KR102384239B1 - Composition for preventing hair loss or promoting hair growth containing essential oil mixture of Schisandra fruit, cornus fruit, mint, and Evening Primrose seeds - Google Patents
Composition for preventing hair loss or promoting hair growth containing essential oil mixture of Schisandra fruit, cornus fruit, mint, and Evening Primrose seeds Download PDFInfo
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- KR102384239B1 KR102384239B1 KR1020200151525A KR20200151525A KR102384239B1 KR 102384239 B1 KR102384239 B1 KR 102384239B1 KR 1020200151525 A KR1020200151525 A KR 1020200151525A KR 20200151525 A KR20200151525 A KR 20200151525A KR 102384239 B1 KR102384239 B1 KR 102384239B1
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- essential oil
- derived
- hair
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- oil
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Abstract
Description
본 발명은 오미자, 산수유, 박하 및 월견자 정유 혼합물을 포함하는 탈모 예방 또는 발모 촉진용 조성물에 관한 것으로, 구체적으로 오미자 유래 정유, 산수유 유래 정유, 박하 유래 정유 및 월견자 유래 정유 혼합물을 포함하는 탈모 예방 또는 발모 촉진용 조성물에 관한 것이다.The present invention relates to a composition for preventing hair loss or promoting hair growth, comprising a mixture of Schisandra, cornus oil, peppermint, and moonshine essential oil, and specifically, hair loss comprising a mixture of omija-derived essential oil, cornus oil-derived essential oil, peppermint-derived essential oil and moongyeonja-derived essential oil mixture It relates to a composition for preventing or promoting hair growth.
모발은 모근과 모간으로 나뉘며, 모근을 둘러싸고 있는 모낭에서 모발이 생장한다. 모낭에서 생물학적 특성을 조절하는 두 가지 중요한 요소는 모낭상피인 외측모근초 세포 (ORS)와 중간엽 유래의 모유두 (DP)이며, 모주기의 반복을 통하여 모발이 성장하고 탈락하게 된다. 모발은 크게 성장기(anagen), 퇴화기(catagen), 휴지기(telogen)의 3단계를 거치며, 각질층에서 모발은 각각 표피와 모낭의 증식 및 분화를 통하여 만들어지고 탈락되는데 모낭 하부의 결직초 (DP)에는 중간엽 유래의 전이증폭세포가 존재하여 성장기 모낭의 모유두를 유지하는 역할을 한다고 알려져 있다. 다양한 호르몬(testosterone), 사이토카인(cytokines) 및 성장인자(growth factors)가 모발 형태 발생과 모발 성장 조절에 관여한다고 알려져 있다. 모낭의 수와 크기의 증가는 성장기에 관찰되었는데, 휴지기의 모낭은 진피층(dermis)에 위치하는 것과 달리 성장기에는 모낭이 깊은 피하조직(subcutis)에 위치하므로 모낭의 수와 크기의 증가는 성장기와 밀접하게 연관되어 있다.Hair is divided into a hair root and a hair shaft, and hair grows from the hair follicle surrounding the hair root. Two important factors regulating the biological properties of hair follicles are lateral root sheath cells (ORS), which are follicular epithelium, and mesenchymal-derived dermal papilla (DP), and hair grows and falls out through repetition of the hair cycle. Hair goes through three stages: anagen, catagen, and telogen. In the stratum corneum, hair is made and removed through the proliferation and differentiation of the epidermis and hair follicle, respectively. It is known that mesenchymal-derived metastasis amplification cells exist in the follicle and play a role in maintaining the dermal papilla of hair follicles during growth. Various hormones (testosterone), cytokines (cytokines) and growth factors (growth factors) are known to be involved in hair morphogenesis and hair growth regulation. An increase in the number and size of hair follicles was observed during the growth phase. Unlike hair follicles in resting phase, which are located in the dermis, in growth phase, hair follicles are located in the deep subcutis. are closely related
모발은 외모의 한 부분으로서 대외적인 이미지 개선에 있어 중요한 역할을 하기 때문에, 최근 발모, 양모 및 탈모예방에 대한 연구의 중요성이 높아지고 있는 추세이다. 특히, 생활패턴이 서구화되면서 삶의 질이 개선되고 스트레스가 증가하면서 탈모와 두피질환 등의 고민이 모든 사람의 관심사로 확대되고 있고, 그 원인도 단순한 유전적 요인과 후천적인 요인이 있으며, 이에 대한 중요성과 관심이 점차 커지고 있다. 탈모는 심리적인 위축감 등을 초래하여 대인관계 기피증과 자신감 상실 등으로 이어질 수 있기 때문에 개인의 윤택한 삶 유지에도 많은 영향을 미칠 수 있어 탈모산업 시장은 지속적으로 급성장하고 있는 추세이다.Since hair plays an important role in improving external image as a part of appearance, the importance of research on hair growth, wool, and hair loss prevention is increasing in recent years. In particular, as life patterns are westernized, quality of life is improved and stress is increasing, worries about hair loss and scalp diseases are expanding to everyone's interest, and the causes are simple genetic factors and acquired factors, The importance and interest are gradually increasing. Since hair loss can cause psychological atrophy, etc., which can lead to interpersonal phobias and loss of self-confidence, it can have a great impact on maintaining an individual's rich life, and the hair loss industry market is continuously growing rapidly.
현재 미국 식품의약품안전청(FDA)으로부터 승인을 받은 대표적인 탈모치료제로는 합성의약품으로 도포용 미녹시딜과 경구용 프로페시아가 있는데, 이들은 몇 가지 부작용들이 지속적으로 보고되고 있다. 프로페시아는 남성호르몬 (testosterone)에서 탈모의 원인물질인 dihydrotestosterone(DHT)으로 변환되는 과정을 억제하여 효과를 나타내지만 남성의 성욕을 감소시킬 수 있다는 문제가 제기되고 있으며 미녹시딜은 고혈압 치료제로 개발되다가 모낭 활성을 통한 모발 성장 촉진이 보고되면서 양모제로 개발되었지만 다양한 피부질환 등의 부작용이 보고되고 있다.Currently, as representative hair loss treatment agents approved by the US Food and Drug Administration (FDA), there are minoxidil for application and Propecia for oral use as synthetic drugs, and some side effects are continuously reported. Propecia is effective by inhibiting the conversion of male hormone (testosterone) to dihydrotestosterone (DHT), which is the causative agent of hair loss, but there is a problem that it can reduce male sexual desire. Although it has been developed as a hair growth agent as it has been reported to promote hair growth through
지금까지 연구된 모발성장에 유용한 천연물에는 콩(Glycine linne, isoflavone), 생강 (Zingiber officinale, 6-gingerol), 고추 (Capsicum annuum), 알로에 (Aloe arborescens), 감초 (Glycyrrhiza glabra), 차나무(Camellia sinensis), 은행나무(Ginkgo biloba), 아보카도(Persea americana), 백하수오(Polygonum multiflorum) 등이 보고되어 있다. Natural products useful for hair growth studied so far include soybeans ( Glycine linne , isoflavone ), ginger ( Zingiber officinale , 6-gingerol ), red pepper ( Capsicum annuum ), aloe ( Aloe arborescens ), licorice ( Glycyrrhiza glabra ), and tea tree ( Camellia sinensis ). ), Ginkgo biloba ( Ginkgo biloba ), avocado ( Persea americana ), and white hawthorn ( Polygonum multiflorum ) have been reported.
