Another object of the present invention is to provide a synergistic cocktail effect in preventing scalp hair loss and hair growth, using the mixture of azelamide mye, pyrimidine oxide derivative and sucrose extract in a ratio of 1: 1: 1, The present invention is also directed to a cosmetic composition comprising a cosmetic composition, a shampoo, a scalp essence, a hair treatment, and the like.

이와 같은 기술적 과제를 해결하기 위해 본 발명은, According to an aspect of the present invention,

정제수 100 중량부에 대하여, 아젤라마이드엠이에이 0.1 ~ 10.0 중량부와 피리미딘옥사이드 유도체 0.1 ~ 10.0 중량부 및 하수오 추출물 0.1 ~ 10.0 중량부를 혼합한 것을 특징으로 한다.0.1 to 10.0 parts by weight of azelamide mie, 0.1 to 10.0 parts by weight of a pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of a sucrose extract are mixed with 100 parts by weight of purified water.

또, 하수오 추출물은 하수오 뿌리를 세척 건조시켜 분말 성형한 하수오 50 ~ 150 중량부에 정제수 800 ~ 1000 중량부를 1: 9의 비율로 혼합하고, 상기 혼합액을 70 ~ 80℃의 온도로 10 ~ 14 시간 가열한 다음 여과한 상등액을 제공받아, 상기 상등액을 100 ~ 110℃의 항온 항습실 내에 30 ~ 90분 보관시켜 상기 초기 공급된 상등액과 대비해 0.4 ~ 0.6 %를 증발시켜 구성된다.In addition, the extract of Sasso is obtained by washing and drying the roots of Sasa roots, mixing 800-1000 parts by weight of purified water with 50-150 parts by weight of powdered Sasao powder at a ratio of 1: 9, heating the mixture at 70-80 ° C for 10-14 hours The supernatant is heated and then filtered. The supernatant is stored in a temperature and humidity chamber of 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the initial supernatant.

그리고, 피리미딘옥사이드 유도체는 피롤리디닐디아미노피리미딘옥사이드인 것을 특징으로 한다.And, the pyrimidine oxide derivative is characterized by being pyrrolidinyl diaminopyrimidine oxide.

이러한 본 발명에 의하면, 5 알파-리덕타제 효소의 저해 효과가 있는 아젤라마이드엠이에이성분과, 칼륨통로 개방효과가 있는 피리미딘옥사이드 유도체성분으로 피롤리디닐디아미노피리미딘옥사이드인 성분 및 혈행촉진에 효과적인 하수오 추출물을 3가지 혼합 사용해 제조한 화장료 조성물은 두피의 모낭과 모낭 주변에 침투 효과를 극대화하여 휴지기 상태의 모발을 성장기 상태의 모발로의 촉진을 유도하는 효과가 있다.According to the present invention, the azelamide mental component having the effect of inhibiting the 5 alpha-reductase enzyme and the pyrrolidinyl diaminopyrimidine oxide component having the potassium channel opening effect and the component for promoting blood circulation The cosmetic composition prepared by mixing three effective Sucrose extracts has the effect of maximizing the penetration effect around the hair follicles and hair follicles of the scalp, thereby inducing the hair in the resting state to the hair in the growing state.

아울러, 본 발명에 따르면 염색, 파마 등 반복적으로 모발과 두피에 가해지는 스트레스성 자극과 이로 인한 염증과 비듬 발생 또는 탈모 등을 예방하는 진정 작용의 효과도 제공한다.In addition, according to the present invention, there is also provided an effect of sedation to prevent stress stimulation repeatedly applied to hair and scalp such as dyeing and perming, and thereby preventing inflammation, dandruff or hair loss.

본 발명인 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물은, 피롤리디닐디아미노피리미딘옥사이드 성분과 아젤라마이드엠이에이 성분 및 하수오 추출물 성분을 복합 사용하여, 상기 복합효과의 상승 작용으로 두피의 혈행을 촉진시키며, 가려움증을 예방하고, 모발의 육모 촉진과 탈모를 예방하는 탁월한 효과를 부여하는 화장료 조성물에 관한 것이다.The cosmetic composition for promoting hair growth of the hair of the present invention and preventing hair loss is a hair cosmetic composition comprising a combination of a pyrrolidinyl diaminopyrimidine oxide component, an azelaimide mie agent component and a sulfo extract component, And to provide an excellent effect of preventing itching and promoting hair growth of hair and preventing hair loss.

