KR20180096948A - A cosmetic composition for promoting hair growth and preventing hair loss - Google Patents

Abstract

The present invention relates to a cosmetic composition for promoting hair growth and preventing hair loss. More specifically, the present invention relates to a cosmetic composition which uses a combination of a pyrrolidinyl diaminopyrimidine oxide component, an azelamide MEA component, and a Polygoni multiflori Radix extract component, and through a synergistic effect of the above combination, provides desirable effects in promoting the blood circulation of scalp, preventing itchiness, promoting hair growth, and preventing hair loss. The cosmetic composition comprises, with respect to 100 parts by weight of purified water: 0.1-10.0 parts by weight of azelamide MEA; 0.1-10.0 parts by weight of a pyrimidine oxide derivative; and 0.1-10.0 parts by weight of an extract of Polygoni multiflori Radix. In particular, the extract of Polygoni multiflori Radix is prepared by mixing 50-150 parts by weight of Polygoni multiflori Radix formed by washing, drying, and pulverizing the roots of Polygoni multiflori Radix, with 800-1,000 parts by weight of purified water in 1 : 9 ratio; heating the mixture at 70-80°C for 10-14 hours and filtering the same to provide a supernatant; and storing the supernatant in a thermo-hygrostatat 100-110°C for 30-90 minutes, thereby evaporating 0.4-0.6% of the initially supplied supernatant. In addition, the pyrimidine oxide derivative is pyrrolidinyl diaminopyrimidine oxide.

Description

[0001] The present invention relates to a cosmetic composition for promoting hair growth of a hair and preventing hair loss,

The present invention relates to a cosmetic composition for promoting hair growth of hair and preventing hair loss, and more particularly, to a cosmetic composition for preventing hair loss by combining the pyrrolidinyl diaminopyrimidine oxide component, the azelamide mental component, To promote the blood circulation of the scalp, to prevent itching, and to provide an excellent effect of promoting hair growth of hair and preventing hair loss.

Modern industrial society is an infinite competition society, and beautiful appearance than other people is recognized as another important competitiveness. There are various forms for constant appearance, but as the industrial society develops, environmental pollution and other environmental conditions deteriorate and infinite competition Increased stress, westernized eating habits, frequent perms and dyes, and incorrect scalp care have led to an increasing number of hair loss populations.

As a practical example, there are behaviors such as shampooing, perming, dyeing, etc. during beauty care. The higher the income level, the more frequent the above actions. On the contrary, in hair care, unwanted phenomenon of hair loss due to use of chemical products and stress is appearing It is true.

The growth period of hair is usually represented by anagen and telogen, and resting hair hair loss is a hair loss that occurs when the normal growth cycle of the hair enters the resting period.

Human hair grows and disappears repeatedly every three to six years. Hair that has grown for about three to six years is degraded over about three to four weeks, and then falls into a resting state in which hair remains missing for about three to five months.

It is known that the hair that falls into the rest period is about 10% of the total hair, and the hair loss in the form in which the hair falls out as the hair breaks into the resting period is called the resting hair loss, and the resting hair loss is generally known to recover normally over time.

Common causes of hair loss include genetic factors and stress. Hair loss due to genetic factors and hair loss due to stress are very different. Stress-induced hair loss is generally known as round hair loss and treatment is possible , Hair loss caused by genetic factors is known to be difficult to treat.

As a genetic cause of hair loss, hair loss genes can be inherited from both the paternal and maternal lines. It is known that testosterone, which is a male hormone, is involved in hair loss, and 5 alpha-reductase is involved It is known that testosterone is rapidly oxidized to dihydrotestosterone (DHT), leading to rapid hair loss.

As described above, ingredients for the purpose of promoting heat circulation, inhibiting male hormone function, and enhancing hair follicle function are sold as products for various complicated hair loss causes, but there is no specific effect yet, Problems were also raised.

First, Merck's Proscar, which was initially used as a treatment for male prostate cancer, is used in patients with hyperplasia of the prostate gland, and it is known that some of them use it to improve hair loss, In 1997, the US Food and Drug Administration (FDA) approved a dose of 1 mg of pinasteride daily for men's hair loss as a 5-alpha-reductase inhibitor.

