KR100930688B1 - Oriental composition for reinforcement of hair-roots and cleanness of scalp and its preparation method - Google Patents

Abstract

PURPOSE: A composition containing medicinal herb extract for strengthening hair bulb and maintaining scalp cleanness is provided to ensure biological stability and prevent hair loss. CONSTITUTION: A composition for strengthening hair and maintaining scalp cleaning comprises 100 weight parts of Morus Alba extract, 5-30 weight parts of Cnidii Rhizoma, 10-60 weight parts of ginseng extract, 5-30 weight parts of polygonum multiflorum thumb, 10-60 weight parts of Sophora flavescenes extract, 15-80 weight parts of Glycyrrhiza extract, and 5-30 weight parts of Acorus calamus var. The extract of Morus Alba, ginseng, polygonum multiflorum thumb, Glycyrrhiza, and Acorus calamus var. is solvent extract using methanol, ethanol or n-butanol or hot water extract. The extract of Cnidii Rhizoma and Sophora flavescenes is hydrocarbon solvent extract of methylacetate, ethylacetate, benzene, n-hexane, diethylether or dichloromethane.

Description

Oriental herbal composition for reinforcement of hair-roots and cleanness of scalp and its preparation method

The present invention can be applied to the cosmetic or pharmaceutical field as a composition for improving the condition of hair and scalp. In particular, the present invention is a composition prepared by extracting natural herbal herbal materials.

In general, the causes of baldness and hair loss include the action of male hormones in organs such as hair roots and sebaceous glands, a decrease in blood flow to follicles, excess sebum secretion, peroxide production, scalp abnormalities caused by bacterial growth, genetic factors, and aging. It is discussed. However, no clear cause for hair loss has yet been identified, and in recent years, more and more people are suffering from alopecia, and their age is decreasing.

As for the treatment of alopecia, there is no clear effect yet, and based on the conventional experience, a compound having a function of applying physical stimulation to the head with a brush or removing or alleviating the above causes has been used.

There are more than 1.3 million hairs and 100,000 hairs in the human body. These hairs go through three stages of growth, anagen, catagen, and telogen. Hair loss, which means less or no hair than normal due to hair or hair for some reason, can be distinguished from general hair loss (telogen effluvium) in which hair falls out of a resting state and anagen effluvium, which is abnormal hair loss. In general, the term alopecia refers to the latter.

Conventionally, in the treatment of such alopecia, there are preparations based on female hormones in relation to hormonal theory, but there are reports of not only effects but also skin inflammation and side effects caused by hormone administration.

In addition, recently, a hair regrowth agent has a formulation containing minoxidil, trichosaccharide, etc. of Crinos, Co., Ltd. of the United States, but there are no obvious effects and human stability. Side effects are on the rise.

In other words, the conventionally used hair regrowth is a chemical using a temporary blood flow to expand the capillaries to stimulate the hair roots because it is not only temporary but also limited to the effects of hair loss caused by excessive secretion of sebum have.

In addition, the method of activating the hair follicles by immunity enhancing action to regenerate the hair follicles by supplying sugars to the nutrient source, and the method of regulating the mechanism of antioxidants, is not the regeneration of the fundamental form of hair, but by cell division and stimulation. As it generates hair, there is a short lifespan.

On the other hand, dandruff refers to an abnormal scalp condition characterized by excessive exfoliation of the scalp without accompanying inflammation. The features of dandruff include small, dry white dandruff pieces and less irritating itch. In addition, due to the deepening of dandruff phenomena, due to poor blood circulation of the scalp may not develop sufficient nutrition to the hair roots may develop as a cause of non-rigid hair loss.

As a cause of dandruff, the dandruff bacteria Pityrosporum ovale has been pointed out, and most of the dandruff treatment agents have used zinc pyrithione or pyroxtonolamine to inhibit the phytirosporum obale. However, in order to obtain the desired effect by using these known antidandruff agents, it is necessary to use them excessively, in this case there is a limit to their use because it is harmful to the human body.

Therefore, many studies have been conducted to solve the above problems, hair regrowth and dandruff treatments have been proposed to prevent and treat hair loss, but it has not been adequate to solve the above problems.

The present invention is to solve the above problems, while strengthening the hair root to prevent hair loss, while effective for hair regrowth, natural herbal hair root strengthening and scalp cleaning composition that has an excellent effect in providing moisturizing and moisture to the hair as well as inhibiting dandruff. And to provide a method for producing the same.