후술(後述)되는 설명에서는 구체적인 구성요소 등과 같은 많은 특정사항들이 설명되어 있는데, 이는 본 발명의 보다 전반적인 이해를 돕기 위해서 제공된 것일 뿐 이러한 특정 사항들 없이도 본 발명이 실시될 수 있음은 이 기술 분야에서 통상의 지식을 가진 자에게는 자명하다 할 것이다. 그리고 본 발명을 설명함에 있어서, 관련된 공지 기능 혹은 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우 그 상세한 설명을 생략한다.In the following description, numerous specific details are set forth, such as specific elements, which are provided to aid a more thorough understanding of the present invention, and it is to be understood that the present invention may be practiced without these specific details It will be obvious to those of ordinary skill. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

본 발명에 따른 육모를 촉진하고 탈모를 예방하는 화장료 조성물은 두피의 모낭과 모낭 주변에 피부 침투 효과를 극대화하여 휴지기 상태이 모발을 성장기 상태의 모발로 촉진 유도하기 위한 것으로, 아젤라마이드엠이에이와 피리미딘옥사이드 유도체 및 하수오 추출물을 혼합 사용해 제조한다.The cosmetic composition for promoting hair growth and preventing hair loss according to the present invention is for promoting hair growth in the resting state by maximizing the skin penetration effect around hair follicles and hair follicles of the scalp, Oxide derivative and Sucrose extract.

상기 아젤라마이드엠이에이(Azelamide MEA)는 화학식(C11H21NO4)을 갖고 아젤라 산 (QV)의 에탄올 아미드의 혼합물이며, 모공세척, C.Acne균을 사멸시키며, 모공관리, 두피관리에 탁월한 효과가 있는 것으로 알려져 있고, 5 알파-리덕타제의 저해효과로 알려진 아젤라익애시드(Azelaic Acid) 유도체로 사용한다.The Azelamide MEA is a mixture of ethanolamide of azelaic acid (QV) having the formula (C11H21NO4), and has an excellent effect in pore cleaning, C. acne kill, pore management, and scalp management And is used as an azelaic acid derivative known as the inhibitory effect of 5 alpha-reductase.

피롤리디닐디아미노피리미딘옥사이드는 현재 임상에서 탈모에 사용되는 치료제와 유사한 미녹시딜(minoxidil)과 아주 유사하면서 실험을 통하여 이 피롤리디닐디아미노피리미딘옥사이드가 미녹시딜과 유사한 작용을 한다는 것이 입증되었다.Pyrrolidinyldiaminopyrimidine oxides are very similar to minoxidil, which is similar to the therapeutic agent currently used in clinical practice, and it has been demonstrated through experimentation that this pyrrolidinyldiaminopyrimidine oxide has a similar action to minoxidil.

피롤리디닐디아미노피리미딘옥사이드(Pyrrolidinyl Diaminopyrimidine Oxide : P.D.Oxide 또는 PDPO)는, 헤테로사이클릭 화합물이며 모발커디셔닝제 및 축모교정제를 목적으로 배합하며, 피부에 쉽게 흡수되므로 이미 모발생성의 촉진에 광범위하게 도움이 되는 것으로 보고되고 있다.Pyrrolidinyl Diaminopyrimidine Oxide (PDOxide or PDPO) is a heterocyclic compound, which is formulated for the purpose of hair curdening agent and hairpin refining, and is easily absorbed into the skin. It has been reported to be of great help.

