KR100581316B1 - Shampoo composition for preventing hair loss and raising hair - Google Patents

Abstract

The present invention relates to a shampoo composition for hair loss prevention and hair growth, characterized in that it contains a medicinal herb mixture extract to simultaneously satisfy the complex functions such as nutrition, blood flow, local stimulation, anti-inflammatory effect, the shampoo composition of the present invention It is not only safe as hypoallergenic to human body but also shows excellent hair loss prevention and hair growth promoting effect when used continuously.

Hair growth, wool, hair growth, hair loss, shampoo, Chungjaja, saengsonghyang, gukgu, sake, cornus, earthenware, schisandra, baekchul, pine needles, donkey

Description

Shampoo composition for preventing hair loss and raising hair}

1 is a photograph showing the hair and hair growth effect of the herbal medicine mixture extract.

Figure 2 is a comparison of the hair growth effect of the present invention shampoo composition and the existing third-party products, a picture showing the first state after hair removal.

Figure 3 is a comparison of the hair growth effect of the present invention shampoo composition and the existing third-party products, a photograph showing a state after 12 days of depilation.

Figure 4 is a comparison of the hair growth effect of the present invention shampoo composition and the existing third-party products, a photograph showing a state after 31 days of depilation.

The present invention relates to a shampoo composition for promoting hair growth, and more particularly, the present invention relates to hair loss prevention and hair growth promotion containing a mixture of herbal medicine extracts that simultaneously satisfy complex functions such as nutrition supply, blood flow promotion, local stimulation, and anti-inflammatory effect. It relates to a shampoo composition which is effective for.

In general, alopecia refers to a condition in which hair falls off and is genital or lost, and it is also called toxicosis or toxin. A typical example is alopecia areata, and hair loss around 20 to 80 per day is physiological and is not abnormal, but a lot of hair is partially bald and is called alopecia. Alopecia is usually divided into congenital alopecia and acquired alopecia. Congenital alopecia has no cure, and a wig must be used. Among alopecia areata are curable and non-healing. There is no good treatment for alopecia areata or senile alopecia, and alopecia areata can be cured by treating dandruff. Alopecia areata is the major alopecia of modern people. There are various theories about the etiology, such as allergy theory, autonomic dysplasia, and endocrine dysfunction, but there is no decisive factor. In the case of symptomatic alopecia, the cause may be treated by a disease, a pillow or a hat.

In addition, modern people are faced with excessive stress and air pollution, and hair loss is spreading regardless of age and gender due to skin irritation caused by hair products such as ultraviolet rays, sprays, and mousse.

Until now, there is no definite treatment for such alopecia, but wigs and transplants are performed, but there is no fundamental hair loss solution. Although studies on the causes and mechanisms of alopecia have been conducted, wool and hair regrowth agents are commercially available without clear identification.

Some types of hair regrowth include promoting blood circulation or nourishing the hair, promoting metabolism in the hair root, inhibiting reductase, and reducing fat. It is known to have failed. In the world, there are thousands of kinds of hair repellents introduced and marketed, but few products are actually recognized by the Hair Society. So far, the US Food and Drug Administration (FDA) has recognized minoxidil and propecia at the end of 1997. Minoxidil was originally used as a blood pressure lowering agent and was used as a hair regrowth agent because it was found to be hairy in patients using this drug. Applying a skin stimulant called "tretin-in" (Retin-A) first is more effective by increasing absorption. Minoxidil should also be applied for a long time, and if you stop using the drug, there is a problem that the hair root becomes weak and falls out soon. MSD's "Propecia", developed by Merck in the US and marketed in the United States since December 1997, inhibits the action of 5-alpha-reductase and inhibits the production of DHT. For hair loss treatment. Propecia inhibits the production of DHT, and has been shown to reduce the levels of DHT in the scalp and serum by 60% and 70%, respectively, without affecting testosterone, which is involved in male sexual function. However, it has been reported that men may suffer from fertility disorders and unidentified side effects that can occur with long-term use of the drug.

In addition, as a hair loss prevention and hair regrowth agent, many types of hair regrowth originated from oriental medicine such as domestic, China, Japan, etc. have emerged. These hair regrowth agents are known to stimulate hair circulation to prevent hair loss or promote hair growth. Its effects are not proven or extremely low, and sometimes have side effects such as scalp hypersensitivity.