Natural herbal hair root strengthening and scalp cleaning composition of the present invention is based on 100 parts by weight of the extract of baekryeok extract 5 ~ 30 parts by weight, ginseng extract 10 ~ 60 parts by weight, sewage extract 5 ~ 30 parts by weight, gosam extract 10 ~ 60 weight Part, licorice extract 15 to 80 parts by weight and 5 to 30 parts by weight of iris extract, the lettuce extract, ginseng extract, sewage extract, licorice extract and iris extract is at least one solvent selected from methanol, ethanol and n-butanol Extract or hot water extract, wherein the cheongung extract and ginseng extract is characterized in that the extract of at least one hydrocarbon solvent selected from methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane.

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In addition, the method for producing a composition for strengthening the natural herbal hair root and scalp clean of the present invention is the temperature of 5 ~ 20 ℃ as one or more lower alcohol solvents selected from methanol, ethanol and n-butanol of lettuce, ginseng, sewage, licorice and irises Extraction for 2 to 10 days or extracting hot water at 80 to 130 ° C. for 8 to 15 hours; Extracting cheonggung and ginseng with at least one hydrocarbon solvent selected from methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether and dichloromethane; And mixing the extracts.

According to the natural herbal hair root strengthening and scalp cleaning composition of the present invention not only prevents hair loss, but also has a very good hair regrowth effect, and has no natural toxicity or side effects to the human body as a natural herbal herbal ingredient.

In addition, the natural herbal hair root strengthening and scalp cleaning composition of the present invention has an excellent effect in providing moisturizing and shine to the hair as well as inhibiting dandruff.

In the present invention, the herbal medicine means to use as a component having a beneficial effect on the human body by processing such as natural or naturally produced natural products as it is, or cut, heated, extracted or powdered.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only intended to illustrate the invention, so the scope of the invention is not limited by these examples.

Natural herbal hair root strengthening and scalp cleaning composition of the present invention preferably contains baekbaekpi, cheongung, ginseng, sewage, ginseng, licorice and irises as herbal ingredients.

Each herbal ingredient has the following characteristics.

Morus bark is a dried bark of the mulberry (Morus Alba) and the same genus plants. Betulinic acid, dihydromorin, dihydrokaempferol, A-Amyrin ), Adenine, betaine, and pectin as main ingredients, and have been widely used in herbal medicine as antitussives, anti-inflammatory agents, and diuretics since ancient times. Efficacy has been reported to include analgesic, diuretic, antitussive, anti-edema, sedative, anticonvulsant and blood pressure lowering effects. It is a traditional Korean folk remedy that is included in the herbal medicine group and has been used for diseases related to dandruff, itching and hair loss. There is a bar.

Cnidii Rhizoma is an important warming tonic in oriental medicine. It contains 1 ~ 2% of essential oils in the rhizome, as well as kinidilide, liger tilide, neokinidlide, butyl peralide, sedonic acid, and secunolide. It can contain, communicate with the body, release the ulcers, remove the customs, promote blood circulation, have analgesic effects, and when the cold causes headaches and dizziness, flanks and abdominal pain, muscle stiffness or cramping Is known to be effective in the treatment of symptoms.

Ginseng contains saponin as its main ingredient, and it has numerous functions such as blood circulation improvement, hematopoietic action, heart strengthening, anti-aging, normalization of blood pressure, normalization of liver function, gastrointestinal disease, diabetes prevention and treatment, anti-cancer, anti-stress and anti-allergy. In addition, when applied to hair, it activates hair cells and improves blood circulation of the scalp, which helps to prevent hair loss by increasing the blood flow of the skin, and contains ingredients such as vitamins and amino acids to nourish damaged hair and make hair healthy.

Sewage is a tuber of polygonum multiflorum thunb, belongs to the perennial herbaceous polygonaceae, also called sewage, white squirrel, silver gourd, or creeper vine. do. Sewage is effective for tonic and anemia, blackening hair, nourishing tonic such as arteriosclerosis and fatigue recovery.

The herb is an herb that contains anthraquinones and mainly contains chrysophanol and emodin monomethylether, rhein, physcione, chrysophanic acid and anthrone. These ingredients strengthen the brain, stabilize the mind, lower blood pressure, and improve the body's immune function. It has the effect of lowering and lowering cholesterol in the blood. Since ancient times, Sewao is a herb that strengthens kidney function, darkens hair, and long life without disease. It is known for its good multiplication by hand with ginseng and wolfberry. It is known that it is effective in treating nerve breakdowns and insomnia and strengthens the bones and muscles, and strengthens the heart, and is effective in treating anemia due to its hematopoietic effect. According to the North Korean synonym, there is a tonic, hematopoietic function, fatigue recovery, and soothing effect, which prevents the hair from whitening early and makes the hair black.