피롤리디닐디아미노피리미딘옥사이드는 모낭주변의 혈관을 확장시켜 혈류량을 증가시키고 두피의 혈액순환과 영양공급을 개선하여 모발생성기능을 향상시킨다. 그 주요 매커니즘으로는 5 알파-리덕타제(α-reductase)의 활성을 억제하고 디하이드로테스토스테론(Dihydrotestosterone, DHT)의 생성을 감소하여 혈액순환과 피지분비를 정상화시킨다. 또한, 피롤리디닐디아미노피리미딘옥사이드는 모낭의 구조를 효과적으로 강화하여 모발의 재건을 돕고 비 생리적요소로 인한 탈모현상을 개선한다.Pyrrolidinyldiaminopyrimidine oxide enhances hair growth by expanding the blood vessels around the hair follicle to increase blood flow and improve blood circulation and nutrition of the scalp. Its main mechanism is to inhibit the activity of 5-alpha-reductase and decrease the production of dihydrotestosterone (DHT), normalizing blood circulation and sebaceous glands. In addition, pyrrolidinyl diaminopyrimidine oxide effectively strengthens the structure of the hair follicle to help rebuild hair and improve hair loss due to non-physiological factors.

하수오(何首烏)는 마디풀과에 속하는 다년생 덩굴성 약용식물로 뿌리줄기가 땅속에 뻗어있고 고구마처럼 굵은 덩이뿌리로 자라로 높은 산이나 계곡, 능선에서 잘 자라고 백하수오와 적하수오로 구분된다. 동의보감에는 정수를 채우고 머리카락과 털을 검게하고, 안색을 좋게 하며, 늙지않고 수명을 연장한다고 쓰여 있으며, 본초강목에서는 혈기를 돋우고 머리카락과 수염을 검게하고 안색을 좋게하며, 오랫동안 복용하면 근골이 튼튼하게 바뀌고 정수가 늘어 나이를 먹어도 늙지 않는다라고 쓰여 있을 정도로 탈모 등으로 스트레스를 받고 있는 현대인들에게 좋은 약용식물이다.It is a perennial herbaceous medicinal plant belonging to the genus Porphyra. It grows in the ground and roots grow like a sweet potato. It grows in a high mountain, a valley, and a ridge, and is divided into a white duck and a red duck. It is said that Donguibogam is filled with water, darkens hair and hair, improves complexion, prolongs its life without aging. In the main herbarium, it promotes blood circulation, darkens hair and whiskers, improves complexion, It is a medicinal plant that is good for modern people who are stressed by hair loss and so much that it is said that they do not grow old even if they change and increase in water.

상기의 구성에서 아젤라마이드엠이에이와 피리미딘유도체인 피롤리디닐디아미노피리미딘옥사이드 및 하수오의 성분은 이미 공지된 구성이므로 더 이상의 자세한 설명은 생략하기로 하며, 아젤라마이드엠이에이 성분과 피롤리디닐디아미노피리미딘옥사이드 성분 및 후술(後述)되는 상기 하수오 추출물의 제조 과정을 통해 얻어진 하수오 추출물을 정제수 100 중량부에 아젤라마이드엠이에이, 피리미딘옥사이드 유도체, 하수오 추출물 성분을 1 : 1: 1 의 비율로 혼합 제조한 것을 특징으로 한다.In the above-mentioned constitution, the components of azelamide mie and pyrimidine derivatives pyrrolidinyldiaminopyrimidine oxide and sulfoxide are already known and will not be described in detail, and azelamide mieae component and pyrrolidinyl The diaminopyrimidine oxide component and the Sasao extract obtained through the process of preparing the Sasa extract described below (to be described later) were mixed with 100 parts by weight of purified water in a ratio of 1: 1: 1 of Azelamide miei, pyrimidine oxide derivative and Sasao extract component .

(하수오 추출물 제조)(Manufacture of Sasa extract)

먼저, 하수오 추출물은 하수오 뿌리를 세척 건조시켜 분말 성형한 하수오 50 ~ 150 중량부에 정제수 800 ~ 1000 중량부를 1: 9의 비율로 혼합하고, 상기 혼합액을 70 ~ 80℃의 온도로 10 ~ 14 시간 가열한 다음 여과한 상등액을 제공받아, 상기 상등액을 100 ~ 110℃의 항온 항습실 내에 30 ~ 90분 보관시켜 상기 초기 공급된 상등액과 대비해 0.4 ~ 0.6 %를 증발시켜 구성된다.First, the extract of Sasao is washed and dried, and 800 to 1000 parts by weight of purified water is mixed in a ratio of 1: 9 to 50 to 150 parts by weight of powdered Sasao, and the mixture is stirred at 70 to 80 ° C for 10 to 14 hours The supernatant is heated and then filtered. The supernatant is stored in a temperature and humidity chamber of 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the initial supernatant.

