KR100668878B1 - Hair growth promoting composition, topical dermatologic drugs for promoting hair growth and the method of the hair growth promoting composition, topical dermatologic drugs for promoting hair growth - Google Patents

Abstract

A hair growth-promoting composition, skin external composition for promoting hair growth and a method for producing the hair growth-promoting composition are provided to supply sufficient nutrients to the scalp, promote hair root cells by stimulating the scalp, remove demodex from the scalp, and avoid side effects by hormone. The hair growth-promoting composition comprises the ethanol extracts of Sophora flavescens Aiton, red pepper and Swertia pseudo-chinensis (Bunge) Hara, and the distillation extracts of Acorus gramineus SOLAND., Artemisia argyi LEV., Mori radicis cortex, Morus alba L. leaf, Thuja orientalis Linn, Panax ginseng C.A Meyer, Glycyrrhiza uralensis FISCH., pine leaf, Paeoniae Radix, Rehmanniae radix, Foeniculi Fructus, Cornus officinalis SIEB, Coiz lacryma-jobi Linne var. ma-yuen stapf, Zingiber officinale rhizome, garlic, black bean, Sesamum indicum L., spinach, carrot, tangleweed, brown seaweed and Mentha arvensis L. The skin external composition for promoting hair growth contains 0.1-35 wt.% of the hair growth-promoting composition.

Description

Hair growth promoting composition, topical dermatologic drugs for promoting hair growth and the method of the hair growth promoting composition, topical dermatologic drugs for promoting hair growth }

Figure 1a is a photograph showing the hair condition of female hair loss patients before using the composition for external application for skin regrowth of the present invention.

Figure 1b is a photograph showing the hair condition of female hair loss patients after about 2 months after using the composition for external application for skin regrowth of the present invention.

Figure 1c is a photograph showing the hair condition of female hair loss patients after approximately three months after using the composition for external application for skin regrowth of the present invention.

Figure 2a is a photograph showing the hair condition of the male hair loss patient before using the composition for external application for skin regrowth of the present invention.

Figure 2b is a photograph showing the hair condition of male hair loss patients after about 3 months after using the composition for external application for hair growth for hair growth of the present invention.

The present invention relates to a hair regrowth composition, a hair external preparation composition for hair growth and a method for producing the same. In detail, the present invention supports a large amount of nutrition to the scalp through the smooth metabolism of the body to stimulate the local blood circulation by stimulating the local blood circulation as well as promoting hair follicle cell activity, preventing hair loss by sterilizing hair follicles and hair growth. It relates to a hair regrowth composition and a hair external preparation composition for promoting hair growth.

Hair loss known to date includes excessive sebum production caused by circulatory problems such as endocrine system disorders, autonomic nervous system disorders, and blood circulation disorders, physical factors such as malnutrition of hair roots, allergies and bacterial infections, genetic factors such as the effects of male hormones, and various pollution. , Foods with mainstream foods, environmental factors such as shampoo, soap, mousse, hair gel, hair spray, perm, dyeing, and hair dryer, mental and social factors of modern people who are frequently stressed, and aging It is estimated and revealed to appear. In addition, recently, most hair loss patients have Demodex, and the higher the degree of hair loss, the higher the frequency of incubation. As a result, it has been found that the Demodex worm acts as a cause of hair loss. Demodex is a parasitic mite belonging to spiders and aphids, which live on the sebaceous glands and hair follicles of human eyelids, around the nose, the ear canal, and the head.

Among the conventional hair growth promoting drugs for treating such alopecia, products approved by the US Food and Drug Administration (FDA) as a hair loss treatment to date are oral propescia (component name: Pinasteride) 'from Merck, USA. There are two types of external drug 'minoxidil' from Upjohn, USA.

However, the hair growth promoting agent is prone to side effects such as hormones, and the active ingredient has a problem in its stability in the human body as a synthetic compound, and it has not sufficient effect on hair growth and hair growth.

Therefore, in order to solve the above problems, a composition for promoting hair growth based on oriental medicine in oriental circles has been studied, and as such a composition for promoting hair growth, extracts of mulberry leaves, white leaf, black sesame, kelp and seaweed of Korean Patent No. 10-0476731 There is a hair regrowth for topical coatings prepared by mixing the mixture, there is a hair regrowth composition containing a natural situation mushroom extract of Korean Patent No. 10-0348155, and a method of manufacturing the same, Baekdusan having a hair follicle sterilization function of Korean Patent No. 10-0487275 There is a hair regrowth composition consisting of extract of Daesan, Golden.