Ginseng is used for taste but it has the same effect as ginseng. It is called ginseng. The total alkaloid content of the ginseng root is about 1.1%, it contains about 13% of sugar, and contains isoanhydric karitin, a flavonol compound. In oriental medicine, dried root is called ginseng, and it is tasteless and has the effect of ginseng. It has excellent anti-allergic and antimicrobial activity, so in the private sector, it can be used as an insecticide by attaching stems or leaves. It helps to prevent skin aging with female hormone activating effect and inhibits the growth of dandruff bacteria along with antibacterial action against various bacteria.

Licorice has a detoxifying action, anti-inflammatory and anti-allergic action, gastric acid secretion inhibitory action, and weak coordination action, and has been used for a long time as a herbal medicine.

Iris is a perennial plant with Chunnam Province. In civilian, there was a custom of bathing with irises and washing hair with boiled water. The main component of the iris is methyl eugenol, and other ingredients such as asarone, calamendiol, acorenone, asarylaldehyde, calameone and calamene. In oriental medicine, it is effective for dry stomach, menstruation, expectoration, etc. It is used as a medicine, and roots are used for indigestion, diarrhea and bronchitis. Root stems are also used as aromatic nutrients. Since irises have been known to have good effects on the hair and follicles since ancient times, if you wash your hair for a long time or apply it to your scalp, it will have a massage effect and make your hair roots better.

Natural herbal hair root strengthening and scalp cleaning composition of the present invention is based on 100 parts by weight of the extract of baekryepi (all extracts based on solids) 5 ~ 30 parts by weight, ginseng extract 10 ~ 60 parts by weight, sewage extract 5 ~ 30 weight Part, 10 to 60 parts by weight of ginseng extract, licorice extract 15 to 80 parts by weight and 5 to 30 parts by weight of iris extract, more preferably 10 to 20 parts by weight of the cheongung extract, based on 100 parts by weight of lettuce extract, 20 to 40 parts by weight of ginseng extract, 10 to 20 parts by weight of sewage extract, 20 to 40 parts by weight of ginseng extract, 30 to 60 parts by weight of licorice extract and 10 to 20 parts by weight of iris extract.

Herbal ingredients in the natural herbal hair root strengthening and scalp cleaning composition of the present invention can be prepared by extracting hot water, for example 8 to 15 hours at 80 ~ 130 ℃.

Among the herbal medicines of the present invention, the extracts of lettuce extract, ginseng extract, licorice extract and iris extract can be prepared even with one or more lower alcohol solvents selected from methanol, ethanol and n-butanol. When the herbal medicine material is extracted with a lower alcohol solvent, low temperature extraction is preferable, and particularly preferably, extraction is performed at a temperature of 5 to 20 ° C. for 2 to 10 days.

Among the herbal medicines of the present invention, the extracts of cheongung and ginseng can be extracted with hot water, but more preferably extracted with one or more hydrocarbon solvents selected from methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether and dichloromethane. Do.

In addition, the natural herbal hair root strengthening and scalp cleaning composition of the present invention is also possible to prepare an extract from a mixed herbal medicine mixed with lettuce, cheon gung, ginseng, sewage, ginseng, licorice and irises, but preferably each active ingredient material Since the extraction conditions of the different may be different from the preparation of the extract from each of the herbal medicine material, or for efficient production, it is preferable to extract from the mixed herbal medicines tied to the herbal medicine materials with similar extraction conditions of the active ingredient. In particular, in the present invention, it is preferable to extract the mixed herbal medicines mixed with lettuce, ginseng, licorice and irises, and to extract the mixed herbal medicines mixed with Cheongung and Ginseng.