기존에 알려진 천연물 선행특허들을 살펴보면, 대한민국 공개특허 10-2014-0115400에서는 붉나무 추출물의 탈모 방지 및 발모 촉진 효과를 개시하고 있다. 또한, 대한민국 공개특허 10-2016-0069488에서는 봉독을 발모 촉진 및 탈모 방지에 이용하는 내용을 개시하고 있다.Looking at the previously known natural product prior patents, Korean Patent Application Laid-Open No. 10-2014-0115400 discloses the effect of preventing hair loss and promoting hair growth of the redwood extract. In addition, Korean Patent Laid-Open Patent Publication No. 10-2016-0069488 discloses the use of bee venom to promote hair growth and prevent hair loss.
그러나, 이와 같은 천연물을 활용하려는 노력에도 불구하고 의약품 대비 낮은 활성으로 인해 발모촉진제 또는 탈모억제제의 상용화는 아직 미미한 수준이다.However, despite efforts to utilize such natural products, commercialization of hair growth promoting agents or hair loss inhibitors is still minimal due to low activity compared to pharmaceuticals.
이에, 본 발명자들은 탈모 방지 및 발모 촉진을 위한 효과적인 천연 유래 발모제를 개발하기 위한 연구를 수행한 결과, 오미자, 산수유, 박하 및 월견자 유래 정유 혼합물이 모유두 세포에서 모발 성장에 대한 상승 효과가 있음을 알아내고 본 발명을 완성하였다.Accordingly, the present inventors conducted a study to develop an effective naturally-derived hair growth agent for preventing hair loss and promoting hair growth, and as a result, it was found that a mixture of essential oils derived from Schisandra, Cornus officinalis, peppermint, and Lunar radish had a synergistic effect on hair growth in dermal papilla cells. found out and completed the present invention.
본 발명의 목적은 탈모 예방 또는 발모 촉진용 화장료 조성물을 제공하는 것이다.It is an object of the present invention to provide a cosmetic composition for preventing hair loss or promoting hair growth.
본 발명의 다른 목적은 탈모 예방 또는 발모 촉진용 건강식품 조성물을 제공하는 것이다.Another object of the present invention is to provide a health food composition for preventing hair loss or promoting hair growth.
본 발명의 또 다른 목적은 탈모 예방 또는 발모 촉진용 건강기능식품 조성물을 제공하는 것이다.Another object of the present invention is to provide a health functional food composition for preventing hair loss or promoting hair growth.
본 발명의 다른 목적은 탈모 예방 또는 치료용 약학적 조성물을 제공하는 것이다.Another object of the present invention is to provide a pharmaceutical composition for preventing or treating hair loss.
상기 목적을 달성하기 위하여,In order to achieve the above object,
본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 화장료 조성물을 제공한다.The present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a cosmetic composition for preventing hair loss or promoting hair growth comprising a.
또한, 본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 건강식품 조성물을 제공한다.In addition, the present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a health food composition for preventing hair loss or promoting hair growth, comprising a.
나아가 본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 건강기능식품 조성물을 제공한다.Furthermore, the present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a health functional food composition for preventing hair loss or promoting hair growth, comprising a.
더 나아가 본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 치료용 약학적 조성물을 제공한다.Furthermore, the present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a pharmaceutical composition for preventing or treating hair loss comprising a.
본 발명의 오미자, 산수유, 박하 및 월견자 유래 정유 혼합물은 모유두 세포에서 우수한 모발 성장 효과를 나타냈으며, 각 정유 단독 대비 모유두 세포 증식 증가에 대한 상승효과를 나타내므로, 본 발명의 오미자, 산수유, 박하 및 월견자 유래 정유 혼합물은 탈모 예방 또는 치료용 약학적 조성물과 탈모 예방 또는 발모 촉진용 화장료 조성물 및 탈모 예방 또는 발모 촉진용 식품 조성물로 유용할 수 있다.The mixture of essential oils derived from Schisandra, cornus oil, peppermint and moonshine of the present invention exhibited an excellent hair growth effect in dermal papilla cells, and exhibited a synergistic effect on the increase in dermal papilla cell proliferation compared to each essential oil alone. And a mixture of essential oils derived from moonflower seeds may be useful as a pharmaceutical composition for preventing or treating hair loss, a cosmetic composition for preventing or promoting hair loss, and a food composition for preventing or promoting hair growth.
도 1은 본 발명에 따른 오미자, 산수유, 박하 및 월견자 정유 혼합물의 sub G1 phase에서의 apoptosis 및 G0/G1, S및 G2/M phase로의 cell cycle의 진행과정을 나타낸 결과이다.
도 2는 본 발명에 따른 오미자, 산수유, 박하 및 월견자 정유 혼합물의 모발 성장에 영향을 주는 Wnt의 단백질 발현 정도를 나타낸 도이다.1 is a result showing the progress of apoptosis in the sub G1 phase and the cell cycle to G0/G1, S and G2/M phases of a mixture of essential oils of Schisandra, cornus oil, peppermint, and moongyeonja according to the present invention.
Figure 2 is a diagram showing the protein expression level of Wnt that affects hair growth of a mixture of Schisandra, cornus oil, peppermint, and moongyeonja essential oils according to the present invention.
이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.
탈모 예방 또는 발모 촉진용 화장료 조성물Cosmetic composition for preventing hair loss or promoting hair growth
본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 화장료 조성물을 제공한다.The present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a cosmetic composition for preventing hair loss or promoting hair growth comprising a.
본 발명에 일실시예에 있어서, 상기 오미자 유래 정유, 산수유 유래 정유, 박하 유래 정유 및 월견자 유래 정유는 오미자, 산수유, 박하 및 월견자를 각각 수증기로 증류시켜 얻어진 것일 수 있다.In one embodiment of the present invention, the essential oil derived from omija, the essential oil derived from cornus oil, the essential oil derived from peppermint, and the essential oil derived from wolgyeonja may be obtained by distilling omija, cornus oil, mint, and moongyeonja with steam, respectively.
본 발명에서 사용된 용어 "정유(精油)"란 식물 (식물의 잎, 줄기, 열매, 꽃, 뿌리 등)로부터 추출 분리한 방향유(휘발성 물질)을 통칭하는 용어로서, 추출물, 추출법, 용도 및 목적에 따라 다양하게 분류된다. As used in the present invention, the term "essential oil" is a term that collectively refers to aromatic oils (volatile substances) extracted and separated from plants (leaf, stem, fruit, flower, root, etc. of plants), extract, extraction method, use and purpose are classified in various ways according to
본 발명에 따라 제조된 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유;는 상기 각 정유 단독보다 높은 모유두세포 증식율을 나타내며, 우수한 모발 성장 효과 및 상승 효과를 갖는다(실험예 1 내지 3 참조).Schisandra-derived essential oil prepared according to the present invention; essential oil derived from cornus oil; essential oil derived from peppermint; and Moongyeonja-derived essential oil; shows a higher dermal papilla cell proliferation rate than each of the essential oils alone, and has an excellent hair growth effect and synergistic effect (see Experimental Examples 1 to 3).
본 발명의 화장료 조성물은 상술한 본 발명의 유효성분의 화장품학적 유효량(cosmetically effective amount) 및 화장품학적으로 허용되는 담체를 포함하여 제조할 수 있다.The cosmetic composition of the present invention can be prepared including a cosmetically effective amount of the active ingredient of the present invention described above and a cosmetically acceptable carrier.