However, the above-mentioned conventional technology can be expected to have a slight thickening of hair or healthy hair roots due to nourishment when it is used for a long time, and the effect of sprouting fine hair such as fluffy hair can be expected to effectively prevent hair loss and to promote breakthrough hair growth. Was not. In addition, such a hair loss prevention and hair growth promoting effect is temporary, the use of the material for a long time because the hair will immediately fall out and hair growth stops when the use of the material is stopped. In addition, in the case of the registered patent having the function of the Demodex worms can be expected to a certain extent, the insecticidal effect of the Demodex insects, but there is a problem that hair loss prevention and hair growth promoting function is weak.

In this background, the inventors of the present invention studied herbal materials having not only hair follicle bactericidal function but also effective hair loss prevention and hair growth promoting function, and were able to find the most effective herbal material extracts and the mixing ratio thereof, thereby completing the present invention. It became.

An object of the present invention is to provide a hair regrowth composition and an external composition for hair regrowth for removing hair follicles parasitic on the scalp hair follicles to suppress the acceleration of hair loss in order to solve the above problems.

In addition, an object of the present invention is to provide a hair growth agent composition and an external composition for hair growth for not only supplying sufficient nutrition to the scalp but also promoting the activity of hair follicle cells.

In addition, an object of the present invention is to provide a herbal composition and a hair external composition for hair regrowth, which is harmless to the human body and does not have side effects caused by hormones, etc. using the herbal extract as a main ingredient.

In addition, an object of the present invention is to provide an external composition for skin regrowth that can be easily applied to the scalp and easy to use.

The hair regrowth composition and the external composition for hair regrowth according to the present invention for achieving the above object are ethanol extract, red ginseng extract, red pepper extract, sugar extract, distillation extract, spear extract, leaf extract, lettuce extract, lettuce leaf extract, white leaf extract. , Ginseng Extract, Licorice Extract, Pine Leaf Extract, Peony Extract, Foxglove Extract, Fennel Extract, Cornus Extract, Euphoria Extract, Ginger Extract, Garlic Extract, Black Bean Extract, Black Sesame Extract, Spinach Extract, Carrot Extract, Kelp Extract, Seaweed Extract, Seaweed Extract It comprises an extract, and the ethanol extract and distillation extract are mixed in a constant weight ratio, respectively, to sterilize hair follicles and promote hair root cell activity to prevent hair loss and to promote hair growth.

The present invention is to prevent hair loss by removing hair follicles that cause hair loss by absorbing nutrients of the hair root and paralyzing the sebaceous glands and hair follicles of the hair loss patient's head.

In addition, the present invention not only promotes hair growth by activating the hair root cells, but also maintains the hair growth promoting effect by supplying sufficient nutrition to the hair root and hair.

Hereinafter will be described a material constituting the hair regrowth composition and the external composition for skin regrowth of the present invention.

First, the ethanol extract is an extract solution extracted by immersion using ethanol as the extraction solvent, ethanol is a common ethanol. Ethanol extract of the present invention is a high ginseng extract, pepper extract, sugar extract.

In addition, the distillation extract is an extract solution extracted by distillation using purified water as an extraction solvent, the distillation extract of the present invention, such as stone extract, leaf extract, lettuce extract, lettuce leaf extract, side leaf extract, ginseng extract, licorice extract, pine leaf extract, There are peony extract, turmeric extract, fennel extract, cornus extract, oyster extract, ginger extract, garlic extract, black bean extract, black sesame extract, spinach extract, carrot extract, kelp extract, seaweed extract, and peppermint extract.

Next, look at the general characteristics, pharmacological effects and the like for the herbal medicine used in the present invention.

The ginseng is a dicotyledonous plant of the Rosaceae legume, and its main ingredient is alkaloids, which include matrin, oxymatrine, sophoranol, anagirin, methylcytizin, and the like. It is used for antipyretic and analgesic drugs. In particular, hair loss-related effects have an insecticidal function, which has the effect of preventing hair loss by sterilizing Demodex insects.

The pepper is a perennial herb of the dicotyledon plant moss-plant apaceae, the main ingredient is capsaicin, the main effect is to promote blood circulation, improve blood circulation and stimulate the scalp to activate hair follicle cells to promote hair growth. Use red pepper fruit.