For example, the natural herbal hair root strengthening and scalp cleaning composition of the present invention is one or more lower alcohol solvents selected from methanol, ethanol and n-butanol, respectively, at a temperature of 5 ~ 20 ℃ Extracted for 2 to 10 days or hydrothermal extraction for 8 to 15 hours at 80 to 130 ° C, mixed mixed herbs of lettuce, ginseng, licorice and irises with one or more lower alcohol solvents selected from methanol, ethanol and n-butanol Extraction may be performed for 2 to 10 days at a temperature of 5 to 20 ° C. or hydrothermal extraction for 8 to 15 hours at 80 to 130 ° C. In addition, each of the cheonggung and ginseng may be extracted with one or more hydrocarbon solvents selected from methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane, and the mixed herbal medicines of cheonggung and ginseng may be extracted with methyl acetate, ethyl acetate, It may also be extracted with one or more hydrocarbon solvents selected from benzene, n-hexane, diethyl ether and dichloromethane.

The lower alcohol extracts or hot water extracts of baekbaekpi, ginseng, licorice and irises and the hydrocarbon extracts of cheongung and gosam are powders dried through conventional methods such as vacuum drying, freeze drying and spray drying before or after mixing. It can be prepared as, in the present invention, the properties of the extract does not separate the liquid or solid phase (including powder phase) separately. Mixing the extract of the liquid or solid phase to prepare a natural herbal hair root strengthening and scalp cleaning composition of the present invention.

The composition of the present invention may have a formulation of a conventional hair cosmetic, and may be formulated, for example, with shampoo, rinse, hair conditioner, hair tonic, hair treatment, hair dye, and the like. The composition of each of these formulations may contain a variety of bases and additives necessary for the formulation of the formulation and are suitable, and the types and amounts of these components can be readily selected by those skilled in the art.

Preparation Example 1

After cutting each of baekbaekpi, Cheongung, Ginseng, Sewao, Ginseng, Licorice, and iris as herbal medicine materials, each herbal medicine material was extracted under reflux for 12 hours with 90 ℃ hot water 5 times the weight of herbal medicine, and the residue was removed by 0.3 ㎛ filter paper. After preparing a liquid extract, and dried under reduced pressure to prepare a powdery extract.

The powdery extracts prepared above were mixed in the weight ratio of Table 1 below.

division Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 White skin 15 40 40 40 40 50 Cheongung 15 15 15 - 15 5 Ginseng 15 15 - - 15 10 Shouao 15 15 15 15 - 5 Gosam 15 15 15 15 - 10 licorice 15 - 15 15 15 15 calamus 10 - - 15 15 5

Experimental Example 1

30 males of 30 to 50 years of age with relatively high dandruff and hair loss were selected, and the composition shown in Table 1 was diluted 10% by weight in purified water, and then packaged in a portion of 10g once a day with normal shampoo 2 After using it for months, the sensory test was performed according to the measurement items, and the anti-hair loss, wool, anti-dandruff, hair shine and hair moisturizing effects were evaluated according to the 5-point grading method for male subjects with relatively high dandruff loss. The results are shown in Table 2.

division Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Reference Example 1 Hair loss prevention 1.9 2.2 2.3 2.8 2.2 4.5 wool 2.2 2.4 2.4 2.5 2.1 4.3 Anti dandruff 2.5 1.4 1.8 3.5 3.2 4.8 Hair shine 2.5 3.2 2.1 3.1 2.8 4.2 Hair hydration 2.2 2.5 2.2 2.8 2.8 4.5

1: not improved at all, 2: just yes, 3: slightly improved, 4: somewhat improved,

5: Very improved.

Preparation Example 2

After cutting each raw white skin, Cheonggung, ginseng, sewage, ginseng, licorice, and iris as a herbal medicine material, each herbal medicine material is extracted with 5 ℃ ethanol three times the weight of herbal medicine, and the residue is removed with 0.3 ㎛ filter paper. After preparing a liquid extract, and dried under reduced pressure to prepare a powdery extract ('alcohol' of Table 3).

In addition, the raw material of each herbal was stirred for 12 hours at room temperature with a 3: 1 weight ratio mixed solvent of three times the weight of the crude drug diethyl ether and n-hexane, and the residue was removed by 0.3 μm filter paper to prepare a liquid extract, Drying to prepare a powdery extract ('hydrocarbon' in Table 3).