이를 상세히 설명하면, 시중에 판매하고 있는 하수오 뿌리 부분을 이용하여 흐르는 물에 깨끗이 세척후 건조시킨 다음, 하수오 100g 을 믹서기로 분쇄해 분말 성형하고, 여기에 정제수 900g 을 혼합해 상기 1000g 의 혼합물을 75℃ 의 온도로 12시간을 가열한다.Specifically, 100 g of Sucrose was ground by a blender and powdered, and then 900 g of purified water was mixed to prepare a mixture of 1000 g of the mixture. Lt; 0 > C for 12 hours.

그리고, 상기 가열된 혼합물을 여과해 침전시켜 상부에 위치하는 상등액을 제공받은 다음, 상기 상등액을 105℃로 유지되는 항온 항습실 내에 60분 보관시켜 상기 초기 공급된 상등액과 대비해 0.5 % 이상의 고형분 함량을 갖게 제조한다.Then, the heated mixture was filtered to precipitate the supernatant. Then, the supernatant was stored in a constant temperature and humidity chamber maintained at 105 ° C. for 60 minutes to have a solid content of 0.5% or more as compared with the initial supernatant supplied. .

(혼합 조성물 제조)(Preparation of mixed composition)

먼저, 본 발명에 따른 아젤라마이드엠이에이, 피리미딘옥사이드 유도체, 하수오 추출물을 혼합 제조하기 위해 (표 1)의 제조예 1 ~ 3, 비교예 1 ~ 4의 조성물을 제조하였다.First, the compositions of Production Examples 1 to 3 and Comparative Examples 1 to 4 of Table 1 were prepared in order to prepare the azelaimide emulsion, the pyrimidine oxide derivative and the Sasa extract according to the present invention.

모발의 육모를 촉진하는 성분으로 아젤라마이드엠이에이, 피리미딘옥사이드 유도체로 피롤리디닐디아미노피리미딘옥사이드(Pyrrolidinyl Diaminopyrimidine Oxide : P.D.Oxide 또는 PDPO), 하수오 추출물 3종을 1 : 1 : 1의 중량비로 혼합 사용하였다.(Pyrrolidinyl Diaminopyrimidine Oxide: PDOxide or PDPO) as a component promoting the hair growth of hair, and three kinds of Sasao extract as a pyrimidine oxide derivative at a weight ratio of 1: 1: 1 Respectively.

특히, 정제수 100중량부에 아젤라마이드엠이에이 0.1 ~ 10.0 중량부와 피리미딘옥사이드 유도체 0.1 ~ 10.0 중량부 및 하수오 추출물 0.1 ~ 10.0 중량부를 포함해 혼합한다.Particularly, 0.1 to 10.0 parts by weight of azelamide mieae, 0.1 to 10.0 parts by weight of pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of sucrose extract are mixed in 100 parts by weight of purified water.

이때, (표 1)에 도시된 바와 같이 에탄올 및 정제수에 제조예 1은 3종을 혼합하고 제조예 2 ~ 3은 2종을 혼합하며, 비교예 1 ~ 3은 1종을 혼합하고, 비교예 4는 혼합하지 않고 실험하였다. In this case, as shown in Table 1, ethanol and purified water were mixed with three kinds of Preparation Example 1, Production Examples 2 to 3 were mixed with two kinds, Comparative Examples 1 to 3 were mixed with one kind, 4 were tested without mixing.