Accordingly, the present inventors have completed the present invention by developing a shampoo type composition having an excellent wool and hair growth promoting effect as well as safe and no side effects in the human body in consideration of various problems of the existing hair regrowth.

Technical problems of the present invention are 15 to 25 parts by weight of Chungjaul, 5 to 15 parts by weight of Gamsong flavor, 3 to 12 parts by weight of Gamguk, 1 to 12 parts by weight of Doin (인 仁) , 10-20 parts by weight of cornus oil, 0.5-5 parts by weight of Tosa, 1-12 parts by weight of Schisandra chinensis, 20-40 parts by weight of Baekchul, pine needles 0.5-10 A shampoo composition containing a medicinal herb mixture extract consisting of 3 parts by weight and 3 parts by weight of Angelica was prepared, and was verified by verifying the wool and hair growth effects of the shampoo composition, and verifying the safety of the shampoo composition.

The present invention relates to a shampoo composition for promoting hair growth, and more specifically, the present invention is to prevent hair loss characterized in that it contains a herbal medicine mixed extract to simultaneously satisfy the complex functions such as nutrition, blood flow, local stimulation, anti-inflammatory effect And it relates to a hair growth promoting shampoo composition.

The present invention is 15 to 25 parts by weight of Chungjaja, 5 to 15 parts by weight of Gamsong-hyang (甘 松香), 3 to 12 parts by weight of persimmon soup, 1 to Doin (桃仁) 12 parts by weight, 10-20 parts by weight of arithmetic oil, 0.5-5 parts by weight of Tosa, 1-12 parts by weight of Schisandra chinensis, 20-40 parts by weight of Baekchul, pine needles (松葉) ) 0.5 to 10 parts by weight and Angelica mixed extract consisting of 3 to 15 parts by weight, characterized in that it contains a conventional solvent, moisturizer, surfactant, stabilizer, solubilizer, preservative, fragrance And a shampoo composition prepared by mixing a colorant and the like.

The herbal medicine mixture extract is preferably contained in 0.5 to 30% by weight in the shampoo composition. If it is included in less than 0.5% by weight and the hair loss prevention and hair growth promoting effect is insufficient, when contained in more than 30% by weight may deteriorate the cleaning power as a shampoo.

The present invention is 15 to 25 parts by weight of Chungjaja, 5 to 15 parts by weight of persimmon scent (甘 松香), 3 to 12 parts by weight of gamguk, 1 to 12 parts by weight of Doin, Sansuyu (山茱萸) 10 ~ 20 parts by weight, 0.5 to 5 parts by weight of Tosa, 1 to 12 parts by weight of Schisandra chinensis, 20 to 40 parts by weight of Baekchul, 0.5 to 10 parts by weight of pine needles and Angelica ) Preparing a herbal medicine mixture extract consisting of 3 to 15 parts by weight; Preparing a shampoo composition for promoting wool and hair growth by mixing the herbal extracts with additives such as conventional solvents, humectants, surfactants, stabilizers, solubilizers, preservatives, fragrances, and colorants; Verifying the wool and hair growth effects of the herbal medicine mixture extract through an experiment; Verifying the wool and hair growth effects of the shampoo composition through comparative experiments with existing products; And testing the irritability of the shampoo composition.

The shampoo composition of the present invention is characterized in that it consists of 10 kinds of herbal extracts, normalizes the scalp and has a very high result on wool and hair growth, not only has a remarkable effect on the prevention of hair loss and hair growth, but also prevents dandruff. . In addition, it contains herbal extracts that are harmless to the human body, so it can be applied to sensitive skin as it does not irritate the scalp even when used daily, and helps to relieve itching.

The hair loss prevention and hair growth promoting effect of the shampoo composition of the present invention can be used safely because it is very excellent compared to the existing products and hypoallergenic to the skin. The method of using the shampoo composition of the present invention is the same as the method of using a normal shampoo, and after foaming the shampoo for effective penetration of the active hair ingredient, massage the scalp for 10-30 seconds lightly and wash off with lukewarm water. Consistent daily use is more effective in preventing wool, hair growth, hair loss and dandruff.

Hereinafter, the present invention will be described in more detail with reference to the following examples, which are intended to illustrate the present invention, and the scope of the present invention is not limited to the embodiments, which will be apparent to those skilled in the art. will be.