화장료 조성물의 외형은 화장품학 또는 피부과학적으로 허용 가능한 매질 또는 기제를 함유한다. 이는 국소적용에 적합한 모든 제형으로, 예를 들면, 용액, 겔, 고체, 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는, 이온형(리포좀) 및 비이온형의 소낭 분산제의 형태로, 또는 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱의 형태로 제공될 수 있다. 이들 조성물은 당해 분야의 통상적인 방법에 따라 제조될 수 있다. 본 발명에 따른 조성물은 또한 포말(foam)의 형태로 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 사용될 수 있다.The appearance of the cosmetic composition contains a cosmetically or dermatologically acceptable medium or base. It is in any formulation suitable for topical application, for example solutions, gels, solids, kneaded dry products, emulsions obtained by dispersing the oily phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or, ionic (liposomes) and It may be provided in the form of a non-ionic vesicular dispersant, or in the form of a cream, skin, lotion, powder, ointment, spray or concealer stick. These compositions can be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.
본 발명의 일 실시예에 따른 상기 화장료 조성물은 그 제형에 있어서 특별히 한정되는 바가 없으며, 예를 들면, 헤어토닉, 헤어크림, 헤어팩, 헤어로션, 헤어샴푸, 헤어린스, 헤어컨디셔너, 헤어스프레이, 헤어에어졸, 포마드, 분말, 젤, 솔젤, 에멀젼, 오일, 왁스 및 에어로졸로 이루어진 군으로부터 선택되는 형태의 모발 또는 두피용 화장료인 것일 수 있다.The cosmetic composition according to an embodiment of the present invention is not particularly limited in its formulation, for example, hair tonic, hair cream, hair pack, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair It may be a cosmetic for hair or scalp in a form selected from the group consisting of aerosol, pomade, powder, gel, sol gel, emulsion, oil, wax and aerosol.
본 발명의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액의 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component, water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.
본 발명의 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide as carrier components Ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolin derivative or ethoxylated glycerol fatty acid ester and the like may be used.
본 발명의 일 실시예에 따르면 유효성분의 함량은 특별히 제한되지 않으나, 본 발명에 따른 정유 혼합물을 조성물 총 중량에 대하여 0.001 내지 20 중량%로 포함할 수 있다. 상기 함량을 만족하는 경우 부작용없이 우수한 효능을 나타낼 수 있다.According to an embodiment of the present invention, the content of the active ingredient is not particularly limited, but the essential oil mixture according to the present invention may be included in an amount of 0.001 to 20% by weight based on the total weight of the composition. When the above content is satisfied, excellent efficacy can be exhibited without side effects.
본 발명의 일 실시예에 따른 화장료 조성물에는 상기 정유 혼합물 이외에 기능성 첨가물 및 일반적인 화장료 조성물에 포함되는 성분이 추가로 포함될 수 있다. 상기 기능성 첨가물로는 수용성 비타민, 유용성 비타민, 고분자 펩티드, 고분자 다당, 스핑고 지질 및 해초 엑기스로 이루어진 군에서 선택된 성분을 포함할 수 있다.The cosmetic composition according to an embodiment of the present invention may further include functional additives and components included in general cosmetic compositions in addition to the essential oil mixture. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids, and seaweed extract.
본 발명의 화장료 조성물에는 또한, 상기 기능성 첨가물과 더불어 필요에 따라 일반적인 화장료 조성물에 포함되는 성분을 배합해도 된다. 이외에 포함되는 배합 성분으로서는 유지 성분, 보습제, 에몰리엔트제, 계면 활성제, 유기 및 무기 안료, 유기 분체, 자외선 흡수제, 방부제, 살균제, 산화 방지제, 식물 추출물, pH 조정제, 알콜, 색소, 향료, 혈행 촉진제, 냉감제, 제한(制汗)제, 정제수 등을 들 수 있다.In the cosmetic composition of the present invention, a component contained in a general cosmetic composition may be further blended with the functional additive as needed. Other ingredients included include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation An accelerator, a cooling agent, a limiting agent, purified water, etc. are mentioned.
탈모 예방 또는 발모 촉진용 건강기능식품 또는 건강식품 조성물Health functional food or health food composition for preventing hair loss or promoting hair growth
본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 건강기능식품 또는 건강식품 조성물을 제공한다.The present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a health functional food or health food composition for preventing hair loss or promoting hair growth, including.
본 발명에 일실시예에 있어서, 상기 오미자 유래 정유, 산수유 유래 정유, 박하 유래 정유 및 월견자 유래 정유는 오미자, 산수유, 박하 및 월견자를 각각 수증기로 증류시켜 얻어진 것일 수 있다.In one embodiment of the present invention, the essential oil derived from omija, the essential oil derived from cornus oil, the essential oil derived from peppermint, and the essential oil derived from wolgyeonja may be obtained by distilling omija, cornus oil, mint, and moongyeonja with steam, respectively.
본 발명에서 사용되는 용어 "건강기능식품"이란 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 정제, 캅셀, 분말, 과립, 액상 및 환 등의 형태로 제조 및 가공한 식품을 말한다. 여기서 '기능성'이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다. 본 발명의 건강기능식품은 통상의 기술분야에서 통상적으로 사용되는 방법에 의하여 제조가능하며, 상기 제조시에는 통상의 기술분야에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다.The term "health functional food" used in the present invention refers to food manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. using raw materials or ingredients useful in the human body. Here, 'functionality' refers to obtaining useful effects for health purposes, such as regulating nutrients or physiological effects on the structure and function of the human body. The health functional food of the present invention can be manufactured by a method commonly used in the ordinary technical field, and at the time of the preparation, it can be prepared by adding raw materials and components commonly added in the conventional technical field.
또한, 상기 건강기능식품의 제형 또한 건강기능식품으로 인정되는 제형이면 제한없이 제조될 수 있다. 본 발명의 식품용 조성물은 다양한 형태의 제형으로 제조될 수 있으며, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어나, 본 발명의 건강기능식품은 탈모방지제 또는 발모제의 효과를 증진시키기 위한 보조제로 섭취가 가능하다. 예를들어, 상기 건강기능식품은 정제, 캡슐제, 환제 또는 액제 형태의 식품인 것일 수 있고, 상기 건강식품은 각종 드링크제, 육류, 소세지, 빵, 캔디류, 스넥류, 면류, 아이스크림, 유제품, 스프, 이온음료, 음료수, 알코올 음료, 껌, 차 및 비타민 복합제에서 선택되는 것일 수 있다.In addition, the dosage form of the health functional food may also be manufactured without limitation as long as it is a dosage form recognized as a health functional food. The composition for food of the present invention can be prepared in various forms, and unlike general drugs, it has the advantage that there are no side effects that may occur during long-term administration of the drug using food as a raw material, and it is excellent in portability, and the present invention of health functional food can be consumed as a supplement to enhance the effect of a hair loss prevention agent or a hair growth agent. For example, the health functional food may be food in the form of tablets, capsules, pills, or liquids, and the health food includes various drinks, meat, sausages, bread, candy, snacks, noodles, ice cream, dairy products, soups, It may be selected from ionic beverages, beverages, alcoholic beverages, gum, tea, and vitamin complexes.