The medicinal herb is a biennial plant with a gentian of dicotyledonous plant gentian. It is also known as bitter grass, bitter grass, edamcho, jangchae and suhwangyeon. Its main ingredient contains crystalline glycosides such as swertiamarin, swediside, and genthiopicroside, and it is used as a gastric agent, anti-diabetic agent, anti-inflammatory and bitter agent in oriental medicine. In particular, it improves the blood circulation and relaxes the scalp, relaxes the scalp, prevents whitening, etc. The present invention uses the root of the drug.

The Seokchangpo is a perennial herb of the monocotyledonous plant Cheonnamseong Mok Cheonnamseong, and its active ingredient is various essential oils such as 0.5-0.8% of calmenol, asaron, palmitine, sekishon, saprol, etc. contained in the root stem. This essential oil contains about 0.25% of the leaves, in addition to the phenolic palmitic acid and various trace elements. In oriental medicine, it is used for pain relief, sedation, and sedative. It has sedative effect. In particular, there is a washing, moisturizing, nutritional effect is useful as a component of the hair regrowth composition and in the present invention uses a changchang root.

The leaves are about 30 kinds of perennial grass belonging to the Asteraceae and are used in various ways for food and medicinal use. Commonly used soft and young mugwort is called aqua or sesame and dried and used as a medicine or moxibustion is generally called a wormwood. Mugwort has the functions of hematopoiesis, sterilization, microvascular expansion, metabolism promotion, anti-allergic action, detoxification function and effective in promoting hair follicle sterilization and hair root cell activity, and used leaves and stems in the present invention.

The baekbaekpi is a mulberry root bark mulberry is a deciduous tree or shrub belonging to the genus Pinus mulberry nettle mulberry and mulberry genus. In oriental medicine, it is used for antipyretic, antitussive, diuretic, small-species and promotes hair growth and prevents hair loss.

The upper leaf is a mulberry leaf is rich in capillary-enhancing substance Rutin, blood sugar-enhancing substance DNJ component, blood pressure-enhancing substance GABA component. In addition, it eliminates arteriosclerosis, blood clots, cleanses the blood and allows it to flow well.

The cypress lobe is a cypress leaf, the cypress is an evergreen arboretum of the creeper plant conifer subfamily conifer tree. The white leaf has a lot of essential oils and releases blood, especially hemostatic effect is used as a hemostatic drug in oriental medicine.

The ginseng is a perennial herb of the dicotyledonous plant hawthorn arboraceae, and consists of glycosides, panacen, polyacetylene-based compounds, nitrogen-containing components, flavonoids, and the like. In ginseng, ginseng is used for medicines such as tonic, deep seaweed and dry stomach because it has a restorative effect. Especially, ginseng is a powerful nutritional effect, supplying sufficient nutrition to the scalp, moisturizing, protecting damaged hair, strengthening hair strength, treating white hair, preventing hair loss. It is effective on the back. In the present invention, ginseng root was used.

The licorice is a perennial herb of the dicotyledonous plant Rosaceae, the main components are glycyrrhizin, glabraic acid, flavonoids, chaponaretin and the like. Licorice has functions such as anti-inflammatory, tissue repair, sebum control, detoxification, and weakening (neutralizer), and especially keeps the scalp healthy. Licorice root was used in the present invention.

The pine needles are pine needles used for medicinal purpose is the winter pine needles of the Korean peninsula native pine, called Chosun sol or Chamsol. Pine needles contain various nutrients such as vitamins A, C, K, chlorophyll, calcium, and iron. It is also an excellent protein source that contains all eight essential amino acids that cannot be synthesized in the body. In particular, it has a hair regrowth effect and also prevents white hair.

The peony is a perennial herb of the dicotyledonous plant of the genus Buttercup of the genus Buttercup, called the root of the peony peony, and has the efficacy of ganganjitong, yangjeungeum, pacific accent. In particular, there is a function to activate the hair follicle cells, open the pores.

The jihwang is a perennial herb of the dicotyledon plant currency plant Hyunsam and use the fresh root of the jihwang itself as raw jihwang, dried jigunji, and put it in the liquor and steamed several times is called sujijihwang. In oriental medicine, it is a medicine that is formulated without falling into prescription of tonic.