구 분division 제조예1 Production Example 1 제조예2Production Example 2 제조예3Production Example 3 비교예1Comparative Example 1 비교예2Comparative Example 2 비교예3Comparative Example 3 비교예4Comparative Example 4 하수오추출물Sashou extract 5.05.0 -- 5.05.0 5.05.0 -- -- -- 아젤라마이드엠이에이Azelaide miai 5.05.0 5.05.0 -- -- 5.05.0 -- -- PDPOPDPO 5.05.0 5.05.0 5.05.0 -- -- 5.05.0 -- 에탄올ethanol 40.040.0 40.040.0 40.040.0 40.040.0 40.040.0 40.040.0 40.040.0 정제수Purified water 45.045.0 50.050.0 50.050.0 55.055.0 55.055.0 55.055.0 60.060.0

(실시예)(Example)

헤어 에센스 제조Hair essence manufacturing

본 발명은 (표 2)의 제형 예에서와 같이 주성분으로 실시예 1 ~ 7을 함유한 헤어 에센스를 제조하였다.The present invention produced hair essences containing Examples 1 to 7 as main components as in the formulation examples of Table 2.

제형 예Formulation Example 성분ingredient 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 실시예7Example 7 정제수Purified water to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 to 100to 100 글리세린glycerin 6.06.0 6.06.0 6.06.0 6.06.0 6.06.0 6.06.0 6.06.0 카보머Carbomer 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 피이지60하이드로제네이티드캐스터오일Piggy 60 Hydrogenated Castor Oil

1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0


1.0
에탄올ethanol 1.01.0 1.01.0 1.01.0 1.01.0 1.01.0 1.01.0 1.01.0 페녹시에탄올Phenoxyethanol 0.50.5 0.50.5 0.50.5 0.50.5 0.50.5 0.50.5 0.50.5 트리에탄올아민Triethanolamine 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 0.30.3 조성물
(제조예1)
Composition
(Production Example 1)
10.010.0
조성물
(제조예2)
Composition
(Production Example 2)
10.010.0
조성물
(제조예3)
Composition
(Production Example 3)
10.010.0
조성물
(비교예1)
Composition
(Comparative Example 1)
10.010.0
조성물
(비교예2)
Composition
(Comparative Example 2)
10.010.0
조성물
(비교예3)
Composition
(Comparative Example 3)
10.010.0
조성물
(비교예4)
Composition
(Comparative Example 4)
10.010.0

(실험 예)(Experimental Example)

본 발명의 발모 가능성 임상 평가 시험The hairy potential clinical evaluation test of the present invention

본 발명의 헤어 에센스를 가지고 스스로 탈모증상이 있다고 느끼는 남성 30명 피험자를 대상으로 실지 임상 실험을 실시하였다.A clinical trial was conducted on 30 male subjects who feel themselves having hair loss symptoms with the hair essence of the present invention.

피험자는 5 명씩 각 그룹별로 나누고 매일 저녁 샴푸 후 실시예1 ~ 7을 피험자가 인식하지 못하게 하고, 헤어 에센스를 바르고 3주 후 샴푸 후 평균 탈모 정도, 육안 판정, 자각 발모증상 개선 정도, 이외에 비듬 발생 정도를 평가 척도로 5단계로 나누고 단계에 따라 스스로 점수를 평가하였으며 5명 평균값으로 나타내었다.The subjects were divided into groups of 5 persons. After shampooing, the subjects were not allowed to recognize Examples 1 to 7, and after 3 weeks of applying the hair essence, the average degree of hair loss, visual determination, The scale was divided into 5 stages by the evaluation scale, and the scores were evaluated by the steps and expressed as the average value of 5 persons.

평가 기준은 다음과 같다.The evaluation criteria are as follows.

1점 : 탈모 증상이 악화 되었다.1 point: Hair loss symptoms worsened.

2점 : 효과가 없는 것 같다. (그대로이다)2 points: It does not seem to be effective. (As it is)

3점 : 효과가 있는 것 같은 느낌이다. (탈모가 되지는 않는다)Three points: It feels like an effect. (It does not become hair loss)

4점 : 효과를 약간 느낀다. (증상이 개선되는 것 같다)4 points: I feel a bit of an effect. (Symptoms seem to improve)

5점 : 효과가 매우 좋다. (발모가 된다)5 points: The effect is very good. (Hair growth)

실험예1) 세발 후 탈모 정도(3주후 세면대에 있는 모발 수 자가 평가)Experimental Example 1) Degree of hair loss after hair removal (after 3 weeks,

성분ingredient 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 실시예7Example 7 평균Average 4.24.2 3.53.5 3.53.5 3.33.3 3.23.2 3.43.4 3.03.0

실험 결과 피험자는 각 제품을 브라인드로 3주간 사용하고 이후 샴푸 후 세면대에 탈모가 되는 모발 수를 자가 판정하고 그 평균값을 나타내었다.As a result of the experiment, the subjects used each product with a blind for 3 weeks, and after that, self - determination of the number of hair loss on the washbasin after the shampooing was shown and the average value was shown.