본 발명의 조성물을 건강기능식품 조성물 또는 건강식품 조성물로 사용하는 경우, 상기 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용할 수 있고, 통상의 방법에 따라 적절하게 사용할 수 있다. 상기 조성물은 유효성분 이외에 식품학적으로 허용가능한 식품보조첨가제를 포함할 수 있으며, 유효성분의 혼합량은 사용 목적(예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있다.When using the composition of the present invention as a health functional food composition or health food composition, the essential oil derived from Schisandra; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; can be added as it is or used together with other foods or food ingredients, and can be used appropriately according to a conventional method. In addition to the active ingredient, the composition may include a food additive that is pharmaceutically acceptable, and the mixing amount of the active ingredient may be suitably determined according to the purpose of use (prevention, health or therapeutic treatment).
본 발명에서 사용되는 용어 "식품보조첨가제"란 식품에 보조적으로 첨가될 수 있는 구성요소를 의미하며, 각 제형의 건강기능식품 또는 건강식품을 제조하는데 첨가되는 것으로서 당업자가 적절히 선택하여 사용할 수 있다. 식품보조첨가제의 예로는 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 충진제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등이 포함되지만, 상기 예들에 의해 본 발명의 식품보조첨가제의 종류가 제한되는 것은 아니다.As used in the present invention, the term "food supplement additive" refers to a component that can be supplementally added to food, and is added to manufacture health functional food or health food of each formulation, and those skilled in the art can appropriately select and use it. Examples of food supplement additives include various nutrients, vitamins, minerals (electrolytes), synthetic flavoring agents and flavoring agents such as natural flavoring agents, coloring agents and fillers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners , pH adjuster, stabilizer, preservative, glycerin, alcohol, carbonation agent used in carbonated beverages, etc., but the above examples are not limited to the type of food supplement additive of the present invention.
또한, 본 발명의 조성물이 사용될 수 있는 건강기능식품 또는 건강식품의 종류에는 제한이 없다. 아울러 본 발명의 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 조성물은 당업자의 선택에 따라 건강기능식품에 함유될 수 있는 적절한 기타 보조 성분과 공지의 첨가제를 혼합하여 제조할 수 있다. 첨가할 수 있는 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림 류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 본 발명에 따른 정유 혼합물을 주성분으로 하여 제조한 즙, 차, 젤리 및 주스 등에 첨가하여 제조할 수 있다.In addition, there is no limitation on the type of health functional food or health food in which the composition of the present invention can be used. In addition, Schisandra-derived essential oil of the present invention; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; A composition comprising a can be prepared by mixing known additives with other suitable auxiliary ingredients that may be contained in health functional foods according to the selection of those skilled in the art. Examples of foods that can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages and There is a vitamin complex, and it can be prepared by adding the essential oil mixture according to the present invention as a main component to juice, tea, jelly, juice, and the like.
본 발명의 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유;는 천연 식물을 원료로 하므로 약학적 조성물 또는 식품 조성물로 사용할 경우에도 일반적인 합성 화합물에 비하여 부작용이 덜할 수 있으므로, 안전하게 약학적 조성물, 건강기능식품 및 건강식품에 포함되어 유용하게 사용될 수 있다.Schisandra-derived essential oil of the present invention; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oil derived from moonflower; is made from natural plants, so even when used as a pharmaceutical composition or food composition, side effects may be less than that of a general synthetic compound, so it is safely included in pharmaceutical compositions, health functional foods and health foods to be useful can be used
탈모 예방 또는 치료용 약학적 조성물Pharmaceutical composition for preventing or treating hair loss
본 발명은 오미자 유래 정유; 산수유 유래 정유; 박하 유래 정유; 및 월견자 유래 정유; 를 포함하는 탈모 예방 또는 치료용 약학적 조성물을 제공한다.The present invention is Schisandra-derived essential oil; essential oil derived from cornus oil; essential oil derived from peppermint; and essential oils derived from moonshine; It provides a pharmaceutical composition for preventing or treating hair loss comprising a.
본 발명에 일실시예에 있어서, 상기 오미자 유래 정유, 산수유 유래 정유, 박하 유래 정유 및 월견자 유래 정유는 오미자, 산수유, 박하 및 월견자를 각각 수증기로 증류시켜 얻어진 것일 수 있다.In one embodiment of the present invention, the essential oil derived from omija, the essential oil derived from cornus oil, the essential oil derived from peppermint, and the essential oil derived from wolgyeonja may be obtained by distilling omija, cornus oil, mint, and moongyeonja with steam, respectively.
본 발명에서 사용되는 용어 "예방"이란 본 발명에 따른 약학적 조성물의 투여에 의해 탈모 질환의 발생, 확산 및 재발을 억제 또는 지연시키는 모든 행위를 의미하고, 본 발명에서 사용된 용어 "치료"란 본 발명의 조성물의 투여로 탈모 진행이 지연 또는 멈춰 탈모 증세를 호전시키거나, 모발이 길어지거나 수가 많아지는 등의 발모 및 육모가 촉진되는 등의 탈모 증세를 이롭게 변경하는 모든 행위를 의미한다. 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자라면, 대한의학협회 등에서 제시된 자료를 참조하여 본원의 조성물이 효과가 있는 질환의 정확한 기준을 알고, 개선, 향상 및 치료된 정도를 판단할 수 있을 것이다.The term "prevention" as used in the present invention means any action that suppresses or delays the occurrence, spread, and recurrence of hair loss disease by administration of the pharmaceutical composition according to the present invention, and the term "treatment" used in the present invention means By administration of the composition of the present invention, hair loss progression is delayed or stopped to improve the symptoms of hair loss, or hair growth and hair growth, such as lengthening or increasing the number of hairs, refers to any action that beneficially changes the symptoms of hair loss. Those of ordinary skill in the art to which the present invention pertains, with reference to the data presented by the Korean Medical Association, etc., know the exact standard of the disease for which the composition of the present application is effective, and can determine the degree of improvement, improvement and treatment will be.
일 구현예에서, 상기 약학적 조성물은 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸의 경구형 제형, 액상, 크림상, 로션상, 페이스트상 또는 고체상의 경피 국소 도포형 제형(피부 외용제), 좌제, 멸균 주사용액 및 분무제를 포함하는 군으로부터 선택되는 하나 이상의 제형일 수 있다. 바람직하게는 피부 외용제 형태인 것일 수 있다. 상기 피부 외용제는 피부 외부에서 도포되는 어떠한 것이라도 포함될 수 있는 총칭으로서 다양한 제형의 의약품 및 화장품이 여기에 포함될 수 있다.In one embodiment, the pharmaceutical composition is a powder, granule, tablet, capsule, suspension, emulsion, syrup, oral formulation of an aerosol, liquid, cream, lotion, paste or solid transdermal topical application formulation ( It may be one or more formulations selected from the group including external preparations for skin), suppositories, sterile injection solutions, and sprays. Preferably, it may be in the form of an external preparation for skin. The external preparation for skin is a generic term that can include anything applied outside the skin, and various types of pharmaceuticals and cosmetics can be included here.