The fennel is a perennial herb of the dicotyledon plant hawthorn apiaceae, the fruit is called fennel and is used as a dry medicine and a quarantine in Chinese medicine. The essence of fennel has a calming effect, so the central nerve is slightly excited at first, then gradually calms down.

The cornus is the fruit of the dogwood and cornus (山茱萸) is used as a medicine for headache, tinnitus, seawater disease, fever, excessive menstruation in oriental medicine. In particular, it provides smooth nutrition to the scalp and strengthens the hair roots.

The uiyiin is also removed from the bark of Yulmu fruit is called yiginyiin. Ingredients are 18% protein, 7% fat, 50% starch, 2% ash, etc., and are used as anti-inflammatory, drainage, diuretic and analgesics in Chinese medicine. It is also used to remove edema and warts and as a tonic for pulmonary tuberculosis patients and pleurisy patients. It is especially effective for maintaining scalp and hair health.

The ginger is a perennial herb of the monocotyledonous plant, Ginger-necked Ginger, which is used as a medicinal herb to dry the rhizome, which is effective for indigestion, vomiting and diarrhea, promotes blood circulation, and has anti-inflammatory and analgesic effects.

The garlic is a perennial herb of the monocotyledonous genus Liliaceae, which is generally known to have Gangjeong, tonic, blood circulation improvement, hypertension, arteriosclerosis, detoxification, and bactericidal action. In particular, garlic roots are effective in maintaining healthy hair condition and are effective for removing hairworms due to their strong bactericidal action.

The black bean is a perennial perennial plant of the legume as black beans (rat eye). In general, it is known to promote blood circulation, detoxification, and lipolysis. Isoflavin among the components of the black bean to regulate the male hormone to suppress the cause of hair loss, in particular, it is effective for alopecia areata.

The black sesame refers to black sesame, the protein of black sesame is the raw material of keratin, the main component of the hair, in particular, has a hair loss prevention effect.

The spinach is a perennial or biennial herb of the dicotyledonous plant, which is rich in vitamin A, calcium, iron, beta-carotene, lutein, phenol, vitamin C · E, and dietary fiber. In oriental medicine, spinach is used to make blood flow through and clogged chest. In particular, spinach supplies abundant nutrition to the scalp has the effect of promoting hair growth.

The carrot is a biennial herb of the dicotyledonous plant Asteraceae in oriental medicine, the root of the carrot is used as a medicine called Hakseulung, dysentery, pertussis, seawater, abdominal distension and is also used as an insect repellent. In particular, carrot root is effective in preventing scalp drying and sterilizing Demodex.

The kelp is a genus of seaweed kelp, kelp, and is rich in carbohydrates such as carotene, xanthophylls, chlorophyll, and carbohydrates such as manit and laminarin, and alginic acid, iodine, vitamin B2, and amino acids. It lowers cholesterol levels and blood pressure, and is effective against goiter and nephritis. Especially, it has excellent bactericidal and insecticidal effects.

The seaweed has a coercive action, anticancer action, anticoagulant action, detoxification action to lower the blood pressure without the side effects of the year-end seaweed with brown seaweed seaweed. In particular, the iodine component stimulates the thyroid hormone secretion needed for hair to grow and strengthens the hair with abundant nutrition.

The peppermint is a perennial root of perennial plant with moss-flowered dicotyledonous plant. The content of essential oil is 2 ~ 3% in leaves, 4 ~ 6% in flower ears, 0.3% in stems, and 70 ~ 90% of essential oil is menthol. It has the effect of jingyeong, analgesic, antiseptic, especially the insect repellent effect. Not only is it effective for sterilizing Demodex insects, but it also smells good, improving the feeling of use.

On the other hand, look at the method for producing the hair regrowth composition and the composition for external application for skin regrowth as follows.

First, ethanol is added to each of red ginseng, red pepper, and sugar as a solvent to extract the ethanol in a weight ratio of 1: 6, and soaked at room temperature for 7 days to obtain an ethanol extract. Next, Seokchangpo, leafy leaf, lettuce leaf, lettuce leaf, white leaf leaf, ginseng, licorice, pine needles, peony, phoenix, fennel, cornus, Uiin, ginger (health), garlic, black bean, black sesame, spinach, carrot, kelp, seaweed, mint To the purified water was added a weight ratio of 1: 9 to distillation to obtain a distillation extract. Next, by mixing the ethanol extract and distillation extract in a constant ratio to prepare a hair restorer composition. In addition, one or more selected from nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki thiol, menthol, and fragrance may be added to the hair repellent composition at a concentration of 0.1 to 10% by weight. On the other hand, it is also possible to prepare the hair external composition for hair growth by adding the hair repellent composition in a concentration of 0.1 to 35% by weight to shampoo, rinse, hair tonic, hair lotion, hair cream and the like.