실험 결과 아젤라마이드엠이에이 성분과 피롤리디닐디아미노피리미딘옥사이드 성분, 하수오 추출물 성분을 혼합하여 제조한 헤어 에센스 실시예1에서 가장 좋은 탈모 예방 효과가 있음을 확인하였고, 주성분이 2개 또는 각각 함유된 실시예2 ~ 6 에서는 유의미한 효과를 확인할 수 없었으며, 주성분이 아무것도 함유하지 않은 실시예7에서는 탈모 효과가 가장 낮음을 확인하였다.As a result of the experiment, it was confirmed that the best hair loss prevention effect was obtained in Example 1 of hair essence prepared by mixing azelaimide myei component, pyrrolidinyl diaminopyrimidine oxide component and sulfo extract component. It was confirmed that the hair loss effect was lowest in Example 7 in which the main ingredient was not contained.

이는 3가지 주성분을 함유한 형태의 헤어 에센스가 시너지 효과를 보이면서 가장 좋은 탈모 예방 효과가 있음을 확인한 것이다.This shows that hair essence containing three main ingredients shows synergy effect and has the best hair loss preventive effect.

실험예2) 발모 자각 만족도Experimental Example 2)

탈모증상이 있다고 느끼는 피험자 30명이 실험예1과 마찬가지로 매일 샴푸 후 각 제품을 브라인드로 사용하고 스스로 발모가 되고 있다고 느끼는 정도를 5점 척도로 표기한 후 그 평균값으로 수치화하였다.30 subjects who felt hair loss symptoms were used as a blind after daily shampooing as in Experimental Example 1, and the degree to which they felt that they were hairs themselves were expressed as a 5-point scale, and the results were expressed as an average value.

성분ingredient 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 실시예7Example 7 평균Average 4.34.3 3.13.1 3.33.3 3.33.3 3.23.2 3.43.4 2.82.8

실험 결과 각 제품을 블라인드로 사용한 후 3주 후 스스로 발모가 되었다고 느끼는 자각 점수를 5점 척도로 평가한 결과 탈모 방지와 마찬가지로 아젤라마이드엠이에이 성분과 피롤리디닐디아미노피리미딘옥사이드 성분, 하수오 추출물 성분이 모두 함유된 실시예1에서 아주 뚜렷한 발모 효과가 있음을 확인할 수 있었고, 단순히 2가지 또는 1가지만 선택한 실시예2 ~ 6 까지는 큰 차이를 느끼는 발모 효과가 나타나지 않았으며, 아무것도 함유하지 않은 실시예7에서는 발모 효과가 가장 낮음을 확인하였다.As a result of evaluating the self-awareness score, which is felt as if it was self-raised after 3 weeks after each product was used as a blind, it was evaluated on a 5-point scale. As a result, as in the case of preventing hair loss, the azelamide- myei component, the pyrrolidinyldiaminopyrimidine oxide component, It was confirmed that there was a very distinct hair growth effect in Example 1 containing both of them, and no hair growth effect showing a large difference was observed between merely two or one selected only Examples 2 to 6, and in Example 7 The hair growth effect was the lowest.

이는 발모에는 칵테일 시너지 효과 즉, 5 알파-리덕타제 저해력, 칼륨통로개방관여, 혈행촉진 등의 3가지 효과를 함께 고려하는 것이 발모 효과에 보다 좋은 결과를 얻을 수 있음을 확인한 것이다.It was confirmed that the three effects such as cocktail synergistic effect, 5 alpha-reductase inhibiting ability, potassium channel open involvement, and blood circulation promotion, together with hair growth, could obtain better results in the hair growth effect.