본 발명의 조성물의 치료적으로 유효한 양은 여러 요소, 예를 들면 투여방법, 목적부위, 환자의 상태 등에 따라 달라질 수 있다. 따라서, 인체에 사용 시 투여량은 안전성 및 효율성을 함께 고려하여 적정량으로 결정되어야 한다. 동물실험을 통해 결정한 유효량으로부터 인간에 사용되는 양을 추정하는 것도 가능하다. 유효한 양의 결정시 고려할 이러한 사항은, 예를 들면 Hardman and Limbird, eds., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed.(2001), Pergamon Press; 및 E.W. Martin ed., Remington's Pharmaceutical Sciences, 18th ed.(1990), Mack Publishing Co.에 기술되어있다.The therapeutically effective amount of the composition of the present invention may vary depending on several factors, for example, the administration method, the target site, the condition of the patient, and the like. Therefore, when used in the human body, the dosage should be determined as an appropriate amount in consideration of both safety and efficiency. It is also possible to estimate the amount used in humans from the effective amount determined through animal experiments. These considerations in determining effective amounts are found, for example, in Hardman and Limbird, eds., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed. (2001), Pergamon Press; and E.W. Martin ed., Remington's Pharmaceutical Sciences, 18th ed. (1990), Mack Publishing Co.
본 발명의 조성물은 또한 생물학적 제제에 통상적으로 사용되는 담체, 희석제, 부형제 또는 둘 이상의 이들의 조합을 포함할 수 있다. 약제학적으로 허용 가능한 담체는 조성물을 생체 내 전달에 적합한 것이면 특별히 제한되지 않으며, 예를 들면, Merck Index, 13th ed., Merck & Co. Inc. 에 기재된 화합물, 식염수, 멸균수, 링거액, 완충 식염수, 덱스트로스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 이용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한, 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주이용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다. 더 나아가 당 분야의 적정한 방법으로 또는 Remington's Pharmaceutical Science(Mack Publishing Company, Easton PA, 18th, 1990)에 개시되어 있는 방법을 이용하여 각 질환에 따라 또는 성분에 따라 바람직하게 제제화할 수 있다.The compositions of the present invention may also include carriers, diluents, excipients or combinations of two or more commonly used in biological agents. A pharmaceutically acceptable carrier is not particularly limited as long as it is suitable for in vivo delivery of the composition, for example, Merck Index, 13th ed., Merck & Co. Inc. Compounds described in , saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol, and one or more of these components can be mixed and used, and if necessary, other antioxidants, buffers, bacteriostats, etc. Conventional additives may be added. In addition, diluents, dispersants, surfactants, binders and lubricants may be additionally added to form an injectable dosage form such as an aqueous solution, suspension, emulsion, etc., pills, capsules, granules or tablets. Furthermore, it can be preferably formulated according to each disease or component using an appropriate method in the art or a method disclosed in Remington's Pharmaceutical Science (Mack Publishing Company, Easton PA, 18th, 1990).
본 발명의 조성물에 추가로 동일 또는 유사한 기능을 나타내는 유효성분을 1종 이상 함유할 수 있다.In addition, the composition of the present invention may contain one or more active ingredients exhibiting the same or similar function.
본 발명의 약학 조성물은 약제학적으로 허용 가능한 첨가제를 더 포함할 수 있으며, 이때 약제학적으로 허용 가능한 첨가제로는 전분, 젤라틴화 전분, 미결정셀룰로오스, 유당, 포비돈, 콜로이달실리콘디옥사이드, 인산수소칼슘, 락토스, 만니톨, 엿, 아라비아고무, 전호화전분, 옥수수전분, 분말셀룰로오스, 히드록시프로필셀룰로오스, 오파드라이, 전분글리콜산나트륨, 카르나우바 납, 합성규산알루미늄, 스테아린산, 스테아린산마그네슘, 스테아린산알루미늄, 스테아린산칼슘, 백당, 덱스트로스, 소르비톨 및 탈크 등이 사용될 수 있다. 본 발명에 따른 약제학적으로 허용 가능한 첨가제는 상기 조성물에 대해 0.1 중량부 내지 90 중량부 포함되는 것이 바람직하나, 이에 한정되는 것은 아니다.The pharmaceutical composition of the present invention may further include a pharmaceutically acceptable additive, wherein the pharmaceutically acceptable additive includes starch, gelatinized starch, microcrystalline cellulose, lactose, povidone, colloidal silicon dioxide, calcium hydrogen phosphate, Lactose, mannitol, syrup, gum arabic, pregelatinized starch, corn starch, powdered cellulose, hydroxypropyl cellulose, Opadry, sodium starch glycolate, lead carnauba, synthetic aluminum silicate, stearic acid, magnesium stearate, aluminum stearate, stearic acid Calcium, sucrose, dextrose, sorbitol and talc and the like can be used. The pharmaceutically acceptable additive according to the present invention is preferably included in an amount of 0.1 to 90 parts by weight based on the composition, but is not limited thereto.
본 발명의 조성물은 목적하는 방법에 따라 비 경구 투여(예를 들어 정맥 내, 경피, 복강 내 또는 국소에 적용)하거나 경구 투여할 수 있으며, 투여량은 환자의 체중, 연령, 성별, 건강상태, 식이, 투여시간, 투여방법, 배설률 및 질환의 중증도 등에 따라 그 범위가 다양하다. The composition of the present invention may be administered parenterally (for example, intravenously, transdermally, intraperitoneally or topically) or orally according to a desired method, and the dosage may vary depending on the patient's weight, age, sex, health status, The range varies depending on the diet, administration time, administration method, excretion rate, and the severity of the disease.
본 발명의 조성물의 경구 투여를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데, 통상적으로 사용되는 단순 희석제인 물, 액체 파라핀 이외에 다양한 부형제, 예컨대 습윤제, 감미제, 방향제, 보존제 등이 함께 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성 용제, 현탁제, 유제, 동결건조 제제, 좌제 등이 포함된다.Liquid formulations for oral administration of the composition of the present invention include suspensions, internal solutions, emulsions, syrups, etc., and various excipients, such as wetting agents, sweetening agents, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. and the like may be included. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, suppositories, and the like.
하기의 실시예를 통하여 본 발명을 보다 상세하게 설명한다. 그러나 하기 실시예는 본 발명의 내용을 구체화하기 위한 것일 뿐 이에 의해 본 발명이 한정되는 것은 아니다.The present invention will be described in more detail through the following examples. However, the following examples are only intended to embody the contents of the present invention, and the present invention is not limited thereto.
<준비예 1> 오미자 정유의 제조<Preparation Example 1> Preparation of Schisandra essential oil
오미자를 수증기 증류법으로 증류하여 수용액성분을 제거하여 오미자 정유를 제조하였다. 오미자 1~3 kg에 물 20 L를 가하고, 가열 온도를 97∼100℃, 냉각 온도는 -2∼5℃로 유지하였다. 총 추출시간은 12시간이었으며, 물과 함께 원심분리 후 상등액을 취하여, 오미자 정유를 수득하였다.Schisandra essential oil was prepared by distilling Schisandra by steam distillation to remove aqueous solution components. 20 L of water was added to 1 to 3 kg of Schisandra, and the heating temperature was maintained at 97 to 100°C and the cooling temperature at -2 to 5°C. The total extraction time was 12 hours, and the supernatant was collected after centrifugation with water to obtain Schisandra essential oil.
<준비예 2> 산수유 정유의 제조<Preparation Example 2> Preparation of essential oil of Cornus officinalis
상기 준비예 1과 동일한 방법으로 산수유 정유를 수득하였다.Cornus oil essential oil was obtained in the same manner as in Preparation Example 1.