Preferably, the mixing ratio of the ethanol extract and the distillation extract is the same weight ratio.

The nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki chiol, licorice extract, menthol, fragrance is a component generally included in hair loss prevention and wool-related quasi-drugs to increase the hair loss prevention and hair growth promoting effect.

The nicotinic acid amide is one of the vitamin B complexes corresponding to pyridine-3-carboxyamide with the formula C ₆ H ₆ N ₂ O, which is a human antipellagrain. It nourishes hair and activates hair follicle cells.

The salicylic acid is a colorless solid which is one of aromatic oxycarboxylic acids of the formula C ₇ H ₆ O ₃ . Remove dead skin cells and dandruff, improve blood circulation, disinfect and sterilize.

The tocopherol acetate is a derivative of vitamin E (tocopherol) has an antioxidant action, anti-inflammatory effect, promote blood circulation, prevent cell aging, smooth skin moisture absorption, and is used as an emollient, skin protectant.

The panthenol has the effect of moisturizing and maintaining the skin with provitamin B5.

The nicotinic acid benzyl (nicotinic acid benzyl) is one of the vitamin B complex serves to promote the blood circulation of the scalp.

The hinoki thiol is a natural extract extracted from cypress, and research on the efficacy of hinoki thiol has been conducted. To date, it is known to have very good bactericidal and anti-inflammatory effects and is effective for stimulating hair follicle cells and promoting hair growth.

The menthol is an alcohol belonging to a monocyclic monoterpene with the formula C ₁₀ H ₂₀ O. Blood circulation, scalp irritation, scalp itching action.

The incense is a substance that smells of incense, and incense includes resins such as trees, such as juniper, sandalwood, incense, and cloves, frankincense, and benzoate. ), There are secretions of animals, such as musk and dragon scents. Inclusion of incense in the present invention is intended to improve the feeling of use by flavoring.

Hereinafter, the present invention will be described in more detail with reference to examples, test examples, and drawings. However, the following Examples and Test Examples are provided to illustrate the present invention, but the present invention is not limited to the Examples and Test Examples.

< Example  1: Manufacturing method of hair regrowth composition and external composition for skin regrowth>

1.Ginseng, Chili and Sugar Ethanol Extract

Prepare 1Kg of red ginseng, red pepper, and sugar each in powder form. 6 L of ethanol was added to each powder and soaked at room temperature for 7 days to obtain 5.25 L of each extract.

2. Sukchangpo, leafy, baekbaekpi, upper leaf, white leaf, ginseng, licorice, pine needles, peony, yellow flower, fennel, cornus, Euiin (Yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot Distillation of kelp, seaweed, mint

Seokchangpo, lobe, evergreen skin, lobe, baekryeop, ginseng, licorice, pine needles, peony, yogurt, fennel, cornus, uiyiin (yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot, kelp Prepare 1Kg of powdered seaweed and mint in powder form. 9 L of purified water is added to each powder, and the mixture is quenched at a temperature of 90 ° C. to 100 ° C. for 12 hours, and then distillation is started to obtain 5.88 L of extract each for 12 hours.

3. Mixing of ethanol extract and distillation extract

Ethanol extract and distillation extract obtained through the extraction are mixed in a constant weight ratio to sterilize hair follicles and promote hair root cell activity, thereby preventing hair loss and promoting hair growth composition.

4. Preparation of skin external preparation composition for hair growth

The hair regrowth composition is added to the shampoo, conditioner, hair tonic, hair lotion, hair cream, etc. at a concentration of 0.1 to 35% by weight to obtain a hair regrowth composition for hair growth.

< Example  2: Manufacturing method of hair regrowth composition and external composition for skin regrowth>

1.Ginseng, Chili and Sugar Ethanol Extract

1 g of powder mixture is prepared by mixing red ginseng, red pepper and sugar in powder form. 6 L of ethanol was added to the powder mixture and soaked at room temperature for 7 days to obtain 5.25 L of extract.