Example 1 Preparation of Herbal Medicine Mixed Extract

20.0 kg of Chungulja, 10.0 kg of persimmon scent, 8.7 kg of persimmon soup, 5.4 kg of corn seed oil, 15.0 kg of cornus oil, 2.5 kg of schisandra chinensis, 6.4 kg of Schisandra chinensis, 30.5 kg of white rice bran, 4.7 kg of pine needles and 9.3 kg of Angelica sinensis (111.5 kg ), The medicinal herb mixture was added to 222 L of 95% ethanol, and then dissolved with 9.5 kg of paraoxybenzoic acid methyl and 9.5 kg of paraoxybenzoic acid propyl, and then 800 L of purified water was added and stirred uniformly.

The solution was chilled for 3 days while stirring and circulating once a day for 1 hour. The extract obtained in the same manner as described above was centrifuged, filtered through a microfilter, and put in a container to seal the final product. The extract may be diluted by adding 20% ethanol as needed.

Example 2 Preparation of Shampoo Composition

Ingredients and Contents of Shampoo Compositions face Ingredient Name Action content(%) One Deionic Water solvent 18.88 Guar Hydroxypropyltrimonium Chloride Thickener 0.22 Disodium Ethylenediaminetetraacetate Sediment stabilizer 0.005 PIG-120 Methyl Glucose Dioleate Moisturizing 1.30 Sodium Laureth Sulfate Surfactants 30.00 TEI-cocoyl glutamate Surfactants 4.00 TEI-Lauryl Sulfate Surfactants 5.00 Lauramide DEA Surfactants 4.20 Cocamido propyl betaine Surfactants 13.00 Propylene Glycol Moisturizing 3.00 Aloe Barbadenis Leaf Extract Moisturizing 2.00 PIG-12 Dimethicone Moisturizing 0.30 Iodopropyl Butylcarbamate antiseptic 0.50 Methylloroisothiazolinone and Methylisothiazolinone (1: 1) Anti dandruff 0.05 2 Ethanol solvent 1.00 Creambasol Anti dandruff 0.50 Menthol air freshener 0.30 Salicylic Acid Anti dandruff 0.25 3 Herbal Herbs Extract Hair loss prevention, wool, hair growth promotion 5.00 Polyquatemium-7 Antistatic 2.50 Pine neddle Extract Hair growth 3.00 Hydrolyzed Keratin Moisturizing 0.50 Sodium PCA Moisturizing 0.50 Silicon Emersion Moisturizing 2.00 4 Perfume incense 1.40 Deionic Water solvent 0.15 Color dyes 0.005 5 Lactic Acid PH control 0.40 Sum 100.00

Guar hydroxypropyltrimonium chloride was first dissolved in purified water in phase 1, and then the remaining raw materials were added and dissolved by raising the temperature to 80 ° C. After lowering the temperature of Face 1 to 45 ° C., creambazole, menthol and salicylic acid were dissolved in ethanol and mixed with Face 1. The temperature of the mixed phases 1 and 2 was lowered to 30 ° C., and then the raw materials of phase 3 were added and mixed. The dyes dissolved in purified water were first mixed into the mixed faces 1, 2, 3, and then mixed with flavor. The pH was adjusted to 6.2 by adding lactic acid to give the final product.

Experimental Example 1: Wool and hair growth effect experiment after using the herbal medicine mixed extract

In order to check the wool and hair growth effect of the herbal medicine mixture extract prepared according to Example 1, the hair of the back area is depilated to 7 male mice of 5 weeks old and the herbal medicine mixture extract is applied twice a day to the hair removal site The hair growth effect was then visually observed for 10 days. After depilation, mice coated with 40% ethanol twice a day instead of the herbal mixture extract were used as controls.

The overall treatment effect was determined by comparing the wool and hair growth for 10 days after the start of the experiment with four stages: very improved (++), improved (+), slightly improved (±), and no response (-). Classification was judged. The results are shown in Table 2 below.

subject 3 days later 5 days later 10 days later One -  ± + 2 - + ++ 3  ± + ++ 4  ± + ++ 5  ± + ++ 6 -  ± ++ 7  ± + ++ <Note> ++: very improved, +: improved, ±: slightly improved,-: no response

As shown in Table 2, the mice coated with a mixture of herbal medicines were hair growth at a high speed to the hair removal site, the hair condition was also shiny and very good. This result can also be confirmed in FIG.