This confirms that the finasteride component prevents the oxidation of testosterone to dihydrotestosterone by inhibition of the 5 alpha-reductase enzyme to prevent hair loss.

In addition, the hair loss due to stress causes the blood circulation disorder and insomnia when the stress is continuously accumulated, and the tension of the scalp caused by this changes the scalp to the intelligence, so that the hair growth as well as the hair growth, .

In addition, the eating habits due to the diet of the modern people is westernized, fatty foods containing a lot of fatty foods, such as food often eat, such as sex hormones, such as the effects of the male hormone to change the scalp to intelligence, causing hair loss .

Alcohol also promotes inflammation and sebum secretion, and smoking lowers body temperature to constrict blood vessels, interfering with blood circulation, leading to vitamin deficiency. These phenomena lead to hair loss, hair growth and development , It is necessary to prevent and control hair loss through appropriate drinking, smoking and vitamin intake.

In addition, strong ultraviolet rays give direct stimulation to the scalp to make the hair follicle dry, increase inflammation, promote hair loss, and damage the keratin, which is a protein layer of hair due to the ultraviolet rays, Causing hair loss.

In order to solve the above problems, researches such as prevention of hair loss and promotion of hair growth have been given to many researchers. Numerous solutions and research achievements have been announced, and many prior arts have been proposed through them. Patent Document 6, and the like.

In addition, the known minoxidil, which is approved by the US FDA among the existing anti-hair restorative drugs, induces vasodilating function as a potassium channel opener, which is inherent in the hair cycle of the resting period, Activity to keep the induced growth period of the hair cycle was reported (British Journal of Dermatology. 2004; 150: 186-194).

The mechanism of the hair growth effect of the pyrimidine derivative minoxidil (2,4-diamino-6piperidino-pyrimidine-3-oxide) is still unclear. However, the mechanism of the hair growth of the potassium channel It is widely recognized that the effect of vasodilatation depends on the effect.

Thereafter, a variety of pyrimidine derivatives and novel compounds have been reported to have a general effect on the opening of potassium channels and thus the hair growth effect (J Invest Dermatol 2005 124 (4): 686-94), that of several derivatives of pyrimidine oxides A patent for hair growth has been filed (U.S. Patent Nos. 5,034,387 and 4,945,093). The patent for the hair growth of the previous pyrimidine oxide derivatives encompasses a wide range of derivational structures including the structure of the previously described minoxidil drugs, and the hair growth action of each individual derivative is a generally accepted technique.

These techniques, however, are mentioned in terms of promoting blood flow for hair growth, inhibition of 5 alpha-reductase, opening of potassium channel, etc. However, no technical progress has been made yet to the exact mechanism and the inhibition of 5 alpha-reductase , The azelamide-mye component of the azelaic acid, the pyrrolidinyldiaminopyrimidine oxide component of the potassium channel opening effect, and the sulfated-water extract component of the blood circulation promoting effect.

[Patent Document 1]. Korean Patent Publication No. 10-2011-0045341. A composition for scalp and hair improving agent comprising a complex extract of yeast, gold, propolis, ginseng, marjoram, clove, and garlic mixed (disclosed on May 04, 2011) [Patent Document 2]. Korean Patent Publication No. 10-2011-0108481. A composition for preventing hair loss or promoting hair growth comprising ginseng saponin metabolite (published on November 06, 2011) [Patent Document 3]. Korean Patent Publication No. 10-2004-0017393. Hair loss prevention shampoo (public date February 27, 2004) [Patent Document 4]. Korean Patent Publication No. 10-2011-0127447. Composition for preventing hair loss or promoting hair growth (published on November 25, 2011) [Patent Document 5]. Korean Patent Publication No. 10-2010-0120332. The present invention relates to a hair growth inhibitor composition containing plant extracts and a process for producing the hair growth inhibitor composition (published on November 16, 2010) [Patent Document 6]. Korean Patent Publication No. 10-2007-0041890. Composition for external application for promoting hair growth (Published date Apr. 20, 2007)

In order to solve the problems of the prior art as described above, the present invention relates to a pharmaceutical composition comprising an azelamide mental component, which is known as a 5-alpano-reducticase inhibitory effect, a pyrimidine oxide component as a potassium channel, It is an object of the present invention to provide a cosmetic composition which promotes hair hair growth more effectively in preventing scalp hair loss and promoting hair growth through synergistic effect as a cocktail therapy which concurrently promotes hair growth promoting effect and hair loss prevention.