<준비예 3> 박하 정유의 제조<Preparation Example 3> Preparation of essential peppermint oil
상기 준비예 1과 동일한 방법으로 박하 정유를 수득하였다.Peppermint essential oil was obtained in the same manner as in Preparation Example 1.
<준비예 4> 월견자 정유의 제조<Preparation Example 4> Preparation of essential oil
상기 준비예 1과 동일한 방법으로 월견자 정유를 수득하였다.Moongyeonja essential oil was obtained in the same manner as in Preparation Example 1.
<실시예 1> 오미자, 산수유, 박하 및 월견자 정유 혼합물 준비<Example 1> Preparation of a mixture of Schisandra, cornus oil, peppermint and moonshine essential oil
상기 준비예 1 내지 4에서 얻은 정유를 하기 표 1과 같이 혼합하여 사용하였다.The essential oils obtained in Preparation Examples 1 to 4 were mixed and used as shown in Table 1 below.
<준비예 1> 세포배양 <Preparation Example 1> Cell culture
Human hair follicle dermal papilla cell (DP cell)을 10% FBS (fetal bovine serum)와 1% penicillin을 첨가한 Low glucose DMEM 배지를 배양액으로 37℃, CO2 incubator에서 배양하였다.Human hair follicle dermal papilla cells (DP cells) were cultured in low glucose DMEM medium supplemented with 10% FBS (fetal bovine serum) and 1% penicillin in a CO2 incubator at 37°C.
<통계처리> <Statistics processing>
실험성적의 통계적 유의성은 평균±표준편차로 표기하였고, 각 군간의 차이는 SPSS 25(SPSS Inc. USA)프로그램을 사용하였으며, ANOVA, Duncan 검정으로 사후 검정을 실시하여 유의성을 분석하였다. P<0.05 이하인 경우에 유의한 것으로 인정하였으며, 정상군과의 통계학적 유의성을 도면에 표기하였다. 각각의 실험은 모두 적어도 3번 이상 실시하여 통계처리하였다. The statistical significance of the experimental results was expressed as mean±standard deviation, and the difference between each group was analyzed for significance by using the SPSS 25 (SPSS Inc. USA) program, and by performing post-hoc tests using ANOVA and Duncan test. A case of P<0.05 or less was considered significant, and the statistical significance with the normal group was indicated in the drawing. Each experiment was performed at least 3 times for statistical processing.
<실험예 1> 오미자, 산수유, 박하 및 월견자 정유 혼합물의 모발 성장 촉진 효능 분석<Experimental Example 1> Analysis of the hair growth promoting effect of a mixture of Schisandra, cornus oil, peppermint and moonshine essential oil
상기 실시예 1 및 비교예 1 내지 14에 대하여 세포 증식을 통한 모발 성장 효능을 확인하였다.For Example 1 and Comparative Examples 1 to 14, the hair growth efficacy through cell proliferation was confirmed.
Human hair follicle dermal papilla cell(모유두세포, DP cell)를 10% FBS(fetal bovine serum)와 1% penicillin을 첨가한 Low glucose DMEM 배지를 배양액으로 37℃, CO2 incubator에서 배양하였다. Human hair follicle dermal papilla cells (hair papilla cells, DP cells) were cultured in a low glucose DMEM medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin as a culture medium at 37°C, CO 2 incubator.
상기 DP cell 현탁액을 적당한 농도로 96-well plate에 가한 다음 배양기에서 24시간 안정화시킨 후 상기 실시예 1 및 비교예 1 내지 14을 각각 농도별로 처리하고 48시간 동안 배양하였다. 48시간 후 media를 제거하고 PBS로 washing 하였다. 1 ㎎/㎖의 농도로 PBS에 녹인 MTT 용액을 100 ㎕씩 분주하여 37℃의 incubator에서 4시간 배양한 다음, 상층액을 제거하고 200 ㎕ DMSO를 넣어 완전히 formazan을 용해시킨 후 ELISA plate reader를 이용하여 540nm에서 OD값을 측정하였다.The DP cell suspension was added to a 96-well plate at an appropriate concentration, and then stabilized for 24 hours in an incubator. Then, Examples 1 and Comparative Examples 1 to 14 were treated for each concentration and cultured for 48 hours. After 48 hours, the media was removed and washed with PBS. 100 μl of MTT solution dissolved in PBS at a concentration of 1 mg/ml was dispensed and incubated for 4 hours in an incubator at 37°C, then the supernatant was removed, 200 μl DMSO was added to completely dissolve formazan, and then an ELISA plate reader was used. to measure the OD value at 540 nm.
실험성적의 통계적 유의성은 평균±표준편차로 표기하였고, 각 군간의 차이는 SPSS 25(SPSS Inc. USA)프로그램을 사용하였으며, ANOVA, Duncan 검정으로 사후 검정을 실시하여 유의성을 분석하였다. P<0.05 이하인 경우에 유의한 것으로 인정하였으며, 정상군과의 통계학적 유의성을 도면에 표기하였다. 각각의 실험은 모두 적어도 3번 이상 실시하여 통계처리하였다.The statistical significance of the experimental results was expressed as mean±standard deviation, and the difference between each group was analyzed for significance by using the SPSS 25 (SPSS Inc. USA) program, and by performing post-hoc tests using ANOVA and Duncan test. A case of P<0.05 or less was considered significant, and the statistical significance with the normal group was indicated in the drawing. Each experiment was performed at least 3 times for statistical processing.
그 결과, 상기 표 2에 나타낸 바와 같이, 100.00±0.00%인 control군에 비해 양성대조군인 minoxidil(MNXD)군은 및 실시예 1, 비교예 1 내지 비교예 14 모두 농도 의존적으로 증가하였다. 비교예 11 내지 비교예 14의 오미자 정유, 산수유 정유, 박하 정유 또는 월견자 정유 단독 처리군에 비해 비교예 1 내지 비교예 10의 오미자 정유, 산수유 정유, 박하 정유 또는 월견자 정유를 1종 이상 혼합 하여 사용할 경우 모유두 세포 증식율이 더 높게 나타났고, 특히 실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물을 처리한 군에서 모유두 세포 증식율이 가장 우수한 상승 효과를 나타내어, 오미자, 산수유, 박하 및 월견자 정유 혼합물이 모발 성장을 촉진하는 효과가 가장 우수한 것을 확인하였다.As a result, as shown in Table 2, the minoxidil (MNXD) group as a positive control group and Example 1 and Comparative Examples 1 to 14 all increased in a concentration-dependent manner compared to the control group of 100.00±0.00%. Compared to the group treated with Schisandra essential oil, Cornus oil essential oil, peppermint essential oil, or Moongrass essential oil of Comparative Examples 11 to 14 alone, one or more types of Schisandra essential oil, Cornus oil essential oil, peppermint essential oil, or Moongrass essential oil of Comparative Examples 1 to 10 were mixed When used as a dermal papilla, the dermal papilla cell proliferation rate was higher, and in particular, in the group treated with the mixture of omija, cornus oil, peppermint and moongyeonja essential oil of Example 1, the dermal papilla cell proliferation rate showed the best synergistic effect, showing the best synergistic effect on the growth rate of dermal papilla cells, omija, cornus oil, peppermint and moonshine. It was confirmed that the silken essential oil mixture had the best effect of promoting hair growth.