2. Sukchangpo, leafy, baekbaekpi, upper leaf, white leaf, ginseng, licorice, pine needles, peony, yellow flower, fennel, cornus, Euiin (Yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot Distillation of kelp, seaweed, mint

Seokchangpo, lobe, evergreen skin, lobe, baekryeop, ginseng, licorice, pine needles, peony, yogurt, fennel, cornus, uiyiin (yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot, kelp 1kg of powder mixture is prepared by mixing seaweed and mint in powder form. 9 L of purified water was added to the powder mixture, and the mixture was cut at a temperature of 90 ° C. to 100 ° C. for 12 hours, and then distillation was started to obtain 5.88 L of extract for 12 hours.

3. Mixing of ethanol extract and distillation extract

The ethanol extract and distillation extract obtained through the extraction are mixed in a constant weight ratio to sterilize hair follicles and to promote hair root cell activity, thereby obtaining a hair regrowth composition which prevents hair loss and promotes hair growth.

4. Preparation of skin external preparation composition for hair growth

The hair regrowth composition is added to the shampoo, conditioner, hair tonic, hair lotion, hair cream, etc. at a concentration of 0.1 to 35% by weight to obtain a hair regrowth composition for hair growth.

< Example  3: Manufacturing method of hair regrowth composition and external composition for skin regrowth>

1.Ginseng, Chili and Sugar Ethanol Extract

Prepare 1Kg of red ginseng, red pepper, and sugar each in powder form. 6 L of ethanol was added to each powder and soaked at room temperature for 7 days to obtain 5.25 L of each extract.

2. Sukchangpo, leafy, baekbaekpi, upper leaf, white leaf, ginseng, licorice, pine needles, peony, yellow flower, fennel, cornus, Euiin (Yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot Distillation of kelp, seaweed, mint

Seokchangpo, lobe, evergreen skin, lobe, cypress lobe, ginseng, licorice, pine needle, peony, yellow flower, fennel, cornus, righteous man (Julmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot, Seaweed, seaweed, and mint are prepared in powder form by 1 kg. 9 L of purified water is added to each powder, and the mixture is quenched at a temperature of 90 ° C. to 100 ° C. for 12 hours, and then distillation is started to obtain 5.88 L of extract each for 12 hours.

3. Mixing of ethanol extract and distillation extract

Ethanol extract and distillation extract obtained through the extraction are mixed in a constant weight ratio to sterilize hair follicles and promote hair root cell activity, thereby preventing hair loss and promoting hair growth composition.

4. Add hair growth promoter auxiliary ingredient

One or more selected from nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki thiol, licorice extract, menthol, and fragrance is added to the hair regrowth composition at a concentration of 0.1 to 10% by weight.

5. Hair external composition for hair growth

The hair regrowth composition is added to the shampoo, conditioner, hair tonic, hair lotion, hair cream, etc. at a concentration of 0.1 to 35% by weight to obtain a hair regrowth composition for hair growth.

< Example  4: Manufacturing method of hair regrowth composition and external composition for skin regrowth>

1.Ginseng, Chili and Sugar Ethanol Extract

1 g of powder mixture is prepared by mixing red ginseng, red pepper and sugar in powder form. 6 L of ethanol was added to the powder mixture and soaked at room temperature for 7 days to obtain 5.25 L of extract.

2. Sukchangpo, leafy, baekbaekpi, upper leaf, white leaf, ginseng, licorice, pine needles, peony, yellow flower, fennel, cornus, Euiin (Yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot Distillation of kelp, seaweed, mint

Seokchangpo, lobe, evergreen skin, lobe, baekryeop, ginseng, licorice, pine needles, peony, yogurt, fennel, cornus, uiyiin (yulmu), ginger, garlic, black bean (black bean), black sesame seed (black sesame), spinach, carrot, kelp 1kg of powder mixture is prepared by mixing seaweed and mint in powder form. 9 L of purified water was added to the powder mixture, and the mixture was cut at a temperature of 90 ° C. to 100 ° C. for 12 hours, and then distillation was started to obtain 5.88 L of extract for 12 hours.

3. Mixing of ethanol extract and distillation extract

The ethanol extract and distillation extract obtained through the extraction are mixed in a constant weight ratio to sterilize hair follicles and to promote hair root cell activity, thereby obtaining a hair regrowth composition which prevents hair loss and promotes hair growth.