실험예3) 비듬 발생 정도Experimental Example 3) Dandruff occurrence degree

실험예1 및 실험예2와 마찬가지로 3주 후 비듬 발생 정도를 5점 척도로 평가하게 하였다.As in Experimental Example 1 and Experimental Example 2, the degree of dandruff occurrence was evaluated on a 5-point scale after 3 weeks.

성분ingredient 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 실시예7Example 7 평균Average 4.34.3 3.33.3 3.23.2 3.13.1 3.23.2 3.43.4 3.23.2

실험 결과 각 제품을 브라인드로 사용한 후 비듬이 발생하는 정도를 평가한 결과 실시예1에서 가장 좋은 비듬 방지 효과가 있었고, 실시예2 ~ 6 및 주성분이 아무것도 함유되지 않은 실시예7에서는 비듬 방지 효과에 대하여 유의미한 결과를 보이지 않았다.As a result of evaluating the degree of occurrence of dandruff after each product was used as a blind, the best dandruff prevention effect was obtained in Example 1, while in Examples 2 to 6 and Example 7 in which none of the main ingredients were included, The results were not significant.

이상에서와 같이 본 발명의 바람직한 실시 예에 대해서 설명하였으나, 본 발명은 상술한 특정의 실시 예에 한정되지 아니하며, 당해 기술분야에서 통상의 지식을 가진 자라면 본원 발명의 요지를 벗어남이 없이 다양한 변형실시가 가능함은 물론이다. 따라서, 본 발명의 범위는 위의 실시 예에 국한해서 해석되어서는 안되며, 후술하는 특허 청구범위뿐만 아니라 이 특허청구범위와 균등한 것들에 의해 정해져야 할 것이다.While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, It goes without saying that the present invention can be practiced. Accordingly, the scope of the present invention should not be construed as being limited to the above-described embodiments, but should be determined by equivalents to the appended claims, as well as the following claims.

Claims (3)

정제수 100 중량부에 대하여, 아젤라마이드엠이에이 0.1 ~ 10.0 중량부와 피리미딘옥사이드 유도체 0.1 ~ 10.0 중량부 및 하수오 추출물 0.1 ~ 10.0 중량부를 포함해 혼합한 것을 특징으로 하는 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물.Wherein 0.1 to 10.0 parts by weight of azelamide miea, 0.1 to 10.0 parts by weight of a pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of a sulfo extract are mixed with 100 parts by weight of purified water to promote hair growth of hair, / RTI > 청구항 1에 있어서, 상기 하수오 추출물은 하수오 뿌리를 세척 건조시켜 분말 성형한 하수오 50 ~ 150 중량부에 정제수 800 ~ 1000 중량부를 1: 9의 비율로 혼합하고, 상기 혼합액을 70 ~ 80℃의 온도로 10 ~ 14 시간 가열한 다음 여과한 상등액을 제공받아, 상기 상등액을 100 ~ 110℃의 항온 항습실 내에 30 ~ 90분 보관시켜 상기 초기 공급된 상등액과 대비해 0.4 ~ 0.6 %를 증발시켜 구성된 것을 특징으로 하는 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물.[7] The method of claim 1, wherein the Sucrose extract is prepared by washing and drying Sasa roots, mixing 800-1000 parts by weight of purified water with 50-150 parts by weight of powdery Sucrose at a ratio of 1: 9, Wherein the supernatant is heated for 10 to 14 hours and filtered, and the supernatant is stored in a temperature and humidity chamber at 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the supernatant as compared with the initially supplied supernatant. A cosmetic composition for promoting hair hair growth and preventing hair loss. 청구항 1에 있어서, 피리미딘옥사이드 유도체는 피롤리디닐디아미노피리미딘옥사이드인 것을 특징으로 하는 모발의 육모를 촉진하고 탈모를 예방하는 화장료 조성물.
The cosmetic composition according to claim 1, wherein the pyrimidine oxide derivative is pyrrolidinyl diaminopyrimidine oxide, which promotes hair hair growth and prevents hair loss.
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