<실험예 2> 오미자, 산수유, 박하 및 월견자 정유 혼합물이 모유두 세포의 세포 주기에 미치는 영향 분석<Experimental Example 2> Analysis of the effect of a mixture of Schisandra, cornus oil, peppermint and moonshine essential oil on the cell cycle of dermal papilla cells
G0/G1, S및 G2/M phase로의 cell cycle의 진행과정은 포유류 세포 증식의 주요 과정이므로 오미자, 산수유, 박하 및 월견자 정유 혼합물이 DP cell의 증식으로 cell cycle의 진행을 유도하는지 알아보기 위해 DNA에 결합하는 형광물질인 PI를 처리하여 Flow Cytometer로 각 세포주기 phase상의 세포 수를 측정하였다. 대조군으로는 정유 대신 DMSO를 처리하였다.Since the cell cycle progresses to G0/G1, S and G2/M phases are the main processes of mammalian cell proliferation, we investigated whether a mixture of Schisandra, cornflower oil, peppermint and moonshine essential oils induces the progression of the cell cycle through the proliferation of DP cells. The number of cells in each cell cycle phase was measured with a flow cytometer by treatment with PI, a fluorescent substance that binds to DNA. As a control, DMSO was treated instead of essential oil.
실험결과, 도 1에 나타낸 바와 같이, 실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물 처리시 Sub G1 phase에서 1, 2.5, 5 ㎍/㎖의 농도에서 각각 9.62±0.12, 7.86±0.01, 10.09±1.52 %으로 측정되는 것으로 보아 11.28±2.70 %인 대조군에 비하여 낮은 apoptosis가 발생하는 것을 확인하였다. 또한 G1 phase에서 각각 61.49±3.27, 62.66±2.55, 66.84±1.21 %로 측정되었으며 G2/M phase에서 각각 20.97±2.16, 21.52±1.78, 16.52±1.49 %로 측정된 것으로 보아 G1 phase는 고농도에서 가장 많이 증가하여 세포증식률이 가장 높은 것으로 나타났다. 또한 16.70±1.52 %인 대조군에 비해 1, 2.5 ㎍/㎖의 농도에서 G2 phase로 빠르게 순환되고 있는 세포가 증가하는 것을 확인하였다. As a result of the experiment, as shown in FIG. 1 , when the mixture of Schisandra, cornus oil, peppermint and moonshine essential oil of Example 1 was treated, in the Sub G1 phase, at concentrations of 1, 2.5, and 5 μg/ml, 9.62±0.12, 7.86±0.01, respectively, As measured by 10.09±1.52%, it was confirmed that apoptosis was lower than that of the control group, which was 11.28±2.70%. Also, 61.49±3.27, 62.66±2.55, and 66.84±1.21 % were measured in the G1 phase, respectively, and 20.97±2.16, 21.52±1.78, and 16.52±1.49 % in the G2/M phase, respectively. increased, and the cell proliferation rate was the highest. In addition, it was confirmed that the cells rapidly circulating in the G2 phase at a concentration of 1, 2.5 μg/ml increased compared to the control, which was 16.70±1.52%.
따라서, 본 발명에 따른 오미자, 산수유, 박하 및 월견자 정유 혼합물이 모발의 성장기를 유지하는데 더 도움이 된다는 것을 확인하였다.Therefore, it was confirmed that the mixture of Schisandra, cornus oil, peppermint, and moongyeonja essential oil according to the present invention is more helpful in maintaining the hair growth phase.
<실험예 3> 오미자, 산수유, 박하 및 월견자 정유 혼합물의 모발 성장에 영향을 주는 단백질 발현 분석<Experimental Example 3> Analysis of protein expression affecting hair growth of a mixture of Schisandra, cornus oil, peppermint and moonshine essential oil
모낭에서 대표적으로 성장 및 재생, 모낭 줄기세포의 활성화 및 세포 증식 등의 과정에서 중요한 역할을 하는 모발의 성장 인자인 Wnt의 단백질 발현에 미치는 오미자, 산수유, 박하 및 월견자 정유 혼합물의 영향을 알아보기 위하여 western blot을 통해 단백질 발현량을 측정하였다.To investigate the effect of a mixture of essential oils of Schisandra, cornus nutmeg, peppermint and moonshine on the protein expression of Wnt, a hair growth factor that plays an important role in the processes of growth and regeneration, activation of hair follicle stem cells, and cell proliferation in hair follicles. For this purpose, the protein expression level was measured by western blot.
실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물을 처리한 DP cell을 DPBS로 세척한 후, Triton X-100 포함된 RIPA buffer 첨가하여 세포용해하였다. 13,000 rpm, 4℃에서 30분간 원심분리한 후에 상층액을 분리하여 브레드포드법으로 단백질량을 정량하였다. 20~80 ㎍의 동일한 양의 단백질을 변성시키고 10~12% SDS-PAGE에서 전기영동으로 단백질 분리한 후, PVDF membrane으로 이동시킨다. Membrane을 TBS-T로 용해한 5% BSA로 1시간 동안 blocking한 다음, rat polyclonal anti-Wnt, rabbit polyclonal anti-β-actin 항체들을 알맞게 각각 처리하여 12시간 동안 4℃에서 반응시켰다. TBST로 세척한 후에 1차 항체에 알맞은 2차 항체로 실온에서 1시간 동안 처리하여 다시 TBST 세척 후 ECL detection 시약으로 각각의 단백질 밴드들을 관찰 분석하였다. After washing the DP cells treated with the mixture of Schisandra, cornus oil, peppermint and moonshine essential oil of Example 1 with DPBS, RIPA buffer containing Triton X-100 was added to lysate the cells. After centrifugation at 13,000 rpm and 4°C for 30 minutes, the supernatant was separated and the amount of protein was quantified by the Breadford method. After denaturing 20-80 μg of the same amount of protein and separating the protein by electrophoresis on 10-12% SDS-PAGE, it is transferred to a PVDF membrane. Membrane was blocked with 5% BSA dissolved in TBS-T for 1 hour, and then treated with rat polyclonal anti-Wnt and rabbit polyclonal anti-β-actin antibodies appropriately, and reacted at 4° C. for 12 hours. After washing with TBST, it was treated with a secondary antibody suitable for the primary antibody at room temperature for 1 hour. After washing again with TBST, each protein band was observed and analyzed with ECL detection reagent.
그 결과, 도 2에 나타낸 바와 같이, 모발성장인자인 Wnt의 단백질 발현 수준은 각 농도별로 1, 2.5, 5 ㎍/㎖에서 0.66±0.04, 0.78±0.13, 0.90±0.09으로 0.53±0.10인 대조군에 비해 실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물을 처리한 군에서 농도 의존적으로 증가하였다. 또한 양성대조군인 minoxidil이 0.64±0.17로 양성대조군 보다 본 발명의 실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물의 처리군이 더 높게 발현되었다.As a result, as shown in FIG. 2 , the protein expression level of Wnt, a hair growth factor, was 0.66±0.04, 0.78±0.13, and 0.90±0.09 at 1, 2.5, and 5 μg/ml at each concentration, 0.53±0.10 in the control group. In comparison, the concentration-dependent increase in the group treated with Schisandra of Example 1, cornus oil, peppermint, and moonshine essential oil mixture. In addition, minoxidil, a positive control, was 0.64±0.17, which was higher in the group treated with Schisandra, cornus oil, peppermint, and moongrass essential oil mixture of Example 1 of the present invention than in the positive control group.