Experimental Example 2 Wool and Hair Regrowth Experiment after Use of Shampoo Composition

In order to confirm the wool and hair growth of the shampoo composition containing the herbal medicine mixed extract prepared according to Example 2, 5 weeks old male hair is subjected to hair removal on the back area and the shampoo composition is applied to the hair removal area twice a day. The hair growth effect was then visually observed for 31 days. In order to compare the effects of the shampoo composition of the present invention with the existing products, a mouse (no control), a mouse coated with 40% ethanol, a mouse coated with Dr. mo, a mouse coated with minoxidil, a mouse coated with hair power, The experiment was divided.

The results are shown in FIGS. 2 to 4. 2 is a photograph showing the first state after hair removal, FIG. 3 is a photograph showing a state after 12 days, and FIG. 4 is a photograph showing a state after 31 days. The more white areas in the hair removal area, the slower the hair grows. 2 to 4, it can be confirmed that the mouse coated with the shampoo composition of the present invention has a better hair regrowth effect and a better hair condition than the mouse coated with other conventional products.

Experimental Example 3: Stimulation test of the shampoo composition

In order to determine the degree of skin irritation of the shampoo composition prepared according to Example 2, a skin irritation test using a rabbit was performed. 24 hours before the sample application, rabbits were depilated and divided into treatment and control sections of normal and wound skin. The coating method was applied once to the application site 1g per rabbit. In the untreated control section, sterile physiological saline was applied in the same amount. After coating, the gauze was covered and then covered with a non-permeable, non-reactive solid foil to prevent evaporation of the sample, and fixed with a tape and then applied for 24 hours. After the end of the application time, the application site was lightly washed with saline solution. The appearance, feed and beverage consumption and clinical symptoms were observed daily for one week after application of the sample material.

Evaluation of skin reactions was made using the 'toxicity test criteria' of medicines. In addition, the degree of irritation to the skin was evaluated by the method of calculating the P.I.I. (Primary Irritation Index) of Draize. The results are shown in Table 3 below.

Test Items Result P.I.I. 0.6 (low stimulation) <Note> (no irritation) 0 ←← →→ 5 (strong stimulation)

In addition, by using the shampoo composition prepared according to Example 2 was measured the degree of irritation to the eyes of the rabbit. Nine rabbits were selected and diluted with 0.1 g of the sample diluted to 30 g / l into the ocular mucosa of all nine rabbits' right eyes, and three of them were immersed in sterile physiological saline solution for 30 minutes in both eyes. The liver was washed and the remaining six were not washed. The left eye which did not receive the sample was used as a control. Eye lesions were evaluated in accordance with Article 94-3, 'Toxicity Test Standards for Drugs and Drugs ('94 .4.14)' of the National Institute of Health and Safety. . The results are shown in Table 4 below.

Test Items Result Eye irritation test (T.O.I., Tentative ocular irritation rating) 15.8 (Low Stimulus) <Note> (No Stimulation) 0 ~ 5 ←← →→ 80 ~ 110 (Very Severe Stimulation)

According to the above results, the shampoo composition of the present invention can be confirmed that the product is not only excellent in promoting wool and hair growth, but also very hypoallergenic and safe to use on the skin.

The present invention relates to a shampoo composition for promoting wool and hair growth, characterized in that it contains a medicinal herb mixture extract that simultaneously satisfies complex functions such as nutrition, blood flow, local stimulation, anti-inflammatory effect, the shampoo composition of the present invention When used as an excellent wool and hair growth promoting effect, as well as hypoallergenic safety to the human body, which is a very useful invention for the cosmetic and pharmaceutical industries.

Claims (2)

15 ~ 25 parts by weight of Chungulja, 5 ~ 15 parts by weight of Gamsong incense, 3 ~ 12 parts by weight of Gamguk, 1 ~ 12 parts by weight of Doin, 10 ~ 20 weight of Sansuyu Tofu, 0.5 to 5 parts by weight of Tosa, 1 to 12 parts by weight of Schisandra chinensis, 20 to 40 parts by weight of Baekchul, 0.5 to 10 parts by weight of pine needles, and 3 to Angelica Hair loss prevention and hair growth shampoo composition, characterized in that it comprises a herbal medicine mixed extract consisting of 15 parts by weight. According to claim 1, wherein the medicinal herb mixture extract is characterized in that 0.5 to 30% by weight based on the total weight of the composition for preventing hair loss and hair growth promoting shampoo composition.

Images