4. Add hair growth promoter auxiliary ingredient

One or more selected from nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki thiol, licorice extract, menthol, and fragrance is added to the hair repellent composition at a concentration of 0.1 to 10% by weight.

5. Hair external composition for hair growth

The hair regrowth composition is added to the shampoo, conditioner, hair tonic, hair lotion, hair cream, etc. at a concentration of 0.1 to 35% by weight to obtain a hair regrowth composition for hair growth.

< Test Example  One: Demodex  Sterilization Effect Test>

In experiments that do not use directly on the human body, first, the human scalp or facial skin is strongly pressed using the Demodex extract tool, and sebum is collected using a dropper. It was observed as (Comparative Example 1).

In addition, after dropping the hair external composition for hair growth of Examples 1 to 4 using the dropper, the survival time of the Demodex worms was observed through a microscope. Meanwhile, the same experiment was performed with the hair repellent composition according to Korean Patent No. 10-0348155 (Comparative Example 2) and Korean Patent No. 10-0487275 (Comparative Example 3).

The results of the experiment are shown in the following table.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Demodex survival time 5 minutes 6 minutes 4 minutes 4 minutes 24 ~ 48 hours 18 hours 10 minutes

< Test Example  2: Demodex  Bactericidal Effect Clinical Trials>

In experiments used directly on the human body, the composition for external application for skin regrowth of Examples 1 to 4 for hair loss patients with hair follicles present in the hair follicles of the scalp and Korean Patent No. 10-0348155 (Comparative Example 1), Korea The hair repellent composition according to Korean Patent No. 10-0487275 (Comparative Example 2) was applied to 2cc twice every morning and evening.

As a result of confirming the presence of Demodex worms at intervals of two weeks (14 days) after the application, the number of Demodex worms were as follows.

Classification (80 people in total) Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Number of people with Demodex 2 weeks past 12 people 12 people 10 people 11 people 72 people 13 people 4 weeks past 6 people 6 people 5 people 6 people 60 people 8 people 6 months 3 people 3 people 2 people 2 people 52 people 6 people

< Test Example  3: Clinical trial of hair growth promoting effect>

In experiments used directly on the human body, the hair loss composition for hair regrowth of Examples 1 to 4 and the Republic of Korea Patent Registration No. 10-0348155 (Comparative Example 1), targeting 80 hair loss patients in the hair follicles of the scalp each The hair repellent composition according to Korean Patent No. 10-0487275 (Comparative Example 2) was applied to 2cc twice every morning and evening.

Six months after application, the number of hairs in a square of 1cm in width and 1cm in length was examined as a sample, and the average increase rate of the number of hairs was observed by comparing the number of hairs before use and the number of hairs after use.

Average growth rate of hair Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 6 months 66% 66% 70% 69% 50% 47%

In addition, 25% of the total 80 patients were visually confirmed to have a hair growth effect one month after applying the composition for applying the external preparation for skin regrowth of the present invention, and 70% of hair loss patients visually confirmed the hair growth effect after two months. It became. In addition, after 3 months, the hair growth effect was visually confirmed in 80 hair loss patients.

< Test Example  4: Clinical trial of hair loss prevention effect>

In experiments used directly on the human body, the composition for external application for skin regrowth of Examples 1 to 4 for hair loss patients with hair follicles present in the hair follicles of the scalp and Korean Patent No. 10-0348155 (Comparative Example 1), Korea The hair repellent composition according to Korean Patent No. 10-0487275 (Comparative Example 2) was applied to 2cc twice every morning and evening.

The number of hairs dropped immediately after the hair was examined and the number of hairs before and after 6 months after application was compared.

Average reduction rate of hair loss Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 6 months 70% 69% 72% 72% 43% 40%

In addition, it was visually confirmed that the hair loss prevention effect after 1 week to 2 weeks after the application of the composition for applying the external preparation for skin regrowth of the present invention.

< Test Example  5: Skin Response Evaluation Experiment>

Evaluation of skin reaction was judged using toxicology test criteria such as pharmaceuticals. In addition, the degree of irritation to the skin was evaluated by Draize's P.I.I (Primary Irritation Index).