따라서, 본 발명의 실시예 1의 오미자, 산수유, 박하 및 월견자 정유 혼합물은 각 단독 정유 대비 우수한 모유두세포 증식 촉진 효과 및 모발 성장 효과를 가짐을 확인하였다.Therefore, it was confirmed that the mixture of essential oils of omija, cornus oil, peppermint, and moongyeonja of Example 1 of the present invention had superior dermal papilla cell proliferation promoting effect and hair growth effect compared to each essential oil alone.
이제까지 본 발명에 대하여 그 바람직한 실시예들을 중심으로 살펴보았다. 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자는 본 발명이 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 구현될 수 있음을 이해할 수 있을 것이다. 그러므로 개시된 실시예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 한다. 본 발명의 범위는 전술한 설명이 아니라 특허 청구범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다.So far, with respect to the present invention, the preferred embodiments have been looked at. Those of ordinary skill in the art to which the present invention pertains will understand that the present invention can be implemented in a modified form without departing from the essential characteristics of the present invention. Therefore, the disclosed embodiments are to be considered in an illustrative rather than a restrictive sense. The scope of the present invention is indicated in the claims rather than the foregoing description, and all differences within the scope equivalent thereto should be construed as being included in the present invention.
Claims (9)
산수유 유래 정유;
박하 유래 정유; 및
월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 화장료 조성물.Schisandra-derived essential oil;
essential oil derived from cornus oil;
essential oil derived from peppermint; and
essential oil derived from moonworm; A cosmetic composition for preventing hair loss or promoting hair growth, comprising a.
산수유 유래 정유;
박하 유래 정유; 및
월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 건강식품 조성물.Schisandra-derived essential oil;
essential oil derived from cornus oil;
essential oil derived from peppermint; and
essential oil derived from moonworm; A health food composition for preventing hair loss or promoting hair growth, comprising a.
산수유 유래 정유;
박하 유래 정유; 및
월견자 유래 정유; 를 포함하는 탈모 예방 또는 발모 촉진용 건강기능식품 조성물.Schisandra-derived essential oil;
essential oil derived from cornus oil;
essential oil derived from peppermint; and
essential oil derived from moonworm; A health functional food composition for preventing hair loss or promoting hair growth, comprising a.
산수유 유래 정유;
박하 유래 정유; 및
월견자 유래 정유; 를 포함하는 탈모 예방 또는 치료용 약학적 조성물.Schisandra-derived essential oil;
essential oil derived from cornus oil;
essential oil derived from peppermint; and
essential oil derived from moonworm; A pharmaceutical composition for preventing or treating hair loss comprising a.
상기 오미자 유래 정유, 산수유 유래 정유, 박하 유래 정유 및 월견자 유래 정유는 오미자, 산수유, 박하 및 월견자를 각각 수증기로 증류시켜 수득된 것을 특징으로 하는 조성물.5. The method according to any one of claims 1 to 4,
The composition, characterized in that the omija-derived essential oil, cornus oil-derived essential oil, peppermint-derived essential oil and moongyeonja-derived essential oil is obtained by distilling Schisandra, cornus oil, mint and wolgyeonja with steam, respectively.
상기 화장료는 헤어토닉, 헤어크림, 헤어팩, 헤어로션, 헤어샴푸, 헤어린스, 헤어컨디셔너, 헤어스프레이, 헤어에어졸, 포마드, 분말, 젤, 솔젤, 에멀젼, 오일, 왁스 및 에어졸로 이루어진 모발용 화장료에서 선택되는 것을 특징으로 하는 화장료 조성물.According to claim 1,
The cosmetic is selected from hair cosmetics consisting of hair tonic, hair cream, hair pack, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, sol gel, emulsion, oil, wax and aerosol. A cosmetic composition, characterized in that
상기 건강식품은 각종 드링크제, 육류, 소세지, 빵, 캔디류, 스넥류, 면류, 아이스크림, 유제품, 스프, 이온음료, 음료수, 알코올 음료, 껌, 차 및 비타민 복합제에서 선택되는 것을 특징으로 하는 건강식품 조성물.3. The method of claim 2,
The health food is selected from various drinks, meat, sausage, bread, candy, snacks, noodles, ice cream, dairy products, soup, ionic beverages, beverages, alcoholic beverages, gum, tea, and vitamin complexes. Health food composition, characterized in that.
상기 건강기능식품은 정제, 캡슐제, 환제 또는 액제 형태의 식품인 것을 특징으로 하는 건강기능식품 조성물.4. The method of claim 3,
The health functional food is a health functional food composition, characterized in that the food in the form of tablets, capsules, pills or liquids.
상기 약학적 조성물은 피부 외용제 형태인 것을 특징으로 하는 약학적 조성물.5. The method of claim 4,
The pharmaceutical composition is a pharmaceutical composition, characterized in that it is in the form of an external preparation for the skin.
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| KR100581316B1 (en) * | 2004-09-15 | 2006-05-17 | 김영숙 | Shampoo composition for preventing hair loss and raising hair |
| KR100668878B1 (en) * | 2005-07-29 | 2007-01-12 | 강민용 | Hair growth promoting composition, topical dermatologic drugs for promoting hair growth and the method of the hair growth promoting composition, topical dermatologic drugs for promoting hair growth |
| KR20140115400A (en) | 2013-02-28 | 2014-10-01 | 바이오스펙트럼 주식회사 | Composition of scalp care for prevention of depilation and improvement of hair growth comprising Rhus javanica L. Extracts |
| KR20160069488A (en) | 2014-12-08 | 2016-06-16 | 고려대학교 산학협력단 | Composition for preventing hair loss and promoting hair growth comprising the effective amount of bee venom |
| KR20180110939A (en) * | 2017-03-30 | 2018-10-11 | (주) 벤우코리아 | Composition for preventing hair loss and promoting hair growth comprising plant extract |
| KR20190008739A (en) * | 2017-07-17 | 2019-01-25 | 신두이 | Hair growth composition using food and herbal medicines and manufacturing method thereof |
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| KR100581316B1 (en) * | 2004-09-15 | 2006-05-17 | 김영숙 | Shampoo composition for preventing hair loss and raising hair |
| KR100668878B1 (en) * | 2005-07-29 | 2007-01-12 | 강민용 | Hair growth promoting composition, topical dermatologic drugs for promoting hair growth and the method of the hair growth promoting composition, topical dermatologic drugs for promoting hair growth |
| KR20140115400A (en) | 2013-02-28 | 2014-10-01 | 바이오스펙트럼 주식회사 | Composition of scalp care for prevention of depilation and improvement of hair growth comprising Rhus javanica L. Extracts |
| KR20160069488A (en) | 2014-12-08 | 2016-06-16 | 고려대학교 산학협력단 | Composition for preventing hair loss and promoting hair growth comprising the effective amount of bee venom |
| KR20180110939A (en) * | 2017-03-30 | 2018-10-11 | (주) 벤우코리아 | Composition for preventing hair loss and promoting hair growth comprising plant extract |
| KR20190008739A (en) * | 2017-07-17 | 2019-01-25 | 신두이 | Hair growth composition using food and herbal medicines and manufacturing method thereof |
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