Another object of the present invention is to provide a synergistic cocktail effect in preventing scalp hair loss and hair growth, using the mixture of azelamide mye, pyrimidine oxide derivative and sucrose extract in a ratio of 1: 1: 1, The present invention is also directed to a cosmetic composition comprising a cosmetic composition, a shampoo, a scalp essence, a hair treatment, and the like.

According to an aspect of the present invention,

0.1 to 10.0 parts by weight of azelamide mie, 0.1 to 10.0 parts by weight of a pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of a sucrose extract are mixed with 100 parts by weight of purified water.

In addition, the extract of Sasso is obtained by washing and drying the roots of Sasa roots, mixing 800-1000 parts by weight of purified water with 50-150 parts by weight of powdered Sasao powder at a ratio of 1: 9, heating the mixture at 70-80 ° C for 10-14 hours The supernatant is heated and then filtered. The supernatant is stored in a temperature and humidity chamber of 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the initial supernatant.

And, the pyrimidine oxide derivative is characterized by being pyrrolidinyl diaminopyrimidine oxide.

According to the present invention, the azelamide mental component having the effect of inhibiting the 5 alpha-reductase enzyme and the pyrrolidinyl diaminopyrimidine oxide component having the potassium channel opening effect and the component for promoting blood circulation The cosmetic composition prepared by mixing three effective Sucrose extracts has the effect of maximizing the penetration effect around the hair follicles and hair follicles of the scalp, thereby inducing the hair in the resting state to the hair in the growing state.

In addition, according to the present invention, there is also provided an effect of sedation to prevent stress stimulation repeatedly applied to hair and scalp such as dyeing and perming, and thereby preventing inflammation, dandruff or hair loss.

The cosmetic composition for promoting hair growth of the hair of the present invention and preventing hair loss is a hair cosmetic composition comprising a combination of a pyrrolidinyl diaminopyrimidine oxide component, an azelaimide mie agent component and a sulfo extract component, And to provide an excellent effect of preventing itching and promoting hair growth of hair and preventing hair loss.

In the following description, numerous specific details are set forth, such as specific elements, which are provided to aid a more thorough understanding of the present invention, and it is to be understood that the present invention may be practiced without these specific details It will be obvious to those of ordinary skill. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

The cosmetic composition for promoting hair growth and preventing hair loss according to the present invention is for promoting hair growth in the resting state by maximizing the skin penetration effect around hair follicles and hair follicles of the scalp, Oxide derivative and Sucrose extract.

The Azelamide MEA is a mixture of ethanolamide of azelaic acid (QV) having the formula (C11H21NO4), and has an excellent effect in pore cleaning, C. acne kill, pore management, and scalp management And is used as an azelaic acid derivative known as the inhibitory effect of 5 alpha-reductase.

Pyrrolidinyldiaminopyrimidine oxides are very similar to minoxidil, which is similar to the therapeutic agent currently used in clinical practice, and it has been demonstrated through experimentation that this pyrrolidinyldiaminopyrimidine oxide has a similar action to minoxidil.

Pyrrolidinyl Diaminopyrimidine Oxide (PDOxide or PDPO) is a heterocyclic compound, which is formulated for the purpose of hair curdening agent and hairpin refining, and is easily absorbed into the skin. It has been reported to be of great help.

Pyrrolidinyldiaminopyrimidine oxide enhances hair growth by expanding the blood vessels around the hair follicle to increase blood flow and improve blood circulation and nutrition of the scalp. Its main mechanism is to inhibit the activity of 5-alpha-reductase and decrease the production of dihydrotestosterone (DHT), normalizing blood circulation and sebaceous glands. In addition, pyrrolidinyl diaminopyrimidine oxide effectively strengthens the structure of the hair follicle to help rebuild hair and improve hair loss due to non-physiological factors.