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 P.I.I 0.2 0.2 0.2 0.2 0.5 0.5

On the other hand, Figures 1A to 2B are photographs showing the results of clinical trials of the hair growth composition of the present invention for applying the external composition for hair regrowth to the hair loss patient twice every morning and evening.

1A is a photograph showing the hair condition of a female hair loss patient before using the composition for external application for skin regrowth of the present invention.

1B is a photograph showing a hair condition of a female alopecia patient after approximately two months of using the composition for external application for skin regrowth of the present invention.

1C is a photograph showing the hair condition of a female hair loss patient after approximately 3 months after using the composition for external application for skin regrowth of the present invention.

2A is a photograph showing the hair condition of a male hair loss patient before using the composition for external application for skin regrowth of the present invention.

2b is a photograph showing the hair condition of a male hair loss patient after approximately 3 months after using the composition for external application for skin regrowth of the present invention.

When the number of hairs before use and the number of hairs after use are applied to a patient without the hair on the head of the head as shown in FIGS. 1A to 2B, the present invention is applied to the hair growth skin. Two months after the application of the external preparation composition can be visually confirmed that there is a hair loss prevention and hair growth promoting effect, and after three months it can be confirmed that the hair loss is considerably disappeared.

As described above, the present invention has a more effective removal of hair follicles, prevents hair loss, and promotes hair growth by combining complementary herbal medicines for removing hair follicles and preventing hair loss and promoting hair growth. .

As described above, the present invention not only supplies sufficient nutrition to the scalp, but also stimulates the scalp and promotes the activity of hair follicle cells (毛 母 細胞), which has an excellent effect on promoting hair growth.

In addition, the present invention is effective in preventing hair loss by removing hair follicles parasitic on the scalp hair follicles of the human body that causes hair loss, and preventing hair loss in advance.

In addition, the present invention is a herbal medicine extract as a main raw material is harmless to the human body because there is no side effect caused by hormones and the like.

In addition, the present invention is easy to use because it can be easily applied to the scalp by providing a topical composition for hair growth.

Claims (8)

In the hair regrowth composition comprising ethanol extract and distillation extract, As the ethanol extract, high ginseng extract, red pepper extract, sugar extract; As the distillation extract, spear extract, leaf extract, lettuce extract, lettuce leaf extract, cypress extract, ginseng extract, licorice extract, pine leaf extract, peony extract, turmeric extract, fenyan extract, ginger extract, ginger extract, black bean extract, garlic extract Extract, black sesame extract, spinach extract, carrot extract, kelp extract, seaweed extract, peppermint extract; The ethanol extract and the hair-repellent composition, characterized in that each of the distillation extract is mixed in a constant weight ratio. The method of claim 1, A hair restorer composition comprising 0.1 to 10% by weight of one or more selected from nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki thiol, menthol, and fragrance. The hair restorer composition of claim 1, wherein the constant weight ratio is the same weight ratio. The hair external composition for hair regrowth selected from shampoo, rinse, hair tonic, hair lotion, and hair cream, wherein the hair regrowth composition of claim 1 or 2 is added at a concentration of 0.1 to 35% by weight. In the method for producing a hair regrowth composition, Adding ethanol to the red ginseng, red pepper, and medicinal extract in a weight ratio of 1: 6 to obtain an ethanol extract by immersion at room temperature for 7 days; Seokchangpo, lobe, evergreen skin, lobe, baekryeop, ginseng, licorice, pine needles, peony, yogurt, fennel, cornus, uiyiin, ginger, garlic, black bean, black sesame seeds, spinach, carrots, kelp, seaweed, peppermint 1 Distillation by distillation by addition at a weight ratio of 9; The ethanol extract and the distillation extract comprising the step of mixing the hair repellent composition, characterized in that it comprises a predetermined weight ratio. The method of claim 5, The constant weight ratio is the same weight ratio hair growth composition manufacturing method. The method of claim 5, A method of preparing a hair restorer composition comprising adding one or more selected from nicotinic acid amide, salicylic acid, tocophenol acetate, panthenol, nicotinic acid benzyl, hinoki thiol, menthol, and fragrance at a concentration of 0.1 to 10% by weight. A method for preparing the hair repellent composition according to any one of claims 5 to 7, comprising adding the hair repellent composition to any one or more of shampoo, rinse, hair tonic, hair lotion, and hair cream at a concentration of 0.1 to 35% by weight. A method for producing a topical skin composition for hair growth, characterized in that.

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