The herbal extracts extracted under the different conditions were mixed in the same weight ratio as in Example 1 to prepare the composition of Table 3 below.

division Reference Example 1 Reference Example 2 Reference Example 3 Reference Example 4 Reference Example 5 Reference Example 6 Reference Example 7 Reference Example 8 Reference Example 9 Example 10 White skin Hydrothermal Alcohol hydrocarbon Alcohol Alcohol Alcohol Alcohol Alcohol Alcohol Alcohol Cheongung Hydrothermal Alcohol Alcohol hydrocarbon Alcohol Alcohol Alcohol Alcohol Alcohol hydrocarbon Ginseng Hydrothermal Alcohol Alcohol Alcohol hydrocarbon Alcohol Alcohol Alcohol Alcohol Alcohol Shouao Hydrothermal Alcohol Alcohol Alcohol Alcohol hydrocarbon Alcohol Alcohol Alcohol Alcohol Gosam Hydrothermal Alcohol Alcohol Alcohol Alcohol Alcohol hydrocarbon Alcohol Alcohol hydrocarbon licorice Hydrothermal Alcohol Alcohol Alcohol Alcohol Alcohol Alcohol hydrocarbon Alcohol Alcohol calamus Hydrothermal Alcohol Alcohol Alcohol Alcohol Alcohol Alcohol Alcohol hydrocarbon Alcohol

Experimental Example 2

30 to 50-year-old males with a relatively large amount of dandruff and hair loss were selected, and the composition shown in Table 3 was diluted 10% by weight in purified water, and then packaged in a portion of 10g once a day with normal shampoo 2 After using it for months, the sensory test was performed according to the measurement items, and the anti-hair loss, wool, anti-dandruff, hair shine and hair moisturizing effects were evaluated according to the 5-point grading method for male subjects with relatively high dandruff loss. The results are shown in Table 4.

division Reference Example 1 Reference Example 2 Reference Example 3 Reference Example 4 Reference Example 5 Reference Example 6 Reference Example 7 Reference Example 8 Reference Example 9 Example 10 Hair loss prevention 4.5 4.5 4.1 4.3 4.2 3.8 4.3 4.2 3.6 4.8 wool 4.3 4.2 3.5 4.3 4.2 3.6 4.2 4.3 3.7 4.9 Anti dandruff 4.8 4.9 4.7 4.4 4.5 3.9 4.5 4.1 3.7 4.8 Hair shine 4.2 4.3 4.2 4.5 3.9 4.2 4.6 4.0 4.2 4.5 Hair hydration 4.5 4.5 4.5 4.6 4.2 4.1 4.5 4.0 4.1 4.8

1: not improved at all, 2: just yes, 3: slightly improved, 4: somewhat improved, 5: very improved.

Experimental Example 3

One month after the use of the composition of the present invention by metabolizing the people included in the experimental group of Examples 2, 6 and 10 who participated in the experiment for 2 months in Experimental Example 2, the same sensory test as in Experimental Example 2 Is shown in Table 5.

division Reference Example 2 Reference Example 6 Example 10 Hair loss prevention 3.1 2.5 4.5 wool 2.8 2.2 4.7 Anti dandruff 3.2 3.4 4.6 Hair shine 3.0 3.1 4.5 Hair hydration 2.7 2.7 4.5

1: not improved at all, 2: just yes, 3: slightly improved, 4: somewhat improved,

5: Very improved.

Claims (5)

5 to 30 parts by weight of cheonggung extract, 10 to 60 parts by weight of ginseng extract, 5 to 30 parts by weight of sewage extract, 10 to 60 parts by weight of red ginseng extract, 15 to 80 parts by weight of licorice extract and iris extract 5 Contains 30 parts by weight, The lettuce extract, ginseng extract, sewage extract, licorice extract and iris extract are one or more solvent extracts or hydrothermal extracts selected from methanol, ethanol and n-butanol, and the cheongung extract and red ginseng extract are methyl acetate, ethyl acetate, benzene , n-hexane, diethyl ether, dichloromethane natural herbal hair root strengthening and scalp cleaning composition, characterized in that the extract of at least one hydrocarbon solvent selected from. delete delete delete Extract baekbaekpi, ginseng, sewage, licorice and irises with at least one lower alcohol solvent selected from methanol, ethanol and n-butanol for 2 to 10 days at a temperature of 5 to 20 ° C or for 8 to 15 hours at 80 to 130 ° C. Hydrothermal extraction; Extracting cheonggung and ginseng with at least one hydrocarbon solvent selected from methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether and dichloromethane; And The extracts based on 100 parts by weight of lettuce extract 5 ~ 30 parts by weight Cheongung extract, ginseng extract 10 ~ 60 parts by weight, sewage extract 5 ~ 30 parts by weight, red ginseng extract 10 ~ 60 parts by weight, licorice extract 15 ~ 80 parts by weight and Mixing 5-30 parts by weight of iris extract; natural herbal hair root strengthening and scalp cleaning composition manufacturing method comprising a.