It is a perennial herbaceous medicinal plant belonging to the genus Porphyra. It grows in the ground and roots grow like a sweet potato. It grows in a high mountain, a valley, and a ridge, and is divided into a white duck and a red duck. It is said that Donguibogam is filled with water, darkens hair and hair, improves complexion, prolongs its life without aging. In the main herbarium, it promotes blood circulation, darkens hair and whiskers, improves complexion, It is a medicinal plant that is good for modern people who are stressed by hair loss and so much that it is said that they do not grow old even if they change and increase in water.

In the above-mentioned constitution, the components of azelamide mie and pyrimidine derivatives pyrrolidinyldiaminopyrimidine oxide and sulfoxide are already known and will not be described in detail, and azelamide mieae component and pyrrolidinyl The diaminopyrimidine oxide component and the Sasao extract obtained through the process of preparing the Sasa extract described below (to be described later) were mixed with 100 parts by weight of purified water in a ratio of 1: 1: 1 of Azelamide miei, pyrimidine oxide derivative and Sasao extract component .

(Manufacture of Sasa extract)

First, the extract of Sasao is washed and dried, and 800 to 1000 parts by weight of purified water is mixed in a ratio of 1: 9 to 50 to 150 parts by weight of powdered Sasao, and the mixture is stirred at 70 to 80 ° C for 10 to 14 hours The supernatant is heated and then filtered. The supernatant is stored in a temperature and humidity chamber of 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the initial supernatant.

Specifically, 100 g of Sucrose was ground by a blender and powdered, and then 900 g of purified water was mixed to prepare a mixture of 1000 g of the mixture. Lt; 0 > C for 12 hours.

Then, the heated mixture was filtered to precipitate the supernatant. Then, the supernatant was stored in a constant temperature and humidity chamber maintained at 105 ° C. for 60 minutes to have a solid content of 0.5% or more as compared with the initial supernatant supplied. .

(Preparation of mixed composition)

First, the compositions of Production Examples 1 to 3 and Comparative Examples 1 to 4 of Table 1 were prepared in order to prepare the azelaimide emulsion, the pyrimidine oxide derivative and the Sasa extract according to the present invention.

(Pyrrolidinyl Diaminopyrimidine Oxide: PDOxide or PDPO) as a component promoting the hair growth of hair, and three kinds of Sasao extract as a pyrimidine oxide derivative at a weight ratio of 1: 1: 1 Respectively.

Particularly, 0.1 to 10.0 parts by weight of azelamide mieae, 0.1 to 10.0 parts by weight of pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of sucrose extract are mixed in 100 parts by weight of purified water.

In this case, as shown in Table 1, ethanol and purified water were mixed with three kinds of Preparation Example 1, Production Examples 2 to 3 were mixed with two kinds, Comparative Examples 1 to 3 were mixed with one kind, 4 were tested without mixing.

division  Production Example 1 Production Example 2 Production Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Sashou extract 5.0 - 5.0 5.0 - - - Azelaide miai 5.0 5.0 - - 5.0 - - PDPO 5.0 5.0 5.0 - - 5.0 - ethanol 40.0 40.0 40.0 40.0 40.0 40.0 40.0 Purified water 45.0 50.0 50.0 55.0 55.0 55.0 60.0

(Example)

Hair essence manufacturing

The present invention produced hair essences containing Examples 1 to 7 as main components as in the formulation examples of Table 2.

Formulation Example ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 glycerin 6.0 6.0 6.0 6.0 6.0 6.0 6.0 Carbomer 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Piggy 60 Hydrogenated Castor Oil

1.0

1.0

1.0

1.0

1.0

1.0

1.0 ethanol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Triethanolamine 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Composition
(Production Example 1) 10.0 Composition
(Production Example 2) 10.0 Composition
(Production Example 3) 10.0 Composition
(Comparative Example 1) 10.0 Composition
(Comparative Example 2) 10.0 Composition
(Comparative Example 3) 10.0 Composition
(Comparative Example 4) 10.0

(Experimental Example)

The hairy potential clinical evaluation test of the present invention

A clinical trial was conducted on 30 male subjects who feel themselves having hair loss symptoms with the hair essence of the present invention.

The subjects were divided into groups of 5 persons. After shampooing, the subjects were not allowed to recognize Examples 1 to 7, and after 3 weeks of applying the hair essence, the average degree of hair loss, visual determination, The scale was divided into 5 stages by the evaluation scale, and the scores were evaluated by the steps and expressed as the average value of 5 persons.

The evaluation criteria are as follows.

1 point: Hair loss symptoms worsened.

2 points: It does not seem to be effective. (As it is)

Three points: It feels like an effect. (It does not become hair loss)

4 points: I feel a bit of an effect. (Symptoms seem to improve)

5 points: The effect is very good. (Hair growth)

Experimental Example 1) Degree of hair loss after hair removal (after 3 weeks,

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Average 4.2 3.5 3.5 3.3 3.2 3.4 3.0

As a result of the experiment, the subjects used each product with a blind for 3 weeks, and after that, self - determination of the number of hair loss on the washbasin after the shampooing was shown and the average value was shown.

As a result of the experiment, it was confirmed that the best hair loss prevention effect was obtained in Example 1 of hair essence prepared by mixing azelaimide myei component, pyrrolidinyl diaminopyrimidine oxide component and sulfo extract component. It was confirmed that the hair loss effect was lowest in Example 7 in which the main ingredient was not contained.

This shows that hair essence containing three main ingredients shows synergy effect and has the best hair loss preventive effect.

Experimental Example 2)

30 subjects who felt hair loss symptoms were used as a blind after daily shampooing as in Experimental Example 1, and the degree to which they felt that they were hairs themselves were expressed as a 5-point scale, and the results were expressed as an average value.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Average 4.3 3.1 3.3 3.3 3.2 3.4 2.8

As a result of evaluating the self-awareness score, which is felt as if it was self-raised after 3 weeks after each product was used as a blind, it was evaluated on a 5-point scale. As a result, as in the case of preventing hair loss, the azelamide- myei component, the pyrrolidinyldiaminopyrimidine oxide component, It was confirmed that there was a very distinct hair growth effect in Example 1 containing both of them, and no hair growth effect showing a large difference was observed between merely two or one selected only Examples 2 to 6, and in Example 7 The hair growth effect was the lowest.

It was confirmed that the three effects such as cocktail synergistic effect, 5 alpha-reductase inhibiting ability, potassium channel open involvement, and blood circulation promotion, together with hair growth, could obtain better results in the hair growth effect.

Experimental Example 3) Dandruff occurrence degree

As in Experimental Example 1 and Experimental Example 2, the degree of dandruff occurrence was evaluated on a 5-point scale after 3 weeks.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Average 4.3 3.3 3.2 3.1 3.2 3.4 3.2

As a result of evaluating the degree of occurrence of dandruff after each product was used as a blind, the best dandruff prevention effect was obtained in Example 1, while in Examples 2 to 6 and Example 7 in which none of the main ingredients were included, The results were not significant.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, It goes without saying that the present invention can be practiced. Accordingly, the scope of the present invention should not be construed as being limited to the above-described embodiments, but should be determined by equivalents to the appended claims, as well as the following claims.

Claims (3)

Wherein 0.1 to 10.0 parts by weight of azelamide miea, 0.1 to 10.0 parts by weight of a pyrimidine oxide derivative and 0.1 to 10.0 parts by weight of a sulfo extract are mixed with 100 parts by weight of purified water to promote hair growth of hair, / RTI > [7] The method of claim 1, wherein the Sucrose extract is prepared by washing and drying Sasa roots, mixing 800-1000 parts by weight of purified water with 50-150 parts by weight of powdery Sucrose at a ratio of 1: 9, Wherein the supernatant is heated for 10 to 14 hours and filtered, and the supernatant is stored in a temperature and humidity chamber at 100 to 110 ° C for 30 to 90 minutes to evaporate 0.4 to 0.6% of the supernatant as compared with the initially supplied supernatant. A cosmetic composition for promoting hair hair growth and preventing hair loss. The cosmetic composition according to claim 1, wherein the pyrimidine oxide derivative is pyrrolidinyl diaminopyrimidine oxide, which promotes hair hair growth and prevents